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Phenotype: Flightless is an inherited disorder of metabolism in drakes.
Drakes homozygous for the recessive allele (flls/flls) typically exhibit symptoms around the time of maturity.
The disease gets its name, which is misleading, from the tendency of affected drakes to avoid vigorous exercise, such as flying.
Following forced extreme exercise, drakes exhibit obvious distress and have elevated myoglobin in excreted waste, an indication of rhabdomyolysis, the breakdown of muscle fibers.
Biochemically, these drakes exhibit a very low level of basal lipolysis.
Bezafibrate, a commonly used hypolipidemic drug, restores the capacity for normal fatty acid oxidation in muscle cells of affected drakes.
Phenotype Terms:
mortality
metabolism phenotype
skeletal muscle phenotype
behavior/neurological phenotype
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