Home Search Reports Help

Gene Model: Tyrp1

NomenclatureGenomic Location
SymbolTyrp1ChromosomeX
NameTyrosinase-Related Protein 1Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesX: 20 Mbp

Molecular Function

Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.

Molecular Function Terms:

binding
   ion binding
      cation binding
         metal ion binding
   protein binding
      protein dimerization activity
         protein heterodimerization activity

catalytic activity
   oxidoreductase activity
      monooxygenase activity
         monophenol monooxygenase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATCCAGAGTGTTATTATGCACCTATCCATATTACTACTCCTCACCTTTTTTCAAGAAATT
    61 CATGCTCAGTTCCCCCGGCAGTGTGCTACAGTTGCGGCTCTGACAAGCGGTGAATGTTGC
   121 CCAGATCTGTCTCCCGTGGTGATACCCGGTTCAGACCGTTGTGGATCATCTATTGGAAGG
   181 GGTCAATGTGTCCAAGTGATGGCAGACAGTCGGCCCCATGGACCACAGTACATGCATGAT
   241 GGTCAAGATGACCGAGAGCAGTGGCCTCTGCGCTTTTTCAATCGAACCTGTCAATGCAAC
   301 AGAAATTTTTCAGGATATAATTGTGGGTCCTGCCGTCCTGGTTGGAGTGGACCTGCATGT
   361 GATCAGCAGACTCAGACAGTCAGACGAAACATTCTGGATCTGAGTAACGAGGAAAGGAAT
   421 CAATTCCTAAGAGTCCTTCATCAAGCCAAAAACACAGTGCATCCCAACATTGTGATTGCT
   481 ATCCGGAGGCGGGAAGAGATACTGGGTCCTGATGGCAACACACCACAATTCGAAAATGTG
   541 ACAATTTATAATTACTTTGTGTGGTCCCATTACTACTCTGTCAGAAAGACATTCCTTGGC
   601 CCAGGGCTGCCCAGTTTTGGGGGAATAGATTTCTCCCATGAAGGGCCAGCATTTCTCACC
   661 TGGCATAGATACCACCTCCTACAGCTGGAAAAAGATATCCAGGATATGATCCGGGATCCT
   721 TCTTTTGCACTTCCCTACTGGAACTTTGCAACAGGTAGAAACACTTGTGACATCTGTACA
   781 GATGAACTCATGGGAGCTAGAAGCAACTTTGATACCAATCTTCTAAGCCAAAACTCTGTC
   841 TTCTCTCAGTGGCGTGTTTTGTGTGAAAATGTTGATGACTATGACACCTTGGGAACCATA
   901 TGCAACAGCTCAGAAGGGGGTCCAATTAGACGAAACCCAGCTGGAAATGTTGCTCGGCCA
   961 ATGGTGCAGCGCCTTCCTGAGCCACAGGATGTAGCTCTTTGCTTAGAAGTCGGATTGTTT
  1021 GATACACCGCCATTCTATTCAAATTCAACAGACAGTTTTCGCAATTCGCTGGAAGGCTAC
  1081 AGCCAACCTTCTGGAAAGTATGATCCCATAGTACGCAGTCTTCACAACCTGGCCCATCTG
  1141 TTTTTGAATGGCACGGGAGGGCAAACCCATCTCTCGCCAAATGATCCTATCTTTGTTCTC
  1201 CTTCATACCTTTACTGATGCACTTTTTGATGAATGGCTGAGGAGGCACAATACCGATATT
  1261 TCAATATTTCCTCTGGAGAATGCCCCCATTGGACACAACAGACAGTACAACATGGTGCCA
  1321 TTCTGGCCTCCAGTGACCAACAATGAGATGTTTGTTTCAGCACCAGAAAATCTGGGCTAC
  1381 AGTTATGAAGTTCAATGGCCAACTCGGGCCCTCCACATCACTGAGATCATAACTATCGCA
  1441 ATTGTGACAGCCTTGATCCTGGTTGCAATTATATTTGCCGGTGCCACATGCATAGTTCAC
  1501 GCCAGACGGAGGGACGATGAAATTCACCAGCCTCTTCTCAATGAACAATATCAGACCTAC
  1561 TCAGACGATTACGACAGTATACCCACCCCAAGCCAGTCAGTTGTGTGA

Predicted Protein Product
IQSVIMHLSILLLLTFFQEIHAQFPRQCATVAALTSGECCPDLSPVVIPGSDRCGSSIGR
GQCVQVMADSRPHGPQYMHDGQDDREQWPLRFFNRTCQCNRNFSGYNCGSCRPGWSGPAC
DQQTQTVRRNILDLSNEERNQFLRVLHQAKNTVHPNIVIAIRRREEILGPDGNTPQFENV
TIYNYFVWSHYYSVRKTFLGPGLPSFGGIDFSHEGPAFLTWHRYHLLQLEKDIQDMIRDP
SFALPYWNFATGRNTCDICTDELMGARSNFDTNLLSQNSVFSQWRVLCENVDDYDTLGTI
CNSSEGGPIRRNPAGNVARPMVQRLPEPQDVALCLEVGLFDTPPFYSNSTDSFRNSLEGY
SQPSGKYDPIVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDALFDEWLRRHNTDI
SIFPLENAPIGHNRQYNMVPFWPPVTNNEMFVSAPENLGYSYEVQWPTRALHITEIITIA
IVTALILVAIIFAGATCIVHARRRDDEIHQPLLNEQYQTYSDDYDSIPTPSQSVV
Protein Alignment to Mouse
>sp|P07147|TYRP1_MOUSE 5,6-dihydroxyindole-2-carboxylic acid oxidase OS=Mus
            musculus GN=Tyrp1 PE=1 SV=1
      MGI:98881 Tyrp1 tyrosinase-related protein 1 (Chr 4)
        Length = 537

 Score = 2128 (754.2 bits), Expect = 4.6e-221, P = 4.6e-221
 Identities = 368/531 (69%), Positives = 439/531 (82%)

Query:     5 IMHLSILLLLTFFQEIHAQFPRQCATVAALTSGECCPDLSPVVIPGSDRCGSSIGRGQCV 64
             + ++S+ L+L  F ++ AQFPR+CA + AL  G CCPDL P   PG+D CGSS GRG+CV
Sbjct:     9 LAYISLFLML--FYQVWAQFPRECANIEALRRGVCCPDLLPSSGPGTDPCGSSSGRGRCV 66

Query:    65 QVMADSRPHGPQYMHDGQDDREQWPLRFFNRTCQCNRNFSGYNCGSCRPGWSGPACDQQT 124
              V+ADSRPH   Y HDG+DDRE WPLRFFNRTCQCN NFSG+NCG+CRPGW G AC+Q+ 
Sbjct:    67 AVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCNDNFSGHNCGTCRPGWRGAACNQKI 126

Query:   125 QTVRRNILDLSNEERNQFLRVLHQAKNTVHPNIVIAIRRREEILGPDGNTPQFENVTIYN 184
              TVRRN+LDLS EE++ F+R L  AK T HP  VIA RR E+ILGPDGNTPQFEN+++YN
Sbjct:   127 LTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFVIATRRLEDILGPDGNTPQFENISVYN 186

Query:   185 YFVWSHYYSVRKTFLGPGLPSFGGIDFSHEGPAFLTWHRYHLLQLEKDIQDMIRDPSFAL 244
             YFVW+HYYSV+KTFLG G  SFG +DFSHEGPAFLTWHRYHLLQLE+D+Q+M+++PSF+L
Sbjct:   187 YFVWTHYYSVKKTFLGTGQESFGDVDFSHEGPAFLTWHRYHLLQLERDMQEMLQEPSFSL 246

Query:   245 PYWNFATGRNTCDICTDELMGARSNFDTNLLSQNSVFSQWRVLCENVDDYDTLGTICNSS 304
             PYWNFATG+N CD+CTD+LMG+RSNFD+ L+S NSVFSQWRV+CE++++YDTLGT+CNS+
Sbjct:   247 PYWNFATGKNVCDVCTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEEYDTLGTLCNST 306

Query:   305 EGGPIRRNPAGNVARPMVQRLPEPQDVALCLEVGLFDTPPFYSNSTDSFRNSLEGYSQPS 364
             EGGPIRRNPAGNV RP VQRLPEPQDV  CLEV +FDTPPFYSNSTDSFRN++EGYS P+
Sbjct:   307 EGGPIRRNPAGNVGRPAVQRLPEPQDVTQCLEVRVFDTPPFYSNSTDSFRNTVEGYSAPT 366

Query:   365 GKYDPIVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDALFDEWLRRHNTDISIFP 424
             GKYDP VRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDA+FDEWLRR+N DIS FP
Sbjct:   367 GKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFP 426

Query:   425 LENAPIGHNRQYNMVPFWPPVTNNEMFVSAPENLGYSYEVQWPTRALHXXXXXXXXXXXX 484
             LENAPIGHNRQYNMVPFWPPVTN EMFV+AP+NLGY+YEVQWP +               
Sbjct:   427 LENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYAYEVQWPGQEFTVSEIITIAVVAA 486

Query:   485 XXXXXXXFAGATCIVHARRRDDEIHQPLLNEQYQTYSDDYDSIPTPSQSVV 535
                    F  A+C++ +R   +E +QPLL + YQ Y++DY+ +P P+ S+V
Sbjct:   487 LLLVAAIFGVASCLIRSRSTKNEANQPLLTDHYQRYAEDYEELPNPNHSMV 537