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Gene Model: Myo5a

NomenclatureGenomic Location
SymbolMyo5aChromosomeX
NameMyosin VALinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesX: 40 Mbp

Molecular Function

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation.

Molecular Function Terms:

binding
   protein binding
      cytoskeletal protein binding
         actin binding
      protein dimerization activity
         protein heterodimerization activity

catalytic activity
   hydrolase activity
      hydrolase activity, acting on acid anhydrides
         hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
            pyrophosphatase activity
               motor activity

Human Disease Association

Defects in MYO5A are a cause of Griscelli syndrome type 1 (GS1) [MIM:214450]; also known as Griscelli syndrome with primary neurologic impairment. Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, silvery-gray hair and accumulation of melanosomes in melanocytes. GS1 patients show developmental delay, hypotonia and mental retardation, without apparent immune abnormalities.

Defects in MYO5A are a cause of Griscelli syndrome type 3 (GS3) [MIM:609227]. GS3 is characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, silvery-gray hair and accumulation of melanosomes in melanocytes, without other clinical manifestations.

Defects in MYO5A are a cause of Elejalde syndrome (ELEJAS) [MIM:256710]; also known as neuroectodermal melanolysosomal disease. Elejalde syndrome is an autosomal recessive condition characterized by skin hypopigmentation, the presence of large clumps of pigment in hair shafts, silvery-gray hair, accumulation of melanosomes in melanocytes and primary neurological abnormalities. Elejalde syndrome may be the same entity as Griscelli syndrome type 1.

Predicted Transcript
     1 CAGTATGCAAGGATTTGGATACCTGATTCAGAAGTGGTCTGGAAGTCAGCAGAACTTGTG
    61 AAAGATTATAAGCCAGGAGACAAAGTCCTCCATCTTCGACTTGAGGATGGCAAGGATCTT
   121 GAATACAGCCTCGATCCAAAGAAAAAGGATCTGCCACCCTTGCGAAACCCTGATATACTT
   181 GTGGGAGAAAATGACCTGACAGCACTCAGCTATCTCCATGAACCTGCTGTTCTCCATAAC
   241 CTAAAAGTTCGGTTTATAGACTCGAAGCTCATTTACACATATTGTGGCATAGTTTTGGTA
   301 GCTATAAATCCTTACGAACAGCTGCCCATCTATGGCGAAGACATCATCAATGCGTACAGT
   361 GGCCAGAATATGGGGGATATGGACCCCCACATCTTTGCTGTGGCTGAGGAAGCATATAAA
   421 CAGATGGCCAGGTATTTTGGAATTCTGAATGCTGGCTACTCAGCCTACACTATTACTGTT
   481 TTAGAAATCATTTTAAAGTATCTGCTACCTAATTGGCTGTGTTTGGCGCTTTTCGTGACG
   541 GTGCAAATTGAGCAAACTCAAACCCTTTCCGTGTTTTGTTTCCCCCCACAGTCCATTGGG
   601 AACGCCAAAACCACGCGGAATGATAACAGCAGTCGCTTTGGGAAGTACATTGAGATAGGT
   661 TTTGATAAGCGGTATCGAATTACTGGTGCTAACATGAGAACATACCTCCTAGAAAAATCA
   721 AGAGTGGTCTTCCAGGCCGACGAAGAGCGAAATTACCATATCTTTTATCAGCTTTGTGCT
   781 TCTGCAGCAGTGCCGGAATTTAAAACATTGCGGTTAGGCAATGCAGACTATTTTTACTAT
   841 ACAAAGCAAGGGGGCAGCCCAGTGATTGATGGTGTTGATGATGCAAAGGAGATGGCAAAC
   901 ACGAGGCGTGCGTGCACATTGTTAGGGATTGTTGATTCCTGCCAGATGGGAATTTTTCAA
   961 ATCCTTGCTGCTATTCTTCACCTGGGCAATGTAGCATTTCAGTCTCGCGATTCCGACAGC
  1021 TGTGTAATACCACCAAAACACGAACCTCTCAAGATTTTCTGTGACCTCATGGGAGTGGAG
  1081 TATGACCAAATGGCTCACTGGCTCTGCCATAAGAAACTTGCCACTGCCACAGAGACATAC
  1141 ATCAAGCCTATTTCCAAGCTGCAAGCCATCAACGGCAGGGATGCTCTTGCAAAACACATT
  1201 TATGCCAATCTCTTTAACTGGATTGTCGATCACGTGAACAAAGCTCTTTATTCTCCCACG
  1261 AAACAGCATTCGTTTATTGGTGTATTGGACATTTACGGGTTTGAAACATTTGAGATCAAC
  1321 AGCTTTGAACAATTTTGTATCAACTATGCCAATGAGAAACTGCAGCAACAGTTCAATATG
  1381 CATGTATTTAAGCTAGAGCAAGAAGAATATATGAGGGAAGAAATTCCATGGACCTTGATT
  1441 GATTTCTATGACAATCAACCCTGCATTAATCTCATAGAGGCCAAATTGGGAATTTTGGAT
  1501 TTATTAGATGAGGAATGTAAGATGCCTAAAGGTTCAGATAATAGTTGGGCCCAGAAATTA
  1561 TACAATACGCATTTGAACAAGACTTCGCTTTTTGAAAAACCCCGCTTGTCAAACAAGGCC
  1621 TTTATCATCCAACACTTTGCAGATAAGGTAGGGGTTTTCTGTTTCAACAAAATGTGTTTT
  1681 GACCAGAGCCATAGGCCAGGGGTCCCCAAACTAAGGCCCTCCAAGGTCATTGACCTGGCC
  1741 CCTATGGCCTTTGAGGATCACTTTCCTTACCTATGGTCTTCTGATGGCCTGATGAGATCA
  1801 TCTAGATGCCCTTTGAGGGTCCCTTTCCTTACCGATGGTCTTATGAGACCATCTATGACT
  1861 TCAGCACGGGGTCCGCGAATGGTGGGAGTTGCATTCAGAAATTCCCTGCATCTTCTCATG
  1921 GAGACCCTTAATGCCACGACGCCACATTATGTGCGGTGTATTAAACCAAATGACTTCAAG
  1981 ATTCCATTCATGTTTGATGAAAAACGGACTGTGCAGCAGCTCCGGGCTTGCGGTGTGTTG
  2041 GAAACCATCCGAATCAGTGCAGCTGGTTTTCCCTCGAGGTGGACATATCAAGAATTCTTC
  2101 AGCCGCTACCGCGTCCTGATGAAGCAGAAGGACGTTCTCAGTGACAGAAAGCAGACCTGT
  2161 AAAAACGTCTTGGAGAAGCTGATTCTGGACAAGGATAAATACCAGTTTGGGAAGACGAAA
  2221 ATATTTTTCCGGGCTGGCCAGGTGGCTTACATGGAAAAAATAAGGGCGGACAAACTCAGA
  2281 GAGGCTTGCATCCGCATCCAAAAGACCATCAGAGGGTGGCTGTTCAGGAAGAAGTACCTG
  2341 CGCATGCGGAAAGCGGCCATCACGGTTCAAAGATATGTCCGAGGATACCAGGCGCGATGC
  2401 CTTGCCAGCTTTCTTCGGAGAACCAAAGCTGCCACCATTATCCAGAAATTCCGGCGCATG
  2461 TACGCTACACGCAAGCGATACCGTCGCACACGAGCATCCACCGTGGCCCTTCAGTCCTAC
  2521 ATGCGAGGTTATCTTGCCAGGAAGAAGTACCGCAGGATGCTTGAAGAGCACAAGGCCATC
  2581 ATTATCCAGAAGCACGTGCGCGGGTGGCTGAGCCGCAAGCGCTACCAGAAGACCTTGAAG
  2641 GGCATTGTCTACTTGCAATGTTGCTGCCGGCGCATGATAGCCAAGAGGGAGTTGAAGAAG
  2701 CTGAAGATCGAAGCCCGCTCTGTGGAACACTACAAGAAGCTCAACGTTGGCATGGAGAAC
  2761 AAGATCATGCAGCTCCAGCGTAAAATCAATGAGCAGTCAAAAGACTCCAAATCCCTGCTT
  2821 GAGAAACTGACCACTCTTGAGGCAACATACAATTCTGAGACAGAAAAACTGAAGAATGAT
  2881 GTGGAAAGGCTTAGGATGAGTGAAGAAGAGGCCAAGAATGCGACCAACCGGCTCCTTACG
  2941 CTTCAAGATGAGATCAGCAAGCTCCGAAAGGAACTGCACCAGACGCAGATTGCAAAGAAG
  3001 ACCATCGAGGAACAGGCAGATGTATATAAACAGGAGACAGACAAGCTGGTGCTAGAACTT
  3061 ACAGAGCAAAACACCCTGCTTAAAAAAGAAAAAGATGAGCTGAACCATCATATCCAGGAG
  3121 CAGGCCAAAGAGATAACAGAGGTCATGGAGAAAAAGCTTCTTGAGGAGACGAAACAGCTG
  3181 GACCTGGATCTGAATAATGAAAGGCAGCGGTATCAGAACCTCCTCCAAGAGTTTAGTCGG
  3241 TTAGAGGAGCGATACGATGACCTCAAGGATGAGATGAATTTGATGGTGAACATCTCTAAG
  3301 CCTGGACACAAACGAAGAGATTCCACACATAGCAACGAATCCGAAAATACCTATAGCTCT
  3361 GAGATCACTGAACCAGAAGAGCTGCAAATGAGAACAGAGGATGAACCAAGTGAGAAGAAA
  3421 GCTCCACTGGACATGTCTCTCTTCCTCAAGCTTCAAAAACGGGTTTCGGAGCTGGAGCAG
  3481 GAAAAGCAATCCATGCAGGATGAGTTGGACAGGAAAGAAGAACAAGTTCTCCGAGCCAAG
  3541 GCCAAGGAGGAGGAAAGGCCTCAAATGAGAGGTGCTGAGCTGGAATATGAATCACTTAAG
  3601 CGTCAAGAGCTTGAATCAGAAAATAAGAAACTGAAGAATGAGTTGAATGAGCTGAGGAAA
  3661 GCCCTGCTGGAAAAGAGCTCTCCAGATGCAACGGCTCCTGGTGCCCCGGGGTACAGAGTC
  3721 CTCTTGGATCAGATGGCCTCTGTTAGCGAGGAACTAGAAGTGCGCAAGGAGGAAGTCCTC
  3781 ATCTTGAGATCTCAGCTGATGAGCCAGAAGGAGGCAATTCCACCCAAGGATGACAAGAAC
  3841 ACGATGACTGACTCCACAATCCTTTTGGAGGATGTACAGAAGATGAAGGACAAAGGAGAG
  3901 ATAGCTCAGGCGTACATTGGTTTGAAGGAGACAAACAGGCTTCTGGAGTCTCAGCTACAG
  3961 ACTCAGAAAAGGAGCCATGACAATGAATTGGAAGCCCTCCGCGGAGAGATTCAAAGCCTG
  4021 AAGGAGGAAAACAACCGCCAGCAACAGTTGCTGGCACAAAATCTCCAGTTGCCCCCAGAG
  4081 GCCCGGATAGAAGCTAGCTTACAGCACGAGATCACCCGCCTGACGAATGAAAACCTGGAT
  4141 TTGATGGAACAGCTTGAAAAACAGGACAAGACTGTTCGCAAACTGAAAAAGCAACTCAAA
  4201 GTCTTTGCTAAAAAGATTGACGAACTTGAAGTGGGTCAGATGGAGAACATTTCGCCTGGA
  4261 CAAATAATCGACGAGCCGATCCATCCTGTGAATATTCCAAGGAAAGAAAAAGACTTCCAG
  4321 GGAATGTTGGAGTATAAGAGAGAGGATGAGCCCAAACTCATCAAGAACCTTATTTTAGAA
  4381 CTGAAACCACGTGGTGTTGCAGTCAATCTCATCCCAGGATTGCCTGCTTATATTCTGTTC
  4441 ATGTGCGTCCGCCATGCAGACTATGTTAATGATGATCAAAAAGTGAGGTCCTTGCTGACT
  4501 TCCACGATTAATGGCATCAAGAAAATTTTGAAGAAAAGAGGTGATGACTTTGAAGCGGTT
  4561 TCCTTCTGGCTGTCTAACACGTGCCGATTTTTGCACTGTTTGAAGCAGTACAGTGGCGAA
  4621 GAGGCAAGTTTTGGGTTTATGAAGCACAACACGCCTCGTCAAAATGAACACTGCCTCCAC
  4681 AATTTTGACCTTGCCGAATACAGGCAAGTGCTGAGTGATTTGGCCATTCAGATTTATCAG
  4741 CAGCTTGTAAGAGTGTTGGAGAATATTCTTCAGCCAATGATTGTTTCAGGGATGTTGGAA
  4801 CACGAAACTATCCAAGGGGTCTCGGGCGTAAAACCAACCGGCCTCCGAAAGAGAACCTCC
  4861 AGCATTGCTGATGAAGGGACATACACACTAGACTCTATCATTCGGCAACAGAACACTTTC
  4921 CACTCCATCATGTGTCAACATGGGATGGATCCAGAACTGATCAAACAGGTGGTCAAGCAG
  4981 ATGTTTTACATCATTGGGGCTGTGACCCTCAACAACCTCCTCCTGCGAAAAGACATGTGC
  5041 TCCTGGAGTAAAGGGATGCAGATAAGGTACAATGTAAGTCAGCTTGAAGAATGGCTTCGG
  5101 GACAAAAACCTGATGAATAGTGGTGCTAAGGAAACTCTGGAGCCCCTTATCCAGGCAGCA
  5161 CAGTTGTTGCAAGTGAAAAAGAAGACGGATGAAGATGCAGAGGCCATTTGCTGCATGTGC
  5221 AATGCCTTAACTACTGCACAGATTGTTAAAGTTTTGAACTTGTATACTCCAGTTAATGAG
  5281 TTTGAAGAAAGAGTGTCTGTGTCCTTCATCCGGACGATACAGCTGCGTATGAGAGACCGG
  5341 AAAGACTCTCCTCAACTGCTGATGGATGCTAAGCATATTTTCCCCGTTACTTTCCCATTT
  5401 AATCCCTCATCCCTTGCATTAGAAACCATCCAGATCCCAGCAAGTTTGGGTCTAGGATTC
  5461 ATCACTCGTGTCTGA

Predicted Protein Product
QYARIWIPDSEVVWKSAELVKDYKPGDKVLHLRLEDGKDLEYSLDPKKKDLPPLRNPDIL
VGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYS
GQNMGDMDPHIFAVAEEAYKQMARYFGILNAGYSAYTITVLEIILKYLLPNWLCLALFVT
VQIEQTQTLSVFCFPPQSIGNAKTTRNDNSSRFGKYIEIGFDKRYRITGANMRTYLLEKS
RVVFQADEERNYHIFYQLCASAAVPEFKTLRLGNADYFYYTKQGGSPVIDGVDDAKEMAN
TRRACTLLGIVDSCQMGIFQILAAILHLGNVAFQSRDSDSCVIPPKHEPLKIFCDLMGVE
YDQMAHWLCHKKLATATETYIKPISKLQAINGRDALAKHIYANLFNWIVDHVNKALYSPT
KQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMREEIPWTLI
DFYDNQPCINLIEAKLGILDLLDEECKMPKGSDNSWAQKLYNTHLNKTSLFEKPRLSNKA
FIIQHFADKVGVFCFNKMCFDQSHRPGVPKLRPSKVIDLAPMAFEDHFPYLWSSDGLMRS
SRCPLRVPFLTDGLMRPSMTSARGPRMVGVAFRNSLHLLMETLNATTPHYVRCIKPNDFK
IPFMFDEKRTVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQTC
KNVLEKLILDKDKYQFGKTKIFFRAGQVAYMEKIRADKLREACIRIQKTIRGWLFRKKYL
RMRKAAITVQRYVRGYQARCLASFLRRTKAATIIQKFRRMYATRKRYRRTRASTVALQSY
MRGYLARKKYRRMLEEHKAIIIQKHVRGWLSRKRYQKTLKGIVYLQCCCRRMIAKRELKK
LKIEARSVEHYKKLNVGMENKIMQLQRKINEQSKDSKSLLEKLTTLEATYNSETEKLKND
VERLRMSEEEAKNATNRLLTLQDEISKLRKELHQTQIAKKTIEEQADVYKQETDKLVLEL
TEQNTLLKKEKDELNHHIQEQAKEITEVMEKKLLEETKQLDLDLNNERQRYQNLLQEFSR
LEERYDDLKDEMNLMVNISKPGHKRRDSTHSNESENTYSSEITEPEELQMRTEEPSEKKA
PLDMSLFLKLQKRVSELEQEKQSMQDELDRKEEQVLRAKAKEEERPQMRGAELEYESLKR
QELESENKKLKNELNELRKALLEKSSPDATAPGAPGYRVLLDQMASVSEELEVRKEEVLI
LRSQLMSQKEAIPPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRLLESQLQT
QKRSHDNELEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASLQHEITRLTNENLDL
MEQLEKQDKTVRKLKKQLKVFAKKIDELEVGQMENISPGQIIDEPIHPVNIPRKEKDFQG
MLEYKREDEPKLIKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYVNDDQKVRSLLTS
TINGIKKILKKRGDDFEAVSFWLSNTCRFLHCLKQYSGEEASFGFMKHNTPRQNEHCLHN
FDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSS
IADEGTYTLDSIIRQQNTFHSIMCQHGMDPELIKQVVKQMFYIIGAVTLNNLLLRKDMCS
WSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDEDAEAICCMCN
ALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQLRMRDRKDSPQLLMDAKHIFPVTFPFN
PSSLALETIQIPASLGLGFITRV
Protein Alignment to Mouse
>sp|Q99104|MYO5A_MOUSE Myosin-Va OS=Mus musculus GN=Myo5a PE=1 SV=1
      MGI:105976 Myo5a myosin VA (Chr 9)
        Length = 1853

 Score = 5265 (1858.4 bits), Expect = 0., P = 0.
 Identities = 1047/1399 (74%), Positives = 1163/1399 (83%)

Query:     1 QYARIWIPDSEVVWKSAELVKDYKPGDKVLHLRLEDGKDLEYSLDPKKKDLPPLRNPDIL 60
             ++AR+WIPD E VWKSAEL+KDYKPGDKVL L LE+GKDLEY LDPK  +LP LRNPDIL
Sbjct:     9 KFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYRLDPKTGELPHLRNPDIL 68

Query:    61 VGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYS 120
             VGENDLTALSYLHEPAVLHNL+VRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYS
Sbjct:    69 VGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYS 128

Query:   121 GQNMGDMDPHIFAVAEEAYKQMAR---YFGILNAGYSAYTITVLEIILKYLLPNWLCLAL 177
             GQNMGDMDPHIFAVAEEAYKQMAR      I+ +G S    TV     KY +  +  ++ 
Sbjct:   129 GQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSA---KYAMRYFATVSG 185

Query:   178 FVT-VQIEQTQTLSVFCFPP--QSIGNAKTTRNDNSSRFGKYIEIGFDKRYRITGANMRT 234
               +   +E+     V    P  +SIGNAKTTRNDNSSRFGKYIEIGFDKRYRI GANMRT
Sbjct:   186 SASEANVEE----KVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRT 241

Query:   235 YLLEKSRVVFQADEERNYHIFYQLCASAAVPEFKTLRLGNADYFYYTKQGGSPVIDGVDD 294
             YLLEKSRVVFQA+EERNYHIFYQLCASA +PEFK LRLGNAD F+YTKQGGSP+I+GVDD
Sbjct:   242 YLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADSFHYTKQGGSPMIEGVDD 301

Query:   295 AKEMANTRRACTLLGIVDSCQMGIFQILAAILHLGNVAFQSRDSDSCVIPPKHEPLKIFC 354
             AKEMA+TR+ACTLLGI +S QMGIF+ILA ILHLGNV F SRDSDSC IPPKHEPL IFC
Sbjct:   302 AKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHEPLTIFC 361

Query:   355 DLMGVEYDQMAHWLCHKKLATATETYIKPISKLQAINGRDALAKHIYANLFNWIVDHVNK 414
             DLMGV+Y++M HWLCH+KLATATETYIKPISKLQA N RDALAKHIYA LFNWIVDHVN+
Sbjct:   362 DLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVDHVNQ 421

Query:   415 ALYSPTKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMREE 474
             AL+S  KQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYM+E+
Sbjct:   422 ALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQ 481

Query:   475 IPWTLIDFYDNQPCINLIEAKLGILDLLDEECKMPKGSDNSWAQKLYNTHLNKTSLFEKP 534
             IPWTLIDFYDNQPCINLIE+KLGILDLLDEECKMPKG+D++WAQKLYNTHLNK +LFEKP
Sbjct:   482 IPWTLIDFYDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKP 541

Query:   535 RLSNKAFIIQHFADKVGVFC--FNKMCFDQSHRPGVPKLRPSKVIDLAPMAFEDHFPYLW 592
             R+SNKAFII+HFADKV   C  F +   D      +  L+ SK   + P  F+D    + 
Sbjct:   542 RMSNKAFIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSK-FKMLPELFQDDEKAI- 599

Query:   593 SSDGLMRSSRCPL-RVPFL-TDGLMRPSMTSARGPRMVGVAFRNSLHLLMETLNATTPHY 650
             S      S R PL RVP   T G  RP  T+    + VG  FRNSLHLLMETLNATTPHY
Sbjct:   600 SPTSATSSGRTPLTRVPVKPTKG--RPGQTAKEHKKTVGHQFRNSLHLLMETLNATTPHY 657

Query:   651 VRCIKPNDFKIPFMFDEKRTVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQK 710
             VRCIKPNDFK PF FDEKR VQQLRACGVLETIRISA GFPSRWTYQEFFSRYRVLMKQK
Sbjct:   658 VRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISARGFPSRWTYQEFFSRYRVLMKQK 717

Query:   711 DVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYMEKIRADKLREACIRIQKTI 770
             DVL DRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAY+EK+RADKLR ACIRIQKTI
Sbjct:   718 DVLGDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTI 777

Query:   771 RGWLFRKKYLRMRKAAITVQRYVRGYQARCLASFLRRTKAATIIQKFXXXXXXXXXXXXX 830
             RGWL RK+YL M++AAITVQRYVRGYQARC A FLRRTKAAT IQK+             
Sbjct:   778 RGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRRYKIR 837

Query:   831 XXSTVALQSYMRGYLARKKYRRMLEEHKAIIIQKHVRGWLSRKRYQKTLKGIVYLQCCCR 890
               +T+ +QSY+RGYL R +YR++L E+KA+IIQK VRGWL+R  Y++T+K IVYLQCC R
Sbjct:   838 RAATIVIQSYLRGYLTRNRYRKILREYKAVIIQKRVRGWLARTHYKRTMKAIVYLQCCFR 897

Query:   891 RMIAKRELKKLKIEARSVEHYKKLNVGMENKIMQLQRKINEQSKDSKSLLEKLTTLEATY 950
             RM+AKR++KKLKIEARSVE YKKL++GMENKIMQLQRK++EQ+KD K L+EKLT LE  Y
Sbjct:   898 RMMAKRDVKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVY 957

Query:   951 NSETEKLKNDVERLRMSEEEAKNATNRLLTLQDEISKLRKELHQTQIAKKTIEEQADVYK 1010
             NSETEKL+NDVERL++SEEEAK AT R+L+LQ+EI+KLRK+L QT+  KK+IEE+AD YK
Sbjct:   958 NSETEKLRNDVERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKSIEERADKYK 1017

Query:  1011 QETDKLVLELTEQNTLLKKEKDELNHHIQEQAKEITEVMEKKLLEETKQLDLDLNNERQR 1070
             QETD+LV  L E+NTLLK+EK+ LNH I EQAKE+TE ME+KL+EETKQL+LDLN+ER R
Sbjct:  1018 QETDQLVSNLKEENTLLKQEKETLNHRIVEQAKEMTETMERKLVEETKQLELDLNDERLR 1077

Query:  1071 YQNLLQEFSRLEERYDDLKDEMNLMVNISKPGHKRRDSTHS-NESENTYSSEITEPEELQ 1129
             YQNLL EFSRLEERYDDLK+EM LM+N+ KPGHKR DSTHS NESE T+SSE  E E++ 
Sbjct:  1078 YQNLLNEFSRLEERYDDLKEEMTLMLNVPKPGHKRTDSTHSSNESEYTFSSEFAETEDIA 1137

Query:  1130 MRTEEPSEKKAPLDMSLFLKLQKRVSELEQEKQSMQDELDRKEEQVLRAKAKEEERPQMR 1189
              RTEEP EKK PLDMSLFLKLQKRV+ELEQEKQ MQDELDRKEEQV R+KAKEEERPQ+R
Sbjct:  1138 PRTEEPIEKKVPLDMSLFLKLQKRVTELEQEKQLMQDELDRKEEQVFRSKAKEEERPQIR 1197

Query:  1190 GAELEYESLKRQXXXXXXXXXXXXXXXXXXXXXXXSSPDATAPGAPGYRVLLDQMASVSE 1249
             GAELEYESLKRQ                       S+P+ TAPGAP YRVL++Q+ SVSE
Sbjct:  1198 GAELEYESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSE 1257

Query:  1250 ELEVRKEEVLILRSQLMSQKEAIPPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKE 1309
             EL+VRKEEVLILRSQL+SQKEAI PKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKE
Sbjct:  1258 ELDVRKEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKE 1317

Query:  1310 TNRLLESQLQTQKRSHDNELEALRGEIQSLKEEXXXXXXXXXXXXXXPPEARIEASLQHE 1369
             TNRLLESQLQ+QKRSH+NE EALRGEIQSLKEE              PPEARIEASLQHE
Sbjct:  1318 TNRLLESQLQSQKRSHENEAEALRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASLQHE 1377

Query:  1370 ITRLTNENLDLMEQLEKQD 1388
             ITRLTNENL   E+L   D
Sbjct:  1378 ITRLTNENL-YFEELYADD 1395