| Nomenclature | Genomic Location |
| Symbol | Dll3 | Chromosome | 1 |
| Name | Delta-like 3 | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | 1: 10 Mbp |
| Molecular Function |
|
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway.
Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Molecular Function Terms:
binding
protein binding
receptor binding
Notch binding
|
| Human Disease Association |
|
Defects in DLL3 are the cause of spondylocostal dysostosis type 1 (SCDO1) [MIM:277300]. An autosomal
recessive condition of variable severity associated with vertebral and rib segmentation defects. The main
skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib
malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural
consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants
frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening
complications in the first year of life.
|
1 GCTGGTGTGTTTGAACTCCAGATCCACTCCTTCACCACAAGCAGCCCCCGAAACCTATGC
61 CACGGGGTCCGCCCCTGCCGCATCTTCTTCCGCGTCTGCCTCAAACATGCCCAAGCCGTG
121 GTGTCCCCGGAGCCCCCTTGCACCTTCGGGGCAGCCCTTAGCGATATCGTCCCTGCGGAC
181 CGCAACACAGTGGCCACCAGCACACCCATCCGGGTCCCCTTCCATTTCAAGTGGCCGGGG
241 ACATTTTCCCTCATTATTGAATCCTGGAGGGCTGAGTCAGGGGAGCCATCAACAGAGGAT
301 GCCCAGAGGCTGATCAGCCGCTTGGCCACCCGCCGCCGCCTGGCCGTCGGTGAAGACTGG
361 TCGCAAGATGTGCAACTGGGAGACCAGAGCGAGCTGCGCTACTCCTACCATGTCACCTGC
421 GACGAGCACTACTATGGGGAGAGCTGCTCGGACTATTGCCGGCCGCGGGACGATACCTTT
481 GGGCACTACAGCTGTGACGAACTGGGCAGCCGGATCTGCTTAGCAGGGTGGCGGGGCGAA
541 TATTGCTCCGAGCCTGTTTGTTTGCCCGGCTGCAGCCACAGCCACGGGTTCTGCGAGAAG
601 CCCGGTGAGTGCAAGTGCCGCATCGGCTGGCAGGGCCCCCTCTGCGATGCCTGCGTCCGC
661 TACCCGGGCTGCCTCCACGGGACCTGCGCCCAGCCCTGGCAGTGCAACTGTCGGGAAGGC
721 TGGGGCGGGCTCTTCTGCAACCAGGACCTCAACTATTGCACCAACCACCGTCCCTGCAAG
781 AACGGGGCCACCTGCACCAACACGGGCCAAGGGAGCTACACCTGCGGCTGCCGGGCTGGC
841 TTTGCGGGCACCAGCTGCGAGATGGAGATCAATGAGTGCGACAGCAACCCCTGCAAGAAC
901 GGAGGCAGCTGCAACGACCTGGAGAATGACTACAAATGCACCTGTCCTCAAGGCTTCTAC
961 GGCAAGAATTGTGAAATCAGTGCCATGACCTGCGCTGACGGACCGTGTTTCAATGGCGGG
1021 ACTTGCATTGAGAAGCACTTGGGTGGCTACAGTTGTCACTGCCCAGTCAACTACCATGGC
1081 TCCAATTGCGAGAAGAAGATAGACCGATGTAGTAACAACCCTTGCTTGAACAACGGCCAC
1141 TGTCTGGATCTGGGCCGCAGCATGATCTGCAAATGCCGCCCGGGCTTCGTTGGCTCCTTC
1201 TGTGAGCTGAACATCGACGACTGCGCGGGCAACCCATGTGCCAATGGAGGCACCTGCATT
1261 GATGGTCCAAACAGCTACACCTGTTCTTGCACATTGGGCTACGGTGGGAAGGACTGCAGC
1321 ACCCGCATGGATGCCTGTGGCTCCAGCCCCTGCTTGAACAGCGGCACTTGCTATACCCAC
1381 TTCTCCGGCCACGTCTGCGAGTGTTCGGCAGGCTACATGGGTTCCAACTGTGAATTCAAA
1441 GTTCAGATCCCAACCCCTGTTAGCAGCCAACGGGTGGCCGAAAGCCCTTTCCCTGTTGCA
1501 CTAGCTGTTTCCTTTACTCTGGGCCTCATGATGTTGGTGCTTGCCGCCTGTGCCACCGCA
1561 GCAATGCTTCGGCACATGAGG
| Predicted Protein Product |
AGVFELQIHSFTTSSPRNLCHGVRPCRIFFRVCLKHAQAVVSPEPPCTFGAALSDIVPAD
RNTVATSTPIRVPFHFKWPGTFSLIIESWRAESGEPSTEDAQRLISRLATRRRLAVGEDW
SQDVQLGDQSELRYSYHVTCDEHYYGESCSDYCRPRDDTFGHYSCDELGSRICLAGWRGE
YCSEPVCLPGCSHSHGFCEKPGECKCRIGWQGPLCDACVRYPGCLHGTCAQPWQCNCREG
WGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDSNPCKN
GGSCNDLENDYKCTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYSCHCPVNYHG
SNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCANGGTCI
DGPNSYTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYMGSNCEFK
VQIPTPVSSQRVAESPFPVALAVSFTLGLMMLVLAACATAAMLRHMR
| Protein Alignment to Mouse |
tr|Q7TQ52|Q7TQ52_MOUSE Transmembrane receptor Notch1 B OS=Mus musculus
GN=Notch1 PE=2 SV=1
MGI:1096877 Dll3 delta-like 3 (Drosophila) (Chr 7)
Length = 2516
Score = 697 (250.4 bits), Expect = 9.5e-68, P = 9.5e-68
Identities = 141/360 (39%), Positives = 195/360 (54%)
Query: 139 TCDEHYYGESCS---DYCRPRDDTFGHYS-C-DELGSRIC--LAGWRGEYCSEPV--CLP 189
TC Y G +CS D C + H C + LGS C L G+ G C V C+
Sbjct: 384 TCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECIS 443
Query: 190 GCSHSHGFC-EKPGE--CKCRIGWQGPLC----DACVRYPGCLH-GTCAQP---WQCNCR 238
+ C ++ GE C C G++G C D C P CLH G C +QC C
Sbjct: 444 NPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSP-CLHNGHCMDKINEFQCQCP 502
Query: 239 EGWGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDSNPC 298
+G+ G C D++ C + PCKNGA C + G +YTC C G+ GT CE++I+ECD +PC
Sbjct: 503 KGFNGHLCQYDVDECAS-TPCKNGAKCLD-GPNTYTCVCTEGYTGTHCEVDIDECDPDPC 560
Query: 299 KNGGSCNDLENDYKCTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYSCHCPVNY 358
+ GSC D + C C G+ G +CE + C PC +GGTC ++ Y C C
Sbjct: 561 -HYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRD-NSYLCLCLKGT 618
Query: 359 HGSNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCANGGT 418
G NCE +D C++NPC ++G CLD C C PG+ GS C +NID+CAG+PC NGGT
Sbjct: 619 TGPNCEINLDDCASNPC-DSGTCLDKIDGYECACEPGYTGSMCNVNIDECAGSPCHNGGT 677
Query: 419 CIDGPNSYTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYMGSNCE 478
C DG +TC C GY C + ++ C S+PC++ G C +G+ C+C+ G+ G+NC+
Sbjct: 678 CEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIH-GACRDGLNGYKCDCAPGWSGTNCD 736
Score = 666 (239.5 bits), Expect = 1.9e-64, P = 1.9e-64
Identities = 130/376 (34%), Positives = 189/376 (50%)
Query: 136 YHVTCDEHYYGESC---SDYCRPRDDTFGHYSCDELGSRI---CLAGWRGEYCSEPV--C 187
Y C + G +C ++ C G +C ++ S C G+ G C + C
Sbjct: 722 YKCDCAPGWSGTNCDINNNECESNPCVNGG-TCKDMTSGYVCTCREGFSGPNCQTNINEC 780
Query: 188 LPGCSHSHGFC--EKPG-ECKCRIGWQGPLCDA----CVRYPGCLHGTCAQP-----WQC 235
+ G C + G +C C + + G C+ C P G C + + C
Sbjct: 781 ASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSC 840
Query: 236 NCREGWGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDS 295
C GW G C D+N C PC++GA+C NT GSY C C+AG+ G +CE +I++C
Sbjct: 841 VCPTGWQGQTCEVDINECVKS-PCRHGASCQNTN-GSYRCLCQAGYTGRNCESDIDDCRP 898
Query: 296 NPCKNGGSCNDLENDYKCTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYSCHCP 355
NPC NGGSC D N C C GF G CE CA PC NG C + + Y+C CP
Sbjct: 899 NPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDC-VDSYTCTCP 957
Query: 356 VNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCAN 415
V ++G +CE C+ + C N G C+D S C C PGF GS+C+ ++++C PC +
Sbjct: 958 VGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPCLH 1017
Query: 416 GGTCIDGPNSYTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYMGS 475
GGTC D +Y C+C GY G +C + C S+PC N G C+ + + CEC +G+ G
Sbjct: 1018 GGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSGWTGV 1077
Query: 476 NCEFKVQIPTPVSSQR 491
NC+ + + V++Q+
Sbjct: 1078 NCDV-LSVSCEVAAQK 1092
Score = 662 (238.1 bits), Expect = 5.0e-64, P = 5.0e-64
Identities = 133/368 (36%), Positives = 177/368 (48%)
Query: 136 YHVTCDEHYYGESCS---DYCRPRDDTFGHYSCDELGSRICLAGWRGEYCSEPVCLPG-- 190
Y C+ Y G C+ D C G D + C E +P CL
Sbjct: 647 YECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCP---EGYHDPTCLSEVN 703
Query: 191 -CSHS---HGFCEKP--G-ECKCRIGWQGPLCDA----CVRYPGCLHG-TC---AQPWQC 235
C+ + HG C G +C C GW G CD C P C++G TC + C
Sbjct: 704 ECNSNPCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNP-CVNGGTCKDMTSGYVC 762
Query: 236 NCREGWGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDS 295
CREG+ G C ++N C ++ PC N TC + G Y C C + G +CE+ + C +
Sbjct: 763 TCREGFSGPNCQTNINECASN-PCLNQGTCIDDVAG-YKCNCPLPYTGATCEVVLAPCAT 820
Query: 296 NPCKNGGSCNDLEN--DYKCTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYSCH 353
+PCKN G C + E+ + C CP G+ G+ CE+ C PC +G +C + G Y C
Sbjct: 821 SPCKNSGVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTN-GSYRCL 879
Query: 354 CPVNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPC 413
C Y G NCE ID C NPC N G C D + C C PGF G+FCE +I++CA NPC
Sbjct: 880 CQAGYTGRNCESDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPC 939
Query: 414 ANGGTCIDGPNSYTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYM 473
NG C D +SYTC+C +G+ G C C S C N GTC + C C G+
Sbjct: 940 QNGANCTDCVDSYTCTCPVGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFT 999
Query: 474 GSNCEFKV 481
GS C++ V
Sbjct: 1000 GSYCQYDV 1007
Score = 656 (236.0 bits), Expect = 2.2e-63, P = 2.2e-63
Identities = 123/339 (36%), Positives = 180/339 (53%)
Query: 158 DTFGHYSCDELGSRICLAGWRGEYCSEPV--CLPGCSHSHGFC-EKPGE--CKCRIGWQG 212
+T G Y+C +C+ GW GE CSE + C C ++ C+C G G
Sbjct: 299 NTHGGYNC------VCVNGWTGEDCSENIDDCASAACFQGATCHDRVASFYCECPHGRTG 352
Query: 213 PLC---DACVRYPGCLHGT-C-AQPWQ----CNCREGWGGLFCNQDLNYCT-NHRPCKNG 262
LC DAC+ P C G+ C P C C G+ G C+QD++ C PC++
Sbjct: 353 LLCHLNDACISNP-CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGANPCEHA 411
Query: 263 ATCTNTGQGSYTCGCRAGFAGTSCEMEINECDSNPCKNGGSCNDLENDYKCTCPQGFYGK 322
C NT GS+ C C G+ G CE+++NEC SNPC+N +C D +++C C G+ G
Sbjct: 412 GKCLNT-LGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGV 470
Query: 323 NCEISAMTCADGPCFNGGTCIEKHLGGYSCHCPVNYHGSNCEKKIDRCSNNPCLNNGHCL 382
CEI+ CA PC + G C++K + + C CP ++G C+ +D C++ PC N CL
Sbjct: 471 YCEINTDECASSPCLHNGHCMDK-INEFQCQCPKGFNGHLCQYDVDECASTPCKNGAKCL 529
Query: 383 DLGRSMICKCRPGFVGSFCELNIDDCAGNPCANGGTCIDGPNSYTCSCTLGYGGKDCSTR 442
D + C C G+ G+ CE++ID+C +PC + G+C DG ++TC C GY G C T
Sbjct: 530 DGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCQPGYTGHHCETN 588
Query: 443 MDACGSSPCLNSGTCYTHFSGHVCECSAGYMGSNCEFKV 481
++ C S PC + GTC + ++C C G G NCE +
Sbjct: 589 INECHSQPCRHGGTCQDRDNSYLCLCLKGTTGPNCEINL 627
Score = 654 (235.3 bits), Expect = 3.5e-63, P = 3.5e-63
Identities = 122/327 (37%), Positives = 165/327 (50%)
Query: 173 CLAGWRGEYCSEPV--C--LPGCSHSHGFCEKP--G-ECKCRIGWQGPLC----DACVRY 221
C W G+YC+E V C +P + G C G C C GW G C D C
Sbjct: 268 CPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCAS- 326
Query: 222 PGCLHG-TC---AQPWQCNCREGWGGLFCNQDLNYCTNHRPCKNGATC-TNTGQGSYTCG 276
C G TC + C C G GL C+ LN PC G+ C TN G C
Sbjct: 327 AACFQGATCHDRVASFYCECPHGRTGLLCH--LNDACISNPCNEGSNCDTNPVNGKAICT 384
Query: 277 CRAGFAGTSCEMEINEC--DSNPCKNGGSCNDLENDYKCTCPQGFYGKNCEISAMTCADG 334
C +G+ G +C +++EC +NPC++ G C + ++C C QG+ G CEI C
Sbjct: 385 CPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISN 444
Query: 335 PCFNGGTCIEKHLGGYSCHCPVNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRP 394
PC N TC+++ +G + C C Y G CE D C+++PCL+NGHC+D C+C
Sbjct: 445 PCQNDATCLDQ-IGEFQCICMPGYEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPK 503
Query: 395 GFVGSFCELNIDDCAGNPCANGGTCIDGPNSYTCSCTLGYGGKDCSTRMDACGSSPCLNS 454
GF G C+ ++D+CA PC NG C+DGPN+YTC CT GY G C +D C PC +
Sbjct: 504 GFNGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HY 562
Query: 455 GTCYTHFSGHVCECSAGYMGSNCEFKV 481
G+C + C C GY G +CE +
Sbjct: 563 GSCKDGVATFTCLCQPGYTGHHCETNI 589
Score = 651 (234.2 bits), Expect = 7.4e-63, P = 7.4e-63
Identities = 133/365 (36%), Positives = 181/365 (49%)
Query: 135 SYHVTCDEHYYGESCS---DYCRPRDDTFGHYSC-DELGSRICLA--GWRGEYCSEPV-- 186
+Y C E Y G C D C P +G SC D + + CL G+ G +C +
Sbjct: 534 TYTCVCTEGYTGTHCEVDIDECDPDPCHYG--SCKDGVATFTCLCQPGYTGHHCETNINE 591
Query: 187 C-LPGCSHSHGFCEKPGE---CKCRIGWQGPLC----DACVRYPGCLHGTCAQP---WQC 235
C C H G C+ C C G GP C D C P C GTC ++C
Sbjct: 592 CHSQPCRHG-GTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNP-CDSGTCLDKIDGYEC 649
Query: 236 NCREGWGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDS 295
C G+ G CN +++ C PC NG TC + G +TC C G+ +C E+NEC+S
Sbjct: 650 ACEPGYTGSMCNVNIDECAGS-PCHNGGTCED-GIAGFTCRCPEGYHDPTCLSEVNECNS 707
Query: 296 NPCKNGGSCNDLENDYKCTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYSCHCP 355
NPC +G +C D N YKC C G+ G NC+I+ C PC NGGTC + GY C C
Sbjct: 708 NPCIHG-ACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDM-TSGYVCTCR 765
Query: 356 VNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCAN 415
+ G NC+ I+ C++NPCLN G C+D C C + G+ CE+ + CA +PC N
Sbjct: 766 EGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKN 825
Query: 416 GGTCIDGPN--SYTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYM 473
G C + + S++C C G+ G+ C ++ C SPC + +C + C C AGY
Sbjct: 826 SGVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYT 885
Query: 474 GSNCE 478
G NCE
Sbjct: 886 GRNCE 890
Score = 638 (229.6 bits), Expect = 1.8e-61, P = 1.8e-61
Identities = 133/367 (36%), Positives = 181/367 (49%)
Query: 136 YHVTCDEHYYGESCS---DYCRPRDDTFGHYSC-DELGSRICLA--GWRGEYCS-EPVCL 188
Y+ C + GE CS D C F +C D + S C G G C C+
Sbjct: 304 YNCVCVNGWTGEDCSENIDDCASAA-CFQGATCHDRVASFYCECPHGRTGLLCHLNDACI 362
Query: 189 PGCSHSHGFCE-KP--GE--CKCRIGWQGPLC----DACVRYPG-CLH-GTCAQP---WQ 234
+ C+ P G+ C C G+ GP C D C C H G C ++
Sbjct: 363 SNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFE 422
Query: 235 CNCREGWGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECD 294
C C +G+ G C D+N C ++ PC+N ATC + G + C C G+ G CE+ +EC
Sbjct: 423 CQCLQGYTGPRCEIDVNECISN-PCQNDATCLDQ-IGEFQCICMPGYEGVYCEINTDECA 480
Query: 295 SNPCKNGGSCNDLENDYKCTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYSCHC 354
S+PC + G C D N+++C CP+GF G C+ CA PC NG C++ Y+C C
Sbjct: 481 SSPCLHNGHCMDKINEFQCQCPKGFNGHLCQYDVDECASTPCKNGAKCLDGP-NTYTCVC 539
Query: 355 PVNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCA 414
Y G++CE ID C +PC + G C D + C C+PG+ G CE NI++C PC
Sbjct: 540 TEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQPCR 598
Query: 415 NGGTCIDGPNSYTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYMG 474
+GGTC D NSY C C G G +C +D C S+PC +SGTC G+ C C GY G
Sbjct: 599 HGGTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNPC-DSGTCLDKIDGYECACEPGYTG 657
Query: 475 SNCEFKV 481
S C +
Sbjct: 658 SMCNVNI 664
Score = 614 (221.2 bits), Expect = 6.3e-59, P = 6.3e-59
Identities = 130/359 (36%), Positives = 169/359 (47%)
Query: 135 SYHVTCDEHYYGESC-SDYCRPRDDTFGHYSCDELGSRICLAGWRGEYCSEPVCLPGCSH 193
SY C Y G +C SD DD + C GS C G +C CLPG
Sbjct: 875 SYRCLCQAGYTGRNCESDI----DDCRPN-PCHNGGS--CTDGINTAFCD---CLPGFQG 924
Query: 194 SHGFCEKP-GECKCRIGWQGPLCDACVRYPGCLHGTCAQPWQCNCREGWGGLFCNQDLNY 252
+ FCE+ EC G C CV + C C G+ G+ C +
Sbjct: 925 A--FCEEDINECASNPCQNGANCTDCV-----------DSYTCTCPVGFNGIHCENNTPD 971
Query: 253 CTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDSNPCKNGGSCNDLENDYK 312
CT C NG TC + G S+TC C GF G+ C+ ++NECDS PC +GG+C D YK
Sbjct: 972 CTESS-CFNGGTCVD-GINSFTCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQDSYGTYK 1029
Query: 313 CTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYSCHCPVNYHGSNCEKKIDRCSN 372
CTCPQG+ G NC+ C PC NGG C + + Y C C + G NC+ C
Sbjct: 1030 CTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQ-YHCECRSGWTGVNCDVLSVSCEV 1088
Query: 373 NP----------CLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCANGGTCIDG 422
C + G C+D G C C+ G+ GS+CE +D+C+ NPC NG TC D
Sbjct: 1089 AAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTDY 1148
Query: 423 PNSYTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYMGSNCEFKV 481
++C C GY G +CS ++ C S PC N GTC + + C C G G +CE V
Sbjct: 1149 LGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINV 1207
Score = 608 (219.1 bits), Expect = 2.8e-58, P = 2.8e-58
Identities = 138/405 (34%), Positives = 196/405 (48%)
Query: 135 SYHVTCDEHYYGESCSDYCRPRDDTFGHYSCDELGSRICLAGWRGEYCSEPVCLPGCSHS 194
+Y TC + Y G +C + R D C G R C W+ C G +
Sbjct: 1027 TYKCTCPQGYTGLNCQNLVRWCDSA----PCKN-GGR-C---WQTNTQYHCECRSGWTGV 1077
Query: 195 HGFCEKPGECKCRIGWQGPLCDACVRYPGCLHG-TCAQPWQ---CNCREGWGGLFCNQDL 250
+ C+ C + Q D + C HG C C+C+ G+ G +C ++
Sbjct: 1078 N--CDVLS-VSCEVAAQKRGIDVTLL---CQHGGLCVDEGDKHYCHCQAGYTGSYCEDEV 1131
Query: 251 NYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDSNPCKNGGSCNDLEND 310
+ C+ + PC+NGATCT+ G ++C C AG+ G++C EINEC S PC+NGG+C DL N
Sbjct: 1132 DECSPN-PCQNGATCTDY-LGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNS 1189
Query: 311 YKCTCPQGFYGKNCEISAMTC-------ADGP-CFNGGTCIEKHLGGYSCHCPVNYHGSN 362
YKC+CP+G G +CEI+ C + P CFN GTC+++ +GGY+C CP + G
Sbjct: 1190 YKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQ-VGGYTCTCPPGFVGER 1248
Query: 363 CEKKIDRCSNNPCLNNG--HCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCANGGTCI 420
CE ++ C +NPC G +C+ C+CR G G CE I+ C G PC NGG C
Sbjct: 1249 CEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCKNGGVCA 1308
Query: 421 DGPNS---YTCSCTLGYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYMGSNC 477
N+ + C C G+ G C CGS CLN GTC + C C + G C
Sbjct: 1309 VASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSFTGPEC 1368
Query: 478 EFKVQIP----TPVSSQRV----AESPFPVALAVSFTLGLMMLVL 514
+F P P +Q +E+PF L + GL+ +L
Sbjct: 1369 QFPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHIL 1413
Score = 593 (213.8 bits), Expect = 1.1e-56, P = 1.1e-56
Identities = 118/323 (36%), Positives = 158/323 (48%)
Query: 182 CSEPVCLPGCSHSHGFCEKPGECKCRIGWQGPLCDA----CVRYPGCLHG-TCAQ---PW 233
C+ C G + + C C C +G+ G C+ C C +G TC +
Sbjct: 934 CASNPCQNGANCTD--CVDSYTCTCPVGFNGIHCENNTPDCTE-SSCFNGGTCVDGINSF 990
Query: 234 QCNCREGWGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINEC 293
C C G+ G +C D+N C + RPC +G TC ++ G+Y C C G+ G +C+ + C
Sbjct: 991 TCLCPPGFTGSYCQYDVNECDS-RPCLHGGTCQDS-YGTYKCTCPQGYTGLNCQNLVRWC 1048
Query: 294 DSNPCKNGGSCNDLENDYKCTCPQGFYGKNCEISAMTCADGP----------CFNGGTCI 343
DS PCKNGG C Y C C G+ G NC++ +++C C +GG C+
Sbjct: 1049 DSAPCKNGGRCWQTNTQYHCECRSGWTGVNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCV 1108
Query: 344 EKHLGGYSCHCPVNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRSMICKCRPGFVGSFCEL 403
++ Y CHC Y GS CE ++D CS NPC N C D CKC G+ GS C
Sbjct: 1109 DEGDKHY-CHCQAGYTGSYCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSE 1167
Query: 404 NIDDCAGNPCANGGTCIDGPNSYTCSCTLGYGGKDCSTRMDAC-------GSSP-CLNSG 455
I++C PC NGGTCID NSY CSC G G C +D C SP C N+G
Sbjct: 1168 EINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNG 1227
Query: 456 TCYTHFSGHVCECSAGYMGSNCE 478
TC G+ C C G++G CE
Sbjct: 1228 TCVDQVGGYTCTCPPGFVGERCE 1250
Score = 592 (213.5 bits), Expect = 1.4e-56, P = 1.4e-56
Identities = 116/332 (34%), Positives = 165/332 (49%)
Query: 169 GSRICLAGWRGEYC--SEPVCLPGCSHSHGFC---EKPGE----CKCRIGWQGPLC---- 215
G +C + G+ C S P C ++ G C + G C C +G+ GPLC
Sbjct: 29 GPSLCSGAFVGQRCQDSNPCLSTPCKNA-GTCHVVDHGGTVDYACSCPLGFSGPLCLTPL 87
Query: 216 -DACVRYPGCLHG-TC----AQPWQCNCREGWGGLFCNQDLNYCTNHRPCKNGATCTNTG 269
+AC+ P C +G TC ++C C GW G C Q + C ++ PC NG C
Sbjct: 88 DNACLANP-CRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ-ADPCASN-PCANGGQCLPF- 143
Query: 270 QGSYTCGCRAGFAGTSCEMEINECDSNP--CKNGGSCNDLENDYKCTCPQGFYGKNCEIS 327
+ SY C C GF G +C ++NEC NP C++GG+C++ Y+C C G +CE+
Sbjct: 144 ESSYICRCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELP 203
Query: 328 AMTCADGPCFNGGTCIEKHLGGYSCHCPVNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRS 387
+ C+ PC NGGTC + C C + G NCE+ +D C N C N G C+D +
Sbjct: 204 YVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNT 263
Query: 388 MICKCRPGFVGSFCELNIDDCA--GNPCANGGTCIDGPNSYTCSCTLGYGGKDCSTRMDA 445
C+C P + G +C ++D+C N C NGGTC + Y C C G+ G+DCS +D
Sbjct: 264 YNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDD 323
Query: 446 CGSSPCLNSGTCYTHFSGHVCECSAGYMGSNC 477
C S+ C TC+ + CEC G G C
Sbjct: 324 CASAACFQGATCHDRVASFYCECPHGRTGLLC 355
Score = 581 (209.6 bits), Expect = 2.0e-55, P = 2.0e-55
Identities = 123/349 (35%), Positives = 167/349 (47%)
Query: 153 CRPRDDTFGHYSCDELGSRICLAGWRGEYCSEPV--CLPG--CSHSHGFCE---KPGECK 205
CRP DT + C CL G+ G+ C E V C PG C + G C C+
Sbjct: 218 CRPTGDTT--HEC------ACLPGFAGQNCEENVDDC-PGNNCKNG-GACVDGVNTYNCR 267
Query: 206 CRIGWQGPLC----DACVRYPG-CLHG-TCAQP---WQCNCREGWGGLFCNQDLNYCTNH 256
C W G C D C P C +G TC + C C GW G C+++++ C +
Sbjct: 268 CPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCAS- 326
Query: 257 RPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDSNPCKNGGSC--NDLENDYKCT 314
C GATC + S+ C C G G C + + C SNPC G +C N + CT
Sbjct: 327 AACFQGATCHDR-VASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTNPVNGKAICT 384
Query: 315 CPQGFYGKNCEISAMTCADG--PCFNGGTCIEKHLGGYSCHCPVNYHGSNCEKKIDRCSN 372
CP G+ G C CA G PC + G C+ LG + C C Y G CE ++ C +
Sbjct: 385 CPSGYTGPACSQDVDECALGANPCEHAGKCLNT-LGSFECQCLQGYTGPRCEIDVNECIS 443
Query: 373 NPCLNNGHCLDLGRSMICKCRPGFVGSFCELNIDDCAGNPCANGGTCIDGPNSYTCSCTL 432
NPC N+ CLD C C PG+ G +CE+N D+CA +PC + G C+D N + C C
Sbjct: 444 NPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPK 503
Query: 433 GYGGKDCSTRMDACGSSPCLNSGTCYTHFSGHVCECSAGYMGSNCEFKV 481
G+ G C +D C S+PC N C + + C C+ GY G++CE +
Sbjct: 504 GFNGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDI 552
Score = 335 (123.0 bits), Expect = 2.1e-27, P = 2.1e-27
Identities = 66/172 (38%), Positives = 87/172 (50%)
Query: 315 CPQGFYGKNCEISAMTCADGPCFNGGTC-IEKHLG--GYSCHCPVNYHGSNCEKKIDR-C 370
C F G+ C+ S C PC N GTC + H G Y+C CP+ + G C +D C
Sbjct: 33 CSGAFVGQRCQDSN-PCLSTPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPLDNAC 91
Query: 371 SNNPCLNNGHC--LDLGRSMICKCRPGFVGSFCELNIDDCAGNPCANGGTCIDGPNSYTC 428
NPC N G C L L C+C PG+ G C+ D CA NPCANGG C+ +SY C
Sbjct: 92 LANPCRNGGTCDLLTLTEYK-CRCPPGWSGKSCQ-QADPCASNPCANGGQCLPFESSYIC 149
Query: 429 SCTLGYGGKDCSTRMDACGSSP--CLNSGTCYTHFSGHVCECSAGYMGSNCE 478
C G+ G C ++ C +P C + GTC+ + C C A + G +CE
Sbjct: 150 RCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCE 201
Score = 272 (100.8 bits), Expect = 2.2e-20, P = 2.2e-20
Identities = 96/358 (26%), Positives = 134/358 (37%)
Query: 127 GDQSELRYSYHVTCDEHYYGESCS---DYCRPRDDTFGHYSC--DELGSRI-CLAGWRGE 180
G ++ Y TC E + G +C + C + +C D G + C + G
Sbjct: 751 GTCKDMTSGYVCTCREGFSGPNCQTNINECAS-NPCLNQGTCIDDVAGYKCNCPLPYTGA 809
Query: 181 YCS---EPVCLPGCSHSHGFCEKPGE-----CKCRIGWQGPLCDA----CVRYPGCLHGT 228
C P C +S G C++ + C C GWQG C+ CV+ P C HG
Sbjct: 810 TCEVVLAPCATSPCKNS-GVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSP-CRHGA 867
Query: 229 CAQPWQCNCREGWGGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEM 288
+C+ G C C+ G T N C G SC
Sbjct: 868 -------SCQNTNGSYRCL-----------CQAGYTGRNCESDIDDCRPNPCHNGGSCTD 909
Query: 289 EINE--CDSNPCKNGGSCNDLENDYKCT-CPQGFYGKNCEISAMTCADGPCFNG-----G 340
IN CD P G C + N+ C G +C + + TC FNG
Sbjct: 910 GINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDC-VDSYTCTCPVGFNGIHCENN 968
Query: 341 T--CIEKHL--GG--------YSCHCPVNYHGSNCEKKIDRCSNNPCLNNGHCLDLGRSM 388
T C E GG ++C CP + GS C+ ++ C + PCL+ G C D +
Sbjct: 969 TPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQDSYGTY 1028
Query: 389 ICKCRPGFVGSFCELNIDDCAGNPCANGGTCIDGPNSYTCSCTLGYGGKDCSTRMDAC 446
C C G+ G C+ + C PC NGG C Y C C G+ G +C +C
Sbjct: 1029 KCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSGWTGVNCDVLSVSC 1086
Score = 120 (47.3 bits), Expect = 0.00072, P = 0.00072
Identities = 107/390 (27%), Positives = 147/390 (37%)
Query: 140 CDEHYYGESCSDY---CRPRDDTFGHYSCDELGSRICLA--GWRGEYCSEPV--CLPG-- 190
C Y+G +CS+ C + G D S C G +G +C V C P
Sbjct: 1156 CVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINVDDCHPPLD 1215
Query: 191 -CSHS-----HGFC-EKPG--ECKCRIGWQGPLCDACVRYPGCLHGTCAQPWQCNCREGW 241
S S +G C ++ G C C G+ G C+ V CL C NC +
Sbjct: 1216 PASRSPKCFNNGTCVDQVGGYTCTCPPGFVGERCEGDVNE--CLSNPCDPRGTQNCVQRV 1273
Query: 242 GGLFCNQDLNYCTNHRPCKNGATCTNTGQGSYTCGCRAGFAGTSCEMEINECDSNPCK-- 299
C C R G C + G C+ G G C + N C+
Sbjct: 1274 NDFHCE-----C---RAGHTGRRCESVINGCRGKPCKNG--GV-CAVASNTARGFICRCP 1322
Query: 300 ---NGGSCNDLENDYKCTCPQGFYGKNCEISAMTCADGPCFNGGTCIEKHLGGYS---CH 353
G +C END + TC G C ++ TC GP TC+ LG ++ C
Sbjct: 1323 AGFEGATC---ENDAR-TC--G--SLRC-LNGGTCISGP--RSPTCL--CLGSFTGPECQ 1369
Query: 354 CPVNYH--GSN-CEKK--IDRCSNNP---CLN----NG---HCLDLGRSMIC--KCRPGF 396
P + GSN C + + S NP CL NG H LD + P
Sbjct: 1370 FPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHILDYSFTGGAGRDIPPPQ 1429
Query: 397 VGSFCELNIDDC---AGNPCANGGTCIDGPNSYTCSCTLGYGGKDCSTRMDACGSSPCLN 453
+ CEL +C AGN N C N++ C G+ G DCS + + C
Sbjct: 1430 IEEACEL--PECQVDAGNKVCNL-QC----NNHAC----GWDGGDCSLNFNDPWKN-CTQ 1477
Query: 454 SGTCYTHFS-GHV-CEC-SAGYM--GSNCE 478
S C+ +FS GH +C SAG + G +C+
Sbjct: 1478 SLQCWKYFSDGHCDSQCNSAGCLFDGFDCQ 1507
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