| Nomenclature | Genomic Location |
| Symbol | Wnt1 | Chromosome | 1 |
| Name | Proto-oncogene Wnt-1 | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | 1: 70 Mbp |
| Molecular Function |
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Ligand for members of the frizzled family of seven transmembrane receptors.
In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling.
Probable developmental protein. May be a signaling molecule important in CNS development.
Is likely to signal over only few cell diameters. Proeminent role in the induction of the mesencephalon and cerebellum.
May play a crucial role in the morphogenesis of the neural tube and/or the early stages of CNS development.
Molecular Function Terms:
binding
nucleic acid binding
DNA binding
regulatory region DNA binding
transcription regulatory region DNA binding
protein binding
receptor binding
cytokine activity
G-protein-coupled receptor binding
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| Human Disease Association |
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No disease association.
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1 GCCATGGCTTGGAGGGGCTGCTGCCGGCTGGGGCTTCGCTGGAGGCATGGCTGGAGAGAG
61 GCAGGCGGGCGCAGAGGGATTGCCTCCTGCATTGACCCCTCCATGGGTCTGACCGAAGAA
121 CAGAAGGAGTTCCAAAAAGTGGCCTTTGATTTTGCTGCCAAAGAAATGGCCCCACACATG
181 GCGGAGTGGGATGAAAAGGAGATTTTCCCTGTGGAAACCATACGGAGAGCGGCTCAGCTG
241 GGGTTCGGGGGCATCTACGTGAGGCCAGACGTGGGGGGATCTGGACTGTCCCGCCTCGAT
301 ACCTCCATCATCTTCGAGGCTCTTTCAACCGGCTGTGTCAGCACAACTGCCTATCTCAGC
361 ATCCACAATATGTGCGCTTGGATGGTCGACGTCTTCGGGAAGGAGGAGCAGCGGCAGAGG
421 TTTTGCCCCTCACTTTGCAGCATGGAAAAACTGGCCTCTTACTGCCTGACAGAACCAGGC
481 AGTGGCAGTGATGCTGCGTCTTTGCTAACATCGGCCAAGAGGGACGGAGACAATTACATC
541 TTAAATGGTTCCAAGGCTTTCATCAGTGGCGGCGGAGACACCGATCTCTATGTGGTGATG
601 TGCCGAACAGGAGGCCCGGGCCCTAAGGGCATCTCCTGCCTGGTGCTGGAGAAAGGGACC
661 CCTGGATTGAGCTTTGGAAAAAAGGAGAGGAAGGTGGGCTGGAACTCACAGCCGACCCGA
721 GCTGTGGTATTTGAGGACTGTGCTGTCCCAGTAGCCAACCGCCTTGGCGAAGAAGGCCAG
781 GGCTTCAACATCGCAATGAAGGGCTTGAATGGAGGCCGAATTAACATTGCTTCTTGTTCT
841 TTGGGGGCTGCCCATGCTTCGATCCTGCTGGCCCGGGATCACCTTAAGGTCCGTAAACAG
901 TTTGGAGACCTGCTGGCCAACTATCAGTACCTCCAGTTCCAGCTAGCCGAGATGGCCACC
961 CGCTTAGTGGCGGCTCGGCTGATGGTACGCAATGCAGCCAGGGCCCTGCAAGAGGAGCGG
1021 GAGGACGCTGTGGCCTTGTGCTCTATGGCCAAGCTGTTTGCCACGGATGAATGCTTTGCG
1081 GTA
| Predicted Protein Product |
GIINVASSTNLLTDSKNVQLVLDPSLQLLSRKQRKLIRQNPGILHSISSGLQSAIKECKW
QFRNRRWNCPTMPGPNIFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIDSCTCDY
RRRGPGGPDWHWGGCSDNVDFGRVFGREFVDSNEKGRDLRFLMNLHNNEAGRLTVFTEMR
QECKCHGMSGSCTVKTCWMRLPTFRTVGDFLKDRFDGASRVIYGNKGSNRASRVELHHLE
PENPAHKPPSPHDLVYFEKSPNFCTYSGKTGTVGTAGRSCNSSSPALDGCELLCCGRGYR
TRMQRVTERCNCTFHWCCHVSCLNCTNMQVLHECL
| Protein Alignment to Mouse |
sp|P04426|WNT1_MOUSE Proto-oncogene Wnt-1 OS=Mus musculus GN=Wnt1 PE=1 SV=1
MGI:98953 Wnt1 wingless-related MMTV integration site 1 (Chr 15)
Length = 370
Score = 1694 (601.4 bits), Expect = 4.5e-175, P = 4.5e-175
Identities = 295/335 (88%), Positives = 320/335 (95%)
Query: 1 GIINVASSTNLLTDSKNVQLVLDPSLQLLSRKQRKLIRQNPGILHSISSGLQSAIKECKW 60
GI+N+ASSTNLLTDSK++QLVL+PSLQLLSRKQR+LIRQNPGILHS+S GLQSA++ECKW
Sbjct: 36 GIVNIASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKW 95
Query: 61 QFRNRRWNCPTMPGPNIFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIDSCTCDY 120
QFRNRRWNCPT PGP++FGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSI+SCTCDY
Sbjct: 96 QFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDY 155
Query: 121 RRRGPGGPDWHWGGCSDNVDFGRVFGREFVDSNEKGRDLRFLMNLHNNEAGRLTVFTEMR 180
RRRGPGGPDWHWGGCSDN+DFGR+FGREFVDS EKGRDLRFLMNLHNNEAGR TVF+EMR
Sbjct: 156 RRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMR 215
Query: 181 QECKCHGMSGSCTVKTCWMRLPTFRTVGDFLKDRFDGASRVIYGNKGSNRASRVELHHLE 240
QECKCHGMSGSCTV+TCWMRLPT R VGD L+DRFDGASRV+YGN+GSNRASR EL LE
Sbjct: 216 QECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLE 275
Query: 241 PENPAHKPPSPHDLVYFEKSPNFCTYSGKTGTVGTAGRSCNSSSPALDGCELLCCGRGYR 300
PE+PAHKPPSPHDLVYFEKSPNFCTYSG+ GT GTAGR+CNSSSPALDGCELLCCGRG+R
Sbjct: 276 PEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHR 335
Query: 301 TRMQRVTERCNCTFHWCCHVSCLNCTNMQVLHECL 335
TR QRVTERCNCTFHWCCHVSC NCT+ +VLHECL
Sbjct: 336 TRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL 370
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