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Gene Model: Csf1

NomenclatureGenomic Location
SymbolCsf1Chromosome2
NameColony stimulating factor 1Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates2: 10 Mbp

Molecular Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.

Molecular Function Terms:

binding
   protein binding
      receptor binding
         cytokine activity
      identical protein binding
         protein homodimerization activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATTGACAGTCAAATGGAGACATCCTGCAAACAAACCATCATCTATGTAGACAGGAGTGAA
    61 CTGGACACTACAGAATGCTTTCTCAAAGCAGCATATTCTCCACTGTTAAGCCTCCTTCAT
   121 AAAATTAAATTTAAGGACAATTCTGCAAACTTCAATAAGCTAGAAAGAATTAAAGACCTG
   181 CACTTGCAACTTGGAATTTGCATTGATGACTATCCTGATCACCAGACATGCACCAAGAAG
   241 TTCTCCCTGACTCCGGAGAAGATGTTGCAAATGGTGCACGACTATTTCAGCGAAGCTAAG
   301 CATTTCTTGTTCAAATCAGGCTTCACTCAGGATTGTTCTAGTGCCTTCAAGAAGTGTTCA
   361 GACTCTCAGAACACAGACAAGCACATTAAGAGGCCAGAACCCAGCGATACCCGAGGGATG
   421 GCTGTGACTTATGTGACGGTGGCCAGTGTCCTGGGGATTCTGCTGGCAGTGGGAGGCTTG
   481 CTGTTCTACTTGCATAAATCCAGGACCTTAACGAGGAGGCAACCACAGAGGAATGACAAC
   541 AACGTTGAAAGACCAGAAGAAGGAAGGCCACTGAATAGAGGGGAGGAACATATAGAACTG
   601 CAGATC

Predicted Protein Product
IDSQMETSCKQTIIYVDRSELDTTECFLKAAYSPLLSLLHKIKFKDNSANFNKLERIKDL
HLQLGICIDDYPDHQTCTKKFSLTPEKMLQMVHDYFSEAKHFLFKSGFTQDCSSAFKKCS
DSQNTDKHIKRPEPSDTRGMAVTYVTVASVLGILLAVGGLLFYLHKSRTLTRRQPQRNDN
NVERPEEGRPLNRGEEHIELQI
Protein Alignment to Mouse
sp|P07141|CSF1_MOUSE Macrophage colony-stimulating factor 1 OS=Mus musculus
            GN=Csf1 PE=1 SV=2
      MGI:1339753 Csf1 colony stimulating factor 1 (macrophage) (Chr 3)
        Length = 552

 Score = 231 (86.4 bits), Expect = 1.2e-22, Sum P(2) = 1.2e-22
 Identities = 47/125 (37%), Positives = 80/125 (64%)

Query:     1 IDSQMETSCKQTIIYVDRSELDTTECFLKAAYSPLLSLLHK-IKFKDNSANFNKLERIKD 59
             IDSQMETSC+    +VD+ +LD   C+LK A+  +  ++ + ++FKDN+ N N  ER+++
Sbjct:    55 IDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQE 114

Query:    60 LHLQLGICID-DYPD-HQTCTKKFSLTPEKMLQMVHDYFSEAKHFLFKSG--FTQDCSSA 115
             L   L  C   DY + ++ C + F  TP ++L+ + ++F+E K+ L K    FT++C+++
Sbjct:   115 LSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNS 174

Query:   116 FKKCS 120
             F KCS
Sbjct:   175 FAKCS 179

 Score = 55 (24.4 bits), Expect = 1.2e-22, Sum P(2) = 1.2e-22
 Identities = 14/41 (34%), Positives = 21/41 (51%)

Query:   162 FYLHKSRTLTRRQPQRNDNNVERPEEGRPLNRGEEHIELQI 202
             FY  K R+   R PQ  D++V RPE+       +  +EL +
Sbjct:   514 FYKWKWRS--HRDPQTLDSSVGRPEDSSLTQDEDRQVELPV 552

 Score = 35 (17.4 bits), Expect = 1.5e-20, Sum P(2) = 1.5e-20
 Identities = 7/15 (46%), Positives = 8/15 (53%)

Query:   121 DSQNTDKHIKRPEPS 135
             D Q  D  + RPE S
Sbjct:   524 DPQTLDSSVGRPEDS 538