GM008


Home	Search	Reports	Help

Gene Model: Fgf10

Nomenclature		Genomic Location
Symbol	Fgf10	Chromosome	2
Name	Fibroblast growth factor 10	Linkage map	unknown
Species	Dracomimus familiaris	Genome Coordinates	2: 80 Mbp

Molecular Function

Could be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.

Molecular Function Terms:

binding
   carbohydrate binding
      polysaccharide binding
         glycosaminoglycan binding
   protein binding
      receptor binding
         growth factor activity
         growth factor receptor binding

chemoattractant activity

Human Disease Association

Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.

Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.

Predicted Transcript

       .............ATGTGCAAATGGAAAGTGACTAAGGGTGCCTCAGCCTGGTTCCGTCT
    48 GTCCTGCCTTTCCCTGCCGCTGCTGCTTCTGTTCCTGTGTTCGGCTCTGCCTGTGGCCTG
   108 CCATGACACCCACAGGGCCATCCGTGCCCCGAGGGGCACCAACTCCTCATCGTCTGCCGT
   168 GGTGGGGCGGCATGTGCGCAGCTACAACCACCTCACGGGGGACGTGCGCAGGAGGAAACT
   228 CTTCTCCTACCAGAAGTTCTTTCTCAGGATCGATAAGAACGGAAAAGTCAATGGCACCAA
   288 AAGCAAGGACGATCCGTACAGTACACTCGAAATCAAGTCTGTGGATGTGGGCATCGTTGC
   348 CATCAAGGGGATTCAAAGCAATTACTACCTTGCAATTAACAAGAAAGGGGTGGTCTACGG
   408 GGCGAGGGATTTCGGCATTGACTGCAAGCTGATAGAGAGGATAGAGGAGAACAGGTACAA
   468 CACCTATGCCTCGGCAGAATGGATGAACAAGAAGAAGCACATGTTCGTAGGTCTGAGCGC
   528 CAACGGGAGGCCGATGAGGGCCAAAAAGACCCGGAGAAAAAACACAGCCACACACTTTCT
   588 CCCCATTCCTATCGTGTAG.........................................

Predicted Protein Product

MCKWKVTKGASAWFRLSCLSLPLLLLFLCSALPVACHDTHRAIRAPRGTNSSSSAVVGRH
VRSYNHLTGDVRRRKLFSYQKFFLRIDKNGKVNGTKSKDDPYSTLEIKSVDVGIVAIKGI
QSNYYLAINKKGVVYGARDFGIDCKLIERIEENRYNTYASAEWMNKKKHMFVGLSANGRP
MRAKKTRRKNTATHFLPIPIV

Protein Alignment to Mouse

sp|O35565|FGF10_MOUSE Fibroblast growth factor 10 OS=Mus musculus GN=Fgf10
            PE=2 SV=1
      MGI:1099809 Fgf10 fibroblast growth factor 10 (Chr 13)
        Length = 209

 Score = 517 (187.1 bits), Expect = 2.4e-50, P = 2.4e-50
 Identities = 106/207 (51%), Positives = 135/207 (65%)

Query:     1 MCKWKVTKGASAWFRXXXXXXXXXXXXXXXXXXVACHDTHRAIRAPRGTNSSSSAV---- 56
             M KW +T  ASA+                    V C    + + +   TN SSS+     
Sbjct:     1 MWKWILTHCASAFPHLPGCCCCFLLLFLVSSFPVTCQALGQDMVSQEATNCSSSSSSFSS 60

Query:    57 ---VGRHVRSYNHLTGDVRRRKLFSYQKFFLRIDKNGKVNGTKSKDDPYSTLEIKSVDVG 113
                 GRHVRSYNHL GDVR R+LFS+ K+FL I+KNGKV+GTK++D PYS LEI SV++G
Sbjct:    61 PSSAGRHVRSYNHLQGDVRWRRLFSFTKYFLTIEKNGKVSGTKNEDCPYSVLEITSVEIG 120

Query:   114 IVAIKGIQSNYYLAINKKGVVYGARDFGIDCKLIERIEENRYNTYASAEWMNKKKHMFVG 173
             +VA+K I SNYYLA+NKKG +YG+++F  DCKL ERIEEN YNTYAS  W +  + M+V 
Sbjct:   121 VVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVA 180

Query:   174 LSANGRPMRAKKTRRKNTATHFLPIPI 200
             L+  G P R +KTRRKNT+ HFLP+ I
Sbjct:   181 LNGKGAPRRGQKTRRKNTSAHFLPMTI 207