| Nomenclature | Genomic Location |
| Cps1 | Cps1 | Chromosome | 1 |
| Name | Carbamoyl-phosphate synthetase 1 | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | 1: 60 Mbp |
| Molecular Function |
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Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate.
Molecular Function Terms:
binding
amine binding
amino acid binding
carboxylic acid binding
amino acid binding
ion binding
cation binding
metal ion binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
hydrolase activity
peptidase activity
peptidase activity, acting on L-amino acid peptides
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| Human Disease Association |
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Defects in CPS1 are the cause of carbamoyl phosphate synthetase 1 deficiency (CPS1D) [MIM:237300].
CPS1D is an autosomal recessive disorder of the urea cycle causing hyperammonemia. Clinical features
include protein intolerance, intermittent ataxia, seizures, lethargy, developmental delay and mental
retardation.
Note=Genetic variations in CPS1 influence the availability of precursors for nitric oxide (NO)
synthesis and play a role in clinical situations where endogenous NO production is critically important,
such as neonatal pulmonary hypertension, increased pulmonary artery pressure following surgical repair
of congenital heart defects or hepatovenocclusive disease following bone marrow transplantation.
Infants with neonatal pulmonary hypertension homozygous for Thr-1406 have lower L-arginine concentrations
than neonates homozygous for Asn-1406.
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1 GCACAGACTGCCAACTTGGTGCTGGAAGATGGGACCAAGATGAAGGGCTACTCATTTGGT
61 CATCCATCCTCTACAGCTGGAGAAGTCGTATTCAATACTGGCCTTGCTGGCTGCACAGAA
121 AGTCTGACTGATCCCAGCTACCATGGGCAGATCCTCACAATGGTTAATCCCATCATAGGA
181 AACGGTGGCGTCCCAGATACTACGGCTTTGGATGAAATGGGACTCTGCAGATTCTTGGAA
241 TCTGATGGAATCAAGGTTTCAGGTTTGCTGGTGTTGGACTATAGCAATGAATACAGCCAT
301 TGGCGGGCTGTCAAACCCCTTGGGCAGTGGTTGAAAGAAGAAAAGGTCCCAGCTCTTTAT
361 GGGATTGATACCAGGATGCTCTCAAAAATAATTCGAGACAAGGGAACTGTTCTTGGCAAA
421 ATTGAATTTGAAGGTCAGCCGGTGGAATTTTTGGATCCAAACAAGAGAAATTTGATTGCT
481 GAAGTTTCAACTAAGGAAGTCAAAGTATATGGCAAAGGCAACCCACTGAAAGTTGTTGCT
541 GTGGACTGTGGACTCAAGCACAATGCGATTCGTTTGCTGGTAAAGAGAGGTGCTGAAGTA
601 CATCTGGTTCCCTGGAATCATGATTTTACTGGAATGGATTATGATGGACTTTTCATTTCT
661 GGTGGCCCTGGTGATCCAGTCCAAGCACAAGAGCTAATTGAGAACGTCAGGAAGGTCCTA
721 GAGAATAATCGCCAGGAGCCTTTGTTTGGAATCAGTTTGGGGAGTCTTATTACTGGCCTA
781 GCAGCTGGGGCTTCCTCCTACAAAATGCCTATGGCCAACAGAGGACAGAACCAACCAGTT
841 GTAAATATGATAAATGGACAGGCTTTCATTACTGCTCAGAATCATGGCTATGCAATTGAC
901 AGCGACACCCTCCCTTCTGACTGGAAGCCTCTATTTGTGAATGCGAATGATCAGACAAAT
961 GAGGGAATTATGCACGAGAACAAGCCGATTTTCACAGCACAGTTCTATCCAGATGGGAAT
1021 CCAGGGCCGACAGACACAGAGTTCTTATTTGATTCATTTATTTCGCTGATCAAGAAGGAA
1081 AAAGGTACAAGTATTGCTTCAGTACTGCCCAAGGCCACAGCTGCAACTTCGAGAGTTGAG
1141 GTTTCCAAAGTCCTAATTTTAGGATCTGGCGGTTTGTCTATTGGTCAAGCAGGAGAATTT
1201 GATTATTCTGGATCGCAGGCAGTCAAGGCCATGAAGGAGGAAAATGTGAAAACTGTCCTA
1261 ATGAACCCCAACATTGCCTCAGTTCAGACCAATGAAGTTGGCTTAAAGCAAGCAGATACA
1321 GTTTACTTCCTTCCGATCACCCCACATTTTGTTACAGAGGTCATCAAAGCAGAACGGCCA
1381 GATGGGATAATTCTTGGCATGGGTGGGCAGACTGCTCTCAACTGTGGTGTGGAGCTGTTC
1441 AAATGTGGTATTTTGCAAGAGTATGGTGTTAAGGTGCTTGGAACTTCAGTTGAATCCATC
1501 ATGGCCACTGAGGACAGGCAGATGTTTTCAGATAAACTAAATGAAATTAATGAGAAGATT
1561 GCTCCCAGCTTTGCTGTGGAATCGATAGCAGATGCTTTAGAAGCAGCAGAAAAAATTGGC
1621 TACCCAGTCATGATACGTTCAGCTTATGCGTTGGGTGGACTAGGATCAGGCTTATGTCTG
1681 GACAAGGAACAGTTGCTGGATCTTGGTACTAAGGCATTTGCAATGACCAACCAAATTCTT
1741 GTGGAGAAATCAGTTGCAGGATGGAAAGAGATTGAGTATGAAGTTGTGAGAGATGCCGTT
1801 GACAACTGTATTACTGTCTGCAATATGGAAAATGTTGATGCTATGGGAGTTCATACAGAA
1861 ACAGGTGATTCTGTTGTAGTGGCTCCCAGTCAAACACTTTCGAATGAGGAGCTGCAGATG
1921 CTGCGGGAATCGACCATCAAGGTTGTGCGCCACTTGAACATTGTGGGAGAGTGTAACATC
1981 CAGTATGCATTGAATCCCACTTCTCTGGAATACTGCATCATTGAAGTTAATGCTCGGCTT
2041 TCTCGAAGCTCTGCCTTAGCCTCAAAGGCCACAGGATACCCTTTAGCCTTCATTGCTGCC
2101 AAAATAGCCCTTGGGATCCCATTGCCTGAAATGGAGAATGTGGTTTCAGGAAAGACAACT
2161 GCCTGTTTTGAGCCAAGCCTGGATTATATAGTAACTAAGGTACCCCGCTGGGACCTGGAC
2221 CGCTTTCAGGGTGCCTCTAGCAAGATTGGGAGTTCGATGAAAAGTGTGGGTGAGGTTATG
2281 GCTATTGGGCGTACTTTTGAAGAGAGCTTTCAGAAGGCACTAAGAATGTGTCACCCTTCG
2341 GTTGATGGTTTCACCTCATGCTTGCCCATGAACAAAGACTGGCCTTCTGATGTGGATGTC
2401 AGGAAAGAGCTAGCTGAAGCTTCTAGCATACGGTTACACGCAATGGGCAAGGCTTTGGAA
2461 GACAATATGTCTATAGATGATATACATAAACTTACAGCTATTGATAAATGGTTCATCTAC
2521 AAAATGCATGATATTGTGAAAATGGAGAAGTACTTGAAAAGTCTTCACAGGGAAACTATT
2581 CCAGAGGAAAGCCTGAGGAGAGCCAAGCAGATGGGCTTCTCAGATAAGCAGATCGGGAAA
2641 TGTCTGGGAATATCTGAAGCAAGGAGCAGGGATCTGAGGCTGAAGAAGAACATAACACCC
2701 TGGGTGAAACAGATTGACACACTGGCAGGAGAATACCCTGCTGTAACTAATTACCTCTAT
2761 GTCACTTATAATGGCCAGGAGCATGATGTAAAATTTGATGACCATGGAATGATGGTACTG
2821 GGCTGCGGACCGTATCACATAGGGAGCAGCGTGGAGTTTGACTGGTGTGCCGTTTCTTGC
2881 ATCCGCACATTGCGCCAGCTCTGCAAAAAGACAGTTGTAGTGAACTGCAACCCAGAGACA
2941 GTGAGCACTGATTTTGATGAGTGTGACAGGCTCTACTTTGATGAACTGACACTGGAGAGA
3001 ATCTTGGACATCTACCAACAGGAGGCATGTGATGGTTGCATAATCTCTGTAGGTGGACAG
3061 ATTCCAAATAACTTAGCTGTGCCACTCTACAAGAACGGGGTTGAAATTATGGGTACACAC
3121 CCTCTGCAAATTGACCGGGCAGAAGACCGATCTGTATTTTCGACTGTTCTTGATCAGTTA
3181 CAGGTGGCTCAGGCACCCTGGAAAGCAGTTGATTCCTTGGAGGATGCTGTTGAATTTGCA
3241 AATTTGGTTAGCTATCCATGCTTGTTGAGACCTTCTTATGTCTTGAGTGGCTCAGCAATG
3301 AATGTAGTATATAATGAAAAAGAGATGAAAAAGTTCTTAGCAGAGGCAACCAGAGTTTCA
3361 CAGGACCATCCTGTTGTAATAACAAAATTCATTGAGGGAGCTCGGGAGGTGGAAACGGAT
3421 GCCGTTGCCAAGAATGGAGAGGTGATCTGTCATGCTGTATCTGAGCACGTAGAGGATGCA
3481 GGAGTTCATTCTGGAGATGCCACTTTGATGTTCCCTGTGCAAACTATTAGTCAAGGAGCC
3541 TTGGAAAAGTTAAGGACTACAGCAAAGAGAAGTGCTGGCGGCGTTTGTATCCTTCCTCCC
3601 TACTCCGTCTCCAGATTAGCCAAAAATAATGCTGCTTTGGTAATAGAGTGCAACCTGCGA
3661 GCTTCACGCTCTTTCCCCTTTGTATCTAAATCCCTTGGTCTGGATTTCATTGATGTGGCA
3721 GCTAAAGTGATGACTGGAGAACAAATCCACAAGTCTATCCTCCCCACATTGGAAACACCC
3781 ATGATTCCTTCAGAATATGTGGGCATTAAGGCTCCAATGTTCTCCTGGCCTCGTCTGAGA
3841 GATGTTGATCCTGTTCTCCGGTGTGAAATGGCCTCCACTGGAGAGGTTGCCTGCTTTGGA
3901 GGAAATGTCCATTCCGCCTTCCTGAAGGCCATGCTCTCTACAGGGTTTAGGTTGCCACAG
3961 AAAGGAATCCTGCTTGGAATTGAGCATTCTTTCCATCCCAAATTCCTTGATGAAGCACAG
4021 CAGCTCCATAGTCAAGGTTTTAAGCTTTATGCTACAGAAGGAACTTTTAATTGGCTCAGT
4081 GGCAACAACATCCCAGTATCACCAGTAGCATGGCCAACACAGCCAGATGCAGACTCCACA
4141 CTTGTTCCATTCGGAAAACTCATAAAAGATGGAAGCATAGACTTGGTAATTAACCTCCCT
4201 AACAACAACACAAAGTTTGTGCACGAAAATTTCCTGATCCGCAGGACAGCTGTTGATAGT
4261 GGAATCTCTCTCCTCACTAATTTGCAGGTAGCAAAGCTCTTCACTGAAGCCATCAAATAT
4321 TCTGGGAAACTGGACTGCAAAAGTCTCTTTCACTACAGAAAGTTCAATGCCAGCAAAGGA
4381 GCATAG
| Predicted Protein Product |
AQTANLVLEDGTKMKGYSFGHPSSTAGEVVFNTGLAGCTESLTDPSYHGQILTMVNPIIG
NGGVPDTTALDEMGLCRFLESDGIKVSGLLVLDYSNEYSHWRAVKPLGQWLKEEKVPALY
GIDTRMLSKIIRDKGTVLGKIEFEGQPVEFLDPNKRNLIAEVSTKEVKVYGKGNPLKVVA
VDCGLKHNAIRLLVKRGAEVHLVPWNHDFTGMDYDGLFISGGPGDPVQAQELIENVRKVL
ENNRQEPLFGISLGSLITGLAAGASSYKMPMANRGQNQPVVNMINGQAFITAQNHGYAID
SDTLPSDWKPLFVNANDQTNEGIMHENKPIFTAQFYPDGNPGPTDTEFLFDSFISLIKKE
KGTSIASVLPKATAATSRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVL
MNPNIASVQTNEVGLKQADTVYFLPITPHFVTEVIKAERPDGIILGMGGQTALNCGVELF
KCGILQEYGVKVLGTSVESIMATEDRQMFSDKLNEINEKIAPSFAVESIADALEAAEKIG
YPVMIRSAYALGGLGSGLCLDKEQLLDLGTKAFAMTNQILVEKSVAGWKEIEYEVVRDAV
DNCITVCNMENVDAMGVHTETGDSVVVAPSQTLSNEELQMLRESTIKVVRHLNIVGECNI
QYALNPTSLEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEMENVVSGKTT
ACFEPSLDYIVTKVPRWDLDRFQGASSKIGSSMKSVGEVMAIGRTFEESFQKALRMCHPS
VDGFTSCLPMNKDWPSDVDVRKELAEASSIRLHAMGKALEDNMSIDDIHKLTAIDKWFIY
KMHDIVKMEKYLKSLHRETIPEESLRRAKQMGFSDKQIGKCLGISEARSRDLRLKKNITP
WVKQIDTLAGEYPAVTNYLYVTYNGQEHDVKFDDHGMMVLGCGPYHIGSSVEFDWCAVSC
IRTLRQLCKKTVVVNCNPETVSTDFDECDRLYFDELTLERILDIYQQEACDGCIISVGGQ
IPNNLAVPLYKNGVEIMGTHPLQIDRAEDRSVFSTVLDQLQVAQAPWKAVDSLEDAVEFA
NLVSYPCLLRPSYVLSGSAMNVVYNEKEMKKFLAEATRVSQDHPVVITKFIEGAREVETD
AVAKNGEVICHAVSEHVEDAGVHSGDATLMFPVQTISQGALEKLRTTAKRSAGGVCILPP
YSVSRLAKNNAALVIECNLRASRSFPFVSKSLGLDFIDVAAKVMTGEQIHKSILPTLETP
MIPSEYVGIKAPMFSWPRLRDVDPVLRCEMASTGEVACFGGNVHSAFLKAMLSTGFRLPQ
KGILLGIEHSFHPKFLDEAQQLHSQGFKLYATEGTFNWLSGNNIPVSPVAWPTQPDADST
LVPFGKLIKDGSIDLVINLPNNNTKFVHENFLIRRTAVDSGISLLTNLQVAKLFTEAIKY
SGKLDCKSLFHYRKFNASKGA
| Protein Alignment to Mouse |
sp|Q8C196|CPSM_MOUSE Carbamoyl-phosphate synthase [ammonia], mitochondrial
OS=Mus musculus GN=Cps1 PE=1 SV=2
MGI:891996 Cps1 carbamoyl-phosphate synthetase 1 (Chr 1)
Length = 1500
Score = 5950 (2099.6 bits), Expect = 0., P = 0.
Identities = 1119/1461 (76%), Positives = 1286/1461 (88%)
Query: 1 AQTANLVLEDGTKMKGYSFGHPSSTAGEVVFNTGLAGCTESLTDPSYHGQILTMVNPIIG 60
A+TA++VLEDGTKMKGYSFGHPSS AGEVVFNTGL G E+LTDP+Y GQILTM NPIIG
Sbjct: 43 AKTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEALTDPAYKGQILTMANPIIG 102
Query: 61 NGGVPDTTALDEMGLCRFLESDGIKVSGLLVLDYSNEYSHWRAVKPLGQWLKEEKVPALY 120
NGG PDTTA DE+GL +++ESDGIKV+GLLVL+YSN+Y+HW A K LGQWL+EEKVPA+Y
Sbjct: 103 NGGAPDTTARDELGLNKYMESDGIKVAGLLVLNYSNDYNHWLATKSLGQWLQEEKVPAIY 162
Query: 121 GIDTRMLSKIIRDKGTVLGKIEFEGQPVEFLDPNKRNLIAEVSTKEVKVYGKGNPLKVVA 180
G+DTRML+KIIRDKGT+LGKIEFEGQ V+F+DPNK+NLIAEVSTK+VKV+GKGNP KVVA
Sbjct: 163 GVDTRMLTKIIRDKGTMLGKIEFEGQSVDFVDPNKQNLIAEVSTKDVKVFGKGNPTKVVA 222
Query: 181 VDCGLKHNAIRLLVKRGAEVHLVPWNHDFTGMDYDGLFISGGPGDPVQAQELIENVRKVL 240
VDCG+K+N IRLLVKRGAEVHLVPWNHDFT M+YDGL I+GGPG+P AQ LI+NV+K+L
Sbjct: 223 VDCGIKNNVIRLLVKRGAEVHLVPWNHDFTQMEYDGLLIAGGPGNPALAQPLIQNVKKIL 282
Query: 241 ENNRQEPLFGISLGSLITGLAAGASSYKMPMANRGQNQPVVNMINGQAFITAQNHGYAID 300
E++R+EPLFGIS G++ITGLAAGA SYKM MANRGQNQPV+N+ N QAFITAQNHGYA+D
Sbjct: 283 ESDRKEPLFGISTGNIITGLAAGAKSYKMSMANRGQNQPVLNITNRQAFITAQNHGYALD 342
Query: 301 SDTLPSDWKPLFVNANDQTNEGIMHENKPIFTAQFYPDGNPGPTDTEFLFDSFISLIKKE 360
+ TLP+ WKPLFVN NDQTNEGIMHE+KP F QF+P+ +PGPTDTE+LFDSF SLIKK
Sbjct: 343 N-TLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVSPGPTDTEYLFDSFFSLIKKG 401
Query: 361 KGTSIASVLPKATAATSRVEVSKVXXXXXXXXXXXQAGEFDYSGSQAVKAMKEENVKTVL 420
KGT+I SVLPK SRVEVSKV QAGEFDYSGSQAVKAMKEENVKTVL
Sbjct: 402 KGTTITSVLPKPALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVL 461
Query: 421 MNPNIASVQTNEVGLKQADTVYFLPITPHFVTEVIKAERPDGIILGMGGQTALNCGVELF 480
MNPNIASVQTNEVGLKQAD VYFLPITP FVTEVIKAERPDG+ILGMGGQTALNCGVELF
Sbjct: 462 MNPNIASVQTNEVGLKQADAVYFLPITPQFVTEVIKAERPDGLILGMGGQTALNCGVELF 521
Query: 481 KCGILQEYGVKVLGTSVESIMATEDRQMFSDKLNEINEKIAPSFAVESIADALEAAEKIG 540
K G+L+EYGVKVLGTSVESIMATEDRQ+FSDKLNEINEKIAPSFAVES+ DAL+AA+ IG
Sbjct: 522 KRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFAVESMEDALKAADTIG 581
Query: 541 YPVMIRSAYAXXXXXXXXXXDKEQLLDLGTKAFAMTNQILVEKSVAGWKEIEYEVVRDAV 600
YPVMIRSAYA +KE L+DLGTKAFAMTNQILVE+SV GWKEIEYEVVRDA
Sbjct: 582 YPVMIRSAYALGGLGSGICPNKETLIDLGTKAFAMTNQILVERSVTGWKEIEYEVVRDAD 641
Query: 601 DNCITVCNMENVDAMGVHTETGDSVVVAPSQTLSNEELQMLRESTIKVVRHLNIVGECNI 660
DNC+TVCNMENVDAMGVHT GDSVVVAP+QTLSN E QMLR +++ VVRHL IVGECNI
Sbjct: 642 DNCVTVCNMENVDAMGVHT--GDSVVVAPAQTLSNAEFQMLRRTSVNVVRHLGIVGECNI 699
Query: 661 QYALNPTSLEYCIIEVNXXXXXXXXXXXXXTGYPLAFIAAKIALGIPLPEMENVVSGKTT 720
Q+AL+PTS+EYCIIEVN TGYPLAFIAAKIALGIPLPE++NVVSGKT+
Sbjct: 700 QFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTS 759
Query: 721 ACFEPSLDYIVTKVPRWDLDRFQGASSKIGSSMKSVGEVMAIGRTFEESFQKALRMCHPS 780
ACFEPSLDY+VTK+PRWDLDRF G SS+IGSSMKSVGEVMAIGRTFEESFQKALRMCHPS
Sbjct: 760 ACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPS 819
Query: 781 VDGFTSCLPMNKDWPSDVDVRKELAEASSIRLHAMGKALEDNMSIDDIHKLTAIDKWFIY 840
VDGFT LPMNK+WP+++D++KEL+E SS R++A+ KALE+NMS+D+I +LT+IDKWF+Y
Sbjct: 820 VDGFTPRLPMNKEWPANLDLKKELSEPSSTRIYAIAKALENNMSLDEIVRLTSIDKWFLY 879
Query: 841 KMHDIVKMEKYLKSLHRETIPEESLRRAKQMGFSDKQIGKCLGISEARSRDLRLKKNITP 900
KM DI+ M+K LK L+ +++ EE+LR+AK++GFSDKQI KCLG++EA++R+LRLKKNI P
Sbjct: 880 KMRDILNMDKTLKGLNSDSVTEETLRKAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHP 939
Query: 901 WVKQIDTLAGEYPAVTNYLYVTYNGQEHDVKFDDHGMMVLGCGPYHIGSSVEFDWCAVSC 960
WVKQIDTLA EYP+VTNYLYVTYNGQEHD+KFD+HG+MVLGCGPYHIGSSVEFDWCAVS
Sbjct: 940 WVKQIDTLAAEYPSVTNYLYVTYNGQEHDIKFDEHGIMVLGCGPYHIGSSVEFDWCAVSS 999
Query: 961 IRTLRQLCKKTVVVNCNPETVSTDFDECDRLYFDELTLERILDIYQQEACDGCIISVGGQ 1020
IRTLRQL KKTVVVNCNPETVSTDFDECD+LYF+EL+LERILDIY QEAC+GCIISVGGQ
Sbjct: 1000 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACNGCIISVGGQ 1059
Query: 1021 IPNNLAVPLYKNGVEIMGTHPLQIDRAEDRSVFSTVLDQLQVAQAPWKAVDSLEDAVEFA 1080
IPNNLAVPLYKNGV+IMGT PLQIDRAEDRS+FS VLD+L+VAQAPWKAV++L +A+EFA
Sbjct: 1060 IPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFA 1119
Query: 1081 NLVSYPCLLRPSYVLSGSAMNVVYNEKEMKKFLAEATRVSQDHPVVITKFIEGAREVETD 1140
N V YPCLLRPSYVLSGSAMNVV++E EMK+FL EATRVSQ+HPVV+TKF+EGAREVE D
Sbjct: 1120 NSVGYPCLLRPSYVLSGSAMNVVFSEDEMKRFLEEATRVSQEHPVVLTKFVEGAREVEMD 1179
Query: 1141 AVAKNGEVICHAVSEHVEDAGVHSGDATLMFPVQTISQGALEKLRTTAKRSAGGVCILPP 1200
AV K G VI HA+SEHVEDAGVHSGDATLM P QTISQGA+EK++ ++ A I P
Sbjct: 1180 AVGKEGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGP 1239
Query: 1201 YSVSRLAKNNAALVIECNLRASRSFPFVSKSLGLDFIDVAAKVMTGEQIHKSILPTLETP 1260
++V L K N LVIECNLRASRSFPFVSK+LG+DFIDVA KVM GE I + LPTLE P
Sbjct: 1240 FNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIGESIDEKRLPTLEQP 1299
Query: 1261 MIPSEYVGIKAPMFSWPRLRDVDPVLRCEMASTGEVACFGGNVHSAFLKAMLSTGFRLPQ 1320
+IPS+YV IKAPMFSWPRLRD DP+LRCEMASTGEVACFG +H+AFLKAMLSTGF++PQ
Sbjct: 1300 IIPSDYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQ 1359
Query: 1321 KGILLGIEHSFHPKFLDEAQQLHSQGFKLYATEGTFNWLSGNNIPVSPVAWPTQPDADST 1380
KGIL+GI+ SF P+FL A+QLH++GFKL+ATE T +WL+ NN+P +PVAWP+Q + +
Sbjct: 1360 KGILIGIQQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVPATPVAWPSQEGQNPS 1419
Query: 1381 LVPFGKLIKDGSIDLVINLPNNNTKFVHENFLIRRTAVDSGISLLTNLQVAKLFTEAIKY 1440
L KLI+DGSIDLVINLPNNNTKFVH+N++IRRTAVDSGI+LLTN QV KLF EA++
Sbjct: 1420 LSSIRKLIRDGSIDLVINLPNNNTKFVHDNYVIRRTAVDSGIALLTNFQVTKLFAEAVQK 1479
Query: 1441 SGKLDCKSLFHYRKFNASKGA 1461
S +D KSLFHYR+++A K A
Sbjct: 1480 SRTVDSKSLFHYRQYSAGKAA 1500
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