| Nomenclature | Genomic Location |
| Symbol | Arg | Chromosome | 2 |
| Name | Arginase | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | 2: 95 Mbp |
| Molecular Function |
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L-arginine + H2O = L-ornithine + urea.
Molecular Function Terms:
binding
ion binding
cation binding
metal ion binding
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
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| Human Disease Association |
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Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia.
Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood
and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include
developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.
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1 ATGTCGCTTCGCAGCAGCTTCGGCCGGCTCCTCAAGCAGCGGGCGGGATCCACGTTGAGG
61 GTCCAGAAGAGACCGGCGCACTCGGTGGCCCTAATTGGAGCCCCTTTCTCCCGGGGCCAG
121 AAAAAAAGCGGAGTAGACCATGGCCCTGCCGCCATCAGGGACGCGGGGCTGGTGGGCAAG
181 CTCTCCCGCATGGGTTGCCAGGTATATGATCTGGGAGACTTAAATTTCACTCAAATCCCC
241 AATGATGAGCTCTACAACAACCTAGTGAAATATCCACGCTCTGTAGGATCAGCTAGCCAA
301 GTTCTAGCTGACACTGTGAATGGAGCCGTGGCTGCTGGTCATAGCTGTGTAACCATCGGA
361 GGTGATCACAGTTTAGCACTTGGTTCCATCAGTGGCCACACAAGGCAGTACCCACACCTC
421 TGTGTAATCTGGGTAGATGCACATGCGGACATCAATACTCCACTCACCACAAATTCAGGG
481 AATCTCCATGGACAGCCAGTTTCATTTCTTTTAAGGGAGCTTCAAGATAAGGTGCCACAG
541 CTTCCTGGCTTCTCTTGGCTAAAACCCTGTCTTTCACGATCAGATATTGTATATATTGGC
601 TTAAGAGATGTTGATCCTGCTGAACACTATATTCTGAAGAACTATGGCATCCAGTATTTT
661 TCAATGAGAGATATTGATCGCTTAGGGATCCAGAAAGTGATGGAGAGAACCTTTGACCAC
721 CTTTTAAGCAGAGGACAAAGACCTATCCATCTCAGCTTCGACATTGATGCCTTTGATCCA
781 ACATTGGCTCCATCAACTGGGACTCCTGTCTTGGGTGGCTTAACATATCGTGAAGGAATG
841 TACATTTCAGAGGAAATACACAACACAGGCCTGCTTTCAGCAGTGGACCTTGTAGAAGTA
901 AATCCGTTGCTCGGAACGTCCCAGGAAGACGTGGCTGCAACAGCTAACCTTGCAGTGGAA
961 GTGATTGCCACATGCTTTGGCCAAACAAGAGAAGGGGCACACATTGTTTTTGATGGCCTC
1021 CCCACTCCCAGTTCCCCTGATGAATCTGACAGTGAAGAGCAAGTGCGGATTTAG
| Predicted Protein Product |
MSLRSSFGRLLKQRAGSTLRVQKRPAHSVALIGAPFSRGQKKSGVDHGPAAIRDAGLVGK
LSRMGCQVYDLGDLNFTQIPNDELYNNLVKYPRSVGSASQVLADTVNGAVAAGHSCVTIG
GDHSLALGSISGHTRQYPHLCVIWVDAHADINTPLTTNSGNLHGQPVSFLLRELQDKVPQ
LPGFSWLKPCLSRSDIVYIGLRDVDPAEHYILKNYGIQYFSMRDIDRLGIQKVMERTFDH
LLSRGQRPIHLSFDIDAFDPTLAPSTGTPVLGGLTYREGMYISEEIHNTGLLSAVDLVEV
NPLLGTSQEDVAATANLAVEVIATCFGQTREGAHIVFDGLPTPSSPDESDSEEQVRI
| Protein Alignment to Mouse |
sp|O08691|ARGI2_MOUSE Arginase-2, mitochondrial OS=Mus musculus GN=Arg2 PE=1
SV=1
MGI:1330806 Arg2 arginase type II (Chr 12)
Length = 354
Score = 1309 (465.8 bits), Expect = 2.8e-134, P = 2.8e-134
Identities = 249/342 (72%), Positives = 291/342 (85%)
Query: 1 MSLRSSFGRLLKQRAGSTLRVQKRPAHSVALIGAPFSRGQKKSGVDHGPAAIRDAGLVGK 60
M LRSS RLL G V R HSVA++GAPFSRGQKK GV++GPAAIR+AGL+ +
Sbjct: 1 MFLRSSASRLLH---GQIPCVLTRSVHSVAIVGAPFSRGQKKLGVEYGPAAIREAGLLKR 57
Query: 61 LSRMGCQVYDLGDLNFTQIPNDELYNNLVKYPRSVGSASQVLADTVNGAVAAGHSCVTIG 120
LSR+GC + D GDL+FT +P D+ YNNLV YPRSVG A+Q LA+ V+ AV+ G+SCVT+G
Sbjct: 58 LSRLGCHLKDFGDLSFTNVPQDDPYNNLVVYPRSVGLANQELAEVVSRAVSGGYSCVTMG 117
Query: 121 GDHSLALGSISGHTRQYPHLCVIWVDAHADINTPLTTNSGNLHGQPVSFLLRELQDKVPQ 180
GDHSLA+G+I GH R P LCVIWVDAHADINTPLTT SGN+HGQP+SFL++ELQDKVPQ
Sbjct: 118 GDHSLAIGTIIGHARHRPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIKELQDKVPQ 177
Query: 181 LPGFSWLKPCLSRSDIVYIGLRDVDPAEHYILKNYGIQYFSMRDIDRLGIQKVMERTFDH 240
LPGFSW+KPCLS +IVYIGLRDV+P EH+ILKNY IQYFSMR+IDRLGIQKVME+TFD
Sbjct: 178 LPGFSWIKPCLSPPNIVYIGLRDVEPPEHFILKNYDIQYFSMREIDRLGIQKVMEQTFDR 237
Query: 241 LLSRGQRPIHLSFDIDAFDPTLAPSTGTPVLGGLTYREGMYISEEIHNTGLLSAVDLVEV 300
L+ + QRPIHLSFDIDAFDP LAP+TGTPV+GGLTYREG+YI+EEIHNTGLLSA+DLVEV
Sbjct: 238 LIGKRQRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGVYITEEIHNTGLLSALDLVEV 297
Query: 301 NPLLGTSQEDVAATANLAVEVIATCFGQTREGAHIVFDGLPT 342
NP L TS+E+ ATA LAV+VIA+ FGQTREG HIV+D LPT
Sbjct: 298 NPHLATSEEEAKATARLAVDVIASSFGQTREGGHIVYDHLPT 339
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