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Gene Model: Acaca

NomenclatureGenomic Location
SymbolAcacaChromosomeX
NameAcetyl-CoA carboxylase, alphaLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesX: 18 Mbp

Molecular Function

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Molecular Function Terms:

binding
   ion binding
      cation binding
         metal ion binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding
   protein binding
      enzyme binding
         kinase binding

catalytic activity
   ligase activity
      ligase activity, forming carbon-carbon bonds
         CoA carboxylase activity

Human Disease Association

Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.

Predicted Transcript
     1 GACCAGTTGTGCGGCCGAGACCCAACCTTGACAGACGAGCTCATTAATATTCTCACGGAG
    61 CTGACGCAGCTCAGCAAGACCACCAACGCCAAGGTGGCATTGAGAGCCCGACAGGTCCTC
   121 ATTGCTTCCCACTTGCCCTCGTACGAACTGCGCCACAACCAGGTGGAGTCCATCTTCCTT
   181 TCGGCCATCGACATGTATGGGCATCAGTTCTGCATTGAAAACTTGCAGAAACTCATCCTT
   241 TCTGAGACGTCCATCTTTGATGTGCTTCCGAACTTCTTCTACCACAGCAACCAAGTCGTG
   301 AGGATGGCAGCTCTTGAGGTGTATGTTCGAAGAGCATACATCGCCTACGAGCTCAACAGC
   361 GTCCAGCACCGTCAGCTCAAGGACAACACGTGTGTGGTGGAATTCCAGTTCATGTTGCCC
   421 ACGTCGCATCCAAACAGTATTATTATTATTATTATTATTTCTAGACCTCCCTCTCTCCCC
   481 AGAGGGACTCAAATCAAGAGGATACCTCTCCGCAGCATAAGGGGAAAAAAATTATGCTTT
   541 ATAATACATTGTAATTTTGTCAGACTCTTTGACGAAGTCATGGGATGCTTTTGCGACTCT
   601 CCTCCTCAAAGCCCCACCTTCCCGGAAGCAGGCCACCCATCCCTCTACGACGAAGACAAG
   661 AGCGCTCGGGAGGAGCCCATTCACATCTTGAACGTTGCCATCAAGACGGATTGCGATATC
   721 GACGACGAAGGGCTGGCTGCCATGTTTAGAGACTTCACACAGAGCAGAAAATCTATCCTG
   781 ATTGATCACGGCATTCGGCGGCTGACTTTCCTCGTGGCACAAAAGAGAGAATTTCCCAAG
   841 TTTTTCACCTTCCGTGCAAGGGATAAGTTTGAAGAGGACAGGATCTACCGCCACTTGGAG
   901 CCGGCGCTGGCCTTCCAGCTGGAGCTCAACCGCATGCGTAACTTCGACCTCACCGCCATC
   961 CCTTGCGCCAACCACAAAATGCACCTCTACTTGGGTGCCGCCAAAGTCGAGGCTGGGGCG
  1021 GAGGTGACCGACTACAGGTTCTTTGTCCGGGCCATCATCCGGCACTCGGACCTTGTCACC
  1081 AAGGAGGCATCCTTTGAATACCTGCAGAACGAAGGGGAGCGCTTGCTCCTGGAAGCCATG
  1141 GACGAGCTGGAGGTGGCCTTCAACAACACAAACGTGCGCACTGACTGCAACCACATATTC
  1201 CTCAACTTTGTACCCACCGTTATCATGGACCCATCAAAGATTGAGGAGTCTGTCCGGAGC
  1261 ATGGTGATGCGCTACGGCAGCCGCTTGTGGAAGCTCCGGGTGCTGCAGGCCGAGCTCAAG
  1321 ATCAACATCCGCCTGACGCCAACGGGCAAAGCCATCCCCATCCGCCTCTTCCTCACCAAC
  1381 GAGTCCGGATATTACCTAGACATCAGCCTGTACAAGGAGGTGACCGATTCCAGGACGGGA
  1441 CAGATCATGTTCCAAGCTTACGGCGATAAGCAAGGGCCCTTACACGGGATGTTGATCAAC
  1501 ACTCCGTATGTGACGAAGGACCTGCTGCAGTCCAAGCGATTCCAGGCCCAGTCGTTGGGG
  1561 ACCACCTATGTCTATGACATCCCTGAAATGTTCCGACAGTCTTTGATAAAGTTGTGGGAA
  1621 TACATGAAAGAGTTTGCCATCCTCCCGCCGCCTCCGCTGCCTTCGGACATGCTGACCTAT
  1681 ACGGAGCTGGTGCTGGACGACCAAGGACAGCTGGTGCATATGAACCGACTTCCTGGAGGA
  1741 AACGAGATTGGCATGGTGGCATGGCGCATGACCCTCAAGACGCCCGAGTACCCCGACGGG
  1801 CGCGACGTCATCGTCATCAGCAACGACATCACGTATCGGATCGGGTCCTTTGGGCCTCAA
  1861 GAGGACCTGCTCTTCCTGAGGGCCTCGGAGCTGGCCCGGCTGCAGGGCATCCCACGGATT
  1921 TATGTGGCGGCCAACAGCGGTGCCAGGATCGGTTTGGCTGAGGAGATCCGGCACATGTTC
  1981 CACGTCGCGTGGGAAGACCCTGACGATCCATACAAAGGATTCAAGTACTTGTACCTGACT
  2041 CCTCAGGATTACAAGAAAGTCAGTGCTTTGAACTCGGTACACTGTGAACATGTGGAGGAC
  2101 GAAGGGGAATCGAGATATAAAATTACAGATATTATCGGGAAGGAAGAAGGCCTGGGGACT
  2161 GAGAATCTGCGTGGATCTGGTATGATTGCTGGAGAATCCTCTCTGGCCTATGAAGATATC
  2221 ATCACTATCAACCTGGTGACCTGCCGGGCAATTGGAATTGGGGCTTACCTGGTTCGGTTG
  2281 GGACAGAGAACAATCCAAGTGGAAAATTCCCATATTATCTTAACTGGAGCCGGAGCCCTC
  2341 AACAAAGTGCTTGGGAGGGAGGTCTACACTTCCAACAACCAGTTGGGCGGGATCCAGATC
  2401 ATGCACAACAACGGGGTCACCCACACCACCGTCTGCGATGACTTCGAAGGCGTCTACACC
  2461 ATTCTGCTGTGGCTCTCTTACATGCCAAAGAGTGTTTTCAGCCCAGTTCCGATGCTCACG
  2521 GCGAAGGACCCCATTGACAGGATCATTGAGTTTTCTCCCACCAAGACTCCCTATGATCCT
  2581 CGCTGGATGCTTGCCGGACGGCCCCATCCAACTCAGAAGGGCCAGTGGCTCAGTGGCTTC
  2641 TTCGACCACGGCTCTTTCCTGGAGATCATGCAGCCTTGGGCTCAGACGGTTGTGGTCGGC
  2701 AGAGCAAGGCTCGGTGGCATCTCCGTGGGAGTGGTGGCCGTCGAAACGCGGACGGTGGAG
  2761 CTGAGCATCCCGGCCGACCCTGCCAATCTCGACTCCGAGGCCAAGATTATCCAGCAGGCT
  2821 GGCCAAGTGTGGTTCCCGGATTCCGCCTTCAAGACGGCACAAGCCATCAAGGACTTCAAC
  2881 CGGGAAGGGCTCCCGCTGATGGTCTTTGCCAACTGGAGAGGCTTCTCGGGAGGAATGAAA
  2941 GATATGTATGACCAAGTGCTGAAGTTTGGGGCCTACATCGTGGACGGTTTGCGGGAGTAC
  3001 CGCCAGCCCGTCCTGGTCTACATCCCACCCCAGGCGGAGCTGAGAGGAGGCTCCTGGGTC
  3061 GTGATCGACCCCACCATCAACCCGCGACACATGGAGATGTACGCTGACCGGGACAGCAGA
  3121 GGCGGAGTCCTGGAGCCGGAAGGGACCGTGGAGATCAAGTTCCGCAAGAAAGATCTGGTG
  3181 AAGACCATGAGGCGCGTGGATCCCATCTACGTGCGCCTGGCAGAGCGGCTCGGGACCCCG
  3241 GAGCTGAGCCCAGCCGAGCGGAAGGATCTGGAGGGCAAGCTGAAGGAGCGGGAGGAGTTC
  3301 CTCATCCCCATTTACCACCAGGTCGCCGTGCAGTTTGCGGACTTGCACGACACCCCCGGC
  3361 CGGATGCAGGAGAAGGGTGTCATTACGGACATTCTGGAATGGAAGACGTCGCGGACGTTC
  3421 TTCTACTGGAGGCTCCGCCGTCTGCTCCTGGAGGACCTGGTCAAGGAGAAGATCCACGAC
  3481 GCCAACCCTGAGCTCACGGACGGCCAGATCCAGGCGATGCTGAGACGCTGGTTCGTGGAA
  3541 GTGGAAGGCACCGTCAAGGCCTATCTGTGGGACAACAACAAGGACCTGGTGGAGTGGCTG
  3601 GAGAAACAGCTGACCGAAGAAGAAGGCGCCCGCTCCGTGGTGGACGAGAACATCAAATAC
  3661 ATCTCCCGGGACTACATCCTCAAACAAATCCGGAGCTTGGTCCAAGCCAATCCGGAAGTG
  3721 GCCATGGACTCCATCGTCCACATGACCCAACACATATCACCCACTCAGCGGGCCGAGATC
  3781 GTGCGCATCCTCTCCACAATGGACTCTCCTGCCTCCACGTAA

Predicted Protein Product
DQLCGRDPTLTDELINILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFL
SAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNS
VQHRQLKDNTCVVEFQFMLPTSHPNSIIIIIIISRPPSLPRGTQIKRIPLRSIRGKKLCF
IIHCNFVRLFDEVMGCFCDSPPQSPTFPEAGHPSLYDEDKSAREEPIHILNVAIKTDCDI
DDEGLAAMFRDFTQSRKSILIDHGIRRLTFLVAQKREFPKFFTFRARDKFEEDRIYRHLE
PALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEAGAEVTDYRFFVRAIIRHSDLVT
KEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRS
MVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTG
QIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYVYDIPEMFRQSLIKLWE
YMKEFAILPPPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWRMTLKTPEYPDG
RDVIVISNDITYRIGSFGPQEDLLFLRASELARLQGIPRIYVAANSGARIGLAEEIRHMF
HVAWEDPDDPYKGFKYLYLTPQDYKKVSALNSVHCEHVEDEGESRYKITDIIGKEEGLGT
ENLRGSGMIAGESSLAYEDIITINLVTCRAIGIGAYLVRLGQRTIQVENSHIILTGAGAL
NKVLGREVYTSNNQLGGIQIMHNNGVTHTTVCDDFEGVYTILLWLSYMPKSVFSPVPMLT
AKDPIDRIIEFSPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDHGSFLEIMQPWAQTVVVG
RARLGGISVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTAQAIKDFN
REGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLREYRQPVLVYIPPQAELRGGSWV
VIDPTINPRHMEMYADRDSRGGVLEPEGTVEIKFRKKDLVKTMRRVDPIYVRLAERLGTP
ELSPAERKDLEGKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVITDILEWKTSRTF
FYWRLRRLLLEDLVKEKIHDANPELTDGQIQAMLRRWFVEVEGTVKAYLWDNNKDLVEWL
EKQLTEEEGARSVVDENIKYISRDYILKQIRSLVQANPEVAMDSIVHMTQHISPTQRAEI
VRILSTMDSPAST
Protein Alignment to Mouse
sp|Q5SWU9|ACACA_MOUSE Acetyl-CoA carboxylase 1 OS=Mus musculus GN=Acaca PE=1
            SV=1
      MGI:108451 Acaca acetyl-Coenzyme A carboxylase alpha (Chr 11)
        Length = 2345

 Score = 5274 (1861.6 bits), Expect = 0., Sum P(2) = 0.
 Identities = 1002/1103 (90%), Positives = 1050/1103 (95%)

Query:   185 NFVRLFDEVMGCFCDSPPQSPTFPEAGHPSLYDEDKSAREEPIHILNVAIKTDCDIDDEG 244
             +FVR+FDE+MGCFCDSPPQSPTFPE+GH SLYDEDK  R+EPIHILNVAIKTD DI+D+ 
Sbjct:  1243 DFVRIFDEIMGCFCDSPPQSPTFPESGHTSLYDEDKVPRDEPIHILNVAIKTDGDIEDDR 1302

Query:   245 LAAMFRDFTQSRKSILIDHGIRRLTFLVAQK---------------REFPKFFTFRARDK 289
             LAAMFR+FTQ  K+ L++HGIRRLTFLVAQK               REFPKFFTFRARDK
Sbjct:  1303 LAAMFREFTQQNKATLVEHGIRRLTFLVAQKDFRKQVNCEVDQRFHREFPKFFTFRARDK 1362

Query:   290 FEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEAGAEVTDYRFFV 349
             FEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVE G EVTDYRFFV
Sbjct:  1363 FEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFV 1422

Query:   350 RAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIM 409
             RAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIM
Sbjct:  1423 RAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIM 1482

Query:   410 DPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDIS 469
             DPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLT TGKAIPIRLFLTNESGYYLDIS
Sbjct:  1483 DPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTTTGKAIPIRLFLTNESGYYLDIS 1542

Query:   470 LYKEVTDSRTGQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYVYDIPE 529
             LYKEVTDSRT QIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTY+YDIPE
Sbjct:  1543 LYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPE 1602

Query:   530 MFRQSLIKLWEYMKEFAILPPPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWR 589
             MFRQSLIKLWE M   A LP PPLPSD+LTYTELVLDDQGQLVHMNRLPGGNEIGMVAW+
Sbjct:  1603 MFRQSLIKLWESMSTQAFLPSPPLPSDILTYTELVLDDQGQLVHMNRLPGGNEIGMVAWK 1662

Query:   590 MTLKTPEYPDGRDVIVISNDITYRIGSFGPQEDLLFLRASELARLQGIPRIYVAANSGAR 649
             M+LK+PEYPDGRD+IVI NDITYRIGSFGPQEDLLFLRASELAR +GIPRIYVAANSGAR
Sbjct:  1663 MSLKSPEYPDGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVAANSGAR 1722

Query:   650 IGLAEEIRHMFHVAWEDPDDPYKGFKYLYLTPQDYKKVSALNSVHCEHVEDEGESRYKIT 709
             IGLAEEIRHMFHVAW DP+DPYKG+KYLYLTPQDYK+VSALNSVHCEHVEDEGESRYKIT
Sbjct:  1723 IGLAEEIRHMFHVAWVDPEDPYKGYKYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKIT 1782

Query:   710 DIIGKEEGLGTENLRGSGMIAGESSLAYEDIITINLVTCRAIGIGAYLVRLGQRTIQVEN 769
             DIIGKEEGLG ENLRGSGMIAGESSLAY+++ITI+LVTCRAIGIGAYLVRLGQRTIQVEN
Sbjct:  1783 DIIGKEEGLGAENLRGSGMIAGESSLAYDEVITISLVTCRAIGIGAYLVRLGQRTIQVEN 1842

Query:   770 SHIILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHTTVCDDFEGVYTILLWLSYMP 829
             SH+ILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTH+TVCDDFEGV+T+L WLSYMP
Sbjct:  1843 SHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHSTVCDDFEGVFTVLHWLSYMP 1902

Query:   830 KSVFSPVPMLTAKDPIDRIIEFSPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDHGSFLEI 889
             KSV S VP+L +KDPIDRIIEF PTK PYDPRWMLAGRPHPTQKGQWLSGFFD+GSF EI
Sbjct:  1903 KSVHSSVPLLNSKDPIDRIIEFVPTKAPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEI 1962

Query:   890 MQPWAQTVVVGRARLGGISVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSA 949
             MQPWAQTVVVGRARLGGI VGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSA
Sbjct:  1963 MQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSA 2022

Query:   950 FKTAQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLREYRQPVLVYIP 1009
             FKT QAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRE  QPV+VYIP
Sbjct:  2023 FKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECSQPVMVYIP 2082

Query:  1010 PQAELRGGSWVVIDPTINPRHMEMYADRDSRGGVLEPEGTVEIKFRKKDLVKTMRRVDPI 1069
             PQAELRGGSWVVIDPTINPRHMEMYADR+SRG VLEPEGTVEIKFRKKDLVKTMRRVDP+
Sbjct:  2083 PQAELRGGSWVVIDPTINPRHMEMYADRESRGSVLEPEGTVEIKFRKKDLVKTMRRVDPV 2142

Query:  1070 YVRLAERLGTPELSPAERKDLEGKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVIT 1129
             Y+RLAERLGTPELSP ERK+LE KLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVI 
Sbjct:  2143 YIRLAERLGTPELSPTERKELESKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVIN 2202

Query:  1130 DILEWKTSRTFFYWRLRRLLLEDLVKEKIHDANPELTDGQIQAMLRRWFVEVEGTVKAYL 1189
             DIL+WKTSRTFFYWRLRRLLLEDLVK+KIH+ANPELTDGQIQAMLRRWFVEVEGTVKAY+
Sbjct:  2203 DILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYV 2262

Query:  1190 WDNNKDLVEWLEKQLTEEEGARSVVDENIKYISRDYILKQIRSLVQANPEVAMDSIVHMT 1249
             WDNNKDLVEWLEKQLTEE+G RSV++ENIKYISRDY+LKQIRSLVQANPEVAMDSIVHMT
Sbjct:  2263 WDNNKDLVEWLEKQLTEEDGVRSVIEENIKYISRDYVLKQIRSLVQANPEVAMDSIVHMT 2322

Query:  1250 QHISPTQRAEIVRILSTMDSPAS 1272
             QHISPTQRAE+VRILSTMDSP++
Sbjct:  2323 QHISPTQRAEVVRILSTMDSPST 2345

 Score = 1094 (390.2 bits), Expect = 0., Sum P(2) = 0.
 Identities = 226/307 (73%), Positives = 246/307 (80%)

Query:     1 DQLCGRDPTLTDELINILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFL 60
             DQLCGRDPTLTDEL+NILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFL
Sbjct:  1045 DQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFL 1104

Query:    61 SAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNS 120
             SAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNS
Sbjct:  1105 SAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNS 1164

Query:   121 VQHRQLKDNTCVVEFQFMLPTSHPN--SXXXXXXXSRPPSLPR-G-TQIKRI-------- 168
             VQHRQLKDNTCVVEFQFMLPTSHPN  +       S   +L   G T +  +        
Sbjct:  1165 VQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFASNLNHYGMTHVASVSDVLLDNA 1224

Query:   169 --PLRSIRGKKLCFIIHCNFVRLFDEVMGCFCDSPPQSPTFPEAGHPSLYDEDKSAREEP 226
               P     G  + F    +FVR+FDE+MGCFCDSPPQSPTFPE+GH SLYDEDK  R+EP
Sbjct:  1225 FTPPCQRMGGMVSFRTFEDFVRIFDEIMGCFCDSPPQSPTFPESGHTSLYDEDKVPRDEP 1284

Query:   227 IHILNVAIKTDCDIDDEGLAAMFRDFTQSRKSILIDHGIRRLTFLVAQKREFPKFFTFRA 286
             IHILNVAIKTD DI+D+ LAAMFR+FTQ  K+ L++HGIRRLTFLVAQK +F K      
Sbjct:  1285 IHILNVAIKTDGDIEDDRLAAMFREFTQQNKATLVEHGIRRLTFLVAQK-DFRKQVNCEV 1343

Query:   287 RDKFEED 293
               +F  +
Sbjct:  1344 DQRFHRE 1350

 Score = 61 (26.5 bits), Expect = 0., Sum P(2) = 0.
 Identities = 17/70 (24%), Positives = 32/70 (45%)

Query:    51 RHNQVESI---FLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQ-VVRMAALE 106
             RH +V+ +   + +AI ++G    ++   + I+ E       P  F H  Q  V++A + 
Sbjct:   355 RHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPAAIATPAVFEHMEQCAVKLAKMV 414

Query:   107 VYVRRAYIAY 116
              YV    + Y
Sbjct:   415 GYVSAGTVEY 424