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Gene Model: Acadm

NomenclatureGenomic Location
SymbolAcadmChromosomeX
NameAcyl-CoA dehydrogenase,
C-4 to C-12 straight chain
Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChrX: 63 Mbp

Molecular Function

This enzyme is specific for acyl chain lengths of 4 to 16.

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

Molecular Function Terms:

binding
   carboxylic acid binding
      monocarboxylic acid binding
         fatty acid binding
   cofactor binding
      coenzyme binding
         fatty-acyl-CoA binding

catalytic activity
   isomerase activity
   oxidoreductase activity
      oxidoreductase activity, acting on the CH-CH group of donors
         acyl-CoA dehydrogenase activity

Human Disease Association

Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD) [MIM:201450]. It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy.

Predicted Transcript
     1 TTTCAATTTTCTTTCAAAACAAATTTTCAGGTGATAAGAAGCATTGCTACATGTGGTTGG
    61 AGATCACAGTCTAGTCAAGCTACTGCAGCATTACCAAAAAGCAAACATGCAACTGGATTT
   121 AGTTTTGAACTTACAGAAGAGCAGAAAGAATTTCAAGCTACAGCACGTAAATTTGCTAGG
   181 GAGGAAATCTTACCTGCTGCGGCTGAGTATGACAGAACTGGAGAGTATCCCGTTCCTCTC
   241 ATTAAAAGGGCATGGGAGCTTGGCTTGATGAATACTCACATCCCTGAAAGCTGTGGTGGC
   301 CTTGGTCTTGGCACTTTTGATGCCTGCCTCATTACTGAAGAATTAGCATTTGGATGTACA
   361 GGGGTTCAAACTGCCATCGAAGCAAATTCCCTGGGACAAATGCCAGTCATCATTGCAGGG
   421 AATGAGCAGCAACAAAAGAAGTACCTGGGAAGAATGACAGAAGCACCCTTAATGTGTGCC
   481 TACTGTGTAACAGAGCCTGGAGCTGGTTCAGATGTTGCAGGTCTAAAAACAAAAGCAGAA
   541 AAGAAAGGAGACGAATATATAATTAATGGGCAAAAAATGTGGATCACCAATGGTGGCAAA
   601 GCCAACTGGTATTTTTTGCTGGCTCGCACTGTTCCTGATCCCAAAGCTCCTACAAATCAA
   661 GCTTTTACTGGCTTTATCGTGGAAGCAGATAGCCCTGGAATACAAATAGGCAGAAAGGAA
   721 CTTAATATGGGTCAGCGTTGCTCAGATACAAGAGGGATTGTTTTCGAGGATGTAAGAGTG
   781 CCCAAAGAGAATATCCTCATTGGTGAAGGAGCTGGCTTTAAAATAGCCATGGGAGCATTT
   841 GATAAAACAAGGCCCCCAGTAGCAGCTGGTGCTGTAGGACTAGCACAGCGAGCCTTAGAT
   901 GAAGCTACAAGGTATGCTCTGGAAAGAAAAACCTTTGGCAGGGTACTTGCAGAGCACCAA
   961 GCAGTATCTTTCATGTTGGCTGAAATGGCAATGAAAGTTGAGCTTGCTCGCCTGGCT

Predicted Protein Product
FQFSFKTNFQVIRSIATCGWRSQSSQATAALPKSKHATGFSFELTEEQKEFQATARKFAR
EEILPAAAEYDRTGEYPVPLIKRAWELGLMNTHIPESCGGLGLGTFDACLITEELAFGCT
GVQTAIEANSLGQMPVIIAGNEQQQKKYLGRMTEAPLMCAYCVTEPGAGSDVAGLKTKAE
KKGDEYIINGQKMWITNGGKANWYFLLARTVPDPKAPTNQAFTGFIVEADSPGIQIGRKE
LNMGQRCSDTRGIVFEDVRVPKENILIGEGAGFKIAMGAFDKTRPPVAAGAVGLAQRALD
EATRYALERKTFGRVLAEHQAVSFMLAEMAMKVELARLA
Protein Alignment to Mouse
sp|P45952|ACADM_MOUSE Medium-chain specific acyl-CoA dehydrogenase,
            mitochondrial OS=Mus musculus GN=Acadm PE=1 SV=1
      MGI:87867 Acadm acyl-Coenzyme A dehydrogenase, medium chain (Chr 3)
        Length = 421

 Score = 1432 (509.1 bits), Expect = 2.6e-147, P = 2.6e-147
 Identities = 270/336 (80%), Positives = 304/336 (90%)

Query:     4 SFKTNFQVIRSIATCGWRSQSSQATAALPKSKHATGFSFELTEEQKEFQATARKFAREEI 63
             +F+   +V+RS++    R+Q S+A     K +   GFSFELTE+QKEFQATARKFAREEI
Sbjct:     4 AFRRGCRVLRSVSHFECRTQHSKAAH---KQEPGLGFSFELTEQQKEFQATARKFAREEI 60

Query:    64 LPAAAEYDRTGEYPVPLIKRAWELGLMNTHIPESCGGLGLGTFDACLITEELAFGCTGVQ 123
             +P A EYD++GEYP PLIKRAWELGL+N HIPESCGGLGLGTFDACLITEELA+GCTGVQ
Sbjct:    61 IPVAPEYDKSGEYPFPLIKRAWELGLINAHIPESCGGLGLGTFDACLITEELAYGCTGVQ 120

Query:   124 TAIEANSLGQMPVIIAGNEQQQKKYLGRMTEAPLMCAYCVTEPGAGSDVAGLKTKAEKKG 183
             TAIEANSLGQMPVI+AGN+QQ+KKYLGRMTE P+MCAYCVTEP AGSDVA +KTKAEKKG
Sbjct:   121 TAIEANSLGQMPVILAGNDQQKKKYLGRMTEQPMMCAYCVTEPSAGSDVAAIKTKAEKKG 180

Query:   184 DEYIINGQKMWITNGGKANWYFLLARTVPDPKAPTNQAFTGFIVEADSPGIQIGRKELNM 243
             DEY+INGQKMWITNGGKANWYFLLAR+ PDPK P ++AFTGFIVEAD+PGI IG+KELNM
Sbjct:   181 DEYVINGQKMWITNGGKANWYFLLARSNPDPKVPASKAFTGFIVEADTPGIHIGKKELNM 240

Query:   244 GQRCSDTRGIVFEDVRVPKENILIGEGAGFKIAMGAFDKTRPPVAAGAVGLAQRALDEAT 303
             GQRCSDTRGI FEDVRVPKEN+LIGEGAGFKIAMGAFD+TRP VAAGAVGLAQRALDEAT
Sbjct:   241 GQRCSDTRGIAFEDVRVPKENVLIGEGAGFKIAMGAFDRTRPTVAAGAVGLAQRALDEAT 300

Query:   304 RYALERKTFGRVLAEHQAVSFMLAEMAMKVELARLA 339
             +YAL+RKTFG++L EHQ VSF+LAEMAMKVELARL+
Sbjct:   301 KYALDRKTFGKLLVEHQGVSFLLAEMAMKVELARLS 336