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Gene Model: Axin1

NomenclatureGenomic Location
SymbolAxin1Chromosome2
NameAxin 1Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 84 Mbp

Molecular Function

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

Molecular Function Terms:

binding
   protein binding
      beta-catenin binding
      enzyme binding
         kinase binding
      p53 binding
      protein complex binding
      protein domain specific binding
      SMAD binding

enzyme regulator activity
   enzyme activator activity
      GTPase activator activity
   nucleoside-triphosphatase regulator activity
      GTPase regulator activity

Human Disease Association

No disease association.

Predicted Transcript
     1 GCCCTGGCAACAAGGATGAGTGTCCCTGACTTCACGCCAGACCCCGGGGGCGGCTTCTCG
    61 GAGGATGCCCCGCGGCCCCCAGTCCCCGGCGAGGAGGGGGAGCTGGTTTCCGCTGAGACT
   121 GGGCGCCCACCCAGCCACGGGGGCTTCTTCCACAGTGGGGAGGCCCTCAAGGCGGAGGCC
   181 ACGCCCCGGCGGCCGGACCTGGACCTGGGCTACGAGCCCGAAGGCAGCGCTTCCCCGACA
   241 CCCCCTGCCCTGCGCTGGGCCGGCTCCCTGCACTCGCTACTGGACGACCGGGACGGGACC
   301 CAGCTCTTCCGCAGCTTCCTACGGGAGGAGGGCTGCGCCGACCTGCTAGACTTCTGGTTT
   361 GCCTGCAGTGGCTTCCGGAAGCTGGCGCCCGGCGAAGGCAGCGAGGAGAAGCGGCTTAAG
   421 CTGGCCAGGGCCATTTACAAGAAGTACGTTTTGCACGGTGCTGGCGTGGTAGCACGTAGG
   481 GTCAAGCCAGCCACCAAGAGCTTCATCCGGGACTGCGTCCTGCGGCAGCTGGTGGACCCG
   541 GCCGCCTTCGATCAGGCCCAGACCGAGGTTCAGGCTGCCATCGAGGAGCACTCCTACCCA
   601 CTCTTCCTCAAGTCCGACATCTACCTGGAATATGCTAGGAGTGGTGGAGGAGGAGGGGGC
   661 TGCGGAGGCGGGGAAAGCCCCAAGGGCCCCTGTGGAGAACACAGCCCCGAGGGCAACGGG
   721 AAGAGCCTCCCAGGCTACCTGCCCACCCTCAACGAGGACGAGGAGTGGAAGGGCGAGGGG
   781 ACCCCCGAGGGGAAGGGGAAAGGGGGCGTGTGCCGGGTGGTGGCGGAGGGCCCCCGAGAC
   841 CCCCTACTGCCTCCCCCCTCCGGGTGCCTGACCCAGACGCTACGAAGGGAGACCGCTGTC
   901 CAGCAGGCCGCCCCCGGAGCCCCTCCCTCGGCCAGCAGCACTGCCGCAGTGGCCCCCAGG
   961 CGCTACAGCGAGGGACGGGAGTTCAGACCCAGTCCGTGGAGGGAGCCGGTGCACCCCTAT
  1021 TACGTCAACACGGGCTTCGCCTTGGCCCCGGCCGCCAGCGCCAATGACAGCGAGCAACAC
  1081 AGCATGTCCAGCGATGCCGACACCATGTCCCTGACCGACAGCAGCGTAGACGGGATCCCT
  1141 CCCTACCGACTCCGGAAGCAGCATCGCAGAGAGATGCAGGAAAGTGCCAAAGCCAACGGA
  1201 CGTGTGCCTCTACCTCACATTCCTCGTACTTACCGAATGCCAAAGGATATCCACGTTGAA
  1261 CCCCAGAAATTTGCTGCAGAGTTGATCCACCGGCTGGAGGAGGTCCTGAGGGACCGGGAG
  1321 GCCGAGGCCAAGCTGGAGGAGCGCCTGAAGCGCGTCCGTGCAGAGGAAGAAGGCGAGGAG
  1381 CTGGAAATGCCTCTGGGCCCCTGTCTGGGGAGCCACAAAGTGCTCCTACCCCACTTCGGC
  1441 CCCCGTTGCTACTCTGAGGCCCCTCCCAGGGACGCCCATGAGGAGAACCCGGAGAGCATC
  1501 CTGGACGAACACGTCCAGCGGGTGATGAAGACCCCCGGCTGCCAGTCCCCCAAGCCCCGC
  1561 TCCCCAGACAGTGGCCTCGCTACGACCCCCGGCAAGCCCGCCCTCCACGGCCCCATGACA
  1621 GCAATGGGGCCCTCGCTGCCCTTGGGGCATGGGAAACATGCAGGGAAAGTGGGCCCCAGG
  1681 TTGGAGGGCGCTGGCCTGCACCACCACAAGCACGTCTTTCACCATGCGGCACATCATCAC
  1741 GGCCCCCTCAAGGCCAAGGAGCCGCCCCCCGCCGAGGCCGAGGGCCCCGGGGGACGTGGG
  1801 GGTGGTGCCTTCGGTTGGGGCTTGGAAGGCGCCCACAAGCCCCGGCTCTACGGGGAGAGC
  1861 GCCTGCCTGGACCCCGCAGCCTACAGCAGCAAAGCCGGTCTCCTCTCCAAGCGCAGCACC
  1921 AAGAAGGGCGAGGGGGGCAAAGGAGATGGCTATGAAGTCCCTGGTTCACCAGAGGACGTG
  1981 GAGAGGAACCAGAAGATCCTGCAGTGGATCATCGAGGGTGAGAAGGAGATCAGCCGGCAC
  2041 AAGAAGACCGGCCACAGTTCCTCCGGCGTTAAGAAGCAGCTGGGCCATGAACTGGTGCGG
  2101 CCAGCCTCTGTGGAACGCCCGGTGGCCCTGCACCCCTGGGTCAGCGCTCAGCTGCGGAAC
  2161 GTGGTGCAGCCCTCGCACCCCTTCATCCAGGACCCCACCATGCCCCCCAATCCGGCCCCC
  2221 AACCCCCTGACGCAGCTGGAGGAAGCCCGGCGGAGGCTGGAGGAGGAGGAGAAGCGGACG
  2281 GGGAAGGTCCCGGGGAAGCAGAGGGGGAAGACCCAGAAGCGGCCCCCGCCGGCCCCCCAG
  2341 CCGCCTTGCGACAACATTGTGGTGGCCTACTACTTCTGTGGGGAGCCCATCCCCTACCGG
  2401 ACGCTGGTGAAGGGCCGCGTGGTCACCCTAGGCCAGTTCAAGGAGCTGCTCACCAAGAAA
  2461 GGGAACTACAGGTATTACTTCAAGAAAGTGAGCGACGAGTTCGACTGTGGTGTGGTCTTT
  2521 GAAGAGGTGCGGGAAGACGAGGCCGTCCTGCCCATCTTCGAGGAGAAGATCATTGGGAAA
  2581 GTAGAAAAGATCGACTAG

Predicted Protein Product
ALATRMSVPDFTPDPGGGFSEDAPRPPVPGEEGELVSAETGRPPSHGGFFHSGEALKAEA
TPRRPDLDLGYEPEGSASPTPPALRWAGSLHSLLDDRDGTQLFRSFLREEGCADLLDFWF
ACSGFRKLAPGEGSEEKRLKLARAIYKKYVLHGAGVVARRVKPATKSFIRDCVLRQLVDP
AAFDQAQTEVQAAIEEHSYPLFLKSDIYLEYARSGGGGGGCGGGESPKGPCGEHSPEGNG
KSLPGYLPTLNEDEEWKGEGTPEGKGKGGVCRVVAEGPRDPLLPPPSGCLTQTLRRETAV
QQAAPGAPPSASSTAAVAPRRYSEGREFRPSPWREPVHPYYVNTGFALAPAASANDSEQH
SMSSDADTMSLTDSSVDGIPPYRLRKQHRREMQESAKANGRVPLPHIPRTYRMPKDIHVE
PQKFAAELIHRLEEVLRDREAEAKLEERLKRVRAEEEGEELEMPLGPCLGSHKVLLPHFG
PRCYSEAPPRDAHEENPESILDEHVQRVMKTPGCQSPKPRSPDSGLATTPGKPALHGPMT
AMGPSLPLGHGKHAGKVGPRLEGAGLHHHKHVFHHAAHHHGPLKAKEPPPAEAEGPGGRG
GGAFGWGLEGAHKPRLYGESACLDPAAYSSKAGLLSKRSTKKGEGGKGDGYEVPGSPEDV
ERNQKILQWIIEGEKEISRHKKTGHSSSGVKKQLGHELVRPASVERPVALHPWVSAQLRN
VVQPSHPFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRTGKVPGKQRGKTQKRPPPAPQ
PPCDNIVVAYYFCGEPIPYRTLVKGRVVTLGQFKELLTKKGNYRYYFKKVSDEFDCGVVF
EEVREDEAVLPIFEEKIIGKVEKID
Protein Alignment to Mouse
sp|O35625|AXIN1_MOUSE Axin-1 OS=Mus musculus GN=Axin1 PE=1 SV=2
      MGI:1096327 Axin1 axin 1 (Chr 17)
        Length = 863

 Score = 802 (287.4 bits), Expect = 8.8e-240, Sum P(4) = 8.8e-240
 Identities = 157/246 (63%), Positives = 185/246 (75%)

Query:    11 FTPDPGGGFSEDAPRPPVPGEEGELVSAETGRPPSHGGFFHSGEALKAE---ATPRRPDL 67
             F  D G  F+EDAPRPPVPGEEGELVS ++ RP +H      G ++K+E   ATPRR DL
Sbjct:     8 FPLDLGASFTEDAPRPPVPGEEGELVSTDS-RPVNHSFCSGKGTSIKSETSTATPRRSDL 66

Query:    68 DLGYEPEGSASPTPPALRWAGSLHSLLDDRDGTQLFRSFLREEGCADLLDFWFACSGFRK 127
             DLGYEPEGSASPTPP LRWA SLHSLLDD+DG  LFR+FL++EGCADLLDFWFACSGFRK
Sbjct:    67 DLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACSGFRK 126

Query:   128 LAPGEGSEEKRLKLARAIYKKYVLHGAGVVARRVKPATKSFIRDCVLRQLVDPAAFDQAQ 187
             L P + +EEKRLKLARAIY+KY+L   G+V+R+ KPATKSFI+DCV++Q +DPA FDQAQ
Sbjct:   127 LEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPAMFDQAQ 186

Query:   188 TEVQAAIEEHSYPLFLKSDIYLEYARXXXXXXXXXXXXXXXXXXXXHSPEGNGKSLPGYL 247
             TE+Q+ +EE++YP FLKSDIYLEY R                     S  G GK + GYL
Sbjct:   187 TEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQS--------SGSGTGKGMSGYL 238

Query:   248 PTLNED 253
             PTLNED
Sbjct:   239 PTLNED 244

 Score = 768 (275.4 bits), Expect = 8.8e-240, Sum P(4) = 8.8e-240
 Identities = 165/252 (65%), Positives = 184/252 (73%)

Query:   320 RRYSEGREFRPSPWREPVHPYYVNTGFALAPAASANDSEQHSMSSDADTMSLTDSSVDGI 379
             RRY+EGRE R   WREPV+PYYVN+G+ALAPA SANDSEQ S+SSDADT+SLTDSSVDGI
Sbjct:   284 RRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGI 343

Query:   380 PPYRLRKQHRREMQESAKANGRVPLPHIPRTYRMPKDIHVEPQKFAAELIHRLEEVLRDR 439
             PPYR+RKQHRREMQES + NGRVPLPHIPRTYRMPK+I VEPQKFA ELIHRLE V R R
Sbjct:   344 PPYRIRKQHRREMQESIQVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTR 403

Query:   440 EAEAKLEERLKRVRAXXXXXXXXXXXXXCLGSHKV-LLP---HFGPRCYSE---APPRDA 492
             EAE KLEERLKRVR               + SHK+  +P   HF PR Y +   +  RDA
Sbjct:   404 EAEEKLEERLKRVRMEEEGEDGEMPSGP-MASHKLPSVPAWHHFPPR-YVDMGCSGLRDA 461

Query:   493 HEENPESILDEHVQRVMKTPGCQSPKP--RSPDSGLATTPGKPALHGPMTAMGPSLPLGH 550
             HEENPESILDEHVQRVM+TPGCQSP P  RSPDSG          H   TA+      GH
Sbjct:   462 HEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSG----------HVAKTAVLGGTASGH 511

Query:   551 GKHAGKVGPRLE 562
             GKH  K+G +L+
Sbjct:   512 GKHVPKLGLKLD 523

 Score = 419 (152.6 bits), Expect = 8.8e-240, Sum P(4) = 8.8e-240
 Identities = 77/96 (80%), Positives = 85/96 (88%)

Query:   770 KTQKRXXXXXXXXCDNIVVAYYFCGEPIPYRTLVKGRVVTLGQFKELLTKKGNYRYYFKK 829
             K+Q++        CD+IVV YYFCGEPIPYRTLV+GR VTLGQFKELLTKKG+YRYYFKK
Sbjct:   768 KSQRKAGGGSAPPCDSIVVGYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKK 827

Query:   830 VSDEFDCGVVFEEVREDEAVLPIFEEKIIGKVEKID 865
             VSDEFDCGVVFEEVREDE VLP+FEEKIIGKVEK+D
Sbjct:   828 VSDEFDCGVVFEEVREDEPVLPVFEEKIIGKVEKVD 863

 Score = 369 (135.0 bits), Expect = 8.8e-240, Sum P(4) = 8.8e-240
 Identities = 80/160 (50%), Positives = 93/160 (58%)

Query:   613 KPRLYGESACLDPAA----YSSKAGLLSKRSTXXXXXXXXXXYEVPGSPEDVERNQKILQ 668
             KPR Y E+A    +A    +  K    SKR+T           EVP + ED E+NQKI+Q
Sbjct:   571 KPRSYSENAGTTLSAGDLPFGGKTSAPSKRNTKKAESGKNANAEVPSTTEDAEKNQKIMQ 630

Query:   669 WIIEGEKEISRHKKTGHSSSGVKKQLGHELVRPASVERPVALHPWVSAQLRNVVQPSHPF 728
             WIIEGEKEISRH+K GH SSG++KQ  HE  RP S+ERP A+HPWVSAQLRN VQPSH F
Sbjct:   631 WIIEGEKEISRHRKAGHGSSGLRKQQAHESSRPLSIERPGAVHPWVSAQLRNSVQPSHLF 690

Query:   729 IQDXXXXXXXXXXXLTQLXXXXXXXXXXXXXTGKVPGKQR 768
             IQD           LTQL               K+P KQR
Sbjct:   691 IQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQR 730

 Score = 49 (22.3 bits), Expect = 9.5e-72, Sum P(3) = 9.5e-72
 Identities = 17/75 (22%), Positives = 34/75 (45%)

Query:   331 SPWREPVHPYYVNTGFALAPAASANDSEQHSMSSDADTMSLTDSSVDGIPPYRLRKQHRR 390
             S   E  +P ++ +   L    + ++S +  + SD  + S T   + G  P     +  +
Sbjct:   191 STMEENTYPSFLKSDIYLEYTRTGSESPK--VCSDQSSGSGTGKGMSGYLPTLNEDEEWK 248

Query:   391 EMQESAKANGRVPLP 405
               Q++ + +GR PLP
Sbjct:   249 CDQDADEDDGRDPLP 263