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| Gene Model: Apc |
| Nomenclature | Genomic Location | ||
| Symbol | Apc | Chromosome | 1 |
| Name | Adenomatous polyposis coli protein | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 88 Mbp |
| Molecular Function |
|
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Molecular Function Terms: binding
enzyme regulator activity
|
| Human Disease Association |
|
Defects in APC are a cause of familial adenomatous polyposis (FAP) [MIM:175100]; which includes also Gardner syndrome (GS). FAP and GS contribute to tumor development in patients with uninherited forms of colorectal cancer. FAP is characterized by adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract (ampullary, duodenal and gastric adenomas). This is a viciously premalignant disease with one or more polyps progressing through dysplasia to malignancy in untreated gene carriers with a median age at diagnosis of 40 years. Defects in APC are a cause of hereditary desmoid disease (HDD) [MIM:135290]; also known as familial infiltrative fibromatosis (FIF). HDD is an autosomal dominant trait with 100% penetrance and possible variable expression among affected relatives. HDD patients show multifocal fibromatosis of the paraspinal muscles, breast, occiput, arms, lower ribs, abdominal wall, and mesentery. Desmoid tumors appears also as a complication of familial adenomatous polyposis. Defects in APC are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome). Defects in APC are a cause of mismatch repair cancer syndrome (MMRCS) [MIM:276300]; also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots. Defects in APC are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Defects in APC are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. This defect includes also the disease entity termed hepatoblastoma. |
| Predicted Transcript |
...........ATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGA
50 AGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAAC
110 TGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAGCAGCTACAGGGAAGTATTGAAG
170 ATGAGACTATGACTTCTGGACAGATTGACTTACTAGAGCGTCTTAAAGAATTTAACTTAG
230 ATAGTAATTTCCCCGGAGTGAAACTACGCTCAAAAATGTCCCTTCGCTCCTACGGAAGTC
290 GGGAAGGATCTGTATCCAGCCGTTCAGGAGAATGCAGTCCTGTCCCCATGGGGTCATTCC
350 CAAGAAGAACATTTGTAAATGGAAGCAGAGAGAGTACTGGGTATCTAGAAGAGCTTGAAA
410 AAGAAAGATCATTACTCCTTGCTGATCTTGACAAAGAAGAGAAGGAAAAGGACTGGTATT
470 ATGCTCAACTTCAGAACCTCACAAAAAGAATAGATAGCCTGCCTTTAACTGAAAATTTTT
530 CCTTACAGACAGACATGACAAGACGGCAGCTGGAGTATGAAGCAAGGCAGATCAGGGCTG
590 CAATGGAGGAGCAGCTTGGCACCTGCCAGGACATGGAGAAGCGTGCACAGCGAAGAATAG
650 CCAGGATCCAGCAAATAGAAAAGGACATACTGCGCGTGCGCCAGCTTTTACAGTCCCAGG
710 CGGCGGAAGCGGAGAGGTCATCTCAGAGCAGGCATGATGCTGCCTCCCATGAAGCTGGCC
770 GGCAGCACGAAGGCCACGGAGTGGCAGAAAGCAACACCGCAGCCTCCAGTAGTGGTCAGA
830 GTCCAGCTACACGTGTGGATCACGAAACAGCCAGTGTTTTGAGTTCTAGCGGCACGCACT
890 CTGCTCCTCGAAGGTTGACAAGTCATCTGGGGACAAAGGTGGAAATGGTGTATTCCTTGT
950 TGTCAATGCTTGGTACTCATGATAAGGACGATATGTCACGAACTTTGCTAGCTATGTCCA
1010 GCTCCCAAGACAGCTGTATATCCATGCGGCAGTCTGGATGTCTTCCTCTCCTCATCCAGC
1070 TTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGG
1130 CTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGA
1190 GAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGAGCTTACTGTGAAA
1250 CCTGTTGGGAGTGGCAGGAAGCCCACGAACAAGGCATGGACCAGGACAAAAACCCAATGC
1310 CAGCTCCTGTTGAGCATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAGCTTTCATTTG
1370 ATGAAGAGCATAGGCATGCAATGAATGAACTTGGGGGACTGCAGGCCATTGCAGAGTTAT
1430 TGCAGGTGGACTGTGAGATGTATGGGCTTACTAATGACCACTACAGTGTTACTTTAAGAC
1490 GGTATGCTGGAATGGCTTTGACAAACTTGACCTTTGGAGATGTTGCCAACAAGGCTACGC
1550 TGTGTTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAGTTAAAATCTGAGAGTGAAG
1610 ACTTACAGCAGGTTATTGCAAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATA
1670 GCAAAAAGACGTTGAGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTGGAAG
1730 TTAAAAAGGAATCAACCCTCAAAAGCGTTTTGAGTGCCTTATGGAACCTGTCTGCACACT
1790 GCACTGAGAATAAGGCTGACATCTGTGCTGTGGATGGAGCACTGGCATTTCTGGTTGGCA
1850 CCCTCACTTACCGGAGCCAGACAAATACTTTAGCCATTATTGAAAGTGGAGGTGGGATAT
1910 TACGGAATGTGTCCAGCTTGATAGCTACAAACGAAGACCACAGGCAAATCCTAAGAGAGA
1970 ACAATTGCCTACAAACTTTATTACAGCACTTGAAATCTCACAGCTTGACAATAGTCAGTA
2030 ATGCATGTGGAACTTTGTGGAATCTCTCAGCAAGAAATCCTAAAGACCAGGAAGCCTTGT
2090 GGGACATGGGGGCAGTGAGCATGCTCAAGAACCTCATTCATTCCAAGCACAAAATGATTG
2150 CCATGGGAAGTGCAGCAGCTTTAAGGAATCTCATGGCAAACAGACCTGCAAAGTATAAGG
2210 ATGCCAATATCATGTCTCCCGGCTCAAGTCTGCCATCCCTTCACGTTAGGAAACAGAAAG
2270 CTCTAGAAGCTGAGCTAGATGCTCAGCATTTATCAGAAACCTTCGACAACATTGACAACC
2330 TAAGTCCCAAGGCCTCTCACCGGAGTAAGCAGAGACACAAGCAGAATCTTTATGGTGACT
2390 ATGCTTTTGACGCCAATCGACATGATGATAGTAGGTCAGACAATTTCAATACTGGAAACA
2450 TGACTGTTCTTTCACCATATTTAAATACTACGGTATTGCCCAGCTCTTCTTCCTCAAGGG
2510 GAAGTTTAGACAGTTCTCGTTCTGAGAAAGACAGAAGTTTGGAGAGAGAGCGAGGTATTG
2570 GCCTCAGTGCTTACCATCCAACAACAGAAAATGCAGGAACCTCATCAAAACGAGGTCTGC
2630 AGATCACTACCACTGCAGCCCAGATAGCCAAAGTTATGGAAGAAGTATCAGCCATTCATA
2690 CCTCCCAGGACGACAGAAGTTCTGCTTCTACCACCGAGTTCCATTGTGTGGCAGACGACA
2750 GGAGTGCGGCACGAAGAAGCTCTGCCTCCCACACACACTCAAACACATACAACTTCACTA
2810 AGTCGGAAAATTCAAATAGGACATGCTCTATGCCTTATGCCAAAGTGGAATATAAACGAT
2870 CTTCAAATGACAGTTTAAATAGTGTCACTAGTAGTGATGGATATGGTAAAAGAGGCCAAA
2930 TGAAACCCTCAGTTGAATCCTATTCTGAAGATGATGAAAGTAAATTTTGCAGTTATGGTC
2990 AGTATCCAGCTGACCTAGCCCATAAGATACACAGTGCAAATCATATGGATGATAATGATG
3050 GAGAACTGGATACACCAATAAATTACAGTCTTAAATATTCAGATGAGCAGTTGAACTCAG
3110 GAAGGCAGAGTCCCTCACAGAATGAAAGGTGGGCAAGACCAAAGCATGTGATAGAAGATG
3170 AAATAAAGCAAAACGAGCAAAGACAAGCAAGAAGCCAGAACACCAGTTATCCTGTCTATT
3230 CTGAGAATACCGATGACAAACACCTCAAATTCCAACCACATTTTGGACAACAAGAATGTG
3290 TTTCCCCATATAGGTCAAGGGGAACCAGTGGTTCAGAAACAAATCGAATGGGTTCTAGTC
3350 ATGCAATTAATCAAAATGTAAACCAGTCTCTGTGTCAGGAAGATGATTATGAAGATGATA
3410 AACCTACCAACTACAGTGAACGTTATTCTGAGGAAGAACAACATGAAGAAGAAGAAGAGA
3470 GACCGACAAATTATAGCATAAAATATAATGAAGAGAAACATCATGTGGATCAGCCTATTG
3530 ATTATAGTTTAAAATATGCCACTGACATTTCTTCCTCACAAAAACCATCATTTTCATTCT
3590 CAAAGAATTCATCAGCACAAAGCACTAAACCTGAACATCTCTCTCCAAGCAGCGAGAATA
3650 CAGCTGTACCTCCATCTAATGCCAAAAGGCAGAATCAGCTGCGTCCAAGTTCAGCACAAA
3710 GAAATGGCCAGACTCAAAAAGGCACTACTTGCAAAGTCCCCTCCATCAACCAAGAAACAA
3770 TACAGACTTACTGCGTAGAAGACACCCCAATATGTTTTTCAAGGTGCAGTTCATTATCAT
3830 CACTGTCATCAGCTGACGATGAAATAGGATGTGATCAGACAACACAGGAAGCAGATTCTG
3890 CTAATACTCTGCAGACAGCAGAAGTAAAAGAGAATGATGTAACTCGGTCAGCTGAAGATC
3950 CTGCAACTGAAGTTCCAGCAGTGTCCCAGAATGCTAGAGCCAAACCCAGCCGACTCCAGG
4010 CTTCTGGCTTATCTTCAGAATCAACCAGGCATAATAAAGCTGTTGAGTTTTCTTCAGGAG
4070 CCAAGTCTCCCTCCAAAAGTGGTGCTCAGACACCCAAAAGTCCCCCAGAACACTATGTCC
4130 AGGAGACTCCGCTCGTATTCAGCAGGTGTACTTCTGTCAGCTCCCTTGACAGTTTTGAGA
4190 GTCGCTCCATTGCCAGCTCTGTTCAGAGTGAGCCATGTAGTGGAATGGTGAGTGGCATCA
4250 TAAGCCCCAGTGACCTTCCAGATAGTCCTGGGCAGACCATGCCACCAAGCAGAAGCAAAA
4310 CCCCTCCACCTCCTCCACAGACAGTGCAGGCCAAGAGAGAGGTGCCAAAAAGTAAAGTCC
4370 CTGCTGCTGAGAAGAGAGAGAGTGGGCCTAAGCAGACTGCTGTAAATGCTGCCGTGCAGA
4430 GGGTGCAGGTCCTTCCAGACGTGGATACTTTGTTACACTTCGCCACAGAAAGTACTCCAG
4490 ACGGGTTTTCTTGTTCCTCCAGCCTAAGTGCTCTGAGCCTGGATGAGCCATTTATACAGA
4550 AAGATGTAGAATTAAGAATCATGCCTCCAGTTCAGGAAAACGACAATGGGAATGAAACTG
4610 AATCAGAACAGCCTGAGGAATCAAATGAAAACCAGGATAAAGAGGTAGAAAAGCCTGACT
4670 CTGAAAAAGACTTATTAGATGATTCTGATGACGATGATATTGAAATATTAGAAGAATGTA
4730 TTATTTCAGCCATGCCAACAAAGTCATCACGCAAAGCCAAAAAACTAGCCCAGACTGCTT
4790 CAAAATTACCTCCACCTGTGGCAAGGAAACCAAGTCAGCTACCTGTGTATAAACTTCTGC
4850 CAGCACAGAATAGGCTGCAGGCACAAAAACATGTTAGCTTTACACCAGGGGATGATGTGC
4910 CCCGGGTGTACTGTGTAGAAGGGACACCTATAAACTTTTCCACAGCAACGTCTCTAAGTG
4970 ATCTGACAATAGAGTCCCCTCCAAATGAATTGGCTACTGGAGATGGGGTCAGAGCGGGTA
5030 TACAGTCAGGTGAATTTGAAAAACGAGATACCATTCCTACAGAAGGCAGAAGTACAGATG
5090 ATGCTCAGCGAGGAAAAATCTCATCTATAGTTACACCAGACCTGGATGACAACAAAGCAG
5150 AGGAAGGAGATATTCTTGCAGAATGTATCAATTCTGCTATGCCCAAAGGAAAAAGCCACA
5210 AGCCTTTCCGAGTGAAAAAGATAATGGACCAAGTCCAACAAGCATCCTCGACTTCATCTG
5270 GAGCTAACAAAAATCAAGTAGACACTAAGAAAAAGAAGCCTACTTCACCAGTAAAGCCCA
5330 TGCCACAAAATACTGAATATAGAACGCGTGTGAGAAAGAATACAGACTCAAAAGTTAATG
5390 TAAATACTGAAGAAACTTTCTCAGACAACAAAGACTCAAAGAAACCAAGCTTACAAACCA
5450 ATGCCAAGGCCTTCAATGAAAAGCTACCTAACAATGAAGACAGAGTGCGGGGGAGCTTCG
5510 CCTTGGACTCACCGCATCACTACACCCCTATTGAGGGGACGCCGTACTGCTTTTCCCGAA
5570 ATGACTCCTTGAGTTCTCTGGATTTTGATGATGACGATGTTGACCTTTCCAGGGAAAAGG
5630 CCGAGTTAAGAAAGGGCAAAGAAAGCAAGGATTCCGAAGCCAAAGTTACCTGCCGCCCAG
5690 AACCAAACTCAAGCCAGCAGGCAGCTAGTAAGTCACAAGCCAGTATAAAACATCCAGCAA
5750 ACAGAGCACAGTCCAAACCAGTGCTGCAGAAACAGCCCACTTTCCCCCAGTCCTCCAAAG
5810 ACGGACCAGATAGAGGGGCAGCAACTGACGAAAAACTGCAGAATTTTGCTATTGAAAATA
5870 CTCCAGTTTGCTTTTCTCGAAATTCCTCTCTGAGTTCCCTTAGTGACATTGACCAGGAAA
5930 ACAACAATAACAAAGAAAGTGAACCAATCAAAGAAGCTGAACCTGCCAACTCACAAGGAG
5990 AGCCCAGTAAGCCTCAGGCATCCGGGTATGCTCCCAAGTCCTTCCACGTCGAAGACACCC
6050 CTGTCTGTTTCTCAAGAAACAGCTCTCTCAGTTCTCTTAGCATTGACTCTGAGGACGACC
6110 TGTTACAGGAGTGTATAAGTTCTGCCATGCCAAAAAAGAAAAGGCCTTCAAGACTCAAGA
6170 GTGAGAGCGAAAAGCAGAGCCCTAGAAAAGTGGGTGGCATATTAGCTGAAGACCTGACGC
6230 TTGATTTGAAAGATCTACAGAGGCCAGATTCAGAACACGCTTTCTCCCCCGACTCAGAAA
6290 ATTTTGACTGGAAAGCTATTCAGGAAGGCGCAAACTCCATAGTAAGTAGTTTGCACCAAG
6350 CTGCTGCAGCCGCCGCGTGCTTATCTAGACAAGCGTCATCCGACTCAGATTCCATTCTGT
6410 CACTAAAGTCCGGCATTTCTCTGGGATCGCCTTTTCATCTTACACCTGATCAAGAGGAAA
6470 AGCCATTCACAAGCAATAAAGGCCCAAGAATTCTCAAACCTGGAGAGAAAAGCACATTAG
6530 AAGCAAAAAAAATAGAATCTGAAAACAAAGGAATCAAAGGCGGGAAAAAGGTTTATAAAA
6590 GCTTGATTACGGGAAAGATTCGCTCCAATTCAGAAATTTCCAGCCAAATGAAACAACCCC
6650 TCCCGACAAACATGCCTTCAATCTCAAGAGGCAGGACGATGATTCACATCCCAGGGCTTC
6710 GGAATAGCTCCTCTAGTACAAGCCCTGTCTCTAAGAAAGGCCCACCCCTCAAGACTCCAG
6770 CCTCTAAAAGCCCCAGTGAAGGGCCGGGAGCTACCACTTCTCCTCGAGGAACTAAGCCAG
6830 CAGGAAAGTCAGAGCTTAGCCCTATCACCAGGCAAACTTCCCAAATCAGTGGGTCAAATA
6890 AGGGGTCTTCTAGATCAGGATCTAGAGACTCCACTCCCTCAAGACCTACACAGCAACCAT
6950 TAAGTAGGCCAATGCAGTCTCCAGGGCGAAACTCAATTTCCCCTGGTAGAAATGGAATAA
7010 GCCCTCCTAACAAACTGTCTCAGCTGCCCAGAACATCATCTCCCAGTACTGCTTCAACTA
7070 AGTCCTCCGGTTCTGGGAAAATGTCATATACATCCCCAGGTAGACAGCTGAGCCAACAAA
7130 ATCTTACCAAACAAGCAAGTTTATCCAAGAATGCCAGCAGTATCCCCAGAAGTGAGTCGG
7190 CATCTAAAGGACTGAATCAGATGAGTAACGGCAATGGGTCAAATAAAAAGGTAGAACTTT
7250 CTAGAATGTCTTCAACTAAATCAAGTGGAAGTGAATCAGACAGATCAGAAAGGCCTGCAT
7310 TAGTACGCCAGTCTACTTTCATCAAAGAAGCCCCAAGCCCAACCCTGAGGAGGAAACTGG
7370 AGGAATCTGCCTCATTTGAATCCCTTTCTCCATCTTCTAGACCAGATTCTCCCACCAGGT
7430 CGCAGGCACAGACCCCAGTTTTAAGCCCTTCCCTTCCTGATATGTCTCTGTCCACACATC
7490 CATCTGTTCAGGCAGGTGGGTGGCGAAAGCTCCCGCCTAATCTCAGCCCCACTATCGAGT
7550 ATAATGACGGAAGGCCCACAAAACGGCATGATATTGCACGCTCCCATTCTGAAAGTCCTT
7610 CCAGACTACCAATCAACCGGGCGGGAACCTGGAAGCGTGAACACAGCAAACATTCCTCGT
7670 CCCTTCCTCGAGTGAGTACTTGGAGAAGAACTGGAAGCTCATCTTCTATTCTTTCTGCTT
7730 CATCAGAGTCCAGTGAAAAAGCAAAAAGTGAGGATGAAAGGCATGTGAGCTCCATGCCAG
7790 CACCCAGACAGATGAAGGAAAACCAGGTGCCCACCAAAGGAACATGGAGGAAAATCAAGG
7850 AAAGTGACATTTCTCCCACAGGCATGGCTTCTCAGAGCGCTTCCTCAGGTGCTGCCAGTG
7910 GTGCTGAATCCAAGCCTCTGATCTATCAGATGGCACCTCCTGTCTCTAAAACAGAGGATG
7970 TTTGGGTGAGAATTGAGGACTGCCCCATTAACAACCCTAGATCTGGACGGTCCCCCACAG
8030 GCAACACCCCCCCAGTGATTGACAGTGTTTCAGAGAAGGGAAGTTCAAGCATTAAAGATT
8090 CAAAAGACACCCATGGGAAACAGAGTGTGGGCAGTGGCAGTCCTGTGCAAACCGTGGGTC
8150 TGGAAACCCGCCTCAACTCCTTTGTTCAGGTAGAGGCCCCAGAACAGAAAGGAACTGAGG
8210 CAAAACCAGGACAGAGTAACCCAGTCTCTATAGCAGAGACTGCTGAGACGTGTATAGCAG
8270 AGCGTACCCCTTTCAGTTCCAGTAGCTCCAGCAAGCACAGCTCACCTAGCGGGACTGTTG
8330 CTGCCAGAGTGACACCTTTTAATTACAACCCTAGCCCTAGGAAGAGCAGCGCAGACAGCA
8390 CTTCAGCCCGGCCGTCTCAGATCCCTACGCCAGTGAGCACCAACACGAAGAAGAGAGATT
8450 CGAAGACTGACAGCACAGAATCCAGTGGAGCCCAAAGTCCTAAACGCCATTCCGGGTCTT
8510 ACCTCGTGACGTCTGTTTAA...........................
| Predicted Protein Product |
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDETM TSGQIDLLERLKEFNLDSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRT FVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQT DMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRVRQLLQSQAAEA ERSSQSRHDAASHEAGRQHEGHGVAESNTAASSSGQSPATRVDHETASVLSSSGTHSAPR RLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHG NDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWE WQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVD CEMYGLTNDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQ VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN KADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGS AAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPK ASHRSKQRHKQNLYGDYAFDANRHDDSRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLD SSRSEKDRSLERERGIGLSAYHPTTENAGTSSKRGLQITTTAAQIAKVMEEVSAIHTSQD DRSSASTTEFHCVADDRSAARRSSASHTHSNTYNFTKSENSNRTCSMPYAKVEYKRSSND SLNSVTSSDGYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELD TPINYSLKYSDEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENT DDKHLKFQPHFGQQECVSPYRSRGTSGSETNRMGSSHAINQNVNQSLCQEDDYEDDKPTN YSERYSEEEQHEEEEERPTNYSIKYNEEKHHVDQPIDYSLKYATDISSSQKPSFSFSKNS SAQSTKPEHLSPSSENTAVPPSNAKRQNQLRPSSAQRNGQTQKGTTCKVPSINQETIQTY CVEDTPICFSRCSSLSSLSSADDEIGCDQTTQEADSANTLQTAEVKENDVTRSAEDPATE VPAVSQNARAKPSRLQASGLSSESTRHNKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETP LVFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPP PPQTVQAKREVPKSKVPAAEKRESGPKQTAVNAAVQRVQVLPDVDTLLHFATESTPDGFS CSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPEESNENQDKEVEKPDSEKD LLDDSDDDDIEILEECIISAMPTKSSRKAKKLAQTASKLPPPVARKPSQLPVYKLLPAQN RLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELATGDGVRAGIQSG EFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDDNKAEEGDILAECINSAMPKGKSHKPFR VKKIMDQVQQASSTSSGANKNQVDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTE ETFSDNKDSKKPSLQTNAKAFNEKLPNNEDRVRGSFALDSPHHYTPIEGTPYCFSRNDSL SSLDFDDDDVDLSREKAELRKGKESKDSEAKVTCRPEPNSSQQAASKSQASIKHPANRAQ SKPVLQKQPTFPQSSKDGPDRGAATDEKLQNFAIENTPVCFSRNSSLSSLSDIDQENNNN KESEPIKEAEPANSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQE CISSAMPKKKRPSRLKSESEKQSPRKVGGILAEDLTLDLKDLQRPDSEHAFSPDSENFDW KAIQEGANSIVSSLHQAAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFT SNKGPRILKPGEKSTLEAKKIESENKGIKGGKKVYKSLITGKIRSNSEISSQMKQPLPTN MPSISRGRTMIHIPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTSPRGTKPAGKS ELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNGISPPN KLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESASKG LNQMSNGNGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESA SFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDG RPTKRHDIARSHSESPSRLPINRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSES SEKAKSEDERHVSSMPAPRQMKENQVPTKGTWRKIKESDISPTGMASQSASSGAASGAES KPLIYQMAPPVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKGSSSIKDSKDT HGKQSVGSGSPVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIAETAETCIAERTP FSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTD STESSGAQSPKRHSGSYLVTSV
| Protein Alignment to Mouse |
tr|B2RUG9|B2RUG9_MOUSE Adenomatosis polyposis coli OS=Mus musculus GN=Apc PE=2
SV=1
MGI:1923206 Srrm2 serine/arginine repetitive matrix 2 (Chr 17)
Length = 2842
Score = 12127 (4274.0 bits), Expect = 0., P = 0.
Identities = 2393/2842 (84%), Positives = 2393/2842 (84%)
Query: 1 MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDETM 60
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDETM
Sbjct: 1 MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDETM 60
Query: 61 TSGQIDLLERLKEFNLDSNFPGVKLRSKMSLXXXXXXXXXXXXXXXXXXPVPMGSFPRRT 120
TSGQIDLLERLKEFNLDSNFPGVKLRSKMSL PVPMGSFPRRT
Sbjct: 61 TSGQIDLLERLKEFNLDSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRT 120
Query: 121 FVNGSRESTGYXXXXXXXXXXXXXXXXXXXXXXXWYYAQLQNLTKRIDSLPLTENFSLQT 180
FVNGSRESTGY WYYAQLQNLTKRIDSLPLTENFSLQT
Sbjct: 121 FVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQT 180
Query: 181 DMTRRQLEYEARQIRAAMEEQLGTCQDMEKXXXXXXXXXXXXEKDILRVRQLLXXXXXXX 240
DMTRRQLEYEARQIRAAMEEQLGTCQDMEK EKDILRVRQLL
Sbjct: 181 DMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRVRQLLQSQAAEA 240
Query: 241 XXXXXXXHDAASHEAGRQHEGHGVAESNTAASSSGQSPATRVDHETASVLSSSGTHSAPR 300
HDAASHEAGRQHEGHGVAESNTAASSSGQSPATRVDHETASVLSSSGTHSAPR
Sbjct: 241 ERSSQSRHDAASHEAGRQHEGHGVAESNTAASSSGQSPATRVDHETASVLSSSGTHSAPR 300
Query: 301 RLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHG 360
RLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHG
Sbjct: 301 RLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHG 360
Query: 361 NDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWE 420
NDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWE
Sbjct: 361 NDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWE 420
Query: 421 WQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVD 480
WQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVD
Sbjct: 421 WQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVD 480
Query: 481 CEMYGLTNDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQ 540
CEMYGLTNDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQ
Sbjct: 481 CEMYGLTNDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQ 540
Query: 541 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 600
VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN
Sbjct: 541 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 600
Query: 601 KADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL 660
KADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL
Sbjct: 601 KADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL 660
Query: 661 QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGS 720
QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGS
Sbjct: 661 QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGS 720
Query: 721 AAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPK 780
AAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPK
Sbjct: 721 AAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPK 780
Query: 781 ASHRSKQRHKQNLYGDYAFDANRHDDSRSDNFNTGNMTVLSPYLNTTVLPXXXXXXXXXX 840
ASHRSKQRHKQNLYGDYAFDANRHDDSRSDNFNTGNMTVLSPYLNTTVLP
Sbjct: 781 ASHRSKQRHKQNLYGDYAFDANRHDDSRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLD 840
Query: 841 XXXXEKDRSLERERGIGLSAYHPTTENAGTSSKRGLQITTTAAQIAKVMEEVSAIHTSQD 900
EKDRSLERERGIGLSAYHPTTENAGTSSKRGLQITTTAAQIAKVMEEVSAIHTSQD
Sbjct: 841 SSRSEKDRSLERERGIGLSAYHPTTENAGTSSKRGLQITTTAAQIAKVMEEVSAIHTSQD 900
Query: 901 DRSSASTTEFHCVXXXXXXXXXXXXXHTHSNTYNFTKSENSNRTCSMPYAKVEYKRXXXX 960
DRSSASTTEFHCV HTHSNTYNFTKSENSNRTCSMPYAKVEYKR
Sbjct: 901 DRSSASTTEFHCVADDRSAARRSSASHTHSNTYNFTKSENSNRTCSMPYAKVEYKRSSND 960
Query: 961 XXXXXXXXXGYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELD 1020
GYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELD
Sbjct: 961 SLNSVTSSDGYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELD 1020
Query: 1021 TPINYSLKYSDEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENT 1080
TPINYSLKYSDEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENT
Sbjct: 1021 TPINYSLKYSDEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENT 1080
Query: 1081 DDKHLKFQPHFGQQECVSPYRSRGTSGSETNRMGSSHAINQNVNQSLCQEDDYEDDKPTN 1140
DDKHLKFQPHFGQQECVSPYRSRGTSGSETNRMGSSHAINQNVNQSLCQEDDYEDDKPTN
Sbjct: 1081 DDKHLKFQPHFGQQECVSPYRSRGTSGSETNRMGSSHAINQNVNQSLCQEDDYEDDKPTN 1140
Query: 1141 XXXXXXXXXXXXXXXXXPTNYSIKYNEEKHHVDQPIDYSLKYATDIXXXXXXXXXXXXXX 1200
PTNYSIKYNEEKHHVDQPIDYSLKYATDI
Sbjct: 1141 YSERYSEEEQHEEEEERPTNYSIKYNEEKHHVDQPIDYSLKYATDISSSQKPSFSFSKNS 1200
Query: 1201 XXXXTKPEHLSPSSENTAVPPSNAKRQNQLRPSSAQRNGQTQKGTTCKVPSINQETIQTY 1260
TKPEHLSPSSENTAVPPSNAKRQNQLRPSSAQRNGQTQKGTTCKVPSINQETIQTY
Sbjct: 1201 SAQSTKPEHLSPSSENTAVPPSNAKRQNQLRPSSAQRNGQTQKGTTCKVPSINQETIQTY 1260
Query: 1261 CVEDTPICFSRCXXXXXXXXADDEIGCDQTTQEADSANTLQTAEVKENDVTRSAEDPATE 1320
CVEDTPICFSRC ADDEIGCDQTTQEADSANTLQTAEVKENDVTRSAEDPATE
Sbjct: 1261 CVEDTPICFSRCSSLSSLSSADDEIGCDQTTQEADSANTLQTAEVKENDVTRSAEDPATE 1320
Query: 1321 VPAVSQNARAKPSRLQASGLSSESTRHNKAVEFXXXXXXXXXXXXQTPKSPPEHYVQETP 1380
VPAVSQNARAKPSRLQASGLSSESTRHNKAVEF QTPKSPPEHYVQETP
Sbjct: 1321 VPAVSQNARAKPSRLQASGLSSESTRHNKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETP 1380
Query: 1381 LVFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMXXXXXXXXXX 1440
LVFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTM
Sbjct: 1381 LVFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPP 1440
Query: 1441 XXXXXXXXXEVPKSKVPAAEKRESGPKQTAVNAAVQRVQVLPDVDTLLHFATESTPDGFX 1500
EVPKSKVPAAEKRESGPKQTAVNAAVQRVQVLPDVDTLLHFATESTPDGF
Sbjct: 1441 PPQTVQAKREVPKSKVPAAEKRESGPKQTAVNAAVQRVQVLPDVDTLLHFATESTPDGFS 1500
Query: 1501 XXXXXXXXXXDEPFIQKDVELRIMPPVQENDXXXXXXXXXXXXXXXXXDKEVEKPXXXXX 1560
DEPFIQKDVELRIMPPVQEND DKEVEKP
Sbjct: 1501 CSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPEESNENQDKEVEKPDSEKD 1560
Query: 1561 XXXXXXXXXXXXXXXXXXXAMPTKSSRKAKKLAQTASKLPPPVARKPSQLPVYKLLPAQN 1620
AMPTKSSRKAKKLAQTASKLPPPVARKPSQLPVYKLLPAQN
Sbjct: 1561 LLDDSDDDDIEILEECIISAMPTKSSRKAKKLAQTASKLPPPVARKPSQLPVYKLLPAQN 1620
Query: 1621 RLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELATGDGVRAGIQSG 1680
RLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELATGDGVRAGIQSG
Sbjct: 1621 RLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELATGDGVRAGIQSG 1680
Query: 1681 EFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDDNKAEEGDILAECINSAMPKGKSHKPFR 1740
EFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDDNKAEEGDILAECINSAMPKGKSHKPFR
Sbjct: 1681 EFEKRDTIPTEGRSTDDAQRGKISSIVTPDLDDNKAEEGDILAECINSAMPKGKSHKPFR 1740
Query: 1741 VKKIMDQVQQASSTSSGANKNQVDTXXXXXXXXXXXXXQNTEYRTRVRKNTDSKVNVNTE 1800
VKKIMDQVQQASSTSSGANKNQVDT QNTEYRTRVRKNTDSKVNVNTE
Sbjct: 1741 VKKIMDQVQQASSTSSGANKNQVDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTE 1800
Query: 1801 ETFSDNKDSKKPSLQTNAKAFNEKLPNNEDRVRGSFALDSPHHYTPIEGTPYCFSRNXXX 1860
ETFSDNKDSKKPSLQTNAKAFNEKLPNNEDRVRGSFALDSPHHYTPIEGTPYCFSRN
Sbjct: 1801 ETFSDNKDSKKPSLQTNAKAFNEKLPNNEDRVRGSFALDSPHHYTPIEGTPYCFSRNDSL 1860
Query: 1861 XXXXXXXXXXXXXREKAELRKGKESKDSEAKVTCRPEPNXXXXXXXXXXXXIKHPANRAQ 1920
REKAELRKGKESKDSEAKVTCRPEPN IKHPANRAQ
Sbjct: 1861 SSLDFDDDDVDLSREKAELRKGKESKDSEAKVTCRPEPNSSQQAASKSQASIKHPANRAQ 1920
Query: 1921 SKPVLQKQPTFPQSSKDGPDRGAATDEKLQNFAIENTPVCFSRNXXXXXXXDIDQENNNN 1980
SKPVLQKQPTFPQSSKDGPDRGAATDEKLQNFAIENTPVCFSRN DIDQENNNN
Sbjct: 1921 SKPVLQKQPTFPQSSKDGPDRGAATDEKLQNFAIENTPVCFSRNSSLSSLSDIDQENNNN 1980
Query: 1981 KESEPIKEAEPANSQGEPSKPQASGYAPKSFHVEDTPVCFSRNXXXXXXXXXXXXXXXQE 2040
KESEPIKEAEPANSQGEPSKPQASGYAPKSFHVEDTPVCFSRN QE
Sbjct: 1981 KESEPIKEAEPANSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQE 2040
Query: 2041 CISSAMPKKKRPSRLKSESEKQSPRKVGGILAEDLTLDLKDLQRPDSEHAFSPDSENFDW 2100
CISSAMPKKKRPSRLKSESEKQSPRKVGGILAEDLTLDLKDLQRPDSEHAFSPDSENFDW
Sbjct: 2041 CISSAMPKKKRPSRLKSESEKQSPRKVGGILAEDLTLDLKDLQRPDSEHAFSPDSENFDW 2100
Query: 2101 KAIQEGANSIVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPFHLTPDQEEKPFT 2160
KAIQEGANSIV PFHLTPDQEEKPFT
Sbjct: 2101 KAIQEGANSIVSSLHQAAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFT 2160
Query: 2161 SNKGPRILKPGEKSTLEAKKIESENKGIKGGKKVYKSLITGKIRSNSEISSQMKQPLPTN 2220
SNKGPRILKPGEKSTLEAKKIESENKGIKGGKKVYKSLITGKIRSNSEISSQMKQPLPTN
Sbjct: 2161 SNKGPRILKPGEKSTLEAKKIESENKGIKGGKKVYKSLITGKIRSNSEISSQMKQPLPTN 2220
Query: 2221 MPSISRGRTMIHIPGLRNXXXXXXXXXKKGPPLKTPASKSPSEGPGATTSPRGTKPAGKS 2280
MPSISRGRTMIHIPGLRN KKGPPLKTPASKSPSEGPGATTSPRGTKPAGKS
Sbjct: 2221 MPSISRGRTMIHIPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTSPRGTKPAGKS 2280
Query: 2281 ELSPITRQTXXXXXXXXXXXXXXXXXXXXXXPTQQPLSRPMQSPGRNSISPGRNGISPPN 2340
ELSPITRQT PTQQPLSRPMQSPGRNSISPGRNGISPPN
Sbjct: 2281 ELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNGISPPN 2340
Query: 2341 KLSQLPRXXXXXXXXXXXXXXXXXXXXXXGRQLSQQNLTKQASLSKNASSIPRSESASKG 2400
KLSQLPR GRQLSQQNLTKQASLSKNASSIPRSESASKG
Sbjct: 2341 KLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESASKG 2400
Query: 2401 LNQMSNGNGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLXXXX 2460
LNQMSNGNGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKL
Sbjct: 2401 LNQMSNGNGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESA 2460
Query: 2461 XXXXXXXXXXXXXXXXXQAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDG 2520
QAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDG
Sbjct: 2461 SFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDG 2520
Query: 2521 RPTKRHDIARSHSESPSRLPINRAGTWKREHSKHSSSLPRVSTWRRTGXXXXXXXXXXXX 2580
RPTKRHDIARSHSESPSRLPINRAGTWKREHSKHSSSLPRVSTWRRTG
Sbjct: 2521 RPTKRHDIARSHSESPSRLPINRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSES 2580
Query: 2581 XXXXXXXDERHVSSMPAPRQMKENQVPTKGTWRKIKESDISPTGMXXXXXXXXXXXXXES 2640
DERHVSSMPAPRQMKENQVPTKGTWRKIKESDISPTGM ES
Sbjct: 2581 SEKAKSEDERHVSSMPAPRQMKENQVPTKGTWRKIKESDISPTGMASQSASSGAASGAES 2640
Query: 2641 KPLIYQMAPPVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKGSSSIKDSKDT 2700
KPLIYQMAPPVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKGSSSIKDSKDT
Sbjct: 2641 KPLIYQMAPPVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKGSSSIKDSKDT 2700
Query: 2701 HGKQSVGSGSPVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIAETAETCIAERTP 2760
HGKQSVGSGSPVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIAETAETCIAERTP
Sbjct: 2701 HGKQSVGSGSPVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIAETAETCIAERTP 2760
Query: 2761 FXXXXXXXXXXXXGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTD 2820
F GTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTD
Sbjct: 2761 FSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTD 2820
Query: 2821 STESSGAQSPKRHSGSYLVTSV 2842
STESSGAQSPKRHSGSYLVTSV
Sbjct: 2821 STESSGAQSPKRHSGSYLVTSV 2842