| Nomenclature | Genomic Location |
| Symbol | Axin2 | Chromosome | 2 |
| Name | Axin 2 | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr2: 71 Mbp |
| Molecular Function |
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Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Molecular Function Terms:
binding
protein binding
enzyme binding
protein complex binding
protein domain specific binding
enzyme regulator activity
enzyme activator activity
GTPase activator activity
nucleoside-triphosphatase regulator activity
GTPase regulator activity
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| Human Disease Association |
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Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically
associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615].
Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous
lesions of variable types.
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1 ATGAGCAGTGCAGCCTTGCTGACTCACCTTCCAGACCCCAGTAGCAGCTTTAGAGAAGAT
61 GCCCCACGCCCCCCTGTACCAGGGGAAGAAGGAGAGGCACCATGCCACCTGCCTGCCAGT
121 TTGTTTCTTGTGAAAAACCAAAGCTTCAAGGCCATGTCCGTTTCTTCCACGCCCAGAAGG
181 AATGAGGATGGTCTGGGGGAGCCAGAAGGCAGTGCTTCTCCGGATTCCCCTCTGGCGCGA
241 TGGACCAAATCCTTGCATTCCTTGCTGGGAGATCAAGATGGTGCCTATCTCTTCCGGACC
301 TTCCTGGAAAGGGAGAAATGTGTGGATACTTTAGACTTCTGGTTTGCCTGCAATGGCTTC
361 AGGCAGATGGACCTTAAGGATACCAAAACATTAAGAGTCGCCAAAGCTATCTACAAAAGG
421 TACATTGAGAACAACAGCATTGTCTCCAAGCAACTCAAGCCTGCCACCAAGACCTACATA
481 AGGGATAGTATTAAGAAGCAGCAGATCGATTCAATCATGTTTGATCAGGCGCAGACTGAG
541 ATCCAGACTGTGATGGAGGAAAATGCTTACCGGATGTTTTTAACTTCTGATATATACCTC
601 GAATATGTAAGGAGTGGGGGAGAGAATCCTGCTTACATGAACAGCAATGGACTGGGGAGC
661 TTAAAAGTTGACTGTGGCTACCTTCCTACCTTGAATGAAGAAGAGGAATGGAGCTGTGCT
721 GATTTTAAAAACAAACTTTTGCCATCTGTGCTTGGGTTGTCCAGTAAGACGTTGAGGGCC
781 ACAGCAAGCGTCCGAGCTACAGAAGCTGTGGAGAATGGGTTCAGGTCCTTCAAGAGGAAT
841 GATCCTGTTAACCCTTACCATGTGAACTCTGGTTACGTCTTTGCTCCTGCCACTAGTGCA
901 AACGATAGTGAAATATCTAGTGATGCTCTGACTGACGATTCCGTATCAATGACGGATAGC
961 AGTGTTGATGGGATCCCTCCTTATAGACTTGGAAGCAAAAAACAGCTCCAGAGGGAAATG
1021 CATCGTAGTGTCAAGGCCAATGGTCAAGTTTCTCTACCTCACTTTCCGAGAACTCATCGC
1081 CTTCCTAGGGAAATGACCCCCGTGGAACCAGCTGCTTTTGCCGCCGAGCTCATTTCTCGG
1141 TTGGAAAAGCTCAAGCGGGAACAAGAGACCATGGACTCTCTGGAGGAGAGGCTGCAGCAA
1201 ATCACAGAGGATGAAGAGAAGGAGGGATCTGATGTTCCTGTCAGCTCACAGGCCACCCGA
1261 GAACATCCCCTGACTCTCCTCCCCTCCGGCAGCTATGAGGATGATCCCCAGGCTATCCTG
1321 GATGACCATCTTTCACGGGTGCTGAAGACACCGGGGTGCCAATCTCCCGGCATGGGACGG
1381 CATAGTCCTCGCGCACGCTCCCCAGACCGCTTCCAGGTGGTAAATTGCTCCCTGGCACCT
1441 GGCACAGCCTCTGTACCCAATGCCTGTGCTCTTGTCAGCAAAGGATTTGTCACCAAGCAG
1501 ACAACCAAGCATGTTCACCATCACTACATCCACCACCACACCATTCCCAAAACAAAGGAG
1561 CAGATAGAAGCAGAGGCAGCACAACGAGCCCAATGCTTGGGTCCTTCAGGGAGCGACTAC
1621 TATTGCTACTCCAAGTGCAAGGGTCACTCAAAAGGGGTGGAACTTCCTATGGCGCAGCTG
1681 GAGCCCTTCGGCCTCAACAGAACAGGGACGCTTCCGAAGAGGAACTGTAAGCTACCAGAT
1741 GGCGTCCTCCTCCCAGGTGGAGAAGGAGGAGGGCTCTCCATCCCTCCAGGGGTGCAGCTA
1801 CCTGCGGGGGAGGCTGACCGATCACAGAACGTCTGGCAATGGATGCTGGAGAGTGAAAGA
1861 CAATCCAAGCACAAGCCCCATAGCACACAAAGCACAAAGAAGGCCTACAATTCTGAGTCC
1921 TCCAGAGGCGGGCTTGGGGAACGTCCTGCCCGTCACCACCTGTGGGGGAGCAGCAGCCAT
1981 CCACGGGGCGTTCAGCCGGCCCACCCTTTTGTCCAGGATCCGGCCATGCCCCCTCTGACT
2041 CCACCCAATACCCTGGCTCAGTTGGAGGAAGCTTGCCGCAGGCTAGCAGAAGTATCCAAG
2101 CCACAGAAACAACGATGTTCAGCATCAAATCAGCCGAGGGATCGCAACCACTTGACTTCC
2161 GTACCAGGAGGAAATGGTCCTTTTTGCAATGCCAGTGTAGCAACAGAAGATCACAAAGAA
2221 CCAAAGAAACTTCCTGCTACTCACTCCGCCCAGCCTAGTGAGTTGATTGTCACATATTTT
2281 TTCTGTGGAGAAGAAATTCCCTATAGGAGGATGTTAAAGGCCCAGAGCCTGACACTTGGG
2341 CACTTTAAAGAGCAGCTGAGCAAAAAGGGAAATTATAGGTATTACTTCAAAAGGGCAAGT
2401 GATGAGTTTGACTGTGGTGCAGTTTTTGAAGAAATCTGGGATGACGATACCGTTCTGCCC
2461 ATGTACGAGGGAAGGATCCTGGGGAAAGTTGAGAGGATTGACTGA
| Predicted Protein Product |
MSSAALLTHLPDPSSSFREDAPRPPVPGEEGEAPCHLPASLFLVKNQSFKAMSVSSTPRR
NEDGLGEPEGSASPDSPLARWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGF
RQMDLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDSIKKQQIDSIMFDQAQTE
IQTVMEENAYRMFLTSDIYLEYVRSGGENPAYMNSNGLGSLKVDCGYLPTLNEEEEWSCA
DFKNKLLPSVLGLSSKTLRATASVRATEAVENGFRSFKRNDPVNPYHVNSGYVFAPATSA
NDSEISSDALTDDSVSMTDSSVDGIPPYRLGSKKQLQREMHRSVKANGQVSLPHFPRTHR
LPREMTPVEPAAFAAELISRLEKLKREQETMDSLEERLQQITEDEEKEGSDVPVSSQATR
EHPLTLLPSGSYEDDPQAILDDHLSRVLKTPGCQSPGMGRHSPRARSPDRFQVVNCSLAP
GTASVPNACALVSKGFVTKQTTKHVHHHYIHHHTIPKTKEQIEAEAAQRAQCLGPSGSDY
YCYSKCKGHSKGVELPMAQLEPFGLNRTGTLPKRNCKLPDGVLLPGGEGGGLSIPPGVQL
PAGEADRSQNVWQWMLESERQSKHKPHSTQSTKKAYNSESSRGGLGERPARHHLWGSSSH
PRGVQPAHPFVQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCSASNQPRDRNHLTS
VPGGNGPFCNASVATEDHKEPKKLPATHSAQPSELIVTYFFCGEEIPYRRMLKAQSLTLG
HFKEQLSKKGNYRYYFKRASDEFDCGAVFEEIWDDDTVLPMYEGRILGKVERID
| Protein Alignment to Mouse |
sp|O88566|AXIN2_MOUSE Axin-2 OS=Mus musculus GN=Axin2 PE=1 SV=1
Length = 840
Score = 3055 (1080.5 bits), Expect = 0., P = 0.
Identities = 608/845 (71%), Positives = 656/845 (77%)
Query: 1 MSSAALLTHLPDPSSSFREDAPRPPVPGEEGEAPCHLPASLFLVKNQSFKAMSVSSTPRR 60
MSSA L+T LPDPSSSFREDAPRPPVPGEEGE P P + K QS K M VSS RR
Sbjct: 1 MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETP---PCQPSVGKVQSTKPMPVSSNARR 57
Query: 61 NEDGLGEPEGSASPDSPLARWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGF 120
NEDGLGEPEG ASPDSPL RWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGF
Sbjct: 58 NEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGF 117
Query: 121 RQMDLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDSIKKQQIDSIMFDQAQTE 180
RQM+LKDTKTLRVAKAIYKRYIENNS+VSKQLKPATKTYIRD IKKQQI S+MFDQAQTE
Sbjct: 118 RQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTE 177
Query: 181 IQTVMEENAYRMFLTSDIYLEYVRSGGENPAYMNSNGLGSLKVDCGYLPTLNEEEEWSCA 240
IQ VMEENAY++FLTSDIYLEYVRSGGEN AYM++ GLGSLKV CGYLPTLNEEEEW+CA
Sbjct: 178 IQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVLCGYLPTLNEEEEWTCA 237
Query: 241 DFKNKLLPSVLGLSSKTLRATASVRATEAVENGFRSFKRNDPVNPYHVNSGYVFAPATSA 300
D K KL P+V+GLSSKTLRATASVR+TE ENGFRSFKR+DPVNPYHV SGYVFAPATSA
Sbjct: 238 DLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSDPVNPYHVGSGYVFAPATSA 297
Query: 301 NDSEISSDALXXXXXXXXXXXXXGIPPYRLGSKKQLQREMHRSVKANGQVSLPHFPRTHR 360
NDSE+SSDAL G+PPYR+GSKKQLQREMHRSVKANGQVSLPHFPRTHR
Sbjct: 298 NDSELSSDALTDDSMSMTDSSVDGVPPYRMGSKKQLQREMHRSVKANGQVSLPHFPRTHR 357
Query: 361 LPREMTPVEPAAFAAELISRLEKLKREQETMDSLEERLQQITEDEEKEGSDVPVSSQ--A 418
LP+EMTPVEPAAFAAELISRLEKLK E E+ SLEERLQQI EDEEKEGS+ +SS+ A
Sbjct: 358 LPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEGSEQALSSRDGA 417
Query: 419 TREHPLTLLPSGSYEDDPQAILDDHLSRVLKTPGCQSPGMGRHSPRARSPDRF------Q 472
+HPL LLPSGSYE+DPQ ILDDHLSRVLKTPGCQSPG+GR+SPR+RSPD Q
Sbjct: 418 PVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHQHHHHQ 477
Query: 473 VVNCSLAPGTASVP-NACALVS-KGFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 530
+ L+ G P AC L+ K F
Sbjct: 478 QCHTLLSTGGKLPPVAACPLLGGKSFLTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRV 537
Query: 531 XCLGPSGSDYYCYSKCKGHSKGVELPMAQLEPFGLNRTGTLPKRNCKXXX-XXXXXXXXX 589
CL P G+DYYCYSKCK H K E P+ E F +R GTLPKRN K
Sbjct: 538 RCLCPGGTDYYCYSKCKSHPKAPE-PLPG-EQFCGSRGGTLPKRNAKGTEPGLALSARDG 595
Query: 590 XXXXXXXXVQLPAGEADRSQNVWQWMLESERQSKHKPHSTQSTKKAYNSESSRGGLGERP 649
QLP E DRSQ+VWQWMLESERQSK KPHS QS +K+Y ES+R GER
Sbjct: 596 GMSSAAGGPQLPGEEGDRSQDVWQWMLESERQSKSKPHSAQSIRKSYPLESARAAPGERV 655
Query: 650 ARHHLWGSSSHPRGVQPAHPFVQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCSAS 709
+RHHL G+S H R V AHPF QDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRC +
Sbjct: 656 SRHHLLGASGHSRSVARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRCCVA 715
Query: 710 NQPRDRNHLTSVPGGNGPFCNASVATEDHKEPKKLPATHSAQPSELIVTYFFCGEEIPYR 769
+Q RDRNH + G PF N S+A EDHKEPKKL + H+ Q SEL+VTYFFCGEEIPYR
Sbjct: 716 SQQRDRNHSAAGQAGASPFANPSLAPEDHKEPKKLASVHALQASELVVTYFFCGEEIPYR 775
Query: 770 RMLKAQSLTLGHFKEQLSKKGNYRYYFKRASDEFDCGAVFEEIWDDDTVLPMYEGRILGK 829
RMLKAQSLTLGHFKEQLSKKGNYRYYFK+ASDEF CGAVFEEIWDD+TVLPMYEGRILGK
Sbjct: 776 RMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGK 835
Query: 830 VERID 834
VERID
Sbjct: 836 VERID 840
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