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Gene Model: Gsk3b

NomenclatureGenomic Location
SymbolGsk3bChromosome1
NameGlycogen synthase kinase-3 betaLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 52 Mbp

Molecular Function

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1.

Molecular Function Terms:

binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding
   protein binding
      beta-catenin binding
      cytoskeletal protein binding
      protein complex binding
      receptor binding
      transcription factor binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 TCAGGGCGGGTCGGTGCTACTCATTTTAGCCTTTCTTGTAAGCCGCCCCGAGCCCTAGGG
    61 GAGTGGTGGCATATAAGTTTAACAAGAGACAAAGATGGCAGCAAAGTGACCACAGTAGTA
   121 GCTACTCCTGGACAGGGTCCGGACAGGCCTCAGGAAGTTAGTTACACGGACACCAAAGTG
   181 ATTGGAAATGGATCTTTTGGTGTTGTGTATCAAGCCAAACTCTGTGATTCGGGGGAGTTG
   241 GTTGCTATTAAGAAAGTTCTACAAGACAAGAGATTTAAGAATCGGGAGCTTCAAATTATG
   301 AGAAAGCTCGACCATTGCAACATTGTCAGATTGCGTTATTTCTTTTACTCCAGTGGAGAG
   361 AAGAAAGATGAGGTATACCTTAATTTGGTTCTGGACTATGTTCCTGAAACAGTGTACAGA
   421 GTTGCCAGGCATTATAGTCGGGCCAAACAAACACTCCCCATGATATTTGTGAAGTTGTAC
   481 ATGTATCAGCTGTTCCGAAGTTTAGCCTATATCCATTCCTTTGGAATATGCCATCGGGAT
   541 ATAAAACCACAGAACCTTTTACTGGATCCCGACACAGCTGTCTTAAAACTTTGTGATTTT
   601 GGAAGTGCAAAGCAGCTAGTTCGTGGAGAGCCCAATGTCTCTTACATCTGCTCTCGGTAC
   661 TATAGGGCGCCAGAGTTGATCTTTGGAGCCACTGATTATACCTCTAGTATAGATGTTTGG
   721 TCAGCAGGTTGTGTATTGGCAGAACTATTACTAGGACAACCAATTTTCCCAGGAGACAGT
   781 GGTGTAGATCAGTTGGTGGAAATCATAAAGGTCCTTGGAACCCCTACAAGAGAACAAATT
   841 AGAGAAATGAATCCAAACTACACTGAATTTAAATTTCCCCAGATTAAGGCACATCCATGG
   901 ACTAAGGACTCGTCAGGAACAGGACATTTCACCTCAGGAGTACGGGTCTTCCGGCCCCGC
   961 ACTCCACCAGAAGCAATAGCGCTATGTAGCCGTCTGCTGGAATATACTCCCACTGCACGT
  1021 CTGACTCCACTGGAAGCATGTGCACACTCTTTCTTTGATGAATTACGGGACCCAAATATT
  1081 AAACTACCGAGTGGGCGAGAGAAACCAGCCCTCTTTAACTTCACCACTCAAGAACTCTCA
  1141 AGTAATCCGTCTTTGGCTTCAACCCTCATACCTGCTCATGCCCGAAATCAAGCAGCTGCT
  1201 TCAACCCCTACAAATGCTCCAGCAGCCTCAGATGCTAATGCAGGAGATCGAGTTCAGACC
  1261 AATAATGTAGCCTCAGCATCAGCCTCCAACTCC

Predicted Protein Product
SGRVGATHFSLSCKPPRALGEWWHISLTRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV
IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE
KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMIFVKLYMYQLFRSLAYIHSFGICHRD
IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW
SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW
TKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNI
KLPSGREKPALFNFTTQELSSNPSLASTLIPAHARNQAAASTPTNAPAASDANAGDRVQT
NNVASASASNS
Protein Alignment to Mouse
sp|Q9WV60|GSK3B_MOUSE Glycogen synthase kinase-3 beta OS=Mus musculus GN=Gsk3b
            PE=1 SV=2
      MGI:1861437 Gsk3b glycogen synthase kinase 3 beta (Chr 16)
        Length = 420

 Score = 1844 (654.2 bits), Expect = 5.8e-191, P = 5.8e-191
 Identities = 359/420 (85%), Positives = 371/420 (88%)

Query:     1 SGRVGATHFSLSCKPPRALGEWWHISLTRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV 60
             SGR   T F+ SCKP +    +  + ++RDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV
Sbjct:     2 SGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKV 61

Query:    61 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 120
             IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE
Sbjct:    62 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGE 121

Query:   121 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMIFVKLYMYQLFRSLAYIHSFGICHRD 180
             KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP+I+VKLYMYQLFRSLAYIHSFGICHRD
Sbjct:   122 KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRD 181

Query:   181 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW 240
             IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW
Sbjct:   182 IKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVW 241

Query:   241 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 300
             SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW
Sbjct:   242 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPW 301

Query:   301 TKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNI 360
             TK             VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN+
Sbjct:   302 TK-------------VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV 348

Query:   361 KLPSGREKPALFNFTTQELSSNPSLASTLIPAHARNQXXXXXXXXXXXXXXXXXGDRVQT 420
             KLP+GR+ PALFNFTTQELSSNP LA+ LIP HAR Q                 GDR QT
Sbjct:   349 KLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQT 408