| Nomenclature | Genomic Location |
| Symbol | Myb | Chromosome | 1 |
| Name | Transcriptional activator Myb | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 99 Mbp |
| Molecular Function |
|
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Molecular Function Terms:
binding
nucleic acid binding
DNA binding
protein binding
nucleic acid binding transcription factor activity
sequence-specific DNA binding transcription factor activity
|
| Human Disease Association |
|
No disease association.
|
1 AGTATGAGCAGGTCTAAACATGCACATATATACAGCAGTGATGATGAAGATGATGATCTT
61 GAGGCGTATGATCATGACTACGATGGCCTGTTGCCCAAAGGCGGAAAACGTCATTTGGGA
121 AAAACCCGGTGGACTCGAGAAGAGGATGAGAAACTAAAGAAACTTGTGGAACAGAATGGC
181 ACAGAAGATTGGAAAGTTATTGCCAATTTCCTTCCTAACCGAACAGATGTACAATGCCAA
241 CATCGATGGCAGAAGGTTTTAAATCCTGAACTTATCAAAGGCCCATGGACTAAAGAAGAA
301 GACCAGCGGGTAATAGAGCTTGTGCAGAAATACGGCCCCAAGCGTTGGTCTGTCATTGCC
361 AAGCATTTGAAGGGAAGGATCGGAAAGCAATGCAGGGAACGGTGGCACAATCATCTGAAT
421 CCAGAAGTCAAGAAAACCTCCTGGACTGAAGAAGAAGATAGAATTATTTACCAAGCACAC
481 AAGAGGCTGGGAAACAGATGGGCAGAAATTGCAAAGCTGCTGCCTGGAAGAACTGATAAT
541 GCTATCAAGAACCACTGGAATTCTACAATGCGTCGAAAAGTTGAACAGGAAGGTTATCTT
601 CAGGAATCTTCCAAAGTCACCCAGTCTTCAATAGCCACAAATTTTTCGAAGAATAACCAT
661 TTAATGGGTTTTGCTCACACTCCAGCTTCTGTGCATCTGCCAACAGACACCCAAACCCCA
721 GTTACAAATGAGTATTCCTATTACCATATTTCTGACACTCAAAATGTCTCTTCTCAGATT
781 CCCTATCCAGTAGCACTTCATGTAAATATTGTTAATGTTCCCCAGCCAGCTGCTGCAGCT
841 ATTCAGAGACACTATAATGATGAAGATCCTGAGAAAGAAAAGCGAATAAAGGAATTAGAG
901 TTGCTACTAATGTCGACTGAGAATGAACTGAAAGGGCAGCAGGCATTACCAACAGAGAAT
961 CACACATCAGATTATCAAGGATGGCACAGCACCACAATCACAGACAGTTCCCGAACTAGT
1021 GGCAATAGGGCACCCATTTCCTCTTTGGGTGAACATCACCACTGCACTCCATCTCCACCA
1081 GTGGACCATGGTAGCTTGCCTGAAGAAAGTGCATCTCCTGCAAGGTGCATGATTGTCCAC
1141 CAAAGTAACTTCCTAGATAATGTGAAGAATCTTTTAGAATTTGCGGAAACACTTCAACTA
1201 ATTGATTCTGATCCTTCATCATGGGGTGATCTCAGCAGTTTTGAATTCTCTGAAGAAGCA
1261 GACACTTCGCCTAGCCAAGCTCCCCCAGGCAAAGCGCTTCAGCAAATCGAGGCCAGTGCC
1321 TGTAGGCCTGGAGGATATCCTCTTTCAAACCTGAGCAAAGCCCTGTTGAGTCAGGAATCC
1381 CATACTATGCCAAAGTCCTTGACTGGCTCACAATGTGGCACAGCTCCGTTGGTCTTTCTG
1441 CGTACAAAGAGAGGGCATCCCAGCCACTTAGCCAGTGACCATAATCAGTCTGCTACACAT
1501 GCTGATGTCAGCCGCTCAGTTCCCAAGCGCTCCCCTGACAAAAGCCTGCCATTCTCTCCC
1561 TCGCAGTTTTTGAACACCTCATCCAGCCAAGAAAGTCTGGACCTAGACAATCCTCCTATA
1621 ACGGCTACTCCCCTCTGTTCTCATAAAGTCACTGTTTCAACACCTTTTCACAGAGATCAA
1681 GCATTTAAGACGCAGAAGGAAAACTATGTCTTCAGAACCCCTGCTATCAAAAGATCGATA
1741 TTGGAAAGTACTCCAAGAACACCTACTCCATTTAAAAATGCACTTGCAGCTCAAGAATTC
1801 AAATATGGCCCTTTAAAAGTGTTGCCTCAAACACCTACTCATCATGTTGATGACCTGCAA
1861 GATGTTATCAAGCAAGAGACTGTTGAATCTGGCATTGCAACTGGCTTACGGGAAAATGGA
1921 TCTCCTTTGGTAAAGAAAATCAAACAGGAGGTTGCATCTCCAACAGGTAAAGCAGGAAAC
1981 TTCTTTTGCTCAAACAGTTGGGAAGCTGAAGGTCTGAATGCACAGCTCTTCACATATGCA
2041 TCTCCAGGGGAAGATGTACCGAATCTACTTACCAGTTCTGGTTTGAAGATGGCTGCTTCA
2101 GTGGAAGAAGACAATACACATAAATTGTTCACATTACATAAAAATAAGTCATCAGGTAGT
2161 CCACTTCAGCATTTTAGCAACACGTGGGACCCAGCATCCTGTGGGAAGACAGAGGATCAG
2221 TTGTCTTTCCCTGATCCAGCACGAAAATACATGAATGCCTTCTCAACTCGGACTCTGGTT
2281 ATGTAG
| Predicted Protein Product |
SMSRSKHAHIYSSDDEDDDLEAYDHDYDGLLPKGGKRHLGKTRWTREEDEKLKKLVEQNG
TEDWKVIANFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIA
KHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDN
AIKNHWNSTMRRKVEQEGYLQESSKVTQSSIATNFSKNNHLMGFAHTPASVHLPTDTQTP
VTNEYSYYHISDTQNVSSQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELE
LLLMSTENELKGQQALPTENHTSDYQGWHSTTITDSSRTSGNRAPISSLGEHHHCTPSPP
VDHGSLPEESASPARCMIVHQSNFLDNVKNLLEFAETLQLIDSDPSSWGDLSSFEFSEEA
DTSPSQAPPGKALQQIEASACRPGGYPLSNLSKALLSQESHTMPKSLTGSQCGTAPLVFL
RTKRGHPSHLASDHNQSATHADVSRSVPKRSPDKSLPFSPSQFLNTSSSQESLDLDNPPI
TATPLCSHKVTVSTPFHRDQAFKTQKENYVFRTPAIKRSILESTPRTPTPFKNALAAQEF
KYGPLKVLPQTPTHHVDDLQDVIKQETVESGIATGLRENGSPLVKKIKQEVASPTGKAGN
FFCSNSWEAEGLNAQLFTYASPGEDVPNLLTSSGLKMAASVEEDNTHKLFTLHKNKSSGS
PLQHFSNTWDPASCGKTEDQLSFPDPARKYMNAFSTRTLVM
| Protein Alignment to Mouse |
sp|P06876|MYB_MOUSE Transcriptional activator Myb OS=Mus musculus GN=Myb PE=1
SV=1
MGI:97249 Myb myeloblastosis oncogene (Chr 10)
Length = 636
Score = 1664 (590.8 bits), Expect = 1.2e-251, Sum P(2) = 1.2e-251
Identities = 312/400 (78%), Positives = 331/400 (82%)
Query: 4 RSKHAHIYSSXXXXXXXXXXXXXXXGLLPKGGKRHLGKTRWTREEDEKLKKLVEQNGTED 63
R +H+ IYSS GLLPK GKRHLGKTRWTREEDEKLKKLVEQNGT+D
Sbjct: 4 RPRHS-IYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGTDD 62
Query: 64 WKVIANFLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHL 123
WKVIAN+LPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHL
Sbjct: 63 WKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAKHL 122
Query: 124 KGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIK 183
KGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIK
Sbjct: 123 KGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIK 182
Query: 184 NHWNSTMRRKVEQEGYLQESSKVTQSSIATNFSKNNHLMGFAHTPASVHLPTDTQTPVTN 243
NHWNSTMRRKVEQEGYLQE SK +Q+ +AT+F KNNHLMGF H L Q+ V +
Sbjct: 183 NHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSVNS 242
Query: 244 EYSYYHISDTQNVSSQIPYPVALHVNIVNVPQPAAAAIQRHYNDEDPXXXXXXXXXXXXX 303
EY YYHI++ QN+SS +PYPVALHVNIVNVPQPAAAAIQRHYNDEDP
Sbjct: 243 EYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELELLL 302
Query: 304 MSTENELKGQQALPTENHTSDYQGWHSTTITDSSRTSGNRAPISSLGEHHHCTPSPPVDH 363
MSTENELKGQQALPT+NHT Y GWHST+I D +R G+ AP+S LGEHH TPS P D
Sbjct: 303 MSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHH-ATPSLPADP 361
Query: 364 GSLPEESASPARCMIVHQSNFLDNVKNLLEFAETLQLIDS 403
GSLPEESASPARCMIVHQ LDNVKNLLEFAETLQ IDS
Sbjct: 362 GSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDS 401
Score = 776 (278.2 bits), Expect = 1.2e-251, Sum P(2) = 1.2e-251
Identities = 158/248 (63%), Positives = 186/248 (75%)
Query: 514 KSLPFSPSQFLNTSSSQESLDLDNPPITATPLCSHKVTVSTPFHRDQAFKTQKENYVFRT 573
++L F S FLNTSS+ ES LD P + +TPL HK+T P RDQ KTQKEN +FRT
Sbjct: 394 ETLQFIDS-FLNTSSNHESSGLDAPTLPSTPLIGHKLT---PC-RDQTVKTQKENSIFRT 448
Query: 574 PAIKRSILESTPRTPTPFKNALAAQEFKYGPLKVLPQTPTHHVDDLQDVIKQETVESGIA 633
PAIKRSILES+PRTPTPFK+ALAAQE KYGPLK+LPQTP+H V+DLQDVIK+E+ ESGI
Sbjct: 449 PAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQDVIKRESDESGIV 508
Query: 634 TGLRENGSPLVKKIKQEVASPTGKAGNFFCSNSWEAEGLNAQLFTYASPGEDVPNLLTSS 693
+E+G PL+KKIKQEV SPT K+GNFFCSN W L+ QLF+ ASP D PN+LTSS
Sbjct: 509 AEFQESGPPLLKKIKQEVESPTEKSGNFFCSNHWAENSLSTQLFSQASPVADAPNILTSS 568
Query: 694 GLKMAASVEEDNTHKLFTLHKNKSSGSPLQHFSNTWDPASCGKTEDQLSFPDPARKYMNA 753
L S +EDN K FT+ KN+ PLQ S W+PASCGKTEDQ++ PARKY+NA
Sbjct: 569 VLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPCSGAWEPASCGKTEDQMTASGPARKYVNA 628
Query: 754 FSTRTLVM 761
FS RTLVM
Sbjct: 629 FSARTLVM 636
Score = 37 (18.1 bits), Expect = 1.7e-173, Sum P(2) = 1.7e-173
Identities = 9/23 (39%), Positives = 15/23 (65%)
Query: 509 KRSPDKSLPFSPSQFLNTSSSQE 531
KRS +S P +P+ F + ++QE
Sbjct: 452 KRSILESSPRTPTPFKHALAAQE 474
| 