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Gene Model: Jun

NomenclatureGenomic Location
SymbolJunChromosome2
NameTranscription factor AP-1Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 79 Mbp

Molecular Function

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

Molecular Function Terms:

binding
   nucleic acid binding
      DNA binding
   protein binding
      SMAD binding

enzyme regulator activity
   enzyme activator activity
   nucleoside-triphosphatase regulator activity

nucleic acid binding transcription factor activity
   sequence-specific DNA binding transcription factor activity

protein binding transcription factor activity
   transcription factor binding transcription factor activity
      transcription cofactor activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGACTGCAAAGATGGAACCTACATTCTACGACGATGCCATCAACGCCACCTTCGTCCAG
    61 CCAGAAAGTGGCACTTATGGATACAACAACCCCAAAGTCCTGAAGCAGAGCATGACGCTC
   121 AATCTGGCCGACCCGTCCAGCAACCTCAAGCCACACCTGAGGAACAAGAACGCCGACCTC
   181 CTGACCTCTCCCGACGTGGGCCTCCTCAAGCTGGCTTCTCCTGAGCTTGAGAGGCTGATC
   241 ATCCAGTCTGGCAATGGGCTGATCACCACCACTCCCACCCCGACCCAGTTCCTGTGCCCC
   301 AAAAATGTCACCGACGAACAAGAAGGGTTTGCGGAAGGCTTTGTCAGGGCTCTCGCAGAG
   361 CTACACAATCAAAACACCATGCCAAGTGTTACCTCTGCTGCCCAGCCGGCCAACTCTGGC
   421 ATGGCCCCAGTCTCTTCCATGGCTGGGAACAATGGCTTCAGTGCCAGCTTGCACAGCGAG
   481 CCTCCTGTCTATGCCAACCTCAGCAATTTCAACCCCAGCACCCTCAGCACGGCACCTAAC
   541 TATCCCGCCAGCAACCTGGGCTACCCTCCGCAACATCATCTGAACCCTCCAATGCCGGTG
   601 CAGCATCCCCGCCTCCAGGCTCTGAAAGAAGAGCCTCAGACTGTCCCAGAAATGCCTGGG
   661 GAGACTCCTCCCCTGTCACCAATTGACATGGAGTCCCAGGAGAGGATCAAGGCGGAGAGG
   721 AAGCGCATGAGAAACCGCATTGCCGCCTCCAAGTGCCGGAAAAGAAAGTTGGAGCGGATT
   781 GCCAGGTTGGAAGACAAAGTGAAAACTTTGAAAGCCCAGAACTCGGAACTTGCGTCCACG
   841 GCCAACATGCTGCGAGAGCAGGTTGCGCAGCTGAAACAGAAGGTCATGAATCACGTCAAC
   901 AGTGGGTGCCAGCTCATGCTCACACAGCAGTTGCAAACTTTT

Predicted Protein Product
MTAKMEPTFYDDAINATFVQPESGTYGYNNPKVLKQSMTLNLADPSSNLKPHLRNKNADL
LTSPDVGLLKLASPELERLIIQSGNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHNQNTMPSVTSAAQPANSGMAPVSSMAGNNGFSASLHSEPPVYANLSNFNPSTLSTAPN
YPASNLGYPPQHHLNPPMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAER
KRMRNRIAASKCRKRKLERIARLEDKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVN
SGCQLMLTQQLQTF
Protein Alignment to Mouse
sp|P05627|JUN_MOUSE Transcription factor AP-1 OS=Mus musculus GN=Jun PE=1 SV=3
      MGI:96646 Jun Jun oncogene (Chr 4)
        Length = 334

 Score = 820 (293.7 bits), Expect = 1.9e-82, P = 1.9e-82
 Identities = 185/304 (60%), Positives = 217/304 (71%)

Query:     1 MTAKMEPTFYDDAINATFVQPESGTYGYNNPKVLKQSMTLNLADPSSNLKPHLRNKNADL 60
             MTAKME TFYDDA+NA+F+Q ESG YGY+NPK+LKQSMTLNLADP  +LKPHLR KN+DL
Sbjct:     1 MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL 60

Query:    61 LTSPDVGLLKLASPELERLIIQSGNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120
             LTSPDVGLLKLASPELERLIIQS NG ITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
Sbjct:    61 LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120

Query:   121 LHNQNTMPSVTSAAQPAN-SGM-AP-VSSMAG---NNGFSASLHSEPPVYANLSNFNPST 174
             LH+QNT+PSVTSAAQP + +GM AP V+S+AG     G+SASLHSEPPVYANLSNFNP  
Sbjct:   121 LHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGA 180

Query:   175 LST---APNYPASNLGYP--PQHHLNPPMPVQHPRLQALKEEP--QTVPEMPGETPPLSP 227
             LS+   AP+Y A+ L +P  PQ    PP P  H   Q   + P  Q + E P +T P  P
Sbjct:   181 LSSGGGAPSYGAAGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEP-QTVPEMP 239

Query:   228 IDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEDKVKTLKAQNSELASTANMLREQ 287
              +      I  E +    RI A   RKR   RIA  + + + L+ + + L      L+ Q
Sbjct:   240 GETPPLSPIDMESQE---RIKAE--RKRMRNRIAASKCRKRKLE-RIARLEEKVKTLKAQ 293

Query:   288 VAQL 291
              ++L
Sbjct:   294 NSEL 297

 Score = 733 (263.1 bits), Expect = 3.1e-73, P = 3.1e-73
 Identities = 156/223 (69%), Positives = 169/223 (75%)

Query:   108 EGFAEGFVRALAE--LHNQNTMPSVTSAAQPANSGMAPVSSMAGNNGFSASLHSEPPVYA 165
             EGF        ++  L +  +     S A      +A V+   G  G+SASLHSEPPVYA
Sbjct:   112 EGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYA 171

Query:   166 NLSNFNPSTLST---APNYPASNLGYP-----------PQHHLNPPMPVQHPRLQALKEE 211
             NLSNFNP  LS+   AP+Y A+ L +P           P HHL   +PVQHPRLQALKEE
Sbjct:   172 NLSNFNPGALSSGGGAPSYGAAGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEE 231

Query:   212 PQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEDKVKTLK 271
             PQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLE+KVKTLK
Sbjct:   232 PQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLK 291

Query:   272 AQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF 314
             AQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Sbjct:   292 AQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF 334