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Gene Model: Hipk2

NomenclatureGenomic Location
SymbolHipk2ChromosomeX
NameHomeodomain interacting
protein kinase 2		Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChrX: 19 Mbp

Molecular Function

Protein kinase acting as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. Phosphorylation of TP53 may be mediated by a TP53-HIPK2-AXIN1 complex. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

Molecular Function Terms:

binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding
   protein binding
      SMAD binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity

protein binding transcription factor activity
   transcription factor binding transcription factor activity
      transcription cofactor activity

Human Disease Association

No disease association.

Predicted Transcript
     1 TTTTTGTGTTGTGATACAGGTATGGCCTCACATGTGCAAGTTTTCTCCCCTCACACCCTT
    61 CAATCAAGTGCCTTCTGTAGCGTGAAGAAACTAAAAGTGGAACCGAGTTCTAACTGGGAT
   121 ATGACTGGGTACGGCACACATAGCAAAGTCTACAGTCAGAGCAAGAACGTTCAATCCGCT
   181 CAAGCAGCCGCCACCATCAACGCCTCTCTCCAGATCCCGAACCCAAACATCCCTTATGAG
   241 CAGACCATCATCTTCCCAGCCAGCACAGGACACATTGTGGTGACATCCGCCAACAGCACC
   301 TCTGGTGTGGTTGCAGTATCTGGACAAGCGTTGGGTGGACCACACAACCTGATGCGGCGA
   361 AGCACTGTGAGCCTTTTGGACACCTACCAAAAATGTGGACTTAAGCGAAAGAGTGAGGAA
   421 ATTGAGAACACAAGCAGCGTTCAGATTATCGAAGAGCATCCGCCAATGATTCAGAACAAT
   481 GCCAGTGGGGCCACAGTAGCCACCACAACCACATCCACTGCTACATCCAAAAACAGTGGC
   541 TCCAACAGTGAAGGGGATTATCAGCTGGTACAACATGAAGTTCTGTGTTCCATGACCAAC
   601 ACATATGAAGTATTAGAATTTCTTGGCCGGGGAACCTTTGGGCAAGTGGTCAAATGCTGG
   661 AAACGTGGCACCAATGAAATTGTGGCCATTAAGATCCTTAAAAACCATCCTTCATATGCC
   721 CGGCAAGGCCAAATTGAAGTGAGCATACTGGCCCGGTTAAGCACTGAAAGCGCAGATGAT
   781 TACAACTTTGTCCGCGCCTATGAATGTTTCCAGCATAAGAACCACACCTGCTTGGTCTTT
   841 GAGATGTTGGAACAGAACCTCTATGATTTCCTGAAGCAAAACAAATTCAGCCCACTGCCC
   901 CTTAAGTACATTAGGCCAATTCTGCAACAGGTAGCCACAGCCCTAATGAAATTGAAAAGT
   961 CTGGGCTTGATTCATGCAGACCTCAAGCCGGAAAACATCATGTTAGTAGATCCATCTCGG
  1021 CAGCCATACCGGGTCAAGGTCATAGACTTTGGATCTGCTAGCCATGTGTCGAAAGCTGTA
  1081 TGTTCAACGTACCTTCAGTCCAGATACTATAGAGCCCCTGAAATCATCCTTGGTTTACCC
  1141 TTTTGTGAAGCAATTGATATGTGGTCTCTGGGATGCGTCATTGCAGAACTTTTCTTGGGC
  1201 TGGCCTTTATATCCAGGAGCTTCAGAGTATGATCAGATCCGATACATTTCACAGACACAG
  1261 GGTTTGCCAGCTGAATATTTGTTGAGTGCCGGGACAAAGACAACAAGGTTTTTTAACAGG
  1321 GATACAGACTCACCTTATCCATTGTGGAGGCTAAAGACGCCAGATGATCATGAGACAGAA
  1381 ACAGGAATCAAGTCAAAAGAAGCAAGAAAGTATATTTTCAACTGTTTGGATGATATGGCC
  1441 CAGGTGAATATGACCACAGACTTGGAAGGAAGTGATATGTTGGTGGAAAAGGCAGACCGG
  1501 CGGGAGTTCATTGATCTGTTAAAGAAGATGTTGACAATAGACACAGATAAGAGGATAACG
  1561 CCGATTGAAACGCTGAACCATCCATTTGTCACCATGACACACCTACTTGATTTCCCTCAT
  1621 AGCACTCATGTCAAGTCCTGTTTCCAAAACATGGAGATTTGCAAGCGACGTGTGAACATG
  1681 TATGACACAGTGAACCAGAGCAAAACACCATTCATTACTCATGTGGCCCCAAGTACATCA
  1741 ACCAACCTAACCATGACCTTCAATAACCAGCTCAATACAGTCCATAACCAGGCCACCACC
  1801 CTGGCTCCCACCTCCACCACCAGTGCCACTATTTCCTTAACCAATCCCGAGGTCTCCATA
  1861 CTAAATTACCAATCTGCACTCTACCAGCCCTCGGCAGCATCCATGGCCGCGGTGGCCCAG
  1921 AGGAGCGTGCCCTTGCAGACAGGAACGGCGCAGATATGTGCTCGCCCTGACCCCTTCCAG
  1981 CAAGCCCTCATCGTATGTCCTCCAGGCTTTCAAGGACTGCAAACATCTCCTTCAAAGCAT
  2041 GCTGGCTATTCTGTCCGAATGGAGAATGCTGTCCCAATAGTCACTCAGGCCCCGGGGGCT
  2101 CAGCCCCTTCAAATTCAGCCAGGACTTCTAGCACAGCAAGCTTGGCCTAGCGGTGCTCAG
  2161 CAAATCCTGCTCCCGCCAGCTTGGCAGCAACTGACTGGGGTAGCTGCCCACACCTCGGTC
  2221 CAGCATGCGGCTGTCATCCCAGAAACTATGGCAGGAACCCAGCCCCTGGCAGATTGGAGA
  2281 AATACGCATGCTCATGGCAGCCATTATAATCCCATCATGCAACAGCCTGCACTTTTAGCA
  2341 AGTCACGTCACCCTTCCAGCAGCTCAGCCCTTAAATGTTGGTGTAGCTCACGTTATGAGG
  2401 CAACAGCCAACCAGCACCACCTCCTCGAGGAAGAGCAAACAGCACCAGTCATCAGCAAGA
  2461 AATGTGTCCAACTTTGAGGTGTCCTCTTCTCAGACGATCAGCTCTCCGCAGCGGTCAAAG
  2521 CGCGTGAAGGAGAACACCCCACCTCGCTGTGCCATGGTGCATAACAGCCCTGCCTGCAGC
  2581 ACCTCTGTCACTTGCGGGTGGGGCGATGGGGCTTCCAGTACCACACGGGAACGGCAGCGA
  2581 ACCTCTGTCACTTGCGGGTGGGGCGATGGGGCTTCCAGTACCACACGGGAACGGCAGCGA
  2641 CAGACGATTGTCATTCCTGACACACCCAGTCCTGCAGTCAGTGTTATCACCATCAGTAGT
  2701 GACACGGACGAGGAGGAAGAGCAGAAGCACGCACCCACCAGCCCGGTGTCTAAGCAAAGA
  2761 AAAAACGTCATCAGCTGTGTAACTGTACATGACTCCCCTTACTCTGATTCCTCTGGCAAC
  2821 AACAGTCCCTATGCAGCGCAGCGCCGTGGAGGAAATAACAATGGAAACACCTATGATGCC
  2881 AAGGGAGTCCCGGAAACACATTGCAATGGCAATCCCCGGACAATTATTGTGCCACCGCTG
  2941 AAAACCCAGGCCAGTGAGGTGTTAGTAGAATGTGATAACTTAGTCCCGGTCACCACCAGT
  3001 CACCACTCTTCCTCCTACAAGTCAAAGTCCTCCAGCATCGTGACCTCCACCAGCGGTCAC
  3061 TCTTCAGGGAGCTCATCTGGAGCCATCACCTACAGGCAGCAGCGGCCAGGACCACATTTC
  3121 CAGCAGCAACAGCCTCTTAATCTTAGCCAGGTCCAGCAGCACATCACGACCGATCGCACA
  3181 GGGAGTCATCGGCGACAGCAAGCCTACATCGCTCCCACAATTGCTCAGGCACCATATTCC
  3241 TTCCCACACAACAGCCCCAGCCATGGCACAGTCCACCCACACTTGGCTGCCGCCGCCGCT
  3301 GCTCACCTACCCACTCAACCTCACCTGTACACTTACACCGCTCCTGCTGCTCTGGGCTCC
  3361 ACAGGCACGGTGGCCCATTTGGTGGCTTCGCAAGGCTCGGCTCGCCACACTGTACAGCAC
  3421 GCTACATACCCAGCCAGCATTGTCCACCAAGTTCCAGTCAGCATGGGCCCTCGTGTCCTC
  3481 CCGTCTCCCACAATCCACCCAAGTCAATATCAGGCTCAGTTTGCCCACCAGACCTACATC
  3541 AGTGCGTCTCCCGCCTCCGTCTACACTGGGTACCCCCTGAGCCCTGCCAAGGTCAACCAG
  3601 TACCCCTACATCTAA

Predicted Protein Product
FLCCDTGMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGYGTHSKVYSQSKNVQSA
QAAATINASLQIPNPNIPYEQTIIFPASTGHIVVTSANSTSGVVAVSGQALGGPHNLMRR
STVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATTTTSTATSKNSG
SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYA
RQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP
LKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAV
CSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQ
GLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHETETGIKSKEARKYIFNCLDDMA
QVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDTDKRITPIETLNHPFVTMTHLLDFPH
STHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLNTVHNQATT
LAPTSTTSATISLTNPEVSILNYQSALYQPSAASMAAVAQRSVPLQTGTAQICARPDPFQ
QALIVCPPGFQGLQTSPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGAQ
QILLPPAWQQLTGVAAHTSVQHAAVIPETMAGTQPLADWRNTHAHGSHYNPIMQQPALLA
SHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSARNVSNFEVSSSQTISSPQRSK
RVKENTPPRCAMVHNSPACSTSVTCGWGDGASSTTRERQRQTIVIPDTPSPAVSVITISS
DTDEEEEQKHAPTSPVSKQRKNVISCVTVHDSPYSDSSGNNSPYAAQRRGGNNNGNTYDA
KGVPETHCNGNPRTIIVPPLKTQASEVLVECDNLVPVTTSHHSSSYKSKSSSIVTSTSGH
SSGSSSGAITYRQQRPGPHFQQQQPLNLSQVQQHITTDRTGSHRRQQAYIAPTIAQAPYS
FPHNSPSHGTVHPHLAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQH
ATYPASIVHQVPVSMGPRVLPSPTIHPSQYQAQFAHQTYISASPASVYTGYPLSPAKVNQ
YPYI
Protein Alignment to Mouse
sp|Q9QZR5|HIPK2_MOUSE Homeodomain-interacting protein kinase 2 OS=Mus musculus
            GN=Hipk2 PE=1 SV=2
      MGI:1314872 Hipk2 homeodomain interacting protein kinase 2 (Chr 6)
        Length = 1196

 Score = 5190 (1832.0 bits), Expect = 0., P = 0.
 Identities = 1006/1201 (83%), Positives = 1028/1201 (85%)

Query:     7 GMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGYGTHSKVYSQSKNVQSAQ-AAAT 65
             GMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGYG+HSKVYSQSKN+  +Q A+ T
Sbjct:     7 GMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGYGSHSKVYSQSKNIPPSQPASTT 66

Query:    66 INASLQIPNPNIPYEQTIIFPASTGHIVVTSANSTSGVVAVSGQALGGPHNLMRRSTVSL 125
             ++ SL IPNP++PYEQTIIFP STGHIVVTSA+STS    V+GQ LGGPHNLMRRSTVSL
Sbjct:    67 VSTSLPIPNPSLPYEQTIIFPGSTGHIVVTSASSTS----VTGQVLGGPHNLMRRSTVSL 122

Query:   126 LDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQXXXXXXXXXXXXXXXXXXXXXXXXXEG 185
             LDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQ                         EG
Sbjct:   123 LDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEG 182

Query:   186 DYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 245
             DYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
Sbjct:   183 DYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI 242

Query:   246 EVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIR 305
             EVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIR
Sbjct:   243 EVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIR 302

Query:   306 PILQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYL 365
             P+LQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYL
Sbjct:   303 PVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYL 362

Query:   366 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAE 425
             QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAE
Sbjct:   363 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAE 422

Query:   426 YLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHETETGIKSKEARKYIFNCLDDMAQVNMT 485
             YLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHE ETGIKSKEARKYIFNCLDDMAQVNMT
Sbjct:   423 YLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMT 482

Query:   486 TDLEGSDMLVEKADRREFIDLLKKMLTIDTDKRITPIETLNHPFVTMTHLLDFPHSTHVK 545
             TDLEGSDMLVEKADRREFIDLLKKMLTID DKR+TPIETLNHPFVTMTHLLDFPHS HVK
Sbjct:   483 TDLEGSDMLVEKADRREFIDLLKKMLTIDADKRVTPIETLNHPFVTMTHLLDFPHSAHVK 542

Query:   546 SCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLNTVHNQXXXXXXXX 605
             SCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQL TVHNQ        
Sbjct:   543 SCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPTTSSAT 602

Query:   606 XXXXXXXXXNPEVSILNYQSALYQPSAASMAAVAQRSVPLQTGTAQICARPDPFQQALIV 665
                      NPEVSILNYQSALYQPSAASMAAVA RS+PLQTGTAQICARPDPFQQALIV
Sbjct:   603 LSLA-----NPEVSILNYQSALYQPSAASMAAVAPRSMPLQTGTAQICARPDPFQQALIV 657

Query:   666 CPPGFQGLQTSPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGAQQILLP 725
             CPPGFQGLQ SPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWP GAQQILLP
Sbjct:   658 CPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPGGAQQILLP 717

Query:   726 PAWQQLTGVAAHTSVQHAAVIPETMAGTQPLADWRNTHAHGSHYNPIMQQPALLASHVTL 785
             PAWQQLTGVA HTSVQHAAVIPETMAGTQ LADWRNTHAHGSHYNPIMQQPALL  HVTL
Sbjct:   718 PAWQQLTGVATHTSVQHAAVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTL 777

Query:   786 PAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSARNVSNFEVXXXXXXXXXXXXKRVKEN 845
             PAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSS RNVS  EV            KRVKEN
Sbjct:   778 PAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVTSSQAISSPQRSKRVKEN 837

Query:   846 TPPRCAMVHNSPACSTSVTCGWGDGASSTTRERQRQTIVIPDTPSPAVSVITISSDTDEE 905
             TPPRCAMVH+SPACSTSVTCGWGD ASSTTRERQRQTIVIPDTPSP VSVITISSDTDEE
Sbjct:   838 TPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEE 897

Query:   906 EEQKHAPTSPVSKQRKNVISCVTVHDSPYSDSSGNNSPYAAQRRXXXXXXXTYDAKGVPE 965
             EEQKHAPTS VSKQRKNVISCVTVHDSPYSDSS N SPY+ Q+R       T D KG  E
Sbjct:   898 EEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGGLE 957

Query:   966 THCNGNPRTIIVPPLKTQASEVLVECDNLVP-VTXXXXXXXXXXXXXXXXXXXXXXXXXX 1024
              HC GNPRTIIVPPLKTQASEVLVECD+L P ++                          
Sbjct:   958 NHCTGNPRTIIVPPLKTQASEVLVECDSLGPAISASHHSSSFKSKSSSTVTSTSGHSSGS 1017

Query:  1025 XXXAITYRXXXXXXXXXXXXXXXXXXXXXHITTDRTGSHRRQQAYIAPTIAQAPYSFPHN 1084
                AI YR                     H+  DRTGSHRRQQAYI PT+AQAPY+FPHN
Sbjct:  1018 SSGAIAYRQQRPGPHFQQQQPLNLSQAQQHMAADRTGSHRRQQAYITPTMAQAPYTFPHN 1077

Query:  1085 SPSHGTVXXXXXXXXXXXXXTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHATYP 1144
             SPSHGTV             TQPHLYTYTAP ALGSTGTVAHLVASQGSARHTVQH  YP
Sbjct:  1078 SPSHGTVHPHLAAAAHLP--TQPHLYTYTAPTALGSTGTVAHLVASQGSARHTVQHTAYP 1135

Query:  1145 ASIVHQVPVSMGPRVLPSPTIHPSQYQAQFAHQTYISASPAS-VYTGYPLSPAKVNQYPY 1203
             ASIVHQVPVSMGPRVLPSPTIHPSQY AQFAHQTYISASPAS VYTGYPLSPAKVNQYPY
Sbjct:  1136 ASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPY 1195

Query:  1204 I 1204
             I
Sbjct:  1196 I 1196