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Gene Model: Ryk

NomenclatureGenomic Location
SymbolRykChromosomeX
NameTyrosine-protein kinase RYKLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChrX: 43 Mbp

Molecular Function

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Molecular Function Terms:

binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding
   protein binding
      receptor binding
         G-protein-coupled receptor binding
      Wnt-protein binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity

molecular transducer activity
   signal transducer activity
      receptor activity
         transmembrane receptor activity

receptor activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATTTTAGGTATTGATGCAGAACTTTATTATGTGAGGAATGATCTTATCAATCACTACGCT
    61 TTGTCCTTTAATCTACTAGTACCTGTAGAAACAAACAATCTCCATTTCAGTTGGCATGCT
   121 AAGGCAAAGATTGAATATAAGTTGGGATTTCAGGTTGATAATCTTTTGGCTATGGATATG
   181 CCACAGGCCAATATTTCTGACCAAGGAGAAGTCCCTCGCACATTATCTGTGTTTCGAGTG
   241 GAACTTTCTTGCACTGGCCGACTAGACACTGAGGTTACAGTCCTAATGCAACTCAACATG
   301 ACAGTAAATGCTTCCAAAAATATCACAGTCTTAAATTTCAAACGAAGGAAAATGTGCTAT
   361 AAAAAACTTGAACAAGAAGTAAAAACTCCAGTACTGGAGAAAAATAGCAGCAAGGCTATT
   421 TTTGATCCTGTAAATGCAGCTCCCACTACATCTACACGTGTGTTTTATATCAGTGTTGGT
   481 GTTTGCTGTGCAGTCATTTTCCTGATAGCAATAATACTAGCAGTCTTGCATCTTCAAAGT
   541 ATGAAAAGAATAGAATTGGAAGACAGCATTAGTGACAACAGTAGCTCACAAGGCTTATCC
   601 CAACCTTCAACTCAAACAACTCAGTACTTGAGGGCTGATACACCTAACAACGCAACACCC
   661 ATTACCAGCTCCTCAGGTTATCCTACATTACGGATAGAGAAGAATGACCTTAAAAGTGTA
   721 ACCCTGATGGAAGCAAAAGCTAAAGTGAAAGACATAGCAATCTCTAGGGAGAGGATAACA
   781 CTAAAAGATGTTCTTCAAGAAGGTACATTTGGGCAAATTTTTCATGGAACTCTAATAGAA
   841 GAGAAAGATCCTAGTAAAGAAAAGCAAATGTTTGTCAAAACAGTAAAAGATCAAGCTTCA
   901 GAAGTTCAAGTGACCATGATGTTGACAGAAAGCTGTAAACTCAGAGGCCTTCATCACAGG
   961 AATCTTCTCCCTATCACTCATGTTTGCATAGAGGAAGGAGAAAAGCCTATGGTGCTGTTG
  1021 CCTTATATGAATTGGGGAAATCTTAAGCTGTTCTTACGGCAATGCAAATTAGTAGAAGCA
  1081 AATAATCCGCAGGCAATTTCACAACAAGATCTTGTACATATGGCTATTCAGATCGCCTGT
  1141 GGAATGAGCTACTTGGCCCGCAGAGAGGTCATTCATAAAGACCTGGCTGCTAGAAACTGT
  1201 GTCATTGATGATGCACTTCAGGTAAAGATTACAGACAATGCCCTGTCCAGAGACCTCTTT
  1261 CCCATGGATTATCATTGCCTTGGAGACAATGAAAACAGACCAGTGCGGTGGATGGCTCTT
  1321 GAAAGCTTAGTCAACAATGAATTTTCTGGTGCTAGTGATGTGTGGTCTTTTGGAGTGACC
  1381 TTATGGGAATTGATGACTTTGGGACAAACACCTTATGTAGATATAGACCCCTTTGAGATG
  1441 GCAGCGTATCTAAAAGATGGATACAGAATAGCTCAGCCTATCAACTGCCCTGATGAATTA
  1501 TTTGCTGTGATGGCTTGTTGTTGGGCACTAGATCCTGAGGAGAGACCTAAATTCCAGCAG
  1561 CTGGTACAATGCCTCACTGAATTCCATGCAGCATTGGGAGCCTATGTTTGA

Predicted Protein Product
ILGIDAELYYVRNDLINHYALSFNLLVPVETNNLHFSWHAKAKIEYKLGFQVDNLLAMDM
PQANISDQGEVPRTLSVFRVELSCTGRLDTEVTVLMQLNMTVNASKNITVLNFKRRKMCY
KKLEQEVKTPVLEKNSSKAIFDPVNAAPTTSTRVFYISVGVCCAVIFLIAIILAVLHLQS
MKRIELEDSISDNSSSQGLSQPSTQTTQYLRADTPNNATPITSSSGYPTLRIEKNDLKSV
TLMEAKAKVKDIAISRERITLKDVLQEGTFGQIFHGTLIEEKDPSKEKQMFVKTVKDQAS
EVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVLLPYMNWGNLKLFLRQCKLVEA
NNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDALQVKITDNALSRDLF
PMDYHCLGDNENRPVRWMALESLVNNEFSGASDVWSFGVTLWELMTLGQTPYVDIDPFEM
AAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
Protein Alignment to Mouse
sp|Q01887|RYK_MOUSE Tyrosine-protein kinase RYK OS=Mus musculus GN=Ryk PE=1
            SV=2
      MGI:101766 Ryk receptor-like tyrosine kinase (Chr 9)
        Length = 594

 Score = 2485 (879.8 bits), Expect = 6.8e-259, P = 6.8e-259
 Identities = 473/536 (88%), Positives = 502/536 (93%)

Query:     1 ILGIDAELYYVRNDLINHYALSFNLLVPVETNNLHFSWHAKAKIEYKLGFQVDNLLAMDM 60
             +LG+DAELYYVRNDLI+HYALSFNLLVP ETN LHF+WHAK+K+EYKLGFQVDN +AM M
Sbjct:    60 LLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQVDNFVAMGM 119

Query:    61 PQANISDQGEVPRTLSVFRVELSCTGRLDTEVTVLMQLNMTVNASKNITVLNFKRRKMCY 120
             PQ NIS QGEVPRTLSVFRVELSCTG++D+EV +LMQLN+TVN+SKN TVLNFKRRKMCY
Sbjct:   120 PQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCY 179

Query:   121 KKLEQEVKTPVLEKNSSKAIFDPVNAAPTTSTRVFYISVGXXXXXXXXXXXXXXXXHLQS 180
             KKLE EVKT  L+KN+S+ I+DPV+AAPTTSTRVFYISVG                HL S
Sbjct:   180 KKLE-EVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHS 238

Query:   181 MKRIELEDSISDNSSSQGLSQPSTQTTQYLRADTPNNATPITSSSGYPTLRIEKNDLKSV 240
             MKRIEL+DSIS +SSSQGLSQPSTQTTQYLRADTPNNATPITSSSGYPTLRIEKNDL+SV
Sbjct:   239 MKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSSGYPTLRIEKNDLRSV 298

Query:   241 TLMEAKAKVKDIAISRERITLKDVLQEGTFGQIFHGTLIEEKDPSKEKQMFVKTVKDQAS 300
             TL+EAKAKVKDIAISRERITLKDVLQEGTFG+IFHG L++EKDP+KEKQ FVKTVKDQAS
Sbjct:   299 TLLEAKAKVKDIAISRERITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQAS 358

Query:   301 EVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVLLPYMNWGNLKLFLRQCKLVEA 360
             EVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMV+LPYMNWGNLKLFLRQCKLVEA
Sbjct:   359 EVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNWGNLKLFLRQCKLVEA 418

Query:   361 NNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDALQVKITDNALSRDLF 420
             NNPQAISQQDLVHMAIQIACGMSYLARREVIH+DLAARNCVIDD LQVKITDNALSRDLF
Sbjct:   419 NNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLF 478

Query:   421 PMDYHCLGDNENRPVRWMALESLVNNEFSGASDVWSFGVTLWELMTLGQTPYVDIDPFEM 480
             PMDYHCLGDNENRPVRWMALESLVNNEFS ASDVW+FGVTLWELMTLGQTPYVDIDPFEM
Sbjct:   479 PMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEM 538

Query:   481 AAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 536
             AAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
Sbjct:   539 AAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 594