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Gene Model: Smad1

NomenclatureGenomic Location
SymbolSmad1Chromosome2
NameMothers against decapentaplegic
homolog 1		Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 44 Mbp

Molecular Function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Molecular Function Terms:

binding
   protein binding
      enzyme binding
         kinase binding
      SMAD binding

nucleic acid binding transcription factor activity
   sequence-specific DNA binding transcription factor activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGAATGTGACAAGCTTGTTCTCCTTTACAAGCCCAGCTGTTAAGAGACTGCTGGGATGG
    61 AAGCAAGGAGACGAAGAGGAAAAATGGGCAGAAAAGGCTGTCGATGCTCTAGTTAAGAAG
   121 CTGAAGAAGAAAAAAGGAGCCATGGAAGAGTTAGAGAAAGCATTGAGTTGTCCAGGTCAG
   181 CCCAGCAACTGTGTCACTATTCCCCGTTCATTAGATGGCCGGCTCCAGGTCTCCCATCGG
   241 AAAGGGCTACCACATGTGATTTATTGCCGTGTGTGGCGCTGGCCAGATCTGCAGAGTCAT
   301 CATGAACTTAAACCACTGGAATGCTGTGAGTTTCCCTTTGGTTCAAAGCAGAAGGAAGTT
   361 TGCATCAACCCCTATCATTACAAGCGAGTGGAAAGTCCAGTTCTTCCTCCGGTGCTTGTA
   421 CCCAGGCACAGTGAATACAACCCACAGCACAGTCTTCTGGCTCAGTTTCGCAACCTTGGG
   481 CAAAATGAACCTCACATGCCGCACAATGCTACTTTTCCAGACTCTTTCCAGCAGCCCAAC
   541 AGCCATCCATTTCCTCATTCACCCAACAGCAGCTACCCAAACTCCCCTGGAAGCAGTAGT
   601 GGCACTTATCCTCATTCGCCTGCCAGTTCGGACCCAGGAAGTCCTTTCCAGATGCCAGCT
   661 GATACTCCTCCTCCTGCTTACCTACCTCCAGATGATCAAATGACACAGGATGGGACACAG
   721 CCAATGGACACCAACATGATGGCACCTTCAATTCCTCCAGAAGTAAACAGAGGAGATGTT
   781 CAGGCAGTTGCTTATGAAGAGCCGAAACACTGGTGCTCTATTGTCTACTATGAGCTCAAC
   841 AACCGTGTTGGCGAAGCGTTTCATGCCTCTTCCACAAGCGTCTTGGTGGATGGCTTCACT
   901 GATCCTTCCAACAACAAGAATAGATTTTGCCTTGGGCTGCTCTCTAACGTTAATCGGAAT
   961 TCCACCATTGAGAACACCAGGCGGCATATTGGCAAAGGAGTTCACCTGTATTACGTTGGT
  1021 GGAGAAGTCTATGCAGAGTGCCTTAGTGACAGTAGTATATTTGTGCAAAGTCGAAACTGC
  1081 AATTACCACCATAGTTTCCACCCAACCACGGTTTGCAAAATTCCAAGTGGCTGCAGTTTG
  1141 AAGATTTTCAATAACCAAGAGTTTGCTCAGCTTCTGGCTCAGTCAGTGAATCATGGCTTT
  1201 GAAACAGTGTACGAACTCACTAAGATGTGCACTATCCGGATGAGTTTTGTAAAGGGTTGG
  1261 GGAGCAGAGTATCACCGGCAGGATGTCACAAGCACGCCATGTTGGATTGAGATTCACTTG
  1321 CACGGACCCCTCCAATGGCTGGATAAAGTTCTCACGCAGATGGGCTCCCCTCACAACCCA
  1381 ATCTCTTCTGTATCTTAA

Predicted Protein Product
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPHNATFPDSFQQPN
SHPFPHSPNSSYPNSPGSSSGTYPHSPASSDPGSPFQMPADTPPPAYLPPDDQMTQDGTQ
PMDTNMMAPSIPPEVNRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
NYHHSFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Protein Alignment to Mouse
sp|P70340|SMAD1_MOUSE Mothers against decapentaplegic homolog 1 OS=Mus
            musculus GN=Smad1 PE=1 SV=1
      MGI:109452 Smad1 MAD homolog 1 (Drosophila) (Chr 8)
        Length = 465

 Score = 2018 (715.4 bits), Expect = 2.1e-209, P = 2.1e-209
 Identities = 377/465 (81%), Positives = 382/465 (82%)

Query:     1 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWXXXXXXXXXXXXXXXXXXXXXXXXXXSCPGQ 60
             MNVTSLFSFTSPAVKRLLGWKQGDEEEKW                          SCPGQ
Sbjct:     1 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ 60

Query:    61 PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV 120
             PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRW DLQSHHELKPLECCEFPFGSKQKEV
Sbjct:    61 PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWSDLQSHHELKPLECCEFPFGSKQKEV 120

Query:   121 CINPYHYKRVESXXXXXXXXXRHSEYNPQHSLLAQFRNLGQNEPHMPHNATFPDSFQQXX 180
             CINPYHYKRVES         +HSEYNPQHSLLAQFRNLGQNEPHMP NATFPDSFQQ  
Sbjct:   121 CINPYHYKRVESPVLPPVLVPKHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN 180

Query:   181 XXXXXXXXXXXXXXXXXXXXXXXXHSPASSDPGSPFQMXXXXXXXXXXXXXXQMTQDGTQ 240
                                     HSP SSDPGSPFQM               M QDG+Q
Sbjct:   181 SHPFPHSPNSSYPNSPGGSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMAQDGSQ 240

Query:   241 PMDTNMMAPSIPPEVNRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300
             PMDTNMMAP +P E++RGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
Sbjct:   241 PMDTNMMAPPLPAEISRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT 300

Query:   301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360
             DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
Sbjct:   301 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC 360

Query:   361 NYHHSFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420
             NYHH FHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
Sbjct:   361 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW 420

Query:   421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465
             GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Sbjct:   421 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465