| Nomenclature | Genomic Location |
| Symbol | Crebbp | Chromosome | 2 |
| Name | CREB-binding protein | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr2: 20 Mbp |
| Molecular Function |
|
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator.
Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes.
Acts as a coactivator of ALX1 in the presence of EP300.
Molecular Function Terms:
binding
chromatin binding
protein binding
receptor binding
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
protein binding transcription factor activity
transcription factor binding transcription factor activity
transcription cofactor activity
|
| Human Disease Association |
|
Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
|
1 ATGGCGGAGAACTTGCTGGACGGGCCGCCCAACGCCAAGCGGGCCAAGCTCAACTCGCCG
61 GGCTTCCCGGGCCCGGATCCTAGCGATTTTGGATCCTTTTTCAACTTGGAGAATGACCTC
121 CCCGATGAGCTGATCTCAAACGGAGACCTGGGCCTTTTGAGCAACAGCAGCAGCAGTGGA
181 AGCCTGGTCCCGGATGCAGCCTCCAAACACAAGCAGCTGTCTGAACTGTTGAGGGGCGGC
241 GTGAGTGCAGTGGGGGGCCCGGTCCCGCAGGGGGTCGGGGGCCCAGCACAGGGGCAGCCC
301 AACTCTGGACTCGGCGGCGGCCTGGGAGCCATGGGCAAGAGCCCCCTGGGACCTGGGGAG
361 GCCAAGCCATCCTCGGCGGCCCCACAACAAGCCATGGGTGCCCAGAAGCAGCAGCAGGCT
421 GGCATGGTGGCCGGCAGCCCTGCCTCCTCCGCCGCCCAGGCTGCTGCGGGCGGAGGGATG
481 CACCTGAACGCAAACTTTGGCCAGGCCCTCCCAGGGCTCCTCAATAACAACAGCTCCGGC
541 CACGGACTCCTGGGCCCAGCCCAGCAAGGACAAGGGCAGGTGATGAATGGGTCCCTGGGG
601 GCGGCCGGAAGAGGAGGACGTGGTGGCGCCGGCATGCAGTACTCGGCCGCCGGGATGCAG
661 GGCAGCGCGGGCAACGTCCTGGCAGAAGCCTTGGCGCAGGTGTCCCCCCAAATGGCGGCC
721 CACGCGGGCCTCAACGCCTCCCAGGCTGTATCCATGGCAAAAATGGGGATGGCCAGCAAC
781 CCAGGGCCCTTTGGCCAGGCGTTTGGTCAGACGGCCGGAGGGCAGCAATTGGGAGCAGCC
841 GGAGTCAGCCCTTCTTTACCGAACAAGCCTGGCCTGGCCAGCAGCCTCTCCCCCTTCCCT
901 CCTGACATCAAGAGCGTGTCTGTGACCAGTGTGCCAAATATGATGCCGGGCCAAGTGCAG
961 CAGCAAGTGGGCCTTGTCCCAGCGCAGGCCATGGCCGCGGGGCCCACCGCTGATCCAGAG
1021 AAACGCAAGCTGATCCAGCAGCAATTGGTCCTGCTGCTCCACGCTCACAAGTGCCAGCGG
1081 CGGGAGCAGGCCAACGGGGAAGTGCGGGCCTGTGCCCTGCCCCACTGCCGGACCATGAAG
1141 AACGTCCTCAACCACATGACCCACTGCCAGGCGGGAAAGGCCTGTCAAGTGGCGCATTGT
1201 GCATCATCCCGCCAGATCATATCCCACTGGAAGAACTGCACGCGGCACGACTGCCCTGTC
1261 TGCCTCCCGCTGAAGAATGCCAGTGACAAGAGGAACCAGCAGCCGCTCCTGGGGTCACCG
1321 GTGGCAGGGATGCAGAACTCGGTGGCCTCCGGCGCAGGACAGACAGCAGCAGCGCCCCTC
1381 AGCAACCCCAACCCCATTGACCCCAGCTCCATGCAACGCGCCTATGCAGCCCTGGGCCTT
1441 CCCTATGGCAACCAGCCTCAGGTCCCTCTGCAGCCGCAGGTCCAAGGCCAGCAGCCCACC
1501 TCCCAGCCACAGGCCCCCCATCCACAGATGAGAACCATGAACGTGCTGGGAGCCAATCCC
1561 ATGAACCTTCCTACCGCGGGAATCACGGAGCAAGCACCCGGCATGATCCCTGAGGCGGCG
1621 CTTCCTGCTTCTCTAGGGGCGGCAGCAAACCCCCTGATGAGTGACGGCACAAATTCGGGG
1681 AATGCTGGGAACCTCAGCGGCACGATCACCACCGCAGCTCCTGCTTCTGGCTCCGGGGCA
1741 AGGAAGACCTGGCATGAACACGTCACGCAGGACCTGCGCAACCACTTGGTCCACAAGCTG
1801 GTGCAAGCCATCTTTCCGACTCCCGACCCAGCAGCTCTGAAGGACCGCCGAATGGAGAAC
1861 CTGGTGGCTTATGCCAGGAAAGTGGAAGGGGATATGTATGAATCGGCAAACAGCCGGGAC
1921 GAGTATTACCATTTGTTGGCAGAGAAGATTTATAAGATCCAGAAGGAGCTGGAAGAGAAG
1981 CGGCGGTCACGTTTGCACAAGCAAGGGATATTGGGCAACCAGCCGGCCTTACAGACCCCG
2041 GGAGCCCAGCCCCCTGGCCTCTCCCAGGTGACGGCGGTAGCCCTGGGGCAGACACAGCCC
2101 GCCAGGCCCCCCAATGGCCCTGTGTCCTCCGTGCCAAATGTCCCTGTGAGCCGCATGCAA
2161 GTCTCTCAAGGTATGACGAGAGAATCAATGTTGCCCTCTCTTTCCATAGGGAACGTCCAG
2221 ATGCCCCCGGCCTCAATGGGACCGCGAGCTGCTTCCCCCATGAACCATCCCGTCCAGATG
2281 AACAACATGGGCTCCGTTTCAGCAATGGCCCTGTCTCCTTCCCGGATGCCTCAGTCGCAG
2341 AGCATAATGGCAGCGCATGCCAACAGTCTAATGGGTCCAGCAGCCCCCCAGACCCAGTTC
2401 CTCGGTCAGAGCCAGTTCCCTGCCACATCCGGCGGAGCCCTCAGTGTCGCCATGGGGCAG
2461 GCCCAGGCAGGAGCCTCCTCGCAGGGCCAGGCTCCAGCCGCTTCCCTCCCGGCCTCCGTC
2521 AGCATCCTGGGGCCATCGAGCGGCCAGCTTGCCTGTCCCTCCATCACGCAGCCGTCTCCC
2581 CTCCACCAGCCTGCGGCCCCTCTGCCCACAACTGCGGTCTCCATGCCTTCCTCGGTCCAG
2641 GGAATGATCCCTCCGCCCACAGCACCAGCGGCGCCTGCCCTACCGCTGCCTCCTTCGGGA
2701 CAAGGTCCCTCGCCTGCACCCCCCTCGGCCCCCAACACCAGCGCCATGCAGCTGCAGAGC
2761 ATGCCTTCGGGACAGGCCCAGCCGGCGCCTCAGCCCCGGACCCCTGGGCAGCCCCCCTCT
2821 GTGCCAACGCCGCAGCCGCCGCCATCGTCACAGCCCCAACCAGCCCAGGCTCCGGTTCTG
2881 CCTCAGGCACCCTCCACTCCACTCTCTCAGGCTGCAGCGGGGAGTGTCGACAGCCGGGTG
2941 CCCAGCCCAGGTTCTGCTGCTGGTGCAGACCTCGGGAACCAGCCGTTTGGGCATGAGGCG
3001 CCAGTGACGGAGGGGAAGTCCGAGGTGAAGGCCGAAAAAGCCAAGTCGGAATGCGGCGAA
3061 GCTCCGGTGGAGCCAAAACTCGAGCCAGAGGAAGAGGAGGCGGCGGCAGTAGTGAGGCCC
3121 ACGCAAGCCAAAGAGGAACCCGGTGCGGATGAAGGCAAACAGGAGCCCATGGAAGTGGAA
3181 GGCAGGAAGCCGGAGGTGAAGGAGGAAGAGGACAGTGGAGGGAGCGGAGGCAGTGGCAAC
3241 AGCTCTACTTCTCAGTCCACGTCTCCCTCTCAGCCACGGAAGAAGATCTTTAAGCCTGAA
3301 GAGCTGCGCCAGGCGCTCATGCCCACCTTGGAGGCCCTCTACCGCCAGGACCCAGAGTCT
3361 CTGCCTTTCCGGCAGCCAGTGGACCCTCAGCTCCTGGGCATCCCGGACTATTTTGACATT
3421 GTGAAGAGCCCCATGGACCTGTCCACCATCAAGCGCAAGCTGGACACGGGGCAGTACCAG
3481 GAGCCCTGGCAGTACGTGGAGGACGTCTGGCTGATGTTTAACAATGCCTGGCTCTACAAC
3541 CGCAAGACCTCCAGGGTCTACAAGTTTTGCACGAAGCTGGCGGAGGTCTTCGAGCAGGAG
3601 ATCGACCCTGTCATGCAGTCCCTGGGATACTGCTGTGGACGCAAGTATGAGTTCTCTCCT
3661 CAGACCTTGTGCTGCTATGGGAAGCAGCTCTGCACCATTCCCCGCGATGCAGCCTATTTC
3721 AGCTACCAGAACCGGTACCACTTCTGTGAGAGATGCTTCACTGAAATCCAGGGGGAGAAT
3781 GTTACCCTGGGCGACGACCCGGCTCAGCCTCAGACAACAATTTCAAAAGATCAATTTGAG
3841 AAGAAGAAGAATGACACGCTGGACCCAGAGCCTTTTGTGGACTGCAAGGAATGTGGACGG
3901 AAGATGCACCAGATATGTGTCTTACACTACGATATTATTTGGCCTTCAGGGTTTGTCTGC
3961 GACAACTGCTTGAAGAAAACCGGACGAACCCGCAAAGAGAACAAATTCAGTGCCAAAAGG
4021 TTGCAGGCCACCCGTTTGGGGAACCACTTGGAGGAGCGAGTGAACAAGTTCCTGCGGCGG
4081 CAGAACCATCCGGAGGCTGGGGAGGTTTCTGTCCGCGTCGTAGCCAGCTCCGACAAGACC
4141 GTGGAGGTGAAGCCGGGGATGAAGTCACGACACAGGTTCGTTGACTCCCGAGAGATGTCG
4201 GAGGCTTTTCCCTACCGGACAAAGGCCCTCTTTGCTTTTGAGGAGATTGACGGGGTTGAT
4261 GTCTGCTTCTTCGGGATGCATGTCCAGGAGTACGGCTGGGACTGCCCCCCTCCAAACACC
4321 AGGCGTGTCTACATCTCCTACTTGGACAGTATCCACTTCTTCCGCCCAAGATGCCTTCGG
4381 ACTGCAGTATACCATGAGATCCTCATTGGGTACCTGGAGTATGTCAGAAAACTGGGGTAT
4441 GTGACAGGCCACATCTGGGCCTGCCCTCCCAGCGAAGGGGATGACTACATCTTCCACTGC
4501 CACCCTCCTGACCAGAAGATCCCGAAGCCCAAGCGCCTGCAAGAGTGGTACAAGAAGATG
4561 CTGGACAAGGCCTTTGCTGAGCGCATCATCCACGACTACAAGGACATCTTCAAGCAGGCG
4621 ACTGAGGACCGACTGACCAGTGCCAAGGAGCTGCCGTACTTTGAGGGCGACTTCTGGCCC
4681 AATGTGCTGGAAGAAAGCATCAAGGAGCTGGAGCAGGAGGAGGAAGAGAGGAAGAAGGAG
4741 GAGAGCAGCGCTTCGGGGGAACCCACAGAAGAAGAGGGAAGTCAAGGGGACAGCAAGAAC
4801 GCCAAGAAGAAGAACAACAAGAAGACCAACAAGAACAAGAGCAGCATCAGCAGGGCCAAC
4861 AAGAAGAAGCCCACTTTGCCCAATGTCTCCAACGACCTCTCGCAGAAGCTCTATGCCACC
4921 ATGGAGAAGCATAAGGAGGTCTTCTTTGTAATCCACCTACATGCTGGCCCTGTGGTCAAC
4981 ACCTTGCCGCCCATTGTGGACCCGGACCCGATGCTGAGCTGCGACCTGATGGACGGCCGC
5041 GACGCTTTCCTGACCTTGGCCCGGGACAAGCACTGGGAGTTCTCCTCCTTGCGGCGCTCC
5101 AAGTGGTCCACCCTCTGTATGCTGGTGGAGCTGCACACCCAGGGCCAGGACCGCTTCGTC
5161 TACACCTGCAATGAGTGCCGGCACCATGTCGAGACCCGTTGGCACTGCACCGTCTGCGAG
5221 GATTACGACCTGTGCATCAACTGCTACAACGCTAAGAATCATGAGCACAAGATGGTCAAG
5281 TGGGGCCTGGGCCTGGACGACGACGGTGGGGGCAGCGGCCAGGGCGAGGCGCAGTCCAAG
5341 AGCCCCCAGGAGTCGCGTCGGCTAAGCATCCAGCGCTGCATTCAGTCCCTGGTGCATGCC
5401 TGCCAGTGCCGCAATGCCAACTGCTCGTTGCCCTCCTGTCAGAAGATGAAGCGGGTGGTG
5461 CAGCACACCAAGGGCTGCAAGCGCAAGACCAACGGGGGCTGCCCGGTCTGCAAGCAGCTG
5521 ATTGCCCTGTGCTGCTACCATGCCAAGCACTGCCAGGAGAGCAAGTGCCCCGTGCCCTTC
5581 TGCCTCAACATCAAGCACAAGCTCCGCCAGCAGCAGATCCAGCACCGCCTCCAGCAGGCC
5641 CAGCTCATGCGCCGCAGGATGGCCACCATGTCCACACGCGTGCCTCCGCAGCCGCAGGCA
5701 CAGCAGCCGCCACAGCAGCAGCAACAGCAGCAGAGCTTGCCTTCGCCTACCTCAGCCGCC
5761 CCCGGGACTCCCACCCAGCAGCCGCCCAGTGCCCCGCAGACCCCGCCCCAGCCCTCCCCT
5821 GTCGGCATGGCGACCACCGCCTTTCCTGGCAGGACTCAAGCCCCCCCGCTGCCGCCGGTC
5881 CCCCTCTCAGCCGGAAAGCCCACTCCCCAGGTGCCCGGCCCCCAAATGCCCTCCCAGCCG
5941 CCCCCTGGAGCCGTGGAAGCGGCTAGGCAGATCGAGATCGAGGCCCAACAGCAGCAACAA
6001 CAGCAGCCACCGCAGCAGCTCCCGCCTCCTCAACCCCCACCGGTTGGTCTGAACGTAGCG
6061 CGCCCCAATTCGGCTGGCAGCGGCCCCATGATGCCAGGCCTGGGTCCTGGCCAGTGGTCC
6121 TCGGCTGCCCCCATGGCCCAGGTGGCCCCTCTACAGCCGGGTATGCCACGGCCAGTCCTC
6181 CCAATGCCTCCCCAGCAGCAGCCACCACAGCAGCAGCAGCCACAGGCGGTGGGGGTCCCT
6241 CGGATGAGTGGCGCGCAGTCGGCTCCCTCCCGCAGCATCGCCCCTAACGCCTTGCATGAG
6301 CTGCTCCGGACCCTCAAGTCCCCCAGCTCCCCACAGCAGCAGCAACAGGTGCTGAATATC
6361 CTCAAGTCTAACCCGCAGCTGATGGCCGCCTTCATCAAGCAGCGAACAGCCAAGTACGTG
6421 GCCAGCCAGCCCCAGCAGGCTCCAGCCCTCCAGCAGCCGCAACCGCAGCAGCAGCAGCCT
6481 CCACCTCCACAGGGGCTCCACGCTCAGCCAGGCCTGCAGAACGTGGGCACCATGGCAGCA
6541 GGGGTCCCTCGGCCAGGCCTCTCTGCCCAGCAACCAGGGATGGGGGCCCTCAGCGCCCAG
6601 GGCCAGGCCCTCAGCCTCATGAACTCCGGCGGCGGTCACGGCCCCAGCATGGCCGCCATG
6661 AGCCCCCAGTACCGGGAGATCCTGCGCAGGCAGCTGCTCCAGCAACAACAGCAGCAGCAA
6721 CAGCAGCAGGGGGTGCCTGGGATGGGGGCCCACGGCCAATTCCCGCAGCCGCCTGGGCCC
6781 GTGGGATACTCCCAGGCCGCCTACCTCTCCCTGCCTATGGGGCCGATGGGACCCCTGAAC
6841 TCGTTGGGCCCTGAGGGCAGCACGAGCCTGCAGCAGGCCCTCCAGCAGCGGCTCCTCCAG
6901 CAGCAGCAGTCCGTGCCGCCGCTGATGGGCTCCCCCGGGCCCAACCCCATGAGCCCCCAG
6961 GGGCACCTGCTGCCCGGACAGCCCCCCAGCTCCACGGGGCCCGCGCCGCCCATGCTCCCT
7021 GGACAGCCCCCCCACGGCGGGCAGGTGCGCTCCCCGGCCCCGGTCCAGTCCCCCCGCCCC
7081 CAGTCGCAGCCCCCTCCGCCGCACTCGAGCCCCTCCCCCCGCGTGGCCCCCTCTCCGCAG
7141 ACGGGCTCCCCGCTCTCGCTGCCGGGACTTGCCGGGGGGGGCTTGGACCCGGGGCACCTG
7201 GGGGGGAGGACGCAGAGGGCCATGCTGCCCCAGCTGAACCCCCCCAACCGGGCCGTCCTG
7261 CCGGGGGACCTCTCCCTGGTTGGGGGAGACGCCTCGGGGGGAGATACGCTGGAGAAGTCC
7321 GTGGAGGGCTTGTAG
| Predicted Protein Product |
MAENLLDGPPNAKRAKLNSPGFPGPDPSDFGSFFNLENDLPDELISNGDLGLLSNSSSSG
SLVPDAASKHKQLSELLRGGVSAVGGPVPQGVGGPAQGQPNSGLGGGLGAMGKSPLGPGE
AKPSSAAPQQAMGAQKQQQAGMVAGSPASSAAQAAAGGGMHLNANFGQALPGLLNNNSSG
HGLLGPAQQGQGQVMNGSLGAAGRGGRGGAGMQYSAAGMQGSAGNVLAEALAQVSPQMAA
HAGLNASQAVSMAKMGMASNPGPFGQAFGQTAGGQQLGAAGVSPSLPNKPGLASSLSPFP
PDIKSVSVTSVPNMMPGQVQQQVGLVPAQAMAAGPTADPEKRKLIQQQLVLLLHAHKCQR
REQANGEVRACALPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPV
CLPLKNASDKRNQQPLLGSPVAGMQNSVASGAGQTAAAPLSNPNPIDPSSMQRAYAALGL
PYGNQPQVPLQPQVQGQQPTSQPQAPHPQMRTMNVLGANPMNLPTAGITEQAPGMIPEAA
LPASLGAAANPLMSDGTNSGNAGNLSGTITTAAPASGSGARKTWHEHVTQDLRNHLVHKL
VQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEK
RRSRLHKQGILGNQPALQTPGAQPPGLSQVTAVALGQTQPARPPNGPVSSVPNVPVSRMQ
VSQGMTRESMLPSLSIGNVQMPPASMGPRAASPMNHPVQMNNMGSVSAMALSPSRMPQSQ
SIMAAHANSLMGPAAPQTQFLGQSQFPATSGGALSVAMGQAQAGASSQGQAPAASLPASV
SILGPSSGQLACPSITQPSPLHQPAAPLPTTAVSMPSSVQGMIPPPTAPAAPALPLPPSG
QGPSPAPPSAPNTSAMQLQSMPSGQAQPAPQPRTPGQPPSVPTPQPPPSSQPQPAQAPVL
PQAPSTPLSQAAAGSVDSRVPSPGSAAGADLGNQPFGHEAPVTEGKSEVKAEKAKSECGE
APVEPKLEPEEEEAAAVVRPTQAKEEPGADEGKQEPMEVEGRKPEVKEEEDSGGSGGSGN
SSTSQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDI
VKSPMDLSTIKRKLDTGQYQEPWQYVEDVWLMFNNAWLYNRKTSRVYKFCTKLAEVFEQE
IDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYFSYQNRYHFCERCFTEIQGEN
VTLGDDPAQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVC
DNCLKKTGRTRKENKFSAKRLQATRLGNHLEERVNKFLRRQNHPEAGEVSVRVVASSDKT
VEVKPGMKSRHRFVDSREMSEAFPYRTKALFAFEEIDGVDVCFFGMHVQEYGWDCPPPNT
RRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVRKLGYVTGHIWACPPSEGDDYIFHC
HPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWP
NVLEESIKELEQEEEERKKEESSASGEPTEEEGSQGDSKNAKKKNNKKTNKNKSSISRAN
KKKPTLPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVVNTLPPIVDPDPMLSCDLMDGR
DAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECRHHVETRWHCTVCE
DYDLCINCYNAKNHEHKMVKWGLGLDDDGGGSGQGEAQSKSPQESRRLSIQRCIQSLVHA
CQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQESKCPVPF
CLNIKHKLRQQQIQHRLQQAQLMRRRMATMSTRVPPQPQAQQPPQQQQQQQSLPSPTSAA
PGTPTQQPPSAPQTPPQPSPVGMATTAFPGRTQAPPLPPVPLSAGKPTPQVPGPQMPSQP
PPGAVEAARQIEIEAQQQQQQQPPQQLPPPQPPPVGLNVARPNSAGSGPMMPGLGPGQWS
SAAPMAQVAPLQPGMPRPVLPMPPQQQPPQQQQPQAVGVPRMSGAQSAPSRSIAPNALHE
LLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVASQPQQAPALQQPQPQQQQP
PPPQGLHAQPGLQNVGTMAAGVPRPGLSAQQPGMGALSAQGQALSLMNSGGGHGPSMAAM
SPQYREILRRQLLQQQQQQQQQQGVPGMGAHGQFPQPPGPVGYSQAAYLSLPMGPMGPLN
SLGPEGSTSLQQALQQRLLQQQQSVPPLMGSPGPNPMSPQGHLLPGQPPSSTGPAPPMLP
GQPPHGGQVRSPAPVQSPRPQSQPPPPHSSPSPRVAPSPQTGSPLSLPGLAGGGLDPGHL
GGRTQRAMLPQLNPPNRAVLPGDLSLVGGDASGGDTLEKSVEGL
| Protein Alignment to Mouse |
sp|P45481|CBP_MOUSE CREB-binding protein OS=Mus musculus GN=Crebbp PE=1 SV=2
Length = 2441
Score = 3732 (1318.8 bits), Expect = 0., Sum P(8) = 0.
Identities = 705/898 (78%), Positives = 734/898 (81%)
Query: 966 TPLSQAAAGSVDSRVPSPGSAAGADLGNQPFGHEAPVTXXXXXXXXXXXXXXCGXXXXXX 1025
TPLSQAAA S+D+RVP+P + A+ +Q G + P+
Sbjct: 960 TPLSQAAA-SIDNRVPTPSTVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPE---PTESK 1015
Query: 1026 XXXXXXXXXXXXXRPTQAKEEPGADEGKQEPMEVEGRKPEVKEEEDXXXXXXXXXXXXXX 1085
+Q KEE E K EPMEVE +KPEVK E
Sbjct: 1016 GEPRSEMMEEDLQGSSQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQS 1075
Query: 1086 XXXXXXXRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPM 1145
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVK+PM
Sbjct: 1076 TSPSQP-RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPM 1134
Query: 1146 DLSTIKRKLDTGQYQEPWQYVEDVWLMFNNAWLYNRKTSRVYKFCTKLAEVFEQEIDPVM 1205
DLSTIKRKLDTGQYQEPWQYV+DV LMFNNAWLYNRKTSRVYKFC+KLAEVFEQEIDPVM
Sbjct: 1135 DLSTIKRKLDTGQYQEPWQYVDDVRLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVM 1194
Query: 1206 QSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYFSYQNRYHFCERCFTEIQGENVTLGD 1265
QSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAY+SYQNRYHFC +CFTEIQGENVTLGD
Sbjct: 1195 QSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCGKCFTEIQGENVTLGD 1254
Query: 1266 DPAQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLK 1325
DP+QPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLK
Sbjct: 1255 DPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLK 1314
Query: 1326 KTGRTRKENKFSAKRLQATRLGNHLEERVNKFLRRQNHPEAGEVSVRVVASSDKTVEVKP 1385
KTGR RKENKFSAKRLQ TRLGNHLE+RVNKFLRRQNHPEAGEV VRVVASSDKTVEVKP
Sbjct: 1315 KTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKP 1374
Query: 1386 GMKSRHRFVDSREMSEAFPYRTKALFAFEEIDGVDVCFFGMHVQEYGWDCPPPNTRRVYI 1445
GMKSR FVDS EMSE+FPYRTKALFAFEEIDGVDVCFFGMHVQ+ P VYI
Sbjct: 1375 GMKSR--FVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQDTALIAPHQIQGCVYI 1432
Query: 1446 SYLDSIHFFRPRCLRTAVYHEILIGYLEYVRKLGYVTGHIWACPPSEGDDYIFHCHPPDQ 1505
SYLDSIHFFRPRCLRTAVYHEILIGYLEYV+KL YVT HIWACPPSEGDDYIFHCHPPDQ
Sbjct: 1433 SYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLVYVTAHIWACPPSEGDDYIFHCHPPDQ 1492
Query: 1506 KIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLXX 1565
KIPKPKRLQEWYKKMLDKAFAERII+DYKDIFKQA EDRLTSAKELPYFEGDFWPNVL
Sbjct: 1493 KIPKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEE 1552
Query: 1566 XXXXXXXXXXXXXXXXXXXXXXPTEEEGSQGDSXXXXXXXXXXXXXXXSSISRANKKKPT 1625
E GSQGDS SSISRANKKKP+
Sbjct: 1553 SIKELEQEEEERKKEESTAASETPE--GSQGDSKNAKKKNNKKTNKNKSSISRANKKKPS 1610
Query: 1626 LPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVVNTLPPIVDPDPMLSCDLMDGRDAFLT 1685
+PNVSNDLSQKLYATMEKHKEVFFVIHLHAGPV++T PPIVDPDP+LSCDLMDGRDAFLT
Sbjct: 1611 MPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAFLT 1670
Query: 1686 LARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECRHHVETRWHCTVCEDYDLC 1745
LARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNEC+HHVETRWHCTVCEDYDLC
Sbjct: 1671 LARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLC 1730
Query: 1746 INCYNAKNHEHKMVKWXXXXXXXXXXXXXXEAQSKSPQESRRLSIQRCIQSLVHACQCRN 1805
INCYN K+H HKMVKW E QSKSPQESRRLSIQRCIQSLVHACQCRN
Sbjct: 1731 INCYNTKSHTHKMVKWGLGLDDEGSSQG--EPQSKSPQESRRLSIQRCIQSLVHACQCRN 1788
Query: 1806 ANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQESKCPVPFCLN 1863
ANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQE+KCPVPFCLN
Sbjct: 1789 ANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLN 1846
Score = 1907 (676.4 bits), Expect = 0., Sum P(8) = 0.
Identities = 413/721 (57%), Positives = 463/721 (64%)
Query: 162 LNANFGQAXXXXXXXXXXXXXXXXXXXXXXXXVMNGSLXXXXXXXXXXXXMQYSAAGMQG 221
+NANF Q VMNGSL M Y A MQG
Sbjct: 176 MNANFNQTHPGLLNSNSGHSLMNQAQQGQAQ-VMNGSLGAAGRGRGAG--MPYPAPAMQG 232
Query: 222 SAGNVLAEALAQVSPQMAAHAGLNASQAVSMAKMGMASNPXXXXXXXXXXXXXXXXXXXX 281
+ +VLAE L QVSPQMA HAGLN +QA M KMGM
Sbjct: 233 ATSSVLAETLTQVSPQMAGHAGLNTAQAGGMTKMGMTGT-TSPFGQPFSQTGGQQMGATG 291
Query: 282 VSPSLPNKPGLASSLSPFPPDIKSVSVTSVPNMMXXXXXXXXXXXXXXXMAAGPTADPEK 341
V+P L +K + +SL FP DIK+ SVT+VPNM +A GPTADPEK
Sbjct: 292 VNPQLASKQSMVNSLPAFPTDIKNTSVTTVPNM--SQLQTSVGIVPTQAIATGPTADPEK 349
Query: 342 RKLIQQQLVLLLHAHKCQRREQANGEVRACALPHCRTMKNVLNHMTHCQAGKACQVAHCA 401
RKLIQQQLVLLLHAHKCQRREQANGEVRAC+LPHCRTMKNVLNHMTHCQA KACQVAHCA
Sbjct: 350 RKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAPKACQVAHCA 409
Query: 402 SSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQPLLGSPVAGMQNSVAS-GAGQTAAAPL 460
SSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQ +LGSP +G+QN++ S GAGQ A L
Sbjct: 410 SSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGAGQQNATSL 469
Query: 461 SNPNPIDPSSMQRAYAALGLPYGNXXXXXXXXXXXXXXXXXXXXXXHPQMRTMNVLGANP 520
SNPNPIDPSSMQRAYAALGLPY N H QMRT+N LG NP
Sbjct: 470 SNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPPA--HQQMRTLNALGNNP 527
Query: 521 MNLPTAGIT-EQAPGMIXXXXXXXXXXXXXXXXMSDGTNSGNAGNLSGTITTAAPASGSG 579
M++P GIT +Q P + M+DG+NSGN G+LS TI TAAP S +G
Sbjct: 528 MSVPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGSLS-TIPTAAPPSSTG 586
Query: 580 ARKTWHEHVTQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSR 639
RK WHEHVTQDLR+HLVHKLVQAIFPTPDPAALKDRRMENLVAYA+KVEGDMYESANSR
Sbjct: 587 VRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSR 646
Query: 640 DEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALQTPGAQPPGLSQVTAVALGQTQ 699
DEYYHLLAEKIYKIQKELEEKRR+RLHKQGILGNQPAL GAQPP + +V +
Sbjct: 647 DEYYHLLAEKIYKIQKELEEKRRTRLHKQGILGNQPALPASGAQPPVIPPAQSV-----R 701
Query: 700 PARXXXXXXXXXXXXXXXRMQVSQGMTRESMLPSLSIGNVQMPPASMGPRAASPMNHPVQ 759
P RMQVSQGM S P +S+GNVQ+P A MGPRAASPMNH VQ
Sbjct: 702 PPNGPLPLPVN-------RMQVSQGMN--SFNP-MSLGNVQLPQAPMGPRAASPMNHSVQ 751
Query: 760 MNNMGSVSAMALSPSRMPQSQSIMAAHANSLMGPAAPQTQFLGQSQFPATSGGAL--SVA 817
MN+M SV MA+SPSRMPQ ++M HAN++M A Q QFL Q+QFP++SG SV
Sbjct: 752 MNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQFPSSSGAMSVNSVG 811
Query: 818 MXXXXXXXXXXXXXXXXXXXXX-VSILGPSSGQLACPSITQPSPLHQPAAPLPTTAVSMP 876
M +++L P + QL CP +TQ SPLH P P +TA MP
Sbjct: 812 MGQPAAQAGVSQGQEPGAALPNPLNMLAPQASQLPCPPVTQ-SPLH-PTPPPASTAAGMP 869
Query: 877 S 877
S
Sbjct: 870 S 870
Score = 385 (140.6 bits), Expect = 0., Sum P(8) = 0.
Identities = 129/351 (36%), Positives = 148/351 (42%)
Query: 1941 VGMATTAFPG--RTQAPPLPPVPLSAGKPTXXXXXXXXXXXXXXGAVEAARQIEIEAXXX 1998
V M+ FP RTQ PP +SAGKPT AVEAARQIE EA
Sbjct: 1915 VNMSPAGFPNVARTQ----PPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQ 1970
Query: 1999 XXXXXXXXXXX------------XXXXXVGLNVARPNSAXXXXXXXXXXXXQWSSAAPMA 2046
VGLNV RPN QW A P+
Sbjct: 1971 QHLYRANINNGMPPGRDGMGTPGSQMTPVGLNVPRPNQVSGPVMSSMPPG-QWQQA-PIP 2028
Query: 2047 QVAPLXXXXXXXXXXXXXXXXXXXXXXXXAVGVPRMSGAQSAPSRSIAPNALHELLRTLK 2106
Q P+ AV PRM Q P+RSI+P+AL +LLRTLK
Sbjct: 2029 QQQPMPGMPRPVMSMQAQA----------AVAGPRMPNVQ--PNRSISPSALQDLLRTLK 2076
Query: 2107 XXXXXXXXXXVLNILKSNPQLMAAFIKQRTAKYVASXXXXXXXXXXXXXXXXXXXXXXXX 2166
VLNILKSNPQLMAAFIKQRTAKYVA+
Sbjct: 2077 SPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQ 2136
Query: 2167 XXXXXXXNVGTMAAGVPRPGLSAQQPGMGALSAQGQALSLMNSGGGHGPSMAAMSPQYRE 2226
N+ M AGVPRPG+ QP MG L+ QGQAL++MN G H P+M M+PQYRE
Sbjct: 2137 QPSLQ--NLNAMQAGVPRPGVPPPQPAMGGLNPQGQALNIMNPG--HNPNMTNMNPQYRE 2192
Query: 2227 ILRRXXXXXXXXXX-----------XXXGVPGMGAHGQFPQPPGPVGYSQA 2266
++RR GM H QF QP GP GY+ A
Sbjct: 2193 MVRRQLLQHQQQQQQQQQQQQQQQNSASLAGGMAGHSQFQQPQGPGGYAPA 2243
Score = 174 (66.3 bits), Expect = 0., Sum P(8) = 0.
Identities = 42/78 (53%), Positives = 44/78 (56%)
Query: 1 MAENLLDGPPNAKRAKLNXXXXXXXXXXXXXXXXNLENDLPDELIXXXXXXXXXXXXXXX 60
MAENLLDGPPN KRAKL+ +LENDLPDELI
Sbjct: 1 MAENLLDGPPNPKRAKLSSPGFSANDNTDFGSLFDLENDLPDELIPNGELSLLNSGNL-- 58
Query: 61 XXVPDAASKHKQLSELLR 78
VPDAASKHKQLSELLR
Sbjct: 59 --VPDAASKHKQLSELLR 74
Score = 121 (47.7 bits), Expect = 0., Sum P(8) = 0.
Identities = 28/40 (70%), Positives = 31/40 (77%)
Query: 2405 QRAMLPQLNPPNRAVLPGDLSLVGGDASGGDTLEKSVEGL 2444
Q AMLPQLN PNR+ L +LSLVG D +G DTLEK VEGL
Sbjct: 2404 QSAMLPQLNTPNRSALSSELSLVG-DTTG-DTLEKFVEGL 2441
Score = 111 (44.1 bits), Expect = 6.3e-61, Sum P(8) = 6.3e-61
Identities = 38/102 (37%), Positives = 53/102 (51%)
Query: 340 EKRKL-IQQQLVLLLHAHKCQRREQANGEVRACALPHCRTMKNVLNHMTHCQAGKACQVA 398
E R+L IQ+ + L+HA CQ R AN C+LP C+ MK V+ H C K
Sbjct: 1767 ESRRLSIQRCIQSLVHA--CQCRN-AN-----CSLPSCQKMKRVVQHTKGC---KRKTNG 1815
Query: 399 HCASSRQIIS----HWKNCTRHDCPV--CLPLKNASDKRNQQ 434
C +Q+I+ H K+C + CPV CL +K+ + R QQ
Sbjct: 1816 GCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKH--NVRQQQ 1855
Score = 107 (42.7 bits), Expect = 0., Sum P(8) = 0.
Identities = 27/75 (36%), Positives = 37/75 (49%)
Query: 2260 PVGYSQAAYLSLPMGPMGPLNS--LGPEGSTSXXXXXXXXXXXXXXSVPPLMGSPG-PNP 2316
P+ S ++ PMG +G + LG + ST + +GSPG PNP
Sbjct: 2254 PIQGSSMGQMAAPMGQLGQMGQPGLGAD-STPNIQQALQQRILQQQQMKQQIGSPGQPNP 2312
Query: 2317 MSPQGHLLPGQPPSS 2331
MSPQ H+L GQP +S
Sbjct: 2313 MSPQQHMLSGQPQAS 2327
Score = 103 (41.3 bits), Expect = 1.1e-60, Sum P(6) = 1.1e-60
Identities = 35/90 (38%), Positives = 45/90 (50%)
Query: 1784 ESRRLSIQRCIQSLVHA--CQCRN-AN-----CSLPSCQKMKRVVQHTKGC---KRKTNG 1832
E R+L IQ+ + L+HA CQ R AN CSLP C+ MK V+ H C K
Sbjct: 348 EKRKL-IQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAPKACQVA 406
Query: 1833 GCPVCKQLIALCCYHAKHCQESKCPVPFCL 1862
C +Q+I+ H K+C CPV CL
Sbjct: 407 HCASSRQIIS----HWKNCTRHDCPV--CL 430
Score = 74 (31.1 bits), Expect = 9.9e-58, Sum P(6) = 9.9e-58
Identities = 15/52 (28%), Positives = 25/52 (48%)
Query: 1789 SIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQL 1840
+++ + + H CQ A C + C ++++ H K C R CPVC L
Sbjct: 386 TMKNVLNHMTH-CQAPKA-CQVAHCASSRQIISHWKNCTRHD---CPVCLPL 432
Score = 63 (27.2 bits), Expect = 3.7e-21, Sum P(5) = 3.7e-21
Identities = 39/153 (25%), Positives = 51/153 (33%)
Query: 2189 AQQPGMG-ALSAQGQALSLMNSGGGHGPSMAAMSPQYREILRRXXXXXXXXXXXXXGVPG 2247
A PGM + S Q ++M G H ++ A +P + L + V G
Sbjct: 756 ASVPGMAISPSRMPQPPNMM---GTHANNIMAQAPTQNQFLPQNQFPSSSGAMSVNSV-G 811
Query: 2248 MGAHGQFPQPPGPVGYSQAAYLSLPMGPMGPLNSLGPEGS-------TSXXXXXXXXXXX 2300
MG QP G SQ + P PLN L P+ S T
Sbjct: 812 MG------QPAAQAGVSQGQEPGAAL-P-NPLNMLAPQASQLPCPPVTQSPLHPTPPPAS 863
Query: 2301 XXXSVPPLMG--SPGPNPMSPQGHLLPGQPPSS 2331
+P L +PG P P P P SS
Sbjct: 864 TAAGMPSLQHPTAPGMTPPQPAAPTQPSTPVSS 896
Score = 62 (26.9 bits), Expect = 0., Sum P(7) = 0.
Identities = 42/165 (25%), Positives = 59/165 (35%)
Query: 721 VSQGMTRESMLPSLSIGNVQMPPASMGPRAASPMNHPVQMNNMGSVSAMALSPSRMPQSQ 780
VSQG + LP+ N+ P AS P P PV + + A + + MP Q
Sbjct: 821 VSQGQEPGAALPNPL--NMLAPQASQLP---CP---PVTQSPLHPTPPPASTAAGMPSLQ 872
Query: 781 SIMAAHANSLMGPAAPQTQF--LGQSQFPATSGGALSVAMXXXXXXXXXXXXXXXXXXXX 838
A PAAP + Q P + G++ A
Sbjct: 873 HPTAPGMTPPQ-PAAPTQPSTPVSSGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQVTPQP 931
Query: 839 XVSILGPSSGQLACP--SITQPSPLHQ--PAAPLPTTAVSMPSSV 879
+ PS +A P S QP+P+H P PL A S+ + V
Sbjct: 932 QTPVQPPS---VATPQSSQQQPTPVHTQPPGTPLSQAAASIDNRV 973
Score = 59 (25.8 bits), Expect = 0., Sum P(7) = 0.
Identities = 48/164 (29%), Positives = 64/164 (39%)
Query: 738 NVQMPP-ASMGPRAASPMNHPVQMNNMGSVS--AMALSPSR---MPQSQ---SIMAAHAN 788
+VQM AS+ A SP P N MG+ + MA +P++ +PQ+Q S A N
Sbjct: 749 SVQMNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQFPSSSGAMSVN 808
Query: 789 SL-MG-PAAPQTQFLGQSQFPATSGGALSVAMXXXXXXXXXXXXXXXXXXXXXVSILG-- 844
S+ MG PAA GQ A +A S
Sbjct: 809 SVGMGQPAAQAGVSQGQEPGAALPNPLNMLAPQASQLPCPPVTQSPLHPTPPPASTAAGM 868
Query: 845 PSSGQLACPSITQPSPLH--QPAAPL-----PT-TAVSMPSSVQ 880
PS P +T P P QP+ P+ PT T S+PS+ Q
Sbjct: 869 PSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQ 912
Score = 54 (24.1 bits), Expect = 1.1e-20, Sum P(6) = 1.1e-20
Identities = 43/150 (28%), Positives = 55/150 (36%)
Query: 744 ASMGPRAASPMNHPVQMNN--MGSVSA----MALSPSRMPQSQSIMAAHANSLMGPAAPQ 797
+SMG AA PM QM +G+ S AL + Q Q + P +PQ
Sbjct: 2258 SSMGQMAA-PMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQ 2316
Query: 798 TQFL-GQSQFPATSGGALSVAMXXXXXXXXXXXXXXXXXXXXXVSILGPSSGQLACPSIT 856
L GQ Q G ++ ++ S PS P I
Sbjct: 2317 QHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSS---PS------PRIQ 2367
Query: 857 -QPSPLH---QPAAPLPTTAVSMPSSV-QG 881
QPSP H Q P P AV+M SS+ QG
Sbjct: 2368 PQPSPHHVSPQTGTPHPGLAVTMASSMDQG 2397
Score = 49 (22.3 bits), Expect = 0., Sum P(7) = 0.
Identities = 13/28 (46%), Positives = 15/28 (53%)
Query: 2304 SVPPLMGSPGPNPMSPQGHLLPGQP-PS 2330
S PP G+P P +PQ P QP PS
Sbjct: 1888 SAPP--GTPTQQPSTPQTPQPPAQPQPS 1913
Score = 49 (22.3 bits), Expect = 2.3e-278, Sum P(6) = 2.3e-278
Identities = 12/36 (33%), Positives = 18/36 (50%)
Query: 845 PSSGQLACPSIT-QPSPLHQPAAPLPTTAVSMPSSV 879
PS+ Q P QPSP++ A P A + P ++
Sbjct: 1898 PSTPQTPQPPAQPQPSPVNMSPAGFPNVARTQPPTI 1933
Score = 48 (22.0 bits), Expect = 5.9e-26, Sum P(6) = 5.9e-26
Identities = 20/52 (38%), Positives = 25/52 (48%)
Query: 433 QQPLLGSP--VAGMQNSVASGAGQTAAAPLSNPN-PIDPSSMQRAYAALGLP 481
QQP+ G P V MQ + A+ AG P PN I PS++Q L P
Sbjct: 2030 QQPMPGMPRPVMSMQ-AQAAVAGPRM--PNVQPNRSISPSALQDLLRTLKSP 2078
Score = 47 (21.6 bits), Expect = 0., Sum P(7) = 0.
Identities = 11/27 (40%), Positives = 14/27 (51%)
Query: 2306 PPLMGSPGPNPMSPQG--HLLPGQPPS 2330
PP P P MSP G ++ QPP+
Sbjct: 1906 PPAQPQPSPVNMSPAGFPNVARTQPPT 1932
Score = 46 (21.3 bits), Expect = 0., Sum P(8) = 0.
Identities = 8/23 (34%), Positives = 12/23 (52%)
Query: 1799 HACQCRNANCSLPSCQKMKRVVQ 1821
HA C+ C +P C +K V+
Sbjct: 1830 HAKHCQENKCPVPFCLNIKHNVR 1852
Score = 45 (20.9 bits), Expect = 0., Sum P(8) = 0.
Identities = 20/75 (26%), Positives = 35/75 (46%)
Query: 722 SQGMTRESMLPSLSIGNVQMPPASMGPRAASPMNHPVQM-NNMGSV--SAMALSPSRMPQ 778
+QG + + SL G + P + G +++P N P Q + G ++ AL+P Q
Sbjct: 102 AQGQPNSTNMASL--GAMGKSPLNQGD-SSTP-NLPKQAASTSGPTPPASQALNPQAQKQ 157
Query: 779 SQSIMAAHANSLMGP 793
+ ++ A S GP
Sbjct: 158 VGLVTSSPATSQTGP 172
Score = 44 (20.5 bits), Expect = 3.5e-238, Sum P(5) = 3.5e-238
Identities = 13/47 (27%), Positives = 20/47 (42%)
Query: 1949 PGRTQAPPLPPVPLSAGK-PTXXXXXX-XXXXXXXXGAVEAARQIEI 1993
P + AP P P+S+G+ PT V+AA Q ++
Sbjct: 881 PPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQV 927
Score = 41 (19.5 bits), Expect = 6.3e-61, Sum P(8) = 6.3e-61
Identities = 9/33 (27%), Positives = 19/33 (57%)
Query: 654 QKELEEKRRSRLHKQGILGNQPALQTPGAQPPG 686
Q +L +R + ++ + + Q +L +P + PPG
Sbjct: 1862 QAQLMRRRMATMNTRNV--PQQSLPSPTSAPPG 1892
Score = 40 (19.1 bits), Expect = 0., Sum P(7) = 0.
Identities = 13/23 (56%), Positives = 14/23 (60%)
Query: 215 SAAGMQGSAGNVLAEALAQVSPQ 237
SAA Q S V A A AQV+PQ
Sbjct: 909 SAAQTQ-STPTVQAAAQAQVTPQ 930
Score = 39 (18.8 bits), Expect = 0., Sum P(8) = 0.
Identities = 12/40 (30%), Positives = 19/40 (47%)
Query: 845 PSSGQL-ACPSI---TQPSPLHQPAAPLPTTAVSMPSSVQ 880
PS+ Q + P++ Q QP P+ +V+ P S Q
Sbjct: 908 PSAAQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQ 947
Score = 39 (18.8 bits), Expect = 6.0e-18, Sum P(6) = 6.0e-18
Identities = 17/70 (24%), Positives = 23/70 (32%)
Query: 2251 HGQFPQPPGPVGYSQAAYLSLPMGPMGPLN-SLGPEGSTSXXXXXXXXXXXXXXSVPPLM 2309
+G P P + SQ PM +G + P G + SVP +
Sbjct: 704 NGPLPLPVNRMQVSQGMNSFNPMS-LGNVQLPQAPMGPRAASPMNHSVQMNSMASVPGMA 762
Query: 2310 GSPGPNPMSP 2319
SP P P
Sbjct: 763 ISPSRMPQPP 772
Score = 38 (18.4 bits), Expect = 3.5e-230, Sum P(5) = 3.5e-230
Identities = 11/30 (36%), Positives = 15/30 (50%)
Query: 842 ILGPSSGQLACPSITQPSPLHQPAAPLPTT 871
I G S GQ+A P + Q + QP +T
Sbjct: 2255 IQGSSMGQMAAP-MGQLGQMGQPGLGADST 2283
Score = 38 (18.4 bits), Expect = 2.4e-227, Sum P(4) = 2.4e-227
Identities = 9/19 (47%), Positives = 10/19 (52%)
Query: 2314 PNPMSPQGHLLPGQPPSST 2332
P P Q L P PP+ST
Sbjct: 846 PCPPVTQSPLHPTPPPAST 864
Score = 38 (18.4 bits), Expect = 7.0e-54, Sum P(7) = 7.0e-54
Identities = 7/23 (30%), Positives = 17/23 (73%)
Query: 640 DEYYHLLAEKIYKIQKELEEKRR 662
D + ++L E I ++++E EE+++
Sbjct: 1544 DFWPNVLEESIKELEQEEEERKK 1566
Score = 37 (18.1 bits), Expect = 0., Sum P(8) = 0.
Identities = 9/22 (40%), Positives = 12/22 (54%)
Query: 2306 PPLMGSPGPNPMSPQ-GHLLPG 2326
P + P P+ +SPQ G PG
Sbjct: 2364 PRIQPQPSPHHVSPQTGTPHPG 2385
Score = 37 (18.1 bits), Expect = 9.1e-242, Sum P(6) = 9.1e-242
Identities = 5/10 (50%), Positives = 10/10 (100%)
Query: 1655 AGPVVNTLPP 1664
+GPV++++PP
Sbjct: 2010 SGPVMSSMPP 2019
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