Home Search Reports Help

Gene Model:

NomenclatureGenomic Location
SymbolSmad7Chromosome2
NameMothers against decapentaplegic
homolog 7		Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 38 Mbp

Molecular Function

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Ubiquitinated by WWP1.

Molecular Function Terms:

binding
   protein binding
      collagen binding
      protein complex binding
      receptor binding

molecular transducer activity
   signal transducer activity
      receptor signaling protein activity

nucleic acid binding transcription factor activity
   sequence-specific DNA binding transcription factor activity

Human Disease Association

Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3) [MIM:612229]. Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber.

Predicted Transcript
     1 GAGTCTCCCCCTCCTCCTTACTCCAGATACCCAATGGATTTTCTCAAACCAACTGCAAGT
    61 TGTCCAGACTCTGTGCCTTCCTCCACCGAGACGGGAGGAACTAATTATCTTGCCCCTGGG
   121 GGGCTTTCAGATTCCCAAGTTCTACAAGAACCGGGGGACCCATCACACTGGTGTGTGGTG
   181 GCATACTGGGAAGAAAAGACGCGTGTGGGTCGGCTGTATTCTGTCCAAGAGCCTTCCCTG
   241 GATATCTTCTATGATCTACCTCAGGGGAATGGCTTCTGCCTCGGACAGCTCAATTCGGAC
   301 AATAAGAGCCAGCTGGTGCAGAAGGTCCGGAGCAAGATCGGCTACGGCATCCAGCTGACC
   361 AAGGAAGTCGACGGGGTGTGGGTTTACAATCGAAGCAGTTACCCGATTTTCATCAAGTCG
   421 GCCACACTGGACAACCCCGACTCCAGGACGTTACTGGTTCATAAAGTGTTCCCAGGCTTT
   481 TCCATCAAAGCGTTTGACTATGAGAAAGCGTACAGCTTGCAACGGCCGAACGACCACGAA
   541 TTCATGCAGCAGCCGTGGACTGGTTTCACCGTTCAGATCAGCTTTGTGAAAGGCTGGGGT
   601 CAGTGCTACACGAGACAGTTCATCAGCAGCTGCCCCTGCTGGTTGGAGGTTATATTTAAT
   661 AACCGA

Predicted Protein Product
ESPPPPYSRYPMDFLKPTASCPDSVPSSTETGGTNYLAPGGLSDSQVLQEPGDPSHWCVV
AYWEEKTRVGRLYSVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGYGIQLT
KEVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHE
FMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNNR
Protein Alignment to Mouse
p|O35253|SMAD7_MOUSE Mothers against decapentaplegic homolog 7 OS=Mus
            musculus GN=Smad7 PE=1 SV=1
      MGI:1100518 Smad7 MAD homolog 7 (Drosophila) (Chr 18)
        Length = 426

 Score = 1167 (415.9 bits), Expect = 3.2e-119, P = 3.2e-119
 Identities = 212/222 (95%), Positives = 216/222 (97%)

Query:     1 ESPPPPYSRYPMDFLKPTASCPDSVPSSTETGGTNYLAPGGLSDSQVLQEPGDPSHWCVV 60
             ESPPPPYSRYPMDFLKPTA CPD+VPSS ETGGTNYLAPGGLSDSQ+L EPGD SHWCVV
Sbjct:   205 ESPPPPYSRYPMDFLKPTAGCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVV 264

Query:    61 AYWEEKTRVGRLYSVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGYGIQLT 120
             AYWEEKTRVGRLY VQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIG GIQLT
Sbjct:   265 AYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLT 324

Query:   121 KEVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHE 180
             +EVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHE
Sbjct:   325 REVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHE 384

Query:   181 FMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNNR 222
             FMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFN+R
Sbjct:   385 FMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR 426