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Gene Model: Smad2

NomenclatureGenomic Location
SymbolSmad2Chromosome1
NameMothers against decapentaplegic
homolog 2		Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 59 Mbp

Molecular Function

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.

Molecular Function Terms:

binding
   nucleic acid binding
      DNA binding
   protein binding
      receptor binding
      SMAD binding
      transcription factor binding

molecular transducer activity
   signal transducer activity
      receptor signaling protein activity

nucleic acid binding transcription factor activity
   sequence-specific DNA binding transcription factor activity

Human Disease Association

No disease association.

Predicted Transcript
       ..........................ATGTCCTCCATCTTGCCTTTCACTCCGCCCGTGG
    35 TGAAACGTCTGCTGGGTTGGAAGAAGTCTGCTAGTGGTTCAAGCGGAGCAGGAGGTGGTG
    95 GAGAGCAAAACGGCCAGGAGGAGAAGTGGTGCGAGAAGGCAGTCAAAAGCCTGGTAAAGA
   155 AGTTGAAGAAAACTGGCCAACTGGACGAGCTGGAGAAGGCCATCACCACACAAAACCGCA
   215 ACACCAAGTGTGTCACCATTCCCAGCAATTGCTCTGAAATTTGGGGACTGAGTACACCAA
   275 ATACGATAGAACAGTGGGATACCTCAGGCCTTTACAGCTACCCTGACCAAACCAGATCTC
   335 TGGACGGGCGTTTGCAAGTGTCTCACCGTAAAGGTCTGCCTCATGTCATCTACTGCCGCC
   395 TGTGGCGATGGCCCGACCTGCACAGCCATCACGAGCTGCGCGCCATCGAGACCTGCGAGT
   455 ATGCTTTCAACCTCAAGAAGGATGAAGTCTGCGTCAATCCCTACCACTACCAGCGGGTGG
   515 AGACACCAGTTCTTCCTCCTGTTCTCGTGCCAAGACACACGGAGATCCTGACTGAGTTGC
   575 CACCTTTGGACGACTACACCAACTCCATACCTGAAAACACCAACTTCCCAACAGGGATCG
   635 AGCCCCCCAACAATTACATACCAGAAACTCCTCCACCGGGATACATCAGTGAGGATGGGG
   695 AGGCCAGTGACCAGCAAATGAATCAAAGTATGGACACAGGTTCTCCTGCAGAACTGTCAC
   755 CAAGCACACTCTCGCCTGTCAATCATGGCATGGACCTGCAGCCAGTGACTTACTCAGAGC
   815 CTGCGTTTTGGTGCTCCATAGCTTACTATGAACTTAACCAGCGGGTTGGAGAAACATTCC
   875 ACGCCTCTCAGCCTTCCCTCACCGTGGACGGCTTCACAGACCCCTCCAATTCAGAGCGAT
   935 TCTGCCTGGGCTTGCTGTCCAACGTCAACCGCAACGCCACCGTCGAGATGACCCGAAGAC
   995 ATATAGGACGAGGAGTCAGGCTGTATTATATTGGTGGGGAAGTGTTTGCTGAATGTCTTA
  1055 GCGATAGCGCCATCTTTGTTCAGAGCCCGAACTGTAATCAGAGGTATGGCTGGCATCCTG
  1115 CAACAGTCTGTAAAATCCCCCCAGGCTGTAACCTGAAGATCTTCAACAACCAGGAGTTTG
  1175 CAGCATTGCTGGCTCAGTCGGTGAACCAGGGGTTCGAGGCTGTTTATCAGTTGACCAGGA
  1235 TGTGCACCATTCGCATGAGTTTTGTCAAAGGCTGGGGAGCAGAGTACAGACGGCAGACAG
  1295 TGACGAGCACCCCCTGCTGGATCGAGCTGCATCTGAACGGGCCCCTCCAGTGGCTGGACA
  1355 AGGTTCTGACCCAGATGGGCTCTCCCTCCGTACGCTGCTCCAGTATGTCCTAA.......

Predicted Protein Product
MSSILPFTPPVVKRLLGWKKSASGSSGAGGGGEQNGQEEKWCEKAVKSLVKKLKKTGQLD
ELEKAITTQNRNTKCVTIPSNCSEIWGLSTPNTIEQWDTSGLYSYPDQTRSLDGRLQVSH
RKGLPHVIYCRLWRWPDLHSHHELRAIETCEYAFNLKKDEVCVNPYHYQRVETPVLPPVL
VPRHTEILTELPPLDDYTNSIPENTNFPTGIEPPNNYIPETPPPGYISEDGEASDQQMNQ
SMDTGSPAELSPSTLSPVNHGMDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTV
DGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQS
PNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFV
KGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
Protein Alignment to Mouse
sp|Q62432|SMAD2_MOUSE Mothers against decapentaplegic homolog 2 OS=Mus
            musculus GN=Smad2 PE=1 SV=2
      MGI:108051 Smad2 MAD homolog 2 (Drosophila) (Chr 18)
        Length = 467

 Score = 2159 (765.1 bits), Expect = 2.4e-224, P = 2.4e-224
 Identities = 402/468 (85%), Positives = 413/468 (88%)

Query:     1 MSSILPFTPPVVKRLLGWKKXXXXXXXXXXXXEQNGQEEKWCEXXXXXXXXXXXXTGQLD 60
             MSSILPFTPPVVKRLLGWKK            EQNGQEEKWCE            TG+LD
Sbjct:     1 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGG-EQNGQEEKWCEKAVKSLVKKLKKTGRLD 59

Query:    61 ELEKAITTQNRNTKCVTIPSNCSEIWGLSTPNTIEQWDTSGLYSYPDQTRSLDGRLQVSH 120
             ELEKAITTQN NTKCVTIPS CSEIWGLST NT++QWDT+GLYS+ +QTRSLDGRLQVSH
Sbjct:    60 ELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSH 119

Query:   121 RKGLPHVIYCRLWRWPDLHSHHELRAIETCEYAFNLKKDEVCVNPYHYQRVETXXXXXXX 180
             RKGLPHVIYCRLWRWPDLHSHHEL+AIE CEYAFNLKKDEVCVNPYHYQRVET       
Sbjct:   120 RKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVL 179

Query:   181 XXRHTEILTELPPLDDYTNSIPENTNFPTGXXXXXXXXXXXXXXGYISEDGEASDQQMNQ 240
               RHTEILTELPPLDDYT+SIPENTNFP G              GYISEDGE SDQQ+NQ
Sbjct:   180 VPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQ 239

Query:   241 SMDTGSPAELSPSTLSPVNHGMDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTV 300
             SMDTGSPAELSP+TLSPVNH +DLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTV
Sbjct:   240 SMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTV 299

Query:   301 DGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQS 360
             DGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQS
Sbjct:   300 DGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQS 359

Query:   361 PNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFV 420
             PNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFV
Sbjct:   360 PNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFV 419

Query:   421 KGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 468
             KGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
Sbjct:   420 KGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467