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Gene Model: Rnf111

NomenclatureGenomic Location
SymbolRnf111Chromosome2
NameE3 ubiquitin-protein ligase ArkadiaLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 21 Mbp

Molecular Function

Acts in the Nodal pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

Molecular Function Terms:

binding
   ion binding
      cation binding
         metal ion binding
   protein binding

catalytic activity
   ligase activity
      ligase activity, forming carbon-nitrogen bonds
         acid-amino acid ligase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 CAGCAGGCCTTGCCGGTGGACCTGAGCAGCAACGGGCTCCGGGGCCACGGGGGCGGCTCC
    61 TTCCACGGGGCCTCGGCCTTCGACCCCTGCTGCCCCGGCGCCTCCTCCTCCCGCACCGCC
   121 CTCTACGCGCACCAGCCGCCCGCGCAGACCTTGGCCCTGGTCGACAGCTATGGTGCCAGC
   181 TTGGTGGCCCAGCCCCCGCCGCCCCCTCCGCCGCCCCCGGCCGCGCTCTCCTCCTGCCGG
   241 CACTACATGCACTCGCCTTACGCCTCCCTGTCGCGGCCCCTGCACCACCAAGGGCCGCCC
   301 TGCCCCCACTCCCACGGCAACCCCCCTCCCCCGCCGGCGCCTGTATCGCCGATGGACTAC
   361 GTGATCCCGCACCCGGTGCACCCCTTCCACCCCGCCCTCTCCTCCTCCTCCTCCTCCTCC
   421 CCTCTTCCTCCTCCTCCCCCCTCCTCCTCCTCCTCCTCGGCCGCCGCCCCACTGCCGCAG
   481 CCCCTCCCCTCGGCGCACCAGCCCCTGGGCCACCACATGCCCCCCGCCACGGCCCCCGCC
   541 GCCCAGCGCCTGCACCCCCACGAGGTCATCCAGCGCATGGAGGTCCAGCGGAGGAGGATG
   601 ATGCAGCACCCCACGCGAGCCCACGAGCGGCCCCCGCCCCACCCGCACCGGATGCACCCC
   661 AACTACGGCCACGGGCACCACATCCACGTGCCGCAGACCATGTCTTCGCACCCGCGGCAG
   721 GCGCCAGAGCGGTCCGCCTGGGAACTGGGCCTCGAAGGGGTGGCGGCCGCGACGTATCCT
   781 CCGGGGCCCCTGCACCCGCACCTGGCGCACTACCACCCGCCGCCCCGGCTGCACCACCTC
   841 CAGATCGGGGCCCTGCCCCTCATGGTGCCGGACATGGCGGGCTATCCCCACATCCGCTAC
   901 ATCTCCTCGGGGCTGGACGGGACATCCTTCCGGGGACCCTTCCGGGGCAATTTCGAGGAA
   961 TTAATTCACCTCGAAGAGCGTTTAGGGAACGTGAACCGCGGCGCGTCCCAAGGAACCATC
  1021 GAGCGGTGCACGTACCCCCACAAGTACAAAAAGAGGAAACTCCACTGCAAGCAAGATGGG
  1081 GAGGAAGGGACCGAGGAGGACACCGAGGAAAAGTGCACCATCTGCTTGTCTATATTAGAG
  1141 GAAGGAGAAGATGTCAGGCGCCTGCCCTGCATGCACCTCTTCCACCAGGTCTGCGTGGAC
  1201 CAGTGGCTGATCACCAACAAGAAGTGCCCCATCTGCAGAGTGGACATTGAGGCCCAGCTG
  1261 CCCAGCGAGAGC

Predicted Protein Product
QQALPVDLSSNGLRGHGGGSFHGASAFDPCCPGASSSRTALYAHQPPAQTLALVDSYGAS
LVAQPPPPPPPPPAALSSCRHYMHSPYASLSRPLHHQGPPCPHSHGNPPPPPAPVSPMDY
VIPHPVHPFHPALSSSSSSSPLPPPPPSSSSSSAAAPLPQPLPSAHQPLGHHMPPATAPA
AQRLHPHEVIQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQ
APERSAWELGLEGVAAATYPPGPLHPHLAHYHPPPRLHHLQIGALPLMVPDMAGYPHIRY
ISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKRKLHCKQDG
EEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQL
PSES
Protein Alignment to Mouse
sp|Q99ML9|RN111_MOUSE E3 ubiquitin-protein ligase Arkadia OS=Mus musculus
            GN=Rnf111 PE=1 SV=1
      MGI:1934919 Rnf111 ring finger 111 (Chr 9)
        Length = 989

 Score = 862 (308.5 bits), Expect = 1.6e-120, Sum P(3) = 1.6e-120
 Identities = 166/213 (77%), Positives = 169/213 (79%)

Query:   221 NYGHGHHIHVPQTMSSHPRQAPERSAWELGLE-GVAAATYXXXXXXXXXXXXXXXXXXXX 279
             NYGHGHHIHVPQTMSSHPRQAPER+AWELG+E GV AATY                    
Sbjct:   777 NYGHGHHIHVPQTMSSHPRQAPERTAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHH 836

Query:   280 XQIGALPLMVPDMAGYPHIRYISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGT 339
              Q+GALPLMVPDMAGYPHIRYISSGLDG SFRGPFRGNFEELIHLEERLGNVNRGASQGT
Sbjct:   837 LQLGALPLMVPDMAGYPHIRYISSGLDGASFRGPFRGNFEELIHLEERLGNVNRGASQGT 896

Query:   340 IERCTYPHKYKK--------RKLHCKQXXXXXXXXXXXXKCTICLSILEEGEDVRRLPCM 391
             IERCTYPHKYKK        RKLHCKQ            KCTICLSILEEGEDVRRLPCM
Sbjct:   897 IERCTYPHKYKKVTTDWFSQRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCM 956

Query:   392 HLFHQVCVDQWLITNKKCPICRVDIEAQLPSES 424
             HLFHQVCVDQWLITNKKCPICRVDIEAQLPSES
Sbjct:   957 HLFHQVCVDQWLITNKKCPICRVDIEAQLPSES 989

 Score = 271 (100.5 bits), Expect = 1.6e-120, Sum P(3) = 1.6e-120
 Identities = 61/132 (46%), Positives = 73/132 (55%)

Query:     1 QQALPVDLSSNGLRXXXXXXXXXXXXXDPCCPGASSSRTALYAHQP---PAQTLALVDSY 57
             QQALPVDLS++ LR             DPCCP  +SSR A++ HQ    P Q L+ +D Y
Sbjct:   559 QQALPVDLSNSALRTHGSGGFHGASAFDPCCP-VTSSRAAVFGHQAAAAPTQPLS-IDGY 616

Query:    58 GASLVAQXXXXXXXXXAALSSCRHYMHSPYASLSRPLHHQXXXXXXXXXXXXXXXXXXXX 117
             G+S+VAQ          +LSSCRHYM  PYASL+RPLHHQ                    
Sbjct:   617 GSSMVAQPQPQPPPQ-PSLSSCRHYMPPPYASLTRPLHHQASACHHSHGNAPPQTQPPPQ 675

Query:   118 MDYVIPHPVHPF 129
             +DYVIPHPVH F
Sbjct:   676 VDYVIPHPVHAF 687

 Score = 81 (33.6 bits), Expect = 1.6e-120, Sum P(3) = 1.6e-120
 Identities = 15/20 (75%), Positives = 18/20 (90%)

Query:   171 HHMPPATAPAAQRLHPHEVI 190
             HH+P A AP+AQRLHPHEV+
Sbjct:   728 HHIP-APAPSAQRLHPHEVM 746

 Score = 40 (19.1 bits), Expect = 4.2e-89, Sum P(2) = 4.2e-89
 Identities = 8/18 (44%), Positives = 11/18 (61%)

Query:   171 HHMPPATAPAAQRLHPHE 188
             H+MPP  A   + LH H+
Sbjct:   639 HYMPPPYASLTRPLH-HQ 655