Home Search Reports Help

Gene Model: Tuba1c

NomenclatureGenomic Location
SymbolTuba1cChromosome1
NameTubulin, alpha 1CLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 33 Mbp

Molecular Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

Molecular Function Terms:

binding
   nucleotide binding

catalytic activity
   hydrolase activity
      hydrolase activity, acting on acid anhydrides
         hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
            pyrophosphatase activity
               nucleoside-triphosphatase activity
                  GTPase activity

structural molecule activity

Human Disease Association

No disease association.

Predicted Transcript
     1 CAGCGTGAGTGCATCTCCATCCACGTTGGCCAAGCCGGAGTCCAGATTGGCAATGCCTGC
    61 TGGGAGCTCTACTGCCTTGAGCATGGCATCCAGCCTGATGGGCAGATGCCCAGCGACAAG
   121 ACCATTGGGGGAGGAGACGACTCCTTCAACACTTTCTTCAGTGAGACGGGAGCTGGCAAA
   181 CATGTCCCCAGGGCTGTCTTTGTAGACTTGGAGCCAACTGTGATTGATGAAGTGCGCACA
   241 GGAACCTACCGACAGCTCTTCCACCCTGAGCAGCTCATCACTGGCAAGGAAGATGCAGCC
   301 AACAACTATGCCAGGGGCCACTACACCATTGGCAAGGAGATCATTGACTTGGTCCTGGAC
   361 AGGATCAGGAAGCTGGCTGATCAATGTACAGGTCTCCAGGGCTTTCTGGTCTTCCACAGC
   421 TTTGGTGGTGGCACGGGCTCTGGGTTTACCTCCTTGCTGATGGAGCGTCTCTCTGTTGAC
   481 TATGGGAAGAAGTCCAAGCTGGAGTTCTCCATCTACCCAGCCCCCCAAGTCTCCACAGCC
   541 GTAGTTGAGCCCTACAACTCCATTCTGACCACCCACACCACCCTGGAGCACTCCGACTGC
   601 GCCTTCATGGTAGACAATGAAGCTATCTATGACATCTGCCGCAGAAACCTCGACATCGAG
   661 CGCCCCACTTACACCAACCTTAACCGCCTGATCAGCCAGATTGTGTCCTCCATCACAGCC
   721 TCCCTACGATTTGATGGTGCCCTGAATGTAGATCTAACCGAATTCCAGACCAACTTGGTG
   781 CCCTATCCCCGTATCCACTTCCCCTTGGCCACTTATGCCCCAGTCATCTCTGCTGAGAAA
   841 GCTTACCATGAACAGCTAACTGTAGCTGAGATCACCAATGCTTGCTTTGAGCCGGCCAAC
   901 CAGATGGTGAAATGTGACCCTCGTCACGGTAAATATATGGCCTGCTGCCTCTTATACCGT
   961 GGGGATGTGGTTCCAAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAACGTAGC
  1021 ATCCAGTTTGTGGACTGGTGTCCCACTGGTTTCAAGGTGGGCATCAACTATCAGCCACCC
  1081 ACAGTGGTCCCCGGGGGTGACCTGGCCAAAGTGCAGCGTGCCGTCTGCATGTTGAGCAAC
  1141 ACCACCGCCATTGCGGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
  1201 AAGCGTGCCTTTGTCCACTGGTACGTCGGGGAGGGGATGGAGGAAGGAGAGTTCTCCGAG
  1261 GCCCGGGAAGACATGGCTGCCCTGGAAAAGGATTATGAAGAAGTAGGAGCAGACAGTGCT
  1321 GAGGGGGAAGATGAAGGGGAAGAATACTAA

Predicted Protein Product
QRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSAEGEDEGEEY
Protein Alignment to Mouse
sp|P68373|TBA1C_MOUSE Tubulin alpha-1C chain OS=Mus musculus GN=Tuba1c PE=1
            SV=1
      MGI:1095409 Tuba1c tubulin, alpha 1C (Chr 15)
        Length = 449

 Score = 2215 (784.8 bits), Expect = 2.8e-230, P = 2.8e-230
 Identities = 418/431 (96%), Positives = 419/431 (97%)

Query:     2 RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKH 61
             RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKH
Sbjct:     2 RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKH 61

Query:    62 VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDR 121
             VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDR
Sbjct:    62 VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDR 121

Query:   122 IRKLADQCTGLQGFLVFHXXXXXXXXXXXXLLMERLSVDYGKKSKLEFSIYPAPQVSTAV 181
             IRKLADQCTGLQGFLVFH            LLMERLSVDYGKKSKLEFSIYPAPQVSTAV
Sbjct:   122 IRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAV 181

Query:   182 VEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITAS 241
             VEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITAS
Sbjct:   182 VEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITAS 241

Query:   242 LRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQ 301
             LRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQ
Sbjct:   242 LRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQ 301

Query:   302 MVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPT 361
             MVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKR+IQFVDWCPTGFKVGINYQPPT
Sbjct:   302 MVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPT 361

Query:   362 VVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEA 421
             VVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEA
Sbjct:   362 VVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEA 421

Query:   422 REDMAALEKDY 432
             REDMAALEKDY
Sbjct:   422 REDMAALEKDY 432