| Nomenclature | Genomic Location |
| Symbol | Ttl | Chromosome | 1 |
| Name | Tubulin--tyrosine ligase | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 89 Mbp |
| Molecular Function |
|
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.
Molecular Function Terms:
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
|
| Human Disease Association |
|
No disease association.
|
1 ATGTATACCTTTGTGGTCCGAGACGAGAACAGCAGCGTCTACGCGGAGGTCTCGAAAATC
61 CTCCTCTCCACCGGACAATGGAAAAGGCTGAAGAGAGACAACCCCCGGTTTAACCTCATG
121 CTGGGCGAGAGGAACAGGCTGCCTTTCGGGAGGCTAGGGCATGAGCCTGGCCTTGTACAG
181 CTGGTGAACTACTACAGAGGAGCTGATAAACTTTGTCGCAAAGCTTCTTTAGTGAAACTC
241 ATCAAGACAAGCCCGGAATTGGTGGAGTCTTGCACGTGGTTCCCAGAATCCTATGTGATT
301 TATCCAACTGACCTGAAGACTCCAGTGGCCCCAGCACAGAATGGGATTCAGCACCTGGTA
361 AACAACACAAGAACGGATGAGAGGGAGGTCTTCCTGGCGTCCTATCAGAAGAGGAAAGAG
421 AGCGGAGAAGGAACTGTGTGGATAGCCAAGTCTTCGGCAGGTGCCAAAGGTGAAGGAATT
481 CTTATTTCTTCAGAGGCTTCTGAACTTCTGGAGTTTATAGATACTCAAGGACAAGTACAT
541 GTGATTCAGAAATACCTTGAGAAGCCTTTGCTCTTAGAACCAGGTCATCGCAAATTTGAT
601 ATTCGAAGCTGGGTGCTAGTGGATCACCTGTATAATATCTACCTCTACCGAGAAGGCGTT
661 CTACGGACCTCTTCTGAAGCTTACAATAGTGCTAATTTCCTGGACAAAACCTGCCATTTG
721 ACCAATCACTGCATACAGAAGGAATATTCTAAAAACTATGGGAGATATGAAGAAGGGAAT
781 GAAATGTTCTTTGAGGAGTTTAATCAGTATCTCATGAGTGCTTTGAACACTACTCTGGAA
841 AACTCAATCTTATTACAAGTCAAAAACATAATAAGAAGTTGCCTTATGTGTATAGAACCT
901 GCGATCAGCACCAAACACCTCCATTACCAGAGTTTCCAGCTCTTTGGCTTTGACTTCATG
961 GTGGATGAAGACTTGAAGGTCTGGCTAATTGAAGTCAACGGTGCCCCTGCGTGTGCCCAG
1021 AAACTGTATCCAGAGCTTTGCCAAGGCATAGTGGATGTAGCTATCTCTAGCGTCTTTCCT
1081 CTTAGTGAGACCATGCAAAAGCAGAGCCAGCCACCAATATTTATTAAATTGTGA
| Predicted Protein Product |
MYTFVVRDENSSVYAEVSKILLSTGQWKRLKRDNPRFNLMLGERNRLPFGRLGHEPGLVQ
LVNYYRGADKLCRKASLVKLIKTSPELVESCTWFPESYVIYPTDLKTPVAPAQNGIQHLV
NNTRTDEREVFLASYQKRKESGEGTVWIAKSSAGAKGEGILISSEASELLEFIDTQGQVH
VIQKYLEKPLLLEPGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEAYNSANFLDKTCHL
TNHCIQKEYSKNYGRYEEGNEMFFEEFNQYLMSALNTTLENSILLQVKNIIRSCLMCIEP
AISTKHLHYQSFQLFGFDFMVDEDLKVWLIEVNGAPACAQKLYPELCQGIVDVAISSVFP
LSETMQKQSQPPIFIKL
| Protein Alignment to Mouse |
sp|P38585|TTL_MOUSE Tubulin--tyrosine ligase OS=Mus musculus GN=Ttl PE=2 SV=2
MGI:1916987 Ttl tubulin tyrosine ligase (Chr 2)
Length = 377
Score = 1641 (582.7 bits), Expect = 1.9e-169, P = 1.9e-169
Identities = 312/377 (82%), Positives = 337/377 (89%)
Query: 1 MYTFVVRDENSSVYAEVSKILLSTGQWKRLKRDNPRFNLMLGERNRLPFGRLGHEPGLVQ 60
MYTFVVRDENSSVYAEVS++LL+TG WKRL+RDNPRFNLMLGERNRLPFGRLGHEPGL Q
Sbjct: 1 MYTFVVRDENSSVYAEVSRLLLATGYWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLAQ 60
Query: 61 LVNYYRGADKLCRKASLVKLIKTSPELVESCTWFPESYVIYPTDLKTPVAPAQNGIQHLV 120
LVNYYRGADKLCRKASLVKL+KTSPEL ESC+WFPESYVIYPT+LKTPVAPAQNGIQ V
Sbjct: 61 LVNYYRGADKLCRKASLVKLVKTSPELSESCSWFPESYVIYPTNLKTPVAPAQNGIQLPV 120
Query: 121 NNTRTDEREVFLASYQKRKESGEGTVWIAKSSAGAKGEGILISSEASELLEFIDTQGQVH 180
+N+RTDERE FLASY ++KE GEG VWIAKSSAGAKGEGILISSEASELL+FID+QGQVH
Sbjct: 121 SNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDSQGQVH 180
Query: 181 VIQKYLEKPLLLEPGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEAYNSANFLDKTCHL 240
VIQKYLE+PLLLEPGHRKFDIRSWVLVDH YNIYLYREGVLRT+SE Y+ NF DKTCHL
Sbjct: 181 VIQKYLERPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHL 240
Query: 241 TNHCIQKEYSKNYGRYXXXXXXXXXXXXQYLMSALNTTLENSILLQVKNIIRSCLMCIEP 300
TNHCIQKEYSKNYG+Y QYL SALN TLE+SILLQ+K+IIRSCLM +EP
Sbjct: 241 TNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALNITLESSILLQIKHIIRSCLMSVEP 300
Query: 301 AISTKHLHYQSFQLFGFDFMVDEDLKVWLIEVNGAPACAQKLYPELCQGIVDVAISSVFP 360
AISTKHL YQSFQL GFDFMVDE+LKVWLIEVNGAPACAQKLY ELCQGIVD+AISSVFP
Sbjct: 301 AISTKHLPYQSFQLLGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFP 360
Query: 361 LSETMQKQSQPPIFIKL 377
+T Q QP F+KL
Sbjct: 361 PPDTEQVPQQPAAFVKL 377
| 