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Gene Model: Krt84

NomenclatureGenomic Location
SymbolKrt84Chromosome2
NameKeratin 84Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 11 Mbp

Molecular Function

In skin, only expressed in the suprabasal cells of scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia.

Molecular Function Terms:

structural molecule activity
   structural constituent of epidermis

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGTCCTGCCGATCTTACCATGTTAGTTCTAGGGGCGATGGTGGAGTCAGGAATTACAGT
    61 TCATCCTCAGCTGTGTTCCCAAGGAATGTAAAACGCTACAGTGCTGTCAGCACCATCTCA
   121 TACAAAGGAGGCAGTGGCTTTGGTGCTAAAGGGTTAGGCTTTGGGAGCAAGAGTCTTTGT
   181 GGCGTTGCATCTTGCCGGCCCAGAATTGCACTTGGTACCTACCAGCCTGTAAAATACGGA
   241 TACAATTTGGGAGCCCCGAGTCTTGGATATGGCTATGGTATGCCCAGCTTTGGCAATCGG
   301 TTTGGTGGAGTAAGTGGGCCTCGCCCAGCTGGTATTGCACCTGTCACAGTCAACCCACAC
   361 CTTCTCCAGCCTCTGCACTTAGACATTGACCCCAGTGTCCAAATGGTGAAGCAACAAGAA
   421 AAAGAACAGCTGAAGACCCTCAACAATAAATTTGCATCATTCATCGACAAGGTCCGGTTC
   481 TTGGAACAGCAAAACAAGGTTCTAGAGACAAAATGGAGCTTACTGCAAGAGCAGAAGAGA
   541 GTCAAGAGCAACATAGAGCCCCTGTTTGATGGCTTGATTCATAAGCTAAAGAAACAGCTT
   601 GAGTCTCTGGGATGTGACCGAAATAAGCTTGAGTCAGACCTGACCAGTTCAAGGGACATA
   661 TTGGAAGATTACAGGAAAAGATACGAAGACGAGTGCAATCGGCGGACAAGTGCTGAGAAT
   721 GAATTTGTAACTCTTAAAAAGGCATTGGATGTTGACTGCATATACATGCATAAGGCGGAC
   781 CTGGAAGGCAAGGTGGAAAGCTTAGTGGAAGAGGTCAACTTTCTGAGGTGTTTGCATGAC
   841 ATGGAACTACAGGAGTTGCACTCCTGCATCTCAGATACTTCAGTTATTGTGCAGATGGAT
   901 AACAGCCGGGAACTGGATTTGGATGGCATCATTGCCGAGGTCAAAGCCCAATATGAGGAC
   961 ATTGCAAACAAGAGCCGCTATGAGGCAGAGTCATGGTATCAGTGCAAGTATGAAGAAATG
  1021 AGGGCAACAGCTGGCAAACATAATGACCACCTACGTGACACCAAGAATGAGATCATGGAG
  1081 TTGAACCGTGTGATTCAAAGACTGAAGGCTGAAATTGACACCGCCAAAGGCCAGCGTAGC
  1141 AAGCTGGAGGCTGCCGTTGCAGAAGCTGAGGAGCGAGGAGAGATGGCTCTCAAAGATGCC
  1201 AAGTGCAAGCTGACAGAGTTGGAAGATGCCCTCATAAAAGCGAAGGCAGACATGGCTCGC
  1261 CAGCTGCGGGAGTATCAGGAACTGATGAATGTCAAGCTGGCCTTGGACATTGAAATTGCC
  1321 ACTTATAGGAAGATGCTGGAAGGAGAGGAAAACAGGTTGTATGCTGACTCCTGTCCAGTG
  1381 AATATATCTGTTTGTCGAACCCAAGGTGGACTGGTGTGTGATCCCGATCCTTGCATTGGA
  1441 GGTGGATATGCTTCAAGCAGCAGAAACTTTGTCAGAAGTGGAGGCATTGTGACCAGTGGA
  1501 GGAGGAGGAATGTGCAGCCCTGGCCTTGGGAGAAACCTTTCAGCAGCCAGTTGCATTGAT
  1561 CTGGGGAGCCCTGGCCTGCCCACTGGAGGATATAGCACCGGGAGCGCAAAAAGCTCTAAT
  1621 GTCAAGTTTGTGTCAACTTCCACATCCTTTAGAACAAAATATTAA

Predicted Protein Product
MSCRSYHVSSRGDGGVRNYSSSSAVFPRNVKRYSAVSTISYKGGSGFGAKGLGFGSKSLC
GVASCRPRIALGTYQPVKYGYNLGAPSLGYGYGMPSFGNRFGGVSGPRPAGIAPVTVNPH
LLQPLHLDIDPSVQMVKQQEKEQLKTLNNKFASFIDKVRFLEQQNKVLETKWSLLQEQKR
VKSNIEPLFDGLIHKLKKQLESLGCDRNKLESDLTSSRDILEDYRKRYEDECNRRTSAEN
EFVTLKKALDVDCIYMHKADLEGKVESLVEEVNFLRCLHDMELQELHSCISDTSVIVQMD
NSRELDLDGIIAEVKAQYEDIANKSRYEAESWYQCKYEEMRATAGKHNDHLRDTKNEIME
LNRVIQRLKAEIDTAKGQRSKLEAAVAEAEERGEMALKDAKCKLTELEDALIKAKADMAR
QLREYQELMNVKLALDIEIATYRKMLEGEENRLYADSCPVNISVCRTQGGLVCDPDPCIG
GGYASSSRNFVRSGGIVTSGGGGMCSPGLGRNLSAASCIDLGSPGLPTGGYSTGSAKSSN
VKFVSTSTSFRTKY
Protein Alignment to Mouse
sp|Q99M73|KRT84_MOUSE Keratin, type II cuticular Hb4 OS=Mus musculus GN=Krt84
            PE=2 SV=1
      MGI:96700 Krt84 keratin 84 (Chr 15)
        Length = 603

 Score = 1187 (422.9 bits), Expect = 3.6e-130, Sum P(2) = 3.6e-130
 Identities = 251/475 (52%), Positives = 322/475 (67%)

Query:    81 YNLGAPSLGY-GYGMPSFGNRFGGVSGPRPAGIAPVTVNPHLLQPLHLDIDPSVQMVKQQ 139
             Y  G P  G  G+G P FG R GG+ GP    I  VTVN  LL PL+L+IDP+ Q VK+ 
Sbjct:   113 YGFGGPGFGGPGFGGPGFGYRIGGIGGPSAPAITAVTVNQSLLTPLNLEIDPNAQRVKRD 172

Query:   140 EKEQLKTLNNKFASFIDKVRFLEQQNKVLETKWSLLQEQKRVKSNIEPLFDGLIHKLKKQ 199
             EKEQ+KTLNNKFASFIDKVRFLEQQNK+LETKWS LQEQK  +SN+EPLFD  I  L++Q
Sbjct:   173 EKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCARSNLEPLFDNYITNLRRQ 232

Query:   200 LESLGCDRNKLESDLTSSRDILEDYRKRYEDECNRRTSAENEFVTLKKALDVDCIYMHKA 259
             L+ L  D+ +L+++    +DILE ++K+YE+E   R +AENEFV LKK  DVD  +++K+
Sbjct:   233 LDVLSSDQARLQAERNHLQDILEGFKKKYEEEVVFRANAENEFVALKK--DVDAAFLNKS 290

Query:   260 DLEGKVESLVEEVNFLRCLHDMELQELHSCISDTSVIVQMDNSRELDLDGIIAEVKAQYE 319
             DLE  V++L++E  FL+ L+  E++ L S IS+TSVIV+MDNSR+L+LDGIIAEVKAQYE
Sbjct:   291 DLEANVDTLIQETEFLKALYHEEIEMLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQYE 350

Query:   320 DIANKSRYEAESWYQCKYEEMRATAGKHNDHLRDTKNEIMELNRVIQRLKAEIDTAKGQR 379
             ++A +SR + ESWYQ KYEEMR TAG+H D+LR T++EI EL R+IQRLKAEI+  K Q 
Sbjct:   351 EVARRSRADVESWYQTKYEEMRVTAGQHCDNLRSTRDEINELTRLIQRLKAEIEHTKAQC 410

Query:   380 SKLXXXXXXXXXXXXXXLKDAKCKLTELEDALIKAKADMARQLREYQELMNVKLALDIEI 439
             +KL              L DAKCKL +LE AL +AK DMARQLREYQELMNVKLALDIEI
Sbjct:   411 AKLEAAVAEAEQQGEAALNDAKCKLADLEGALQQAKQDMARQLREYQELMNVKLALDIEI 470

Query:   440 ATYRKMLEGEENRLYADSCPVNISVCRTQGGLVCDPDPCIG------GGYASSSRNFVRS 493
              TYR++LEGEE R+     PVNISV  ++GG++C P+   G      GG   S+ + +R+
Sbjct:   471 VTYRRLLEGEEIRICEGVGPVNISVSSSRGGVLCGPELVSGSSLSHNGGVTFSTSSSIRA 530

Query:   494 XXXXXXXXXXXXXXXXXRNLSAASCIDLG---SPG----LPT-GGYSTGSAKSSN 540
                               + S    + +G   +P     LPT GG+S+ S    N
Sbjct:   531 TGGVLASSSLRAGGDLLSSGSRGGSVLVGDACAPSIPCALPTEGGFSSCSGGRGN 585

 Score = 104 (41.7 bits), Expect = 3.6e-130, Sum P(2) = 3.6e-130
 Identities = 32/94 (34%), Positives = 46/94 (48%)

Query:     1 MSCRSYHVSSRGDGGVRNYSSSSAVFPRNVKRYSAVSTISYXXXXXXXXXXXXXXXXXXC 60
             MSCRSY VSS    G  ++SS SA+ P+++ R+ + S                       
Sbjct:     1 MSCRSYRVSSGRRVG--SFSSCSAMAPQHLNRFRSSSVSCRSGPGFRGLGGFGSRSVINF 58

Query:    61 GVASCRPRIALGTYQPVKYGYNLGAPS-LGYGYG 93
             G +S  PRIA+G  +PV+ G   GA S + +G G
Sbjct:    59 GSSS--PRIAVGCSRPVRCGVGFGAGSGMAFGSG 90