GM072


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Gene Model: Atm

Nomenclature		Genomic Location
Symbol	Atm	Chromosome	X
Name	Serine-protein kinase ATM	Linkage map	unknown
Species	Dracomimus familiaris	Genome Coordinates	ChrX: 9 Mbp

Molecular Function

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation.

Molecular Function Terms:

binding
   nucleic acid binding
      DNA binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding
   protein binding
      protein complex binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity

Human Disease Association

Defects in ATM are the cause of ataxia telangiectasia (AT) [MIM:208900]; also known as Louis-Bar syndrome, which includes four complementation groups: A, C, D and E. This rare recessive disorder is characterized by progressive cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth retardation and sexual immaturity. AT patients have a strong predisposition to cancer; about 30% of patients develop tumors, particularly lymphomas and leukemias. Cells from affected individuals are highly sensitive to damage by ionizing radiation and resistant to inhibition of DNA synthesis following irradiation.

Note=Defects in ATM contribute to T-cell acute lymphoblastic leukemia (TALL) and T-prolymphocytic leukemia (TPLL). TPLL is characterized by a high white blood cell count, with a predominance of prolymphocytes, marked splenomegaly, lymphadenopathy, skin lesions and serous effusion. The clinical course is highly aggressive, with poor response to chemotherapy and short survival time. TPLL occurs both in adults as a sporadic disease and in younger AT patients.

Note=Defects in ATM contribute to B-cell non-Hodgkin lymphomas (BNHL), including mantle cell lymphoma (MCL).

Note=Defects in ATM contribute to B-cell chronic lymphocytic leukemia (BCLL). BCLL is the commonest form of leukemia in the elderly. It is characterized by the accumulation of mature CD5+ B lymphocytes, lymphadenopathy, immunodeficiency and bone marrow failure.

Predicted Transcript

     1 ATGAATCTTGCACTCCATGACCTGTTGACTTGCTGCCGTCAACTTGACAGTGACAAGGCC
    61 ACAGAACGAAAGAAGGAAATTGAAAAGTTCAAACGTCTTCTCCGTGACTCTGAAATAATT
   121 CAGCAGTTGGACCAGAACTCTGATTCCAAACATGGAAAGCAGCTTAACTGGGATACTGTA
   181 TTCAGATTTTTGCAGAAGTACATTCACAAAGAAACTGAAAGTGCCAGGCTTGCAAAGCCA
   241 AATGTGTCTGCATCAACACAAGCAACAAGACAAAAAAAGATGCAGGAAACCAGCAGTCTG
   301 GCCAAAAATTTCATCAGATGTGCCAATAAAAGAGCACCCAGGTTAAAGTGTCAGGACCTT
   361 TTGATGTATTTCACGAACACAGTAAATGATCCATCAAGTTATGCTATTTATGGAGCAGAC
   421 TGTAGTAGCATATTGCTAAAAAATATTCTTGCGGTGAGGAAATACTGGTGTGAAATATCT
   481 TCGCAACAGTGGTCAGATCTCCAGAATTTGTACTTCAGATTGTTCCTCAGCCCATCCAGA
   541 GACATTAACAAGGTTGTGGTGGCTAGAATAATTTACACACTCACCAGAGGATTGTGCTTC
   601 CAAACTGATGGGCTAAATTCTAATATTTTTAACTTCTTTTCAAAAGCTATGCAATACGCA
   661 AGACAAGAAAGAAACCCTGTGGCTCTTGAATATATTTTTGCTACCATGAATGTATTTTTC
   721 AATGTGTTTGCCATGAATTACCGTTTCCGAGTTTGTAAGCTGGGAGAGGAGATTCTGCCT
   781 ACTGTGCTTCGTATATGGGCTCAGCATAAACCAAACAAGTCCCTGAAGGAGCAAATCATT
   841 CGATTAGTTCAGCTTCAAGTCCATGTTCATCATCCAAATAGAGCTAAAAGCCAAGAAGGA
   901 GTCTGTAACTCGGTGGCATGGCAAGGCATTTTATATAACCTCTATGATCTGTTATCTAAT
   961 GAGGTGACTGTCTATAGCAACAGAGGAAAATATTCTGCAGGCTCGCGCAGTGTTGCTGTG
  1021 AAAGAAAACCTTGTTGAGTTATTTGCTGATATTTGTCATCAGCTCTTTACAGAAGGCACA
  1081 AAAGTTTTGGAGATAAGTCAGTGGCATGCTGTTACACAGAGAGAGAGTGGAGATGGAGAA
  1141 GGGCCATCCAAACGAAGGAGAATTGAATTGGGTTGGGAAGTGATTCGTGACAACCTGCAA
  1201 AGATCACAGAAGGACTGTGATGTTGTTCCCTGGCTGCAGATTGCAACCAGATTATTATCG
  1261 AAGTATCCGACAAGCTTTCCTCAGCATGAGTTGCTTCTCCTACTCAACATACTTTACCAG
  1321 CTACTGCCTCAGCAGCGTCGAGGGGAAAGGACACTTTATGTCTTAAGATGTCTCAAAGAG
  1381 GTTGCACTTTGTCAAGGCCAAATAATACATCTGAAAAGCAGTAATAGATTAGAGCTGCAG
  1441 AGAACATGGTCAAAAATTTGGTCTCTTGTGGTTCGTAGCATAAGTCTTCAGCAAATTGAA
  1501 GTAGAAAGTTTTGGATTACTTGGAGCCATGATTCAAGAAAACACAAAAACAATGGACAGA
  1561 GAATTGTGGAAGATATTTTCGGGATCTTCATGCAAGCCTTCAAGATCTGCAGCACAGTTC
  1621 CTGACAATAGCACTTAAAACTTCAGAACTGCCAGAAATTTTGAAAAGTGGGACAGCACAG
  1681 AATAATTGGGAAGGAAGTACGGCTCTTACATTAAAAGAAGAAATTATGAAGTGGCTTCTG
  1741 TTCTGCCATGTGGAGGAAGATACAGAGGATACTATGGAGCTGCCTCCTATTCTATGCAGT
  1801 GACTTTCCTAAATTAGAGTTGCAGAAAATCCTTGTAAGCCTCACTATGAAAAATAGTCGC
  1861 TCAGCCATGAATTTTTTTCACAGTGCTTCTGAATGTTTGCAGCATACACCAGAAAAAGAA
  1921 GTCAGTCTTTCAGAAACAGAAGCATTCTACACACAAACAATTTGTGATGAAATTGATGTA
  1981 TTTACAAACATGACAAACGAGAAATTGGAAAGCAAACCCTCTAGTTCCAGACTGATTGTC
  2041 AGCCAGAAACATCGGCAGGCCTTAGAGCATGATCTCATGGTGATGTCAGAAAAACTTCTT
  2101 AGTAGCTTTTCGCTTGAGGGTACGTCTGCAGAAATCCTGGTACGTTGTAGTGGCCTCTTG
  2161 ACTGGAGTTCTTGGCTGCTATTGCTATGCTGGTGTCCTCACAGCAGAAGAAGCACGTAAA
  2221 TCAGAGCTTTTTCACAAAGCCAAGTCTCTTATTCATTGCATAGGAGAAAGCATTTCTCAG
  2281 TCTAAAAACAAACTAAATGAAGATTCCAGAACCAGTTCAATGAAGAATTTGATAATGCAG
  2341 TGTGCTAGTTGTTTATGTAATTGTAATCAGAACAGCCCCCAAAATAGTATGTCGGACATT
  2401 TGGTTGCATTTGTTAACATCAAAGATGATGAATGATCTTACAGATATTTGCAAACATCTG
  2461 ATGGCTTTTACCACAAAAGCAAATGAAATTGGAGAAGTGGACGTAATGGAAGAAGATCCT
  2521 GAAGAGAGTAGAATGGAAGAAGACCAAGCAGTCTTGGATCTGTTTGATGATGACTCTGCT
  2581 GCAGCTGGTGATGCAAATGAGAACAAAGAATTGCAGAACTTGGCTGGTGCTGTAAGCCCA
  2641 TTATCAGAAGAACATCTGACTAAGCAGGACTTGCTGCTCCTTGACATTTTAAAGTTCTTA
  2701 TGTATTGCTGTCACAGCAACTTCAGGACAAATAGTTTGCTTTAGAGTTTCTGAAATTCGA
  2761 AGGAAACTCTTAATGCTAATAGAGGGAAATACATTTGATTATACAAAACCACTTCATCTC
  2821 CATATGTACTTGATTTTGTTGAAGGAACTCCCAAGTGAAGAAAATCCCTTACTAGAGGAT
  2881 CAGATTGTATCACTTCTCAGTCCTCTTACGGATGTCTGTTCCTTTTATCGTCGAGATCAA
  2941 GAGGTTTGCTCAGCAATTCTCCACAATCTTCTTCCCATGGTGACTGCCTTGGGCATTGCC
  3001 ACGACAAATACTGAAGATTTAAGTAGAGCCCAAGGTTCATTTTTAACTGTTATAGGGGCA
  3061 TTCTGGCATTTAGCAAGTGAAAGAAAATATACTGCTCCAGTAAGAATAGCCTTAGTGAAT
  3121 TGTATGAAAGCCTTACTTCAGGTTGATCCGTATTCAAAATGGACCATGCTCAATGTTAAA
  3181 CATCAAAATCTGACAGTGCATGATGCTTTCTCTAACTTCCTTGCTGACAGCAACTTTCAA
  3241 GTTTGCATGGTTGCTGCAAAATCAGTAACCAGTTTGTTCCAAGATGAAAAACAGAGAGAT
  3301 TCTATTGGTTTACTGAAACCTCTGAAACCTCTTCCTCTGAAGATCCAGCAAAGGGCATTT
  3361 GACAATTTGTACATAAAAGTTCAAGATGGAACAAAGAAACTGCTATGTCATAGTAATCAT
  3421 GAGAATCTTCCTGATGAAGAACGTAATAGAAAATTAGTTCTCCTTACATTGCTAACAATG
  3481 ATTTTACGCTGCAGTCCTGTGTGTGAAAAAAAAGCATTGTTTGCAATTTTCCAGTGTGTC
  3541 AAAGAGAATGGATTAGAGCCTCAGCTTGTAAGAAAGGTTTTAGAAAGAATTTCTGGCACT
  3601 TCTGGCTATAAAAATGCAGAGGATTTTATGAATACCCACTTAGATTATCTTGTTCAAGAA
  3661 TGGTTGAACTGCGGCTATAGCCTTTCACTTTTCCCTTATGCTTTATTGAATTACTCTGAT
  3721 TTAGAGGAATTCTACAGATCCTGCTACAAAATGTTGATTCCGCAACTGGTAATCAGAAAT
  3781 CAGTTTGAAGAGGTCAAATGCATTGCTGACAAGATCAAAAGAGAAGGGAAGCAGCTTCTG
  3841 GCACACTGCTTTCCCAAGATCCTTGTGAATATTCTCCCTTACTTTGCCTACCAGAATCAT
  3901 GAAGATGATGAATTTGCAGAAAAGAGACAGAGAGCTTCTAAAGTCTATGAAACACTGAAA
  3961 AGTGAATGCTGCTTAGGAAGACAGCTGATAGAAAATCTATTTCATAGCAATCTGCCAGAG
  4021 ATTGTGGTAGAGATATTGATGACCCTGCATGAACCAGTTGATATCAAGGCAGGGGAAGAA
  4081 TGTGATTTAAAGAGATTTGCTGGAGATCTGGATCCTTCTCCAAATCCTCCTTATTTCCCA
  4141 TCATACGTCATCAAAACAACATTGGATTACATTAGCAATTGCTGTAAAACAAAGTCAAAA
  4201 GAACTTGTAGCAGTTCTTTCCAAAAACCCTGAGTCATTCCAGAAGATCTTATTTGACATA
  4261 TGTAGGCAAGCATCTGAAACAAATAATATTTACAAAAAACATAGGATTCTTATGGTGTAT
  4321 CACTTTTTTGTAAATTTGTTACTGAAAGAAATAAAAGATGGTCTTGGAGGCGCATGGGCT
  4381 TTTGTGCTTCGGGATGTAATTTATACTATGATTCATCACATCAATAAGAGATCAATACCA
  4441 CTCAGAGGGATATTCCTTCGGAATTTTTTGCTATGTTTAGATCTTCTCAATCACATTTGC
  4501 CACATAACAGTTAAATATTGTCGCGATGCCCTAGGGACTCACCTCCATGTTATTGTGGGT
  4561 ACACTTGTGCCTATTGTGGAAGAGCAACCTGAAGCCCAAGAAGAGATCTTGAGCTTACTG
  4621 AGATATCTGGTAATAGATAATAAGGACAATGAAAATCTGTACCAGGCAATGAAACATCTA
  4681 GATCCTTTTCCTGACCATCCTGCTTTCAAAGAACTGCGAGCTGTTCAGCAACAAATAAAA
  4741 TACAGCAAAGGGGAATTTTCTCTTTTGGAGGAAATAAACCACTTCCTTTCTATAAATATC
  4801 TCTGATTCATTATCATTAACCAGACGGGAAGGTTTAAGTGATTTGCGCAAACGACTGGAA
  4861 AAGCATAAGGAACAAATGAAAAGCCTTATGAAAGAGTTTCAGGAAAATCCAAAGGACTGT
  4921 GTAATAGTGAAGCTTGTGGTATGTCTTTTACAACTTTCAAAAACAGCTATAAACTCTTCA
  4981 GATACAATCTTGGAGGCAGTTGGGAGTTGTTTGGGAGAAATTGGCCCCATCAGTTTTTCT
  5041 ACCACAGCTTTACAACACAATAAAAACATGTCCTGCTTAAGTGCAGCCGATCTCTTTGAA
  5101 GACAGGGAACTTCAGTGGGTCTTCATCATGTTAACTCTCATAAATAATGCTTTAATAGAT
  5161 CAGTGCATTGAAGTTAGATCTGCTGCTGCTTCTTGTTTGAAAAACATTTTAGCCACCAAA
  5221 ACTGGTCATGAATTCTGGGAGATTTACAAAGCCGAAGACGATCCCATGCTGGTTTACCTC
  5281 CATCCTTTCAGAACGTCTAAGAAAAAGTGGGCTCCAATTCCCGCTCTGTTGTTAACTTAT
  5341 TTCTTGAGAACTGTGGAAAAATTTCTGTACAGTGTTCCCTCACTACTTCGCGGTTCACTT
  5401 TTCACGGATTCGCTGTTTTGTGGTTTTTCAATAAACTCTAAAAGGTTGAGCCTCCAAAAT
  5461 CTGAAATGCTCCAATATCCAAAACGTTTGTGTAGTCACTTGTGCCTTTGAAGCAACAGCT
  5521 ACAACAGTCTTGTTTTTTTTTTCATTAACAAGATGGAAGTTTATGGTCTCCTTGAAGATC
  5581 TCCTATCCTCAGTCTTCCTCTAGCCTTGTTTCTCATACAGGACATAGGCAGCAAAGAATG
  5641 AGACCTAAGACTGGAAAGAGACATTCAGAACCGCTTGCTAATGGCAGTTTGGATAAAATA
  5701 TCTCGAAGAACAATGCTTGCTATAGTTGACTACTTAAGACGACAAAAGAAAAATCCTTCA
  5761 AGTACCGTCTTTGATGACAGCTTTTGGCTGGATTTAAATTACCTTCAGGTTGCCATGGCA
  5821 GCCCAGTCTTGTGCTGCTCATTTCACAGCTTTACTGTATGCAGAAATCTATGCTGACAAG
  5881 ATAAACCAGGACAAGCAGCAAGAACGATGTCTAGCATTTGAAGAAGAAAGTCAAAACGAA
  5941 ACTCTTACTTGTTTGAGCAACAAGAGTAAAGAAGACACTGGAATAAGTTTGCAGGATCTT
  6001 CTCATGGAGATTTACAGAAGCATAGGAGAACCGGACAGTATCTATGGCTGTGGTGGAGGG
  6061 AGAATGTTGCAGCCATTAGCTAGAATAAGAACATATGAACATGAAGCAGTGTGGGGGAAA
  6121 GCCCTGGTGACTTACGATATTGAAACAGGCCTTCCACCATCAACTCGACAGGCAGGAATA
  6181 ATGGAGGCCTTGCAAAATTTTGGACTATATGATACACTCTCAATCTATTTAAAAGGACTG
  6241 GAACAGGAAAATGAAGAAAGTACTATGGAATTACAAGAACTACGTTATCAGGCAGCATGG
  6301 AGAAATATGCAGTGGGATCACATTTCTTCAGTCAAAGATGAAATGGGAGGACGAGGCTAT
  6361 CACGAATCACTGTATGATACTCTGCAGTGTTTAAAGGACAAGGAATTCTCTACATTTCAT
  6421 GACAGATTGAAGTGTGCTAGTCATAGAGTGAAGGAAGTAGAAGAGCTGTCTAAAGGTAGC
  6481 CTTGAGTCTGTATATTCATTGCTGCCTGCACTCTGTAGACTGCAGACCATTGGAGAGTTG
  6541 GAATGCATAGGACAACTTTTCACCGGATCAGTTTCTAACAGTGAACTGAATAACATATAT
  6601 CTGAAGTGGCAGAGGCAGTCCCGGCTTCTTCAGGACAGTGACTTTAGTTTCCAAGAACCA
  6661 ATCATGGCTTTGCGCACAGTAATTTTGAACATCCTTCTGGAGAAGGAAATGGACAATACG
  6721 AAAAGGGAATGTATTAAGGACATCCTCACCAGACATCTTGTGGAGTTGTCCAGATTGGGT
  6781 CGAATGGCAAACAACACACAACTTCCAGAAAGAGCAATATTTCAAATCAAGCAGTATAAC
  6841 CCAACGAGACACAGGATATCTGAATGGCAACTAGAAGAAGCTCAGGTGTTCTGGGCTAAA
  6901 AAGGAGCAAAGCTTAGCACTAAATATTCTAAAGGAGATGATTAAAAAATTGGATGACGAT
  6961 TGGACTAAGGTTGAAAAAGATGCAAACTTGAGACTGATTTACACTGAGTGTCTCAGGCTA
  7021 TGTGGAAGCTGGTTGGCAGAGACTTGCTTAGAAAATCCTACAGTTATTATGAGAAATTAC
  7081 TTGGAAAAGGCTATAGAAGTTGCAGGGAGCCAAAAGGGTGACAGCAGTGATGAGCAGAAG
  7141 AGTGGGAAAATGAAGGCTTTTCTATCTCTGGCTCGTTTTTCGGACACTCAGTATCAAAGA
  7201 ATTGAAAATTATATGAAATCATCAGAGTTTGAAAACAAGCAAGCTTTACTGAGGAAAGCC
  7261 AAAGAGGAAGTTGGTCTTCTAAGAGAACATAAGGTGCAAACAAACAGTTATTGCATTGTT
  7321 CAGAAAAGTATACAGTTGGACCAA

Predicted Protein Product

MNLALHDLLTCCRQLDSDKATERKKEIEKFKRLLRDSEIIQQLDQNSDSKHGKQLNWDTV
FRFLQKYIHKETESARLAKPNVSASTQATRQKKMQETSSLAKNFIRCANKRAPRLKCQDL
LMYFTNTVNDPSSYAIYGADCSSILLKNILAVRKYWCEISSQQWSDLQNLYFRLFLSPSR
DINKVVVARIIYTLTRGLCFQTDGLNSNIFNFFSKAMQYARQERNPVALEYIFATMNVFF
NVFAMNYRFRVCKLGEEILPTVLRIWAQHKPNKSLKEQIIRLVQLQVHVHHPNRAKSQEG
VCNSVAWQGILYNLYDLLSNEVTVYSNRGKYSAGSRSVAVKENLVELFADICHQLFTEGT
KVLEISQWHAVTQRESGDGEGPSKRRRIELGWEVIRDNLQRSQKDCDVVPWLQIATRLLS
KYPTSFPQHELLLLLNILYQLLPQQRRGERTLYVLRCLKEVALCQGQIIHLKSSNRLELQ
RTWSKIWSLVVRSISLQQIEVESFGLLGAMIQENTKTMDRELWKIFSGSSCKPSRSAAQF
LTIALKTSELPEILKSGTAQNNWEGSTALTLKEEIMKWLLFCHVEEDTEDTMELPPILCS
DFPKLELQKILVSLTMKNSRSAMNFFHSASECLQHTPEKEVSLSETEAFYTQTICDEIDV
FTNMTNEKLESKPSSSRLIVSQKHRQALEHDLMVMSEKLLSSFSLEGTSAEILVRCSGLL
TGVLGCYCYAGVLTAEEARKSELFHKAKSLIHCIGESISQSKNKLNEDSRTSSMKNLIMQ
CASCLCNCNQNSPQNSMSDIWLHLLTSKMMNDLTDICKHLMAFTTKANEIGEVDVMEEDP
EESRMEEDQAVLDLFDDDSAAAGDANENKELQNLAGAVSPLSEEHLTKQDLLLLDILKFL
CIAVTATSGQIVCFRVSEIRRKLLMLIEGNTFDYTKPLHLHMYLILLKELPSEENPLLED
QIVSLLSPLTDVCSFYRRDQEVCSAILHNLLPMVTALGIATTNTEDLSRAQGSFLTVIGA
FWHLASERKYTAPVRIALVNCMKALLQVDPYSKWTMLNVKHQNLTVHDAFSNFLADSNFQ
VCMVAAKSVTSLFQDEKQRDSIGLLKPLKPLPLKIQQRAFDNLYIKVQDGTKKLLCHSNH
ENLPDEERNRKLVLLTLLTMILRCSPVCEKKALFAIFQCVKENGLEPQLVRKVLERISGT
SGYKNAEDFMNTHLDYLVQEWLNCGYSLSLFPYALLNYSDLEEFYRSCYKMLIPQLVIRN
QFEEVKCIADKIKREGKQLLAHCFPKILVNILPYFAYQNHEDDEFAEKRQRASKVYETLK
SECCLGRQLIENLFHSNLPEIVVEILMTLHEPVDIKAGEECDLKRFAGDLDPSPNPPYFP
SYVIKTTLDYISNCCKTKSKELVAVLSKNPESFQKILFDICRQASETNNIYKKHRILMVY
HFFVNLLLKEIKDGLGGAWAFVLRDVIYTMIHHINKRSIPLRGIFLRNFLLCLDLLNHIC
HITVKYCRDALGTHLHVIVGTLVPIVEEQPEAQEEILSLLRYLVIDNKDNENLYQAMKHL
DPFPDHPAFKELRAVQQQIKYSKGEFSLLEEINHFLSINISDSLSLTRREGLSDLRKRLE
KHKEQMKSLMKEFQENPKDCVIVKLVVCLLQLSKTAINSSDTILEAVGSCLGEIGPISFS
TTALQHNKNMSCLSAADLFEDRELQWVFIMLTLINNALIDQCIEVRSAAASCLKNILATK
TGHEFWEIYKAEDDPMLVYLHPFRTSKKKWAPIPALLLTYFLRTVEKFLYSVPSLLRGSL
FTDSLFCGFSINSKRLSLQNLKCSNIQNVCVVTCAFEATATTVLFFFSLTRWKFMVSLKI
SYPQSSSSLVSHTGHRQQRMRPKTGKRHSEPLANGSLDKISRRTMLAIVDYLRRQKKNPS
STVFDDSFWLDLNYLQVAMAAQSCAAHFTALLYAEIYADKINQDKQQERCLAFEEESQNE
TLTCLSNKSKEDTGISLQDLLMEIYRSIGEPDSIYGCGGGRMLQPLARIRTYEHEAVWGK
ALVTYDIETGLPPSTRQAGIMEALQNFGLYDTLSIYLKGLEQENEESTMELQELRYQAAW
RNMQWDHISSVKDEMGGRGYHESLYDTLQCLKDKEFSTFHDRLKCASHRVKEVEELSKGS
LESVYSLLPALCRLQTIGELECIGQLFTGSVSNSELNNIYLKWQRQSRLLQDSDFSFQEP
IMALRTVILNILLEKEMDNTKRECIKDILTRHLVELSRLGRMANNTQLPERAIFQIKQYN
PTRHRISEWQLEEAQVFWAKKEQSLALNILKEMIKKLDDDWTKVEKDANLRLIYTECLRL
CGSWLAETCLENPTVIMRNYLEKAIEVAGSQKGDSSDEQKSGKMKAFLSLARFSDTQYQR
IENYMKSSEFENKQALLRKAKEEVGLLREHKVQTNSYCIVQKSIQLDQ

Protein Alignment to Mouse

sp|Q62388|ATM_MOUSE Serine-protein kinase ATM OS=Mus musculus GN=Atm PE=1 SV=1
      MGI:107202 Atm ataxia telangiectasia mutated homolog (human) (Chr 9)
        Length = 3066

 Score = 6921 (2441.4 bits), Expect = 0., Sum P(2) = 0.
 Identities = 1392/2470 (56%), Positives = 1761/2470 (71%)

Query:     1 MNLALHDLLTCCRQLDSDKATERKKEIEKFKRLLRDSEIIQQLDQNSDSKHGKQLNWDTV 60
             M+LAL+DLL CCRQL+ D+ATER+KE++KFKRL++D E +Q LD++SDSK GK LNWD V
Sbjct:     1 MSLALNDLLICCRQLEHDRATERRKEVDKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAV 60

Query:    61 FRFLQKYIHKETESARLAKPNVSASTQATRQKKMQETSSLAKNFIRCANKRAPRLKCQDL 120
             FRFLQKYI KE ES R AK NVSA+TQ++RQKKMQE SSL + FI+CANKRAPRLKCQDL
Sbjct:    61 FRFLQKYIQKEMESLRTAKSNVSATTQSSRQKKMQEISSLVRYFIKCANKRAPRLKCQDL 120

Query:   121 LMYFTNTVNDPSSYAIYGADCSSILLKNILAVRKYWCEISSQQWSDLQNLYFRLFLSPSR 180
             L Y  +TV D S+   YGADCS+ILLK+IL+VRKYWCE+S QQW +L +LYFRL+L PS+
Sbjct:   121 LNYVMDTVKDSSNGLTYGADCSNILLKDILSVRKYWCEVSQQQWLELFSLYFRLYLKPSQ 180

Query:   181 DINKVVVARIIYTLTRGLCFQTDGLNSNIFNFFSKAMQYARQERNPVALEYIFATMNVFF 240
             DIN+V+VARII+ +TRG C QTDGL S   + FSKA+QYARQE++   L +I A +N+F 
Sbjct:   181 DINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQYARQEKSSPGLSHILAALNIFL 240

Query:   241 NVFAMNYRFRVCKLGEEILPTVLRIWAQHKPNKSLKEQIIRLVQLQVHVHHPNRAKS-QE 299
                A+N+R RVC+ G+EILPT+L IW QH+ N SLKE II L+QLQ+++HHP  A++ +E
Sbjct:   241 KSLAVNFRKRVCEAGDEILPTLLYIWTQHRLNDSLKEVIIELIQLQIYIHHPQGARAPEE 300

Query:   300 GVCNSVAWQGILYNLYDLLSNEVTVYSNRGKYSAGSRSVAVKENLVELFADICHQLFTEG 359
             G   S+ W+ ILYNLYDLL NE++   +RGKYS+GSR++AVKENL++L ADIC+QLF   
Sbjct:   301 GAYESMKWKSILYNLYDLLVNEISHIGSRGKYSSGSRNIAVKENLIDLMADICYQLFDAD 360

Query:   360 TKVLEISQWHAVTQRESGDGEGPSKRRRIELGWEVIRDNLQRSQKDCDVVPWLQIATRLL 419
             T+ +EISQ + VTQRES D   P KRR+I++GWEVI+D LQ+SQ D D+VPWLQI TRL+
Sbjct:   361 TRSVEISQSY-VTQRESTDYSVPCKRRKIDVGWEVIKDYLQKSQSDFDLVPWLQITTRLI 419

Query:   420 SKYPTSFPXXXXXXXXXXXXXXXXXXRRGERTLYVLRCLKEVALCQGQIIHLKSSNRLEL 479
             SKYP+S P                  RRGER  YVLRCLKEVALCQG+  +L+SS + +L
Sbjct:   420 SKYPSSLPNCELSPLILILYQLLPQQRRGERIPYVLRCLKEVALCQGKKSNLESSQKSDL 479

Query:   480 QRTWSKIWSLVVRSISLQQIEVESFGLLGAMIQENTKTMDRELWKIFSGSSCKPSRSAAQ 539
              + W KIWS+  R IS  Q + E+FGLL A+IQ +   +DRE WK+F+GS+CKPS  +  
Sbjct:   480 LKLWIKIWSITFRGISSGQTQTENFGLLEAIIQGSLVELDREFWKLFTGSACKPSSPSVC 539

Query:   540 FLTIALKTSELPEILKSGTAQNNWEGSTALTLKEEIMKWLLFCHVEEDTEDTMELPPILC 599
              LT+AL    +P+ +K GT Q+  E + + ++KE IM+WLLF  +E+D ED+ ELPPIL 
Sbjct:   540 CLTLALSICVVPDAIKMGTEQSVCEANRSFSVKESIMRWLLFYQLEDDLEDSTELPPILQ 599

Query:   600 SDFPKLELQKILVSLTMKNSRSAMNFFHSASECLQHTPEKEV-SLSETEAFYTQTICDEI 658
              +FP L ++KILVSLTMKNS++AM FF S  EC QH  +KE  S SE E  + QT  D++
Sbjct:   600 RNFPHLVVEKILVSLTMKNSKAAMKFFQSVPECEQHCEDKEEPSFSEVEELFLQTTFDKM 659

Query:   659 DVFTNMTNEKLESKPSSSRLIVSQKHRQALEHDLMVMSEKLLSSFSLEGTSAEILVRCSG 718
             D  T +    +E   SS    V Q  +++L+H L+ +SE+LLS++S E TS+E LVRCS 
Sbjct:   660 DFLTTVKEYAVEKFQSSVGFSVQQNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSS 719

Query:   719 LLTGVLGCYCYAGVLTAEEARKSELFHKAKSLIHCIGESISQSKNKLNEDSRTSSMKNLI 778
             LL GVLGCYCY G++T +EA KSELF KAKSL+ C GESIS  KNK NE+SR  S++N++
Sbjct:   720 LLVGVLGCYCYMGIITEDEAHKSELFQKAKSLMQCAGESISLFKNKTNEESRIGSLRNVM 779

Query:   779 MQCASCLCNCNQNSPQNSMSDIWLHLLTSKMMNDLTDICKHLMAFTTKANEIG----EVD 834
               C SCLC   +++P    S  +L LLTSK+MND+ DICK L + T K  + G    E D
Sbjct:   780 HLCTSCLCIHTKHTPNKIASGFFLRLLTSKLMNDIADICKSLASCTKKPLDHGVHPGEDD 839

Query:   835 VXXXXXXXXXXXXXQAVLDLFDDDSAAA-GDANENKELQNLAGAVSPLSEEHXXXXXXXX 893
                            +   L     A++  DAN+  E QN  GA+SPL+ ++        
Sbjct:   840 EDGGGCDSLMEAEGPSSTGLSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSKQDHLL 899

Query:   894 XXXXXXXCIAVTATSGQIVCFRVSEIRRKLLMLIEGNTFDYTKPLHLHMYLILLKELPSE 953
                      +VTA+    V FR ++IRRKLL+L++ +  D  KPLHLHMYL+LLK+LP  
Sbjct:   900 LDMLRFLGRSVTASQSHTVSFRGADIRRKLLLLLDSSILDLMKPLHLHMYLVLLKDLPGN 959

Query:   954 ENPLLEDQIVSLLSPLTDVCSFYRRDQEVCSAILHNLLPMVTALGIATTNTEDLSRAQGS 1013
             E+ L  + +V LL PL+ VCS +RRDQ+VC  IL N+L +VT LG  + + E    AQG 
Sbjct:   960 EHSLPMEDVVELLQPLSLVCSLHRRDQDVCKTILSNVLHIVTNLGQGSVDMESTRIAQGH 1019

Query:  1014 FLTVIGAFWHLASERKYTAPVRIALVNCMKALLQVDPYSKWTMLNVKHQNLTVHDAFSNF 1073
             FLTV+GAFWHL  E+K    VR+ALV C++ LL+ DPYS+W +LNVK Q+  V++AFS F
Sbjct:  1020 FLTVMGAFWHLTKEKKCVFSVRMALVKCLQTLLEADPYSEWAILNVKGQDFPVNEAFSQF 1079

Query:  1074 LADSNFQVCMVAAKSVTSLFQDEKQRDSIGXXXXXXXXXXXIQQRAFDNLYIKVQDGTKK 1133
             LAD + QV M+AA SV  LFQD +Q D               QQ +F+N Y   + G + 
Sbjct:  1080 LADDHHQVRMLAAGSVNRLFQDMRQGD---FSRSLKALPLKFQQTSFNNAYTTAEAGIRG 1136

Query:  1134 LLCHSNHENLPDEERNRKXXXXXXXXXXXRCSPVCEKKALFAIFQCVKENGLEPQLVRKV 1193
             LLC S + +L DE  NRK            CSPVCEK+ALFA+ + VKEN LEP LV+KV
Sbjct:  1137 LLCDSQNPDLLDEIYNRKSVLLMMIAVVLHCSPVCEKQALFALCKSVKENRLEPHLVKKV 1196

Query:  1194 LERISGTSGYKNAEDFMNTHLDYLVQEWLNCG---YSLSLFPYALLNYSDLEEFYRSCYK 1250
             LE++S + G ++ EDFM +HLDYLV EWLN     YSLS FP+ LLNY+ +E+FYRSCYK
Sbjct:  1197 LEKVSESFGCRSLEDFMISHLDYLVLEWLNLQDTEYSLSSFPFMLLNYTSIEDFYRSCYK 1256

Query:  1251 MLIPQLVIRNQFEEVKCIADKIKREGKQLLAHCFPKILVNILPYFAYQNHEDDEFAEKRQ 1310
             +LIP LVIR+ F+EVK IA++I++  K LL  CFPKILV+ILPYFAY+   D   ++KR+
Sbjct:  1257 ILIPHLVIRSHFDEVKSIANQIQKCWKSLLVDCFPKILVHILPYFAYEGTRDSYVSQKRE 1316

Query:  1311 RASKVYETLKSECCLGRQLIENLFHSNLPEIVVEILMTLHEPVDIKAGEECD----LKRF 1366
              A+KVY+TLK E  LG+Q I+ +F SNLPEIVVE+LMTLHE  D    +       L  F
Sbjct:  1317 TATKVYDTLKGEDFLGKQ-IDQVFISNLPEIVVELLMTLHETADSADSDASQSATALCDF 1375

Query:  1367 AGDLDPSPNPPYFPSYVIKTTLDYISNCCKTKSKELVAVLSKNPESFQKILFDICRQASE 1426
             +GDLDP+PNPPYFPS+VI+ T  YISNC KTK K ++ +LSK P+S+QKIL  IC QA+E
Sbjct:  1376 SGDLDPAPNPPYFPSHVIQATFAYISNCHKTKFKSILEILSKIPDSYQKILLAICEQAAE 1435

Query:  1427 TNNIYKKHRILMVYHFFVNLLLKEIKDGLGGAWAFVLRDVIYTMIHHINKRSIPLRGXXX 1486
             TNN++KKHRIL +YH FV+LLLK+I+ GLGGAWAFVLRDVIYT+IH+INKRS        
Sbjct:  1436 TNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDVSL 1495

Query:  1487 XXXXXXXXXXXXXXXITVKYCRDALGTHLHVIVGTLVPIVEEQPEAQEEILSLLRYLVID 1546
                              V  C+DAL +HLHVIVGTL+P+V+ Q E QE++L LL+YLVID
Sbjct:  1496 RSFSLCCDLLSRVCHTAVTQCKDALESHLHVIVGTLIPLVDYQ-EVQEQVLDLLKYLVID 1554

Query:  1547 NKDNENLYQAMKHLDPFPDHPAFKELRAVQQQIKYSKGEFSLLEEINHFLSINISDSLSL 1606
             NKDN+NL   +K LDPFPDH  FK+LR  QQ+IKYS G FSLLEEINHFLS++  + L L
Sbjct:  1555 NKDNKNLSVTIKLLDPFPDHVIFKDLRLTQQKIKYSGGPFSLLEEINHFLSVSAYNPLPL 1614

Query:  1607 TRREGLSDLRKRLEKHKEQMKSLMKEFQENPKDCVIVKLVVCLLQLSKTAINSSDT--IL 1664
             TR EGL DLR++LE+HK+QM  L++  Q+NP+D ++VKLVV LLQLSK A+N +    +L
Sbjct:  1615 TRLEGLKDLRRQLEQHKDQMLDLLRASQDNPQDGIVVKLVVSLLQLSKMAVNQTGEREVL 1674

Query:  1665 EAVGSCLGEIGPISFSTTALQHNKNMSCLSAADLFEDRELQWVFIMLTLINNALIDQCIE 1724
             EAVG CLGEIGP+ FST A+QHNK++S   A  L EDRELQW  IMLT +NN L++  ++
Sbjct:  1675 EAVGRCLGEIGPLDFSTIAVQHNKDVSYTKAYGLPEDRELQWTLIMLTALNNTLVEDSVK 1734

Query:  1725 VRSAAASCLKNILATKTGHEFWEIYKAEDDPMLVYLHPFRTSKKKWAPIPALLLTYFLRT 1784
             +RSAAA+CLKNILATK GH FWE YK   DPML YL PFRTS+KK+  +P  +    L  
Sbjct:  1735 IRSAAATCLKNILATKIGHIFWENYKTSADPMLTYLQPFRTSRKKFLEVPRSVKEDVLEG 1794

Query:  1785 VEKFLYSVPSLLRGSLFTDSLFCGF----SINSKRLSLQNLKCSNIQNVCVVTCAFEATA 1840
             ++     VP      ++  +L C F     INS+ L L    C    + C +   +    
Sbjct:  1795 LDAVNLWVPQSESHDIWIKTLTCAFLDSGGINSEILQLLKPMCEVKTDFCQMLLPY--LI 1852

Query:  1841 TTVLFFFSLTRWKFMVSLKISYPQSSSSLVSHTGHRQQRMRPKTGKRHSEPLANGSLDKI 1900
               VL   +   W+ ++S  +      +S   H+    +   P      SE      LDK 
Sbjct:  1853 HDVLLQDTHESWRTLLSAHVR--GFFTSCFKHSSQASRSATPANSDSESENFLRCCLDKK 1910

Query:  1901 SRRTMLAIVDYLRRQKKNPSSTVFDDSFWLDLNYLQVAMAAQSCAAHFTALLYAEIYADK 1960
             S+RTMLA+VDYLRRQK+  S T FDD+FWLDLNYL+VA  AQSC+AHFTALLYAEIY+DK
Sbjct:  1911 SQRTMLAVVDYLRRQKRPSSGTAFDDAFWLDLNYLEVAKVAQSCSAHFTALLYAEIYSDK 1970

Query:  1961 INQDKQQERCLAFEEESQNETLTCLSNKSKEDTGISLQDLLMEIYRSIGEPDSIYGCGGG 2020
              + D+Q++R   FEE SQ  T++ LS KSKE+TGISLQDLL+EIYRSIGEPDS+YGCGGG
Sbjct:  1971 KSTDEQEKRSPTFEEGSQGTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGG 2030

Query:  2021 RMLQPLARIRTYEHEAVWGKALVTYDIETGLPPSTRQAGIMEALQNFGLYDTLSIYLKGL 2080
             +MLQPL RIRTYEHEA W KALVTYD+ET +  STRQ+GI++ALQN GL   LS+YLKGL
Sbjct:  2031 KMLQPLTRIRTYEHEATWEKALVTYDLETSISSSTRQSGIIQALQNLGLSHILSVYLKGL 2090

Query:  2081 EQENEESTMELQELRYQAAWRNMQWDHISSVKDEMGGRGYHESLYDTLQCLKDKEFSTFH 2140
             + E  E   ELQELRYQAAWRNMQW   +S   E+ G  YHESLY+ LQCL+++EFSTF+
Sbjct:  2091 DYERREWCAELQELRYQAAWRNMQWGLCASAGQEVEGTSYHESLYNALQCLRNREFSTFY 2150

Query:  2141 DRLKCAS-HRVKEVEELSKGSLESVYSLLPALCRLQTIGELECIGQLFTGSVSNSELNNI 2199
             + L+ AS  RVKEVEELSKGSLESVYSL P L RLQ IGELE  G+LF+ SV++ E +  
Sbjct:  2151 ESLRYASLFRVKEVEELSKGSLESVYSLYPTLSRLQAIGELENSGELFSRSVTDRERSEA 2210

Query:  2200 YLKWQRQSRLLQDSDFSFQEPIMALRTVILNILLEKEMDNTKRECIKDILTRHLVELSRL 2259
             Y KWQ+ S+LL+DSDFSFQEP+MALRTVIL  L++KEM+ ++  C KDILT+HLVE S L
Sbjct:  2211 YWKWQKHSQLLKDSDFSFQEPLMALRTVILETLVQKEMERSQGACSKDILTKHLVEFSVL 2270

Query:  2260 GRMANNTQLPERAIFQIKQYNPTRHRISEWQLEEAQVFWAKKEQSLALNILKEMIKKLDD 2319
              R   NTQLPERAIF+IKQYN     ISEW LEEAQVFWAKKEQSLAL+ILK+MIKKLD 
Sbjct:  2271 ARTFKNTQLPERAIFKIKQYNSAICGISEWHLEEAQVFWAKKEQSLALSILKQMIKKLDS 2330

Query:  2320 DWTKVEKDANLRLIYTECLRLCGSWLAETCLENPTVIMRNYLEKAIEVAGSQKGDSSDEQ 2379
              +   E DA L++IY ECLR+CGSWLAETCLENP VIM+ YLEKA++VAGS  G+S  E 
Sbjct:  2331 SFKDKENDAGLKVIYAECLRVCGSWLAETCLENPAVIMQTYLEKAVKVAGSYDGNSR-EL 2389

Query:  2380 KSGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLRKAKEEVGLLREHKVQTNSYCI 2439
             ++G+MKAFLSLARFSDTQYQRIENYMKSSEFENKQ LL++AKEEVGLLREHK+QTN Y +
Sbjct:  2390 RNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQTLLKRAKEEVGLLREHKIQTNRYTV 2449

Query:  2440 -VQKSIQLDQ 2448
              VQ+ ++LD+
Sbjct:  2450 KVQRELELDE 2459

 Score = 41 (19.5 bits), Expect = 0., Sum P(2) = 0.
 Identities = 14/55 (25%), Positives = 28/55 (50%)

Query:  2204 QRQSRLLQDSDFSFQEPIMALRTVILNILLEKEMDNTKRECIKDILTRHLVELSR 2258
             + + +L++  D   Q+ +M     + N LL++  +  KR+    I T  +V LS+
Sbjct:  2720 KERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLT--ICTYKVVPLSQ 2772