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Gene Model: H2az

NomenclatureGenomic Location
SymbolH2azChromosome2
NameHistone H2A.ZLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 49 Mbp

Molecular Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Essential for early development.

Molecular Function Terms:

binding
   nucleic acid binding
      DNA binding

Human Disease Association

No disease association.

Predicted Transcript
     1 GCCGGTGGCAAAGCTGGGAAGGACTCTGGGAAAACCAAGACCAAGACGGTCTCCCGTTCG
    61 CAGAGAGCTGGCTTGCAGTTCCCTGTTGGCAGAATTCACCGGCATCTGAAATCCAGGACT
   121 ACCAGTCATGGCCGTGTTGGGGCTACTGCTGCTGTATATAGTGCTGCCATTTTGGAGTAT
   181 CTCACAGCTGAGGTTCTTGAACTAGCAGGAAATGCATCCAAAGACTTGAAAGTGAAGCGT
   241 ATCACTCCCCGTCACTTGCAGCTTGCAATAAGAGGTGATGAAGAACTGGATTCCCTCATC
   301 AAAGCAACAATTGCTGGCGGAGGTGTCATTCCACACATCCATAAATCTCTTATTGGAAAG
   361 AAAGGGCAACAGAAAACAGTTTAA

Predicted Protein Product
AGGKAGKDSGKTKTKTVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEY
LTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGK
KGQQKTV
Protein Alignment to Mouse
sp|P0C0S6|H2AZ_MOUSE Histone H2A.Z OS=Mus musculus GN=H2afz PE=1 SV=2
      MGI:1888388 H2afz H2A histone family, member Z (Chr 3)
        Length = 128

 Score = 622 (224.0 bits), Expect = 1.8e-61, P = 1.8e-61
 Identities = 125/127 (98%), Positives = 125/127 (98%)

Query:     1 AGGKAGKDSGKTKTKTVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEY 60
             AGGKAGKDSGK KTK VSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEY
Sbjct:     2 AGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEY 61

Query:    61 LTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGK 120
             LTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGK
Sbjct:    62 LTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGK 121

Query:   121 KGQQKTV 127
             KGQQKTV
Sbjct:   122 KGQQKTV 128