| Nomenclature | Genomic Location |
| Symbol | Abl1 | Chromosome | X |
| Name | Tyrosine-protein kinase ABL1 | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | ChrX: 48 Mbp |
| Molecular Function |
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Protein kinase that regulates key processes linked to cell growth and survival.
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion.
Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics.
Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Molecular Function Terms:
binding
ion binding
cation binding
metal ion binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
protein binding
enzyme binding
kinase binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
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| Human Disease Association |
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Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia.
Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute
myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
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1 ATGTTGGAGATTTGTCTGAAATTAGTAGGTTGCAAGTCGAAGAAAGGACTCTCCTCTTCT
61 TCCAGCTGCTATTTGGAAGAAGCCCTTCAGAGGCCGGTTGCCTCTGAATTTGAGCCCCAA
121 GGCTTGAGCGAAGCTGCCCGCTGGAACTCCAAGGAAAACCTTCTCTCCGGTCCCAGTGAA
181 AATGACCCCAACCTTTTTGTGGCCCTGTATGATTTCGTAGCAAGTGGGGACAACACTCTC
241 AGCATCACTAAAGGTGAGAAGCTCCGTGTCTTAGGCTACAACCACAATGGCGAGTGGTGC
301 GAAGCCCAGACCAAGAACGGCCAGGGCTGGGTCCCCAGCAACTACATCACCCCCGTGAAC
361 AGCTTGGAGAAGCACTCCTGGTACCACGGTCCCGTCTCCCGGAATGCCGCCGAGTACTTG
421 CTCAGCAGCGGCATCAACGGCAGCTTCTTGGTGCGGGAGAGCGAGAGCAGCCCTGGACAG
481 CGGTCCATTTCACTCCGGTACGAGGGGAGGGTTTACCACTACAGGATCAACACCGCCTCC
541 GATGGGAAGCTTTACGTCTCTTCCGAAAGCCGCTTCAACACCTTGGCGGAGCTGGTCCAT
601 CACCACTCGACGGTAGCCGACGGGTTGATCACCACTCTGCACTATCCGGCTCCGAAGCGG
661 AACAAGCCCACCATCTACGGCGTGTCCCCGAACTACGACAAGTGGGAGACGGAGCGGACA
721 GACATCACCATGAAGCACAAACTGGGAGGGGGACAGTACGGGGAGGTGTACGAAGGAGTC
781 TGGAAGAAGTATAACCTCACGGTGGCTGTGAAAACCTTAAAGGAGGACACAATGGAAGTG
841 GAAGAGTTCTTGAAAGAGGCGGCCGTCATGAAGGAGATCAAGCACCCGAACTTGGTGCAA
901 TTACTGGGTGTGTGTACACGGGAGCCTCCGTTTTATATCATCACGGAGTTCATGACATAC
961 GGAAACTTGTTGGACTACCTCCGGGACTGCAACCGGCAGGAGGTGAATGCCGTCGTCCTG
1021 CTGTACATGGCAACCCAGATCTCCTCGGCCATGGAGTACCTGGAGAAGAAGAACTTCATC
1081 CACAGGGACCTTGCTGCCCGGAATTGCCTCGTCGGGGAGAACCATCTGGTGAAGGTGGCC
1141 GATTTTGGCCTGAGCCGACTGATGACGGGCGATACCTACACAGCGCACGCCGGGGCCAAG
1201 TTCCCCATCAAGTGGACCGCCCCAGAAAGCCTCGCTTACAACAAGTTCTCCATTAAGTCG
1261 GATGTCTGGGCCTTCGGCGTCCTGCTTTGGGAAATCGCGACCTACGGCATGTCCCCTTAC
1321 CCTGGGATCGACCTCTCGCAGGTCTATGAGCTCCTGGAGAAAGACTACCGCATGGAACGG
1381 CCCGAGGGCTGTCCGGAGAAGGTCTACGAACTGATGAGAGCATGCTGGCAGTGGAGCCCC
1441 TCTGACAGGCCTTCGTTTGCCGAAATCCACCAAGCTTTTGAAACCATGTTCCAAGAATCC
1501 AGCATCTCCGAAGAGGTGGAGAAAGAGCTGGGCAAGAAAGGCATGAGGAGCGTGGTGAAC
1561 ACGTTCCTGCAGGCTCCGGAGCTGCCGACCAAGACACGGACGTCCAGGAGAGCGACTGAG
1621 TCCAAAGAGGCCAACGAGGGCTTGGAGGCAGCGGCCACGAAAACTCTGGGCGAGTGCGAG
1681 CCTGTGGAGCACGATCCGGCCGTTTCGCCCTTGCTGCCCCGGAAGGAGCGCGTCGCTGCG
1741 GACGCCGGTTTGAACGAAGACGACCGCTTGCTCCCCAAAGACAAGAAGACCAACCTTTTC
1801 AGTGCCCTGATCAAGAAGAAGAAGAAGATGGCCCCCACGCCGCCCAAGCGCAGCAGCTCC
1861 TTCCGGGAAGCGGACAGCCACCTGGACCGGAAGGACGACGGCAAGGAGGCTTTGCTGGCG
1921 CCCCCCGCGGAGGCCGAGGACCGGTCCCGCTTCCAGGGCAACGAGACCGGCATGGCCAAC
1981 GGAACGGTGGGACTGCTCTCGCCTCACCTCTGGAAGAAGTCCGTCCCCGCGTCCGGTAGT
2041 CGACTGGCGGCTGGGGAAGACGAGAACAGCGTGAACTCTTCTGCCTCGTCCTCCAGCAAG
2101 CGCTTCCTCCGGTCGTGTTCGGCCTCCTGCGTCCCCCACGGAGCCAAGGACACCGAGTGG
2161 AAGTCGGTCACGCTGCCCCGGAACATGCAGTCCGTGGGCCGGCAGTTCGATTCCTCCACC
2221 TTTGGTGGCCACAAAAGCGAGAAGCCTGCCCTGCCTCGGAAGCGGGCCAACGAAGCAAAG
2281 CCGGATCCGGTCGCAGCCAGGGGGACGGTGACCCCGCCGCCCCGGGTGCTCAAGAAGAGC
2341 GATGAGCTTCCGCCCGAGGATGCGTCCAAGGATGCCGAGTCCAGCCCCGGCTCCAGCCCC
2401 CCAACCTTGACCCCCAAACTCAGCCGGAGGCAGCCCTTGGCCCCTCCATCCCAGAAGGAG
2461 GAGTCGGTGAAGTCCGGGGCGGCCTCGGAGCAGGCGGCCACCAAGGCGGGGCTGTTCCTG
2521 GGCATCGGCAAGGCCGAGGAGCCGCGGTTGAGGAAGATGAAGCAGCTGTCGGAGAAGGGG
2581 AAACTGTCCAAATTGAAGCCGGCGCCTCCCCCTCCGCTCTCCTCGGCTGCTTCTTCCATT
2641 GCAAAAACTAGCAAAGCGGGGCTCGGCTCTGACGTGACCGAGGGGTCCGTGGCCAAGGCT
2701 AAGCCGTCCCTCCCATCGGCAGACTCGGCCAACGTGGTGGAAGGGACGAAAAAGCCCGCC
2761 CCCAAGCTCTCGCCTTCCGCCAAGTCCCTCCTGATGACCACTGCCCCTTTATCGTCCTCT
2821 CCCTTTTCCGCCCCGTCTCTCTCCACCACGGTTGTGCCGAGCGTGGACTCCGCAGCCTCC
2881 ACGGCCTTCATCCCCCTCATTTCCACCCGGGTTTCCCTGCGGAAGACCCGCCAGCCGCCG
2941 GAGAAGATCGCCAGCGGGGCCGTCACCAAGGACACCATCCTGGAGAGCGCGGAGACCCTG
3001 CGGACGGCCATCAGCCGGAACTCTGAGCAGATGGCCAGCCACAGCGCCGTGCTGGAGGCC
3061 GGCAAGAACCTCTACACCTTCTGCGCCGGTTTCGTGGACTGCATCCAGCAGATGCGCAAC
3121 AAGTTTGCCTTCCGCGAGGCCATCAACAAACTGGAGAACAACCTCCGGGAGCTGCAGATC
3181 TGCCCCGCCACGGCCGGAGGCGGCGGCCCCGCGGCCACGCCGGACTTCAGCAAGCTGCTC
3241 GGTTCTGTGAAGGAAATCAGTGACCTCGTCCAGAGGTAG
| Predicted Protein Product |
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASEFEPQGLSEAARWNSKENLLSGPSE
NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWETERT
DITMKHKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVNAVVLLYMATQISSAMEYLEKKNFI
HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWSP
SDRPSFAEIHQAFETMFQESSISEEVEKELGKKGMRSVVNTFLQAPELPTKTRTSRRATE
SKEANEGLEAAATKTLGECEPVEHDPAVSPLLPRKERVAADAGLNEDDRLLPKDKKTNLF
SALIKKKKKMAPTPPKRSSSFREADSHLDRKDDGKEALLAPPAEAEDRSRFQGNETGMAN
GTVGLLSPHLWKKSVPASGSRLAAGEDENSVNSSASSSSKRFLRSCSASCVPHGAKDTEW
KSVTLPRNMQSVGRQFDSSTFGGHKSEKPALPRKRANEAKPDPVAARGTVTPPPRVLKKS
DELPPEDASKDAESSPGSSPPTLTPKLSRRQPLAPPSQKEESVKSGAASEQAATKAGLFL
GIGKAEEPRLRKMKQLSEKGKLSKLKPAPPPPLSSAASSIAKTSKAGLGSDVTEGSVAKA
KPSLPSADSANVVEGTKKPAPKLSPSAKSLLMTTAPLSSSPFSAPSLSTTVVPSVDSAAS
TAFIPLISTRVSLRKTRQPPEKIASGAVTKDTILESAETLRTAISRNSEQMASHSAVLEA
GKNLYTFCAGFVDCIQQMRNKFAFREAINKLENNLRELQICPATAGGGGPAATPDFSKLL
GSVKEISDLVQR
| Protein Alignment to Mouse |
sp|P00520|ABL1_MOUSE Tyrosine-protein kinase ABL1 OS=Mus musculus GN=Abl1 PE=1
SV=3
MGI:87859 Abl1 c-abl oncogene 1, non-receptor tyrosine kinase (Chr 2)
Length = 1123
Score = 3211 (1135.4 bits), Expect = 0., Sum P(2) = 0.
Identities = 637/848 (75%), Positives = 681/848 (80%)
Query: 1 MLEIXXXXXXXXXXXXXXXXXXXYLEEALQRPVASEFEPQGLSEAARWNSKENLLSGPSE 60
MLEI YLEEALQRPVAS+FEPQGLSEAARWNSKENLL+GPSE
Sbjct: 1 MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE 60
Query: 61 NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 120
NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
Sbjct: 61 NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 120
Query: 121 SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
Sbjct: 121 SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
Query: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWETERT 240
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWE ERT
Sbjct: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERT 240
Query: 241 DITMKHKLXXXXXXXXXXXXWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 300
DITMKHKL WKKY+LTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ 300
Query: 301 LLGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVNAVVLLYMATQISSAMEYLEKKNFI 360
LLGVCTREPPFYIITEFMTYGNLLDYLR+CNRQEV+AVVLLYMATQISSAMEYLEKKNFI
Sbjct: 301 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFI 360
Query: 361 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS 420
HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
Sbjct: 361 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS 420
Query: 421 DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWSP 480
DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQW+P
Sbjct: 421 DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP 480
Query: 481 SDRPSFAEIHQAFETMFQESSISEEVEKELGKKGMRSVVNTFLQAPELPTKTRTSRRATE 540
SDRPSFAEIHQAFETMFQESSIS+EVEKELGK+G R + LQAPELPTKTRT RRA E
Sbjct: 481 SDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRTCRRAAE 540
Query: 541 SKEANEGLEAAATKTLGECEPVEHDPAVSPLLPRKERVAADAGLNEDDRLLPKDKKTNLF 600
K+A + E TK LGE + ++ +PAVSPLLPRKER D LNED+RLLP+D+KTNLF
Sbjct: 541 QKDAPDTPELLHTKGLGESDALDSEPAVSPLLPRKERGPPDGSLNEDERLLPRDRKTNLF 600
Query: 601 SALIXXXXXMAPTPPKRSSSFREADSHLDRK----DDGKXXXXXXXXXXXD-----RSRF 651
SALI MAPTPPKRSSSFRE D DR+ DD + D +S
Sbjct: 601 SALIKKKKKMAPTPPKRSSSFREMDGQPDRRGASEDDSRELCNGPPALTSDAAEPTKSPK 660
Query: 652 QGNETGMANGTV------GLLSPHLWKKSVPASGSRLAAGEDENXXXXXXXXXXXXXXXX 705
N G+ NG G SPH+WKKS +GSRLAA E+E+
Sbjct: 661 ASNGAGVPNGAFREPGNSGFRSPHMWKKSSTLTGSRLAAAEEESGMSSSKRFLRSCSAS- 719
Query: 706 XXXXCVPHGAKDTEWKSVTLPRNMQSVGRQFDSSTFGGHKSEKPALPRKRANEAKPDPVA 765
C+PHGA+DTEW+SVTLPR++ S G+QFDSSTFGGHKSEKPALPRKR +E++ + VA
Sbjct: 720 ----CMPHGARDTEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRSEQVA 775
Query: 766 ARGTVTPPPRVLKKSDELPPEDASKDAEXXXXXXXXXXXXXXXRRQPLAPPSQ----KEE 821
+ T PPPR++KK++E E+ KD E RRQ A PS KEE
Sbjct: 776 -KSTAMPPPRLVKKNEEAA-EEGFKDTESSPGSSPPSLTPKLLRRQVTASPSSGLSHKEE 833
Query: 822 SVKSGAAS 829
+ K G+AS
Sbjct: 834 ATK-GSAS 840
Score = 487 (176.5 bits), Expect = 0., Sum P(2) = 0.
Identities = 100/134 (74%), Positives = 109/134 (81%)
Query: 959 ASTAFIPLISTRVSLRKTRQPPEKIASGAVTKDTILESAETLRTAISRNSEQMASHSAVL 1018
+S AFIPLISTRVSLRKTRQPPE+IASG +TK +L+S E L AISRNSEQMASHSAVL
Sbjct: 991 SSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVL 1050
Query: 1019 EAGKNLYTFCAGFVDCIQQMRNKFAFREAINKLENNLRELQICXXXXXXXXXXXXXDFSK 1078
EAGKNLYTFC +VD IQQMRNKFAFREAINKLE+NLRELQIC DFSK
Sbjct: 1051 EAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQ-DFSK 1109
Query: 1079 LLGSVKEISDLVQR 1092
LL SVKEISD+V+R
Sbjct: 1110 LLSSVKEISDIVRR 1123
Score = 397 (144.8 bits), Expect = 4.5e-80, Sum P(2) = 4.5e-80
Identities = 94/209 (44%), Positives = 120/209 (57%)
Query: 661 GTVGLLSPHLWKKSVPASGSRLAAGEDENXXXXXXXXXXXXXXXXXXXXCVPHGAKDTEW 720
G G SPH+WKKS +GSRLAA E+E+ C+PHGA+DTEW
Sbjct: 676 GNSGFRSPHMWKKSSTLTGSRLAAAEEESGMSSSKRFLRSCSAS-----CMPHGARDTEW 730
Query: 721 KSVTLPRNMQSVGRQFDSSTFGGHKSEKPALPRKRANEAKPDPVAARGTVTPPPRVLKKS 780
+SVTLPR++ S G+QFDSSTFGGHKSEKPALPRKR +E++ + VA + T PPPR++KK+
Sbjct: 731 RSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRSEQVA-KSTAMPPPRLVKKN 789
Query: 781 DELPPEDASKDAEXXXXXXXXXXXXXXXRRQPLAPPSQ----KEESVK---SGAASEQAA 833
+E E+ KD E RRQ A PS KEE+ K SG + A
Sbjct: 790 EEAA-EEGFKDTESSPGSSPPSLTPKLLRRQVTASPSSGLSHKEEATKGSASGMGTPATA 848
Query: 834 TKA--GLFLGIGKA--EEPRLRKMKQLSE 858
A +G+ KA EE R+R+ K SE
Sbjct: 849 EPAPPSNKVGLSKASSEEMRVRRHKHSSE 877
Score = 49 (22.3 bits), Expect = 2.0e-43, Sum P(2) = 2.0e-43
Identities = 15/49 (30%), Positives = 22/49 (44%)
Query: 744 HKSEKPALPRKRANEAKPDPVAARGTVTPPPRVLKKSDELPPEDASKDA 792
H SE P + R + KP P PPP K+ + P + S++A
Sbjct: 874 HSSESPGRDKGRLAKLKPAP-------PPPPACTGKAGK-PAQSPSQEA 914
Score = 39 (18.8 bits), Expect = 2.2e-42, Sum P(2) = 2.2e-42
Identities = 18/65 (27%), Positives = 20/65 (30%)
Query: 778 KKSDELPPEDASKDAEXXXXXXXXXXXXXXXRRQPLAPP---SQKEESVKSGAASEQAAT 834
KK PP+ +S E R PP S E KS AS A
Sbjct: 608 KKMAPTPPKRSSSFREMDGQPDRRGASEDDSRELCNGPPALTSDAAEPTKSPKASNGAGV 667
Query: 835 KAGLF 839
G F
Sbjct: 668 PNGAF 672
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