| Nomenclature | Genomic Location |
| Symbol | Fancd2 | Chromosome | 2 |
| Name | Fanconi anemia group
D2 protein homolog | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr2: 16 Mbp |
| Molecular Function |
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Required for maintenance of chromosomal stability.
Promotes accurate and efficient pairing of homologs during meiosis.
Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing.
May participate in S phase and G2 phase checkpoint activation upon DNA damage.
Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Molecular Function Terms:
(none)
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| Human Disease Association |
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Defects in FANCD2 are a cause of Fanconi anemia complementation group D type 2 (FANCD2) [MIM:227646].
It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.
It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a
predisposition to the development of malignancies. At the cellular level it is associated with
hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage)
and defective DNA repair.
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1 ATGTATTCAAAACGAAAATTGTCAAAAACCGGAGCCCGTGGTGAAAATCTGATAGAAGAA
61 TTACCAAAAGCAAAGAAGTCTCGGGCCTCTGGCAAGAAAATATCTGTTCCCCAAGATGGA
121 GTTATAGAGTTATCCAGTGTCTTTGGGCAGCTCCTTAAGTCTGCAGGGATAATCCTGAAA
181 GCTGGAGAAAGACAGAATGAAATAGCTGTGGATGGAGCCATTTTCCAGAAGAAGTTGCAT
241 CAAGCTTTGAGAAAGCACCCTTCTTATCCACAGGTTGTTGAAGAATTCATCACAGGATTG
301 GAATCTCACATTGAAAATAGAGATCAGTTCAGGAACTGCCTGCTACCATGTGTACCTGTA
361 CAAAATCAGGAAGCAAGTAATGCAGTCCATTCATATTGTGAAAGTCTCATAAAACTGCTC
421 CTTGGAATAGAGATACTACAGTCTACTGTCATAAAATTGCTGTTTGAAAAAGTCCCTGAA
481 TTTTTTGATGAAAGCGTGGGCAGCGATGGGCTCAATTTGCCCCGACTGATTGTCAATCAG
541 TTAAAATGGCTCGACAGGATAGTAAACAGCAAGGAACTTTTGTCAACGATTATGCAGATG
601 ATTTGCGTTTCTCCTCTTTCAATTCAACATGACATTATTACAAGCTTGCCAGAAATCCTG
661 GAAGATGCCCAACATAGTGAAGTTGCCAGAGAACTTAGTTCTTTGCTAAAGGAGAAGACT
721 GAGCTAACAGTTCCAATCCTGGATGCTCTTTCCAGTTTAAATCTTGATCTAGGCCTTCTG
781 TCTGAGGTGCGCCAGTCTATTATGGTCACAGTGGCTGCTGTACAAGTGGAAGATTTGCCT
841 GTAGTAGTAAAGTTTATTCTCCGCTCTATCAAGGAAACTAATGCAGTGGAGGTAATTTCT
901 GACCTTCGTAAGAAGCTGGATCTGGACTCGTTTGTTTCACTGCCACAAATTCAGGCTTCC
961 CAGAGCAAGCTCAGAAACCAGCCTCAGGCAAGTCTCCCTGCAAGCCAAGTGAATGTTAAC
1021 CAGGACTGTATCAAACTTCTTTTTGAAGTCATTAAGTCAGCTATTAAATTCCAGAAGACC
1081 ATTTTAGAAGGCTGGATTAAGGCTATTGAGAATGTTTATTCTGCTTCTGACCATAAGGTT
1141 CTTGATCTGATAGTGCTATTCCTAATTTATGCTACAAATTCAAAGATTAAAAAGCAAATT
1201 GAAAGAATGCTGAGGAACAAGATTCGGTCAGGTTGCCTGCGAGAGCAGCTGCTGCGGAGT
1261 GCCTTCCGATACCATCCACTTGTTATGAGAGATCTCTTTCCAGCCATCCTGTCGCTGGCT
1321 GAGGTTTTTGTACATTCAGCAGACTCCTGTATTGTCTCCTTTGGTAGCTATATGTACAAG
1381 CAAGCATTTACGGCCTTTGATGTTTATTGCCAGCAGGAGATTGTGGGTGCCTTAGTTACT
1441 CATGCATGTGGTGGTAATAGTGAGGAAGTAGATGTCGCTTTGGATATGCTCACTGACCTG
1501 GTGTCTCTTCATACCTCATCAGTGGTTCCTTATGGAGTCTTTCTGAAGAGCATTTTAGAC
1561 TATATGGATAATCTAAGTCCACAGCAGATCCGCAAACTATTCCACATACTTAGTGTGCTG
1621 GCATTTAGCCAAGGGCACAGAAGCAGCCACATTCAGGATGATATACATATGGTGATTAGA
1681 AAGCAACTCTCCAGCACTATTCCCAAATATAGGCGCATTGGAATTATTGGTGCGCTTACC
1741 ATGGTGGGCAGCATGGCAGCAAAGAGAAGTAAAGAAAATGGGCAGATACTGGAACAGGCA
1801 CAGCTGAGCAAGGAGCAATGTAGACAGATCACATCTCTACTGGAGCTAGTGTACTCCTCC
1861 TGTGGGCAGATTCCCCAGGCATTGGCTCTTTACTATGATGAGCTTGCTAACCTGATCCAG
1921 AAAGGGAATATGGACTTGCAAATACTGGACTGGATTGGAAGCAGTGTGGTGAAGGACTTT
1981 GAGGAAGATTTTGTGACAGATCTTGTCCCTATAGAGGACAGTGCTTTCCTGTTCCCAGTG
2041 AAGGCCCTGTATTGCTTAGAAGATGAAGAAAGTGAGGCAACAATTGCTATTAACTTATTG
2101 CCTCTTGTGTCCCAGAGCTATCTGAACAAGCATGAAAATGAAGTCACAGCTAAAAGTAAG
2161 GAAAAAAGGATAGTGTCTCCAGTGTGCTTGTCACCATTCTTTCGGCTGCTGAGGCTCTGC
2221 ATATCAGAACTGAACAGTGGGAACTTGGAGGATATTGATGCTTTATTAGTGTGCCCTTTA
2281 TACCTGACCAACCTGGAAGTAGGAGGAAAGTTAGATTCGTTGTCTAAGGAAGAGCGAGAA
2341 TTCCTCTGTACTCTCTTATTTCATGCACTAAACTGGTTCCATGAGGTTGTGAATGCCTTC
2401 TGTCGACAAAATGATGCTGAGATCAAAGGAAGGGTTTTGGCTCGGTTACAGAACATTACA
2461 GAACTACAGAGTCTGCTGGAGAAAGTCCTGGCAGCAAGCCCTGGATATACTCCTCCTCTT
2521 GCTAATTTTGATTCTGAAACCGTAGAAGGAATGCCTATTAATAATACGGTTGGTACCACC
2581 AAAAAGAAAAATAAAGGAAAAAAAGCCCTCAAATCTGACAGCAAAACCAGTTCTACAGAC
2641 AATTCACAAATGGAGGAGGACACAGAATCAAATCTACCTGAATCTGAGGCCAGCCAGCTA
2701 GAAAAGGACTCCCCAGGAAAGGAATCACGGACATCACTGATACCGCTGCAGAGTTATAGT
2761 GCATATTTTCGCGAATTAGACTTGGAAGTTTTTAATATACTTCACTGCGGGCTGCTGACC
2821 AAATCTATTCTGGATACTGAAATGCACACAAAGACCCGTGAAATAGTGCAGATAGGGCCA
2881 GCTGAGCTCCTGTTCCTTTTGGAAGATCTGTGCCGTAAGCTGGAACATGTGTTAATACCA
2941 GCCCCTGCAAAGAGAGCCCCTTTCTTAAAGGGCAAAGGAAAAAGAAATGCTGGATTCTCA
3001 CATCTTTGTCAAAGAACATCTCAAGAAGTGATTGAGCGTGTTGTTGAATTTTTAAAGCCA
3061 CTGTGCAACCACATGGAAAATATGCACAACTTCTTCCAGGCACTGATGGCAGAGAACCAT
3121 GGTGTAGTTGATGGGCCAGGAGTCAATATTCAGGAACACCAGTTCATGTCATCCTGTTAT
3181 CAGCATTTATTGCAGATCTTCCGCCTTCTATTTGCTTGGAGTGGATTTTCTCAGCATGAA
3241 AACCACAGCTTGCTGAAATCAGGCCTCCATGTCCTTACTGACAGGCTCAAACCAGGAGAG
3301 AAAGAATTCTCTCTTGAAGACTTGCTCAGCCACAGTTTCCAGTATTTACTGAACTTCCAG
3361 CATAGCGTTCCCAATATTTATTGTGCATTGAGTCTTACTCAGCTTCTGCTTGTGATTGCT
3421 GAAAAATCGGTGATCAATCTGAAACACAAAGAAATAGGTTCCATTACTAAATATTTCCTC
3481 TGCCAGTCTTGGATGCAGCCCAATGGAACTCGTCAGAAGGGTACCCAGTTTAATGATGCG
3541 CTCCATACTTTGTTCTGTATATATATGGAGCACACAGATAATGTATTAAAAGCAATAGAA
3601 GACATTTCCAGCATTGGAATTCCTGAGTTGATCAATTCTTCAAAAGATGGATATTCTTCC
3661 ACTTACCCTACCTTGACTAGGCAAACTTTTCCCATTTTCTTTCGAGTGATGATGACTCAG
3721 CTAGAGAGTTCCATAAAAAGCATTTCCCCTGGAACAGCATCATCAGATACCAGAGAGGTC
3781 CAGCTGGAGAAGTTGCTGCAATGGAACATGGCTGTGCGAGATTTTCACATCCTTGTTAAT
3841 TTAGTTAAGGTATTCGACAGTCGGCCAGTGCTTAGTGTTTGCTTGAAGTATGGCCGCCTC
3901 TTTGTGGAAACATTCTTGAAGCATGGCATGCCCCTATTGGACTACAGCTTTAAAAAGCAC
3961 AGGGAAGATGTGCAGAGTTTGTTGAAAACCTTTCAGTTGAGCACTAGACAACTTCATCAC
4021 ATGTGTGGACATTCCAAGATTCATCAAGATACAGGGCTCACCAGCCATGTGCCCTTTCTA
4081 AAGAAGTCCCTTGAGCTGTTTGTATACCGGGTGAAAGCAATGCTGGCTCTCAACCACTGT
4141 CAGGAGGCCTTCTGGGTGGGTGTCCTCAAAAACAGGGACCTCCAGGGAGATGAGATCCTT
4201 TCGCAGGCGTCTGAGGCAAGCCTGACAGAAGATGAGGAGGTTTCTATGATCACAGGAGAA
4261 GACCCTACAGAGGAACAGGACGAGGAAGAAGAGTCAGAAAATAATGGTAGGACAGAT
| Predicted Protein Product |
MYSKRKLSKTGARGENLIEELPKAKKSRASGKKISVPQDGVIELSSVFGQLLKSAGIILK
AGERQNEIAVDGAIFQKKLHQALRKHPSYPQVVEEFITGLESHIENRDQFRNCLLPCVPV
QNQEASNAVHSYCESLIKLLLGIEILQSTVIKLLFEKVPEFFDESVGSDGLNLPRLIVNQ
LKWLDRIVNSKELLSTIMQMICVSPLSIQHDIITSLPEILEDAQHSEVARELSSLLKEKT
ELTVPILDALSSLNLDLGLLSEVRQSIMVTVAAVQVEDLPVVVKFILRSIKETNAVEVIS
DLRKKLDLDSFVSLPQIQASQSKLRNQPQASLPASQVNVNQDCIKLLFEVIKSAIKFQKT
ILEGWIKAIENVYSASDHKVLDLIVLFLIYATNSKIKKQIERMLRNKIRSGCLREQLLRS
AFRYHPLVMRDLFPAILSLAEVFVHSADSCIVSFGSYMYKQAFTAFDVYCQQEIVGALVT
HACGGNSEEVDVALDMLTDLVSLHTSSVVPYGVFLKSILDYMDNLSPQQIRKLFHILSVL
AFSQGHRSSHIQDDIHMVIRKQLSSTIPKYRRIGIIGALTMVGSMAAKRSKENGQILEQA
QLSKEQCRQITSLLELVYSSCGQIPQALALYYDELANLIQKGNMDLQILDWIGSSVVKDF
EEDFVTDLVPIEDSAFLFPVKALYCLEDEESEATIAINLLPLVSQSYLNKHENEVTAKSK
EKRIVSPVCLSPFFRLLRLCISELNSGNLEDIDALLVCPLYLTNLEVGGKLDSLSKEERE
FLCTLLFHALNWFHEVVNAFCRQNDAEIKGRVLARLQNITELQSLLEKVLAASPGYTPPL
ANFDSETVEGMPINNTVGTTKKKNKGKKALKSDSKTSSTDNSQMEEDTESNLPESEASQL
EKDSPGKESRTSLIPLQSYSAYFRELDLEVFNILHCGLLTKSILDTEMHTKTREIVQIGP
AELLFLLEDLCRKLEHVLIPAPAKRAPFLKGKGKRNAGFSHLCQRTSQEVIERVVEFLKP
LCNHMENMHNFFQALMAENHGVVDGPGVNIQEHQFMSSCYQHLLQIFRLLFAWSGFSQHE
NHSLLKSGLHVLTDRLKPGEKEFSLEDLLSHSFQYLLNFQHSVPNIYCALSLTQLLLVIA
EKSVINLKHKEIGSITKYFLCQSWMQPNGTRQKGTQFNDALHTLFCIYMEHTDNVLKAIE
DISSIGIPELINSSKDGYSSTYPTLTRQTFPIFFRVMMTQLESSIKSISPGTASSDTREV
QLEKLLQWNMAVRDFHILVNLVKVFDSRPVLSVCLKYGRLFVETFLKHGMPLLDYSFKKH
REDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTSHVPFLKKSLELFVYRVKAMLALNHC
QEAFWVGVLKNRDLQGDEILSQASEASLTEDEEVSMITGEDPTEEQDEEEESENNGRTD
| Protein Alignment to Mouse |
sp|Q80V62|FACD2_MOUSE Fanconi anemia group D2 protein homolog OS=Mus musculus
GN=Fancd2 PE=2 SV=2
MGI:2448480 Fancd2 Fanconi anemia, complementation group D2 (Chr 6)
Length = 1450
Score = 3701 (1307.9 bits), Expect = 0., P = 0.
Identities = 740/1421 (52%), Positives = 992/1421 (69%)
Query: 1 MYSKRKLSKTGARGENLIEELPKAKKSRASGKKISVPQDGVIELSSVFGQLLKSAGIILK 60
M SKR+ + + ENL E+ K KK S V E SVF +LLK++G+ LK
Sbjct: 1 MISKRRRLDSEDK-ENLTEDASKTMPLSKLAKK-SHNSHEVEENGSVFVKLLKASGLTLK 58
Query: 61 AGERQNEIAVDGAIFQKKLHQALRKHPSYPQVVEEFITGLESHIENRDQFRNCLLPCVPV 120
GE QN++ VD IFQ+KL QALRKHP+YP+V+EEF+ GLES+ E+ + RNCLL C +
Sbjct: 59 TGENQNQLGVDQVIFQRKLFQALRKHPAYPKVIEEFVNGLESYTEDSESLRNCLLSCERL 118
Query: 121 QNQEASNAVHSYCESLIKLLLGIEILQSTVIKLLFEKVPEFFDESVGSDGLNLPRLIVNQ 180
Q++EAS Y +SLIKLLLGI+ILQ +IK+LFEKVP+F ES DG+N+ RLI+NQ
Sbjct: 119 QDEEASMGTF-YSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESENRDGINMARLIINQ 177
Query: 181 LKWLDRIVNSKELLSTIMQMICVSPLSIQHDIITSLPEILEDAQHSEVARXXXXXXXXXX 240
LKWLDRIV+ K+L + +MQ+I V+P+++QHD ITSLPEIL D+QH+ V +
Sbjct: 178 LKWLDRIVDGKDLTAQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELGELLVQNT 237
Query: 241 XXXVPIXXXXXXXXXXXXXXXEVRQSIMVTVAAVQVEDLPVVVKFILRSIKETNAVEVIS 300
VPI ++RQ +M +++V++ED PV+VKF+L S+ +T ++EVI+
Sbjct: 238 SLTVPILDVFSSLRLDPNFLSKIRQLVMGKLSSVRLEDFPVIVKFLLHSVTDTTSLEVIA 297
Query: 301 DLRKKLDLDSFVSLPQIQASQSKLRNQPQASLPASQVNVNQDCIKLLFEVIKSAIKFQKT 360
+LR+ L++ F+ +IQASQSKL+++ AS +Q N ++DCI L+F+VIKSAI+++KT
Sbjct: 298 ELRENLNVQQFILPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLVFDVIKSAIRYEKT 357
Query: 361 ILEGWIKAIENVYSASDHKVLDLIVLFLIYATNSKIKKQIERMLRNKIRSGCLREQLLRS 420
I E W KAIE + SA++HK LD+++L +IY+T+++ KK +E++LRNKI+S C++EQLL S
Sbjct: 358 ISEAWFKAIERIESAAEHKALDVVMLLIIYSTSTQTKKGVEKLLRNKIQSDCIQEQLLDS 417
Query: 421 AFRYHPLVMRDLFPAILSLAEVFVHSADSCIVSFGSYMYKQAFTAFDVYCQQEIVGALVT 480
AF H LV++D+ P+IL LA+ HS D I+ FGS +YK AF FD YCQQE+VGALVT
Sbjct: 418 AFSTHYLVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGALVT 477
Query: 481 HACGGNSEEVDVALDMLTDLVSLHTSSVVPYGVFLKSILDYMDNLSPQQIRKLFHILSVL 540
H C G EVD ALD+L +L+ L+ S++ F+K ILDY++N+SPQQIRK+F ILS L
Sbjct: 478 HVCSGTEAEVDTALDVLLELIVLNASAMRLNAAFVKGILDYLENMSPQQIRKIFCILSTL 537
Query: 541 AFSQGH-RSSHIQDDIHMVIRKQLSSTIPKYRRIGIIGALTMVGSMAAKRSKENGQILEQ 599
AFSQ S+HIQDD+H+VIRKQLSST+ KY+ IGIIGA+TM G MA RS +
Sbjct: 538 AFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRSVPSNSSQRS 597
Query: 600 AQLSKEQCRQITSLLELVYSSCGQIPQALALYYDELANLIQKGNMDLQILDWIGSSVVKD 659
A +S EQ Q+TSLL+LV+S P A +LYYDE ANLIQ+ + + L+W+G ++ D
Sbjct: 598 ANVSSEQRTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIFND 657
Query: 660 FEEDFVTDLVPIEDSAFLFPVKALYCLEDEESEATIAINLLPLVSQSYLNKHENEVTAKS 719
F++ FV D + F FPVKALY LE+ ++ I INLLPL Q K + T++
Sbjct: 658 FQDAFVVDFCAAPEGDFPFPVKALYGLEEYSTQDGIVINLLPLFYQECA-KDASRATSQE 716
Query: 720 KEKRIVSPVCLSPFFRLLRLCISELNSGNLEDIDALLVCPLYLTNLEVGGKLDSLSKEER 779
+R +S +CL+ FRLLRLC++ + GNL++ID LL CPL+L +LE G KL+S+S ++R
Sbjct: 717 SSQRSMSSLCLASHFRLLRLCVARQHDGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKDR 776
Query: 780 EFLCTLLFHALNWFHEVVNAFCRQNDAEIKGRVLARLQNITELQSLLEKVLAASPGYTPP 839
+C+L F NWF EVVNAFC+Q E+KG+VL+RL+++ ELQ +LEK LA P Y PP
Sbjct: 777 SLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQGILEKYLAVIPDYVPP 836
Query: 840 LANFDSETVEGMPIXXXXXXXXXXXXXXXA---LXXXXXXXXXXNSQMEEDT-ESNLPES 895
A+ D +T++ MP ++ + EDT E ++ S
Sbjct: 837 FASVDLDTLDMMPRSSSAVAAKNRNKGKTGGKKQKADSNKASCSDTLLTEDTSECDMAPS 896
Query: 896 EASQLEKDSPGKESRTSLIPLQSYSAYFRELDLEVFNILHCGLLTKSILDTEMHTKTREI 955
S ++K+S GKE +T + LQ+Y A+FRELD+EVF+ILH GL+TK ILDTEMHT+ E+
Sbjct: 897 GRSHVDKESTGKEGKT-FVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEV 955
Query: 956 VQIGPAELLFLLEDLCRKLEHVLIPAPAKRAPFLKGKGKRNAGFSHLCQRTSQEVIERVV 1015
VQ+GPAELLFLLEDL +KLE++L AKR K KG++N GFSHL QR+ Q+++ VV
Sbjct: 956 VQLGPAELLFLLEDLSQKLENMLTAPFAKRICCFKNKGRQNIGFSHLHQRSVQDIVHCVV 1015
Query: 1016 EFLKPLCNHMENMHNFFQALMAENHGVVDGPGVNIQEHQFMSSCYQHLLQIFRLLFAWSG 1075
+ L P+CNH+EN+HNFFQ L AE+ D QE M+ CYQ LLQ+ LFAW G
Sbjct: 1016 QLLTPMCNHLENIHNFFQCLGAEHLSADDKARATAQEQHTMACCYQKLLQVLHALFAWKG 1075
Query: 1076 FSQHENHSLLKSGLHVLTDRLKPGEKEFSLEDLLSHSFQYLLNFQHSVPNIYCALSLTQL 1135
F+ H LL S L VL++RLK E++ LE+L+S SF YL NF HSVP+ C L L +L
Sbjct: 1076 FTHQSKHRLLHSALEVLSNRLKQMEQDQPLEELVSQSFSYLQNFHHSVPSFQCGLYLLRL 1135
Query: 1136 LLVIAEKSVI-NLKHKEIGSITKYFLCQSWMQPNGTRQKGTQFNDALHTLFCIYMEHTDN 1194
L+ + EKS + N K +++ S+ K LC++W P+G ++K FND LH + IY+EHTDN
Sbjct: 1136 LMALLEKSAVPNQKKEKLASLAKQLLCRAW--PHGEKEKNPTFNDHLHDVLYIYLEHTDN 1193
Query: 1195 VLKAIEDISSIGIPELINSSKDGYSSTYPTLTRQTFPIFFRVMMTQLESSIKSISPGTAS 1254
VLKAIE+I+ +G+PEL+++ KD SST+PTLTR TF IFFRVMM +LE ++K + GTA+
Sbjct: 1194 VLKAIEEITGVGVPELVSAPKDAASSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTAA 1253
Query: 1255 SDTREVQLEKLLQWNMAVRDFHILVNLVKVFDSRPVLSVCLKYGRLFVETFLKHGMPLLD 1314
D+++V EKLL WNMAVRDF IL+NL+KVFDS PVL VCLKYGR FVE FLK MPLLD
Sbjct: 1254 -DSQQVHEEKLLYWNMAVRDFSILLNLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLD 1312
Query: 1315 YSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTSHVPFLKKSLELFVYRVKAM 1374
+SF+KHREDV SLL+T QL+TR LHH+CGHSKI QDT LT HVP LKKSLEL V RVKAM
Sbjct: 1313 FSFRKHREDVLSLLQTLQLNTRLLHHLCGHSKIRQDTRLTKHVPLLKKSLELLVCRVKAM 1372
Query: 1375 LALNHCQEAFWVGVLKNRDLQGDEILSQ--ASEASLTEDEE 1413
L LN+C+EAFW+G LKNRDLQG+EI+SQ +S S ED E
Sbjct: 1373 LVLNNCREAFWLGTLKNRDLQGEEIISQDPSSSESNAEDSE 1413
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