| Nomenclature | Genomic Location |
| Symbol | Rad9 | Chromosome | X |
| Name | Cell cycle checkpoint
control protein RAD9A | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | ChrX: 24 Mbp |
| Molecular Function |
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Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.
The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.
Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER).
The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the
primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double,
nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.
RAD9A possesses 3'->5' double stranded DNA exonuclease activity
Molecular Function Terms:
binding
protein binding
enzyme binding
histone deacetylase binding
kinase binding
protein kinase binding
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
nuclease activity
exonuclease activity
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| Human Disease Association |
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No disease association.
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1 ATGAAGTGCATAGTCACCGGGGGCAATGTGAAAGCCCTAGGGAAAGCAATACATTCCCTC
61 GCCCGTGTTGGAGATGAAATCTATGTCGAGCCACTACAAGAAGGGCTGTCCATGCGGACA
121 GTCAGTGCATCTCGCTCAGCTTATGCAAGCTTCCTGTTTGCCCCACTCTTCTTCCAAAAC
181 TACCAGCCAACAGAATCAGGATATGACCCAGATTCAGAGGCTTTCCGGTGCAAAGTTCAC
241 ATGAAGTCTTTCTTGGCTGTTTTCCGTTCACTGCCCTCCCTGGAGAAGACTGTGGAGAAG
301 TGCCTTCTCTCACTAAACCCCCATGCCAGCCGATTCCGGGTGCAGCTCCACTGCAAATAT
361 GGTGTTGTCAAGACCCATGACTTGCCATTCCAGGAATGTGAATCCCTGCAAGCTGACTTT
421 GACACAAGCCAGTGTGCCCATGCTCTGCGTGCCCCTCCCAGGCTGTTGGCGGATGCTGTG
481 GTGCATTTCCCACTGGCTTTGGCTGAGGTGACTCTCGTTGCCAGCCCAGCTGGGAAGGTG
541 AGCTTGCGCAGTTACTTGGAAGGAGACACGGAGGTGACCCGGACAATGGTGACAGAGCTA
601 GGCTTAAATGAGGATGAGTTTCAGACCTTCCACATTAAGCAAGAGGCACAAATCACTTTC
661 TGTCTCAAGGAATTTCGAGGTCTTCTGAGTTTTGCGGAGTCATCTAATCTTTCCCTTAAT
721 ATCTACTTTGACACCCCTGGCAGGCCAGCTATCTTTACCTTGGACGATGCTGTCCTCCAG
781 GTGCACCTGGTCTTGGCTACCCTTGAAGAACCAGAGAGCTGCAGTTCCCAAATGACCTCA
841 TGCACTCCAAAGCCCCTTGCCCCTGCATATGACTTCACCGGTGATGATATTGATGACTAC
901 ATGATAGCCATGGAAACAACATGTGGTGGCCCCGCAGGGACAGAACCGCTTCCCAGCCCC
961 ACCTTCCCTATGGGGCCCACAAGTTCAGAAGCACAAGAGCCAGACAGTGATCACGAGGGG
1021 ACTGTCCCTGGCACGCCGCCACAGAAAAGGTTCCGGTCCTTGTTCTTTGGGTCAGTCCTG
1081 AGCCAGTCACAGTCTTTGGCTCACTCCCGGTCCAGCCAAGAGGTGCTGGCAGAAGACAGC
1141 GAGGGAGAATCATGA
| Predicted Protein Product |
MKCIVTGGNVKALGKAIHSLARVGDEIYVEPLQEGLSMRTVSASRSAYASFLFAPLFFQN
YQPTESGYDPDSEAFRCKVHMKSFLAVFRSLPSLEKTVEKCLLSLNPHASRFRVQLHCKY
GVVKTHDLPFQECESLQADFDTSQCAHALRAPPRLLADAVVHFPLALAEVTLVASPAGKV
SLRSYLEGDTEVTRTMVTELGLNEDEFQTFHIKQEAQITFCLKEFRGLLSFAESSNLSLN
IYFDTPGRPAIFTLDDAVLQVHLVLATLEEPESCSSQMTSCTPKPLAPAYDFTGDDIDDY
MIAMETTCGGPAGTEPLPSPTFPMGPTSSEAQEPDSDHEGTVPGTPPQKRFRSLFFGSVL
SQSQSLAHSRSSQEVLAEDSEGES
| Protein Alignment to Mouse |
sp|Q9Z0F6|RAD9A_MOUSE Cell cycle checkpoint control protein RAD9A OS=Mus
musculus GN=Rad9a PE=1 SV=1
MGI:1328356 Rad9 RAD9 homolog (S. pombe) (Chr 19)
Length = 389
Score = 1019 (363.8 bits), Expect = 1.5e-103, P = 1.5e-103
Identities = 217/398 (54%), Positives = 267/398 (67%)
Query: 1 MKCIVTGGNVKALGKAIHSLARVGDEIYVEPLQEGLSMRTVSASRSAYASFLFAPLFFQN 60
MKC++TGGNVK LGKA+HSL+R+GDE+Y+EPL++GLS+RTV++SRSAYA FLFAPLFFQ
Sbjct: 1 MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSSRSAYACFLFAPLFFQQ 60
Query: 61 YQPTESGYDPDSEAFRCKVHMKSFLAVFRSLPSLEKTVEKCLLSLNPHASRFRVQLHCKY 120
YQ G D RCK+ MK+FL+VFRSL +EK+VEKC +SL+ S VQLHCKY
Sbjct: 61 YQAASPGQD----LLRCKILMKAFLSVFRSLAIVEKSVEKCCISLSGSHSHLVVQLHCKY 116
Query: 121 GVVKTHDLPFQECESLQADFDTSQCAHXXXXXXXXXXDAVVHFPLALAEVTLVASPAGKV 180
GV KTH+L FQ+CESLQA FD + C H +AV+ FPLAL EVTL +V
Sbjct: 117 GVKKTHNLSFQDCESLQAVFDPASCPHLLRTPARVLAEAVLSFPLALTEVTLGIGRGRRV 176
Query: 181 SLRSYLEGDTEVT-RTMVTELGLNEDEFQTFHIKQEAQITFCLKEFRGLLSFAESSNLSL 239
LRSY E + + T + MVTE + +++FQ H + +TFCLKEFRGLLSFAES+NL L
Sbjct: 177 ILRSYQEEEADSTSKAMVTETSIGDEDFQQLHAPEGIAVTFCLKEFRGLLSFAESANLPL 236
Query: 240 NIYFDTPGRPAIFTLDDAVLQVHLVLATLEEPESCSSQMTSCTPKPLAP-----AY---- 290
I+FD PGRP IFT++D++L H VLATL E +SCS C+PKP P A+
Sbjct: 237 TIHFDVPGRPVIFTIEDSLLDAHFVLATLLEQDSCSQG--PCSPKPHQPVPQKQAHSTPH 294
Query: 291 --DFTGDDIDDYMIAMETTCGGPAGTEPLPSPTFPMGPTSSEAQEPDSDHEG---TVPGT 345
DFT DDID YMIAMETT GG G+ PS + P +S P S+ E TVPGT
Sbjct: 295 LDDFTSDDIDCYMIAMETT-GGNEGSGAQPSTSLPPVSLASHDLAPTSEEEAEPSTVPGT 353
Query: 346 PPQKRFRSLFFGSVLXXXXXXXXXXXXXEVLAEDSEGE 383
PP K+FRSLFFGS+L VLAEDS+GE
Sbjct: 354 PPPKKFRSLFFGSILAPVHSPQGPN---PVLAEDSDGE 388
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