GM077


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Gene Model: Brca2

Nomenclature		Genomic Location
Symbol	Brca2	Chromosome	1
Name	Brca2 protein	Linkage map	unknown
Species	Dracomimus familiaris	Genome Coordinates	Chr1: 69 Mbp

Molecular Function

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.

Molecular Function Terms:

binding
   nucleic acid binding
      DNA binding
   protein binding
      cytoskeletal protein binding
         tubulin binding
      enzyme binding
         protease binding

catalytic activity
   transferase activity
      transferase activity, transferring acyl groups
         transferase activity, transferring acyl groups other than amino-acyl groups
            acyltransferase activity
               acetyltransferase activity
                  N-acetyltransferase activity
                     lysine N-acetyltransferase activity
                        histone acetyltransferase activity

Human Disease Association

Defects in BRCA2 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

Defects in BRCA2 are the cause of pancreatic cancer type 2 (PNCA2) [MIM:613347]. It is a malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

Defects in BRCA2 are a cause of susceptibility to breast-ovarian cancer familial type 2 (BROVCA2) [MIM:612555]. A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.

Defects in BRCA2 are the cause of Fanconi anemia complementation group D type 1 (FANCD1) [MIM:605724]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Defects in BRCA2 are a cause of glioma type 3 (GLM3) [MIM:613029]. Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.

Predicted Transcript

     1 GAAACAAAGCATTCAACACCATGTAATATTCCAAGAAAAGGAAATCTTTATTCTCATTGT
    61 CATACTTACTCCCAGACTCCAGAAAATTATTTGGAAACAGAAGCTTCCGAAAGTGCCAGA
   121 GCATTTATGGAAGATGATGATCTCACTGATTCAGAAGCAGAGAGAAATAAAAAAGCATTT
   181 GCCTCTAATTCTGAAATAAATAATTCATATTCATATGCAAGAGCTGGAAAAAGATGTATG
   241 GAAAAAGAGAATACATTTGGGGAACCACCAATTAAAAGAAAATTGCTGCCTGAATTTGAT
   301 CAGTCAGAAAGATCATCTTTGAAAGCCTCCAGAAGTTCTTTGGATGGTACCATGAATGAT
   361 AGAAAAACAAATATTTATGGTATTCTTTTAAAGCCAGTAAATTGTGACTCTCTTAGTTTT
   421 ACCAAAGAAGTTAAGAAACCAAATTTTACTACTCCAGGCCGAGATCTTAAAGGGTTTAAA
   481 TCAGATGGACCTCAACAACATGTTTCAAAACACTCTTCAAGTACATCATCATGTGTTTTT
   541 AAGCAATTTAGTAATACTTCTGTTAGAGAAGAAAGCAAGAAAACAGACAATCCAACAGCA
   601 AAGACAACTATCAAAGTGTTTGTACCCCCTTTCAAAACAAAACCAAGTGCTTCTGAGGAT
   661 GAAATTAACAGCAAAGAATCTTACTTCCAAAATAACAACAGTGTTCATGGGGAGCTAAGT
   721 AATACCAAAGTTCATGAAACTTTCCTTCAACCAGAAAAGGAAAAATATGAAAAGATATCA
   781 GCAGTGGATTCAGAAATCAGAGAAATAGATTTAGGTTTAACAAACATTGCCAGCCTTCAC
   841 TGTGCCAGAAATTTACAAGAAATGAGGATTCTAAAGAAACAGAAGCAAGTCATTGGCCCA
   901 CAACCAGGCACCCTCTACCTCATGAAAATATGTGCTACATCTTGCAGAATCCCTCTAAAA
   961 ACTGCAGTGGATGAGAAATGCCCTGGTTCTTATTTTAGCGAACAGTTGTATGCATTTGGT
  1021 GTTTCCAAGCAGTGCCTAAATGTTAACAGCAGCAACGCAGAACATTTTCAGTTTCACATC
  1081 CAGGATTTTTTTGGTAGAGAGTGTTTCCTAGATGGAAACGGAATACAATTGGCTGATGGA
  1141 GGATATCTTATTCCCACCGATGATGGAAAAGCAGGAAAAGAGGAATTCTACAGGGCATTG
  1201 TGTGACACTCCTGGTGTAGATCCGAAGCTGATTTCCAAAGCCTGGGTCTACAACCATTAC
  1261 AAGTGGATCATATGGAAACTCGCAGCCATGGAAGTTGCATTTCCCCAGGAATTTGCCAGC
  1321 AAGTGTTTGACACCGGAAAGAGTACTACTTCAGCTAAAATACAGGTATGATGTGGAAGTT
  1381 GACAAAAGTTGTCGATCAGCCATCAAAAGAATAACTGAAAGAGATGATGTTGCTGCCAAA
  1441 ACACTTGTCTTGTGCATTTCTAGAATCATATCATTAAGCTCAAATGTATCCTGCATCTCT
  1501 GGCAATAAAAGCACCACGGAGGAAAACAAAAAAGATGTGGCTGTGGTTGAGGTTACAGAT
  1561 GGCTGGTATGGCATCAAGGCTGTTTTAGACCCCTCTCTTCAATCTCTGTTGCATAAACAG
  1621 AAGTTGACTGTAGGCCAGAAAATTGTCGTACATGGAGCAGAACTTATGGGACCTCAGGAT
  1681 GCATGTTCTCCACTGGACGTACCAGAATCCCTCATGCTAAAGATTTCAGGGAACAGTACT
  1741 CGACGTGCACGATGGTATTCCACATTAGGATATTATCGGGATCCCCGGCCATTTACATTG
  1801 CCTTTGTCATCACTCTTTAGTGATGGTGGGATTGTTGGCTGCATTGATGTTGTTGTTCAA
  1861 AGGATTTACCCCACACAGTGGATGGAAAAAACATCAACAGGGTCCTATATGTTTCGCAAC
  1921 TGTCGAGCTGAAGAAAGAGAAGCTGCAAAGCATGCCGAGAACAAACAGAAGACTCTAGAA
  1981 GCATTGCTTGCAAACATACAAGCTGAATTTGAAAAGAATGAAGAAACAGGTGAAGGCAAA
  2041 AGAGTGCTGCGATCCCGCACATTAACCCGGCAACAGATTCGCTCCTTGCAAGATGGGGCA
  2101 GAACTTTACGAGGCAGTTCTTAATGCAGCTGATCCTGCTTACATGGAGGGCTATTTCAGT
  2161 GAAGAGCAATTAAAAGCTTTGAACAGCCACAGACAGATGGTAAATGACAAAAAAAGAGCA
  2221 CAAATAGAAGCAGAATTCAAGAAGGCTGTAGAGTCGGCTGAGCAGGATAAGTCCAGTTCC
  2281 TGCAGCAGGGATGTAACTCCTGTAATCAAAGTACGAATCGTGGATTACAGAAAAGAAGAA
  2341 AAAGAAGTTATACTGACCATCTGGCGCCCATCATCACATGTTTGTACCCTCCTTAAGGAA
  2401 GGGTGCCCATACAGAGTTTTCCACGTAGCAGCATCGCCCTCCAAAGGCCGGGCAGAGCCC
  2461 ACAAACCTTCAGCTCACAGCAACCAAGAAAACTCAGTATTTGCAGCTGCCAGTATCTCAA
  2521 GAAGTTTTGTCCCAAGTTTACAGACCAAGAGAATGTCTGATGTTCAGTGAGCTACTGCTG
  2581 GAGTCTTTCCGACCTGCTTGTTCTGAGGTGGATTTGGTGGGATATGTTGTTTCTCTCAGG
  2641 AAAGGAACAGGTTTCTCTACATTAGTGTACTTGTCTGATAAAGACCATAACCTTATAGCA
  2701 GTTCACATCTGTACAGACCTTAGACAGTTTGCTGTTGAAGACATAATCATTCCTTCTATG
  2761 TTGATCTCTGCAACAAATCTTCAATGGAGGCCTAAATTCTATTCAAATATTCCCAGTTTA
  2821 TTTGCTGGAGATCTCTCCACATTTTCCTCAAAGCCAAAAGAAACCCGTCTTCAAGAAATA
  2881 TTTAATGATCTGAGAAATACTGTAGAGAGTGATAGCTGCTTTCAGAAAGACGCAGAGCGC
  2941 AAACTGGCAACTTTGCTCCAAACAAATGTTCCACAAGTGATGAACTTGCCCAAAGAACAT
  3001 GACTTTGATCCCTTTCCTTCTCCTTGGAGATCTGATGCAGGAAATAAACATTTGATTTCA
  3061 ACTCCTAATACAGAGCTAAGGCTTCCAAGCCCGCTGTCAATCAAGAGACCAAATACAAAG
  3121 GCACCAGGTTCTCTCTGCTCAACAAAAGTGAAAGCAGATCTACAGGAAACTCCTAAGAAC
  3181 CTTGAGAAGAGAAAAGCAATGGACCTCCTCAGTCAAGTCCCTTCCCCTCCACCAGTGAAG
  3241 CCAATTTGCACATTTATTTCTCCATCTTTGAAAAGAGCATTTCAACCTCCTCGAAGTTCT
  3301 GATCCCCACCATGAAAGATTTCTGAAAAAAACTGAATCTACAGTTAGAGAACCTGGAGTG
  3361 AAAAGACCAAATGAGACTAACTTTCAGCTTGAAAACTATTTTGTTGCTGATGAGGAACTT
  3421 GCCATGATAAATACACAAGCTTTCTTAAGCAATTCTACAGAAGAAAAAGAGGCTGGTTTT
  3481 ACAGAGAAAATTGCACATACATCACACAATGATTCATCCAACAGTTTTTCCCTAAGGAAC
  3541 AATTCTTGC

Predicted Protein Product

ETKHSTPCNIPRKGNLYSHCHTYSQTPENYLETEASESARAFMEDDDLTDSEAERNKKAF
ASNSEINNSYSYARAGKRCMEKENTFGEPPIKRKLLPEFDQSERSSLKASRSSLDGTMND
RKTNIYGILLKPVNCDSLSFTKEVKKPNFTTPGRDLKGFKSDGPQQHVSKHSSSTSSCVF
KQFSNTSVREESKKTDNPTAKTTIKVFVPPFKTKPSASEDEINSKESYFQNNNSVHGELS
NTKVHETFLQPEKEKYEKISAVDSEIREIDLGLTNIASLHCARNLQEMRILKKQKQVIGP
QPGTLYLMKICATSCRIPLKTAVDEKCPGSYFSEQLYAFGVSKQCLNVNSSNAEHFQFHI
QDFFGRECFLDGNGIQLADGGYLIPTDDGKAGKEEFYRALCDTPGVDPKLISKAWVYNHY
KWIIWKLAAMEVAFPQEFASKCLTPERVLLQLKYRYDVEVDKSCRSAIKRITERDDVAAK
TLVLCISRIISLSSNVSCISGNKSTTEENKKDVAVVEVTDGWYGIKAVLDPSLQSLLHKQ
KLTVGQKIVVHGAELMGPQDACSPLDVPESLMLKISGNSTRRARWYSTLGYYRDPRPFTL
PLSSLFSDGGIVGCIDVVVQRIYPTQWMEKTSTGSYMFRNCRAEEREAAKHAENKQKTLE
ALLANIQAEFEKNEETGEGKRVLRSRTLTRQQIRSLQDGAELYEAVLNAADPAYMEGYFS
EEQLKALNSHRQMVNDKKRAQIEAEFKKAVESAEQDKSSSCSRDVTPVIKVRIVDYRKEE
KEVILTIWRPSSHVCTLLKEGCPYRVFHVAASPSKGRAEPTNLQLTATKKTQYLQLPVSQ
EVLSQVYRPRECLMFSELLLESFRPACSEVDLVGYVVSLRKGTGFSTLVYLSDKDHNLIA
VHICTDLRQFAVEDIIIPSMLISATNLQWRPKFYSNIPSLFAGDLSTFSSKPKETRLQEI
FNDLRNTVESDSCFQKDAERKLATLLQTNVPQVMNLPKEHDFDPFPSPWRSDAGNKHLIS
TPNTELRLPSPLSIKRPNTKAPGSLCSTKVKADLQETPKNLEKRKAMDLLSQVPSPPPVK
PICTFISPSLKRAFQPPRSSDPHHERFLKKTESTVREPGVKRPNETNFQLENYFVADEEL
AMINTQAFLSNSTEEKEAGFTEKIAHTSHNDSSNSFSLRNNSC

Protein Alignment to Mouse

sp|P97929|BRCA2_MOUSE Breast cancer type 2 susceptibility protein homolog
            OS=Mus musculus GN=Brca2 PE=1 SV=1
      MGI:109337 Brca2 breast cancer 2 (Chr 5)
        Length = 3329

 Score = 2208 (782.3 bits), Expect = 1.9e-253, Sum P(2) = 1.9e-253
 Identities = 479/949 (50%), Positives = 636/949 (67%)

Query:   229 FQNNNSVHG-ELSNTKVHETFLQPEKEKY---EKISAVDSEIREIDLGLTNIASLHCARN 284
             F+  +  HG E  N+K     L+ + +K    ++    DS +R+ +  L  ++SL  AR+
Sbjct:  2355 FKMKSQFHGDEHFNSK--NVNLEGKNQKSTDGDREDGNDSHVRQFNKDL--MSSLQSARD 2410

Query:   285 LQEMRILKKQKQVIGPQPGTLYLMKICATSCRIPLKTAVDEKCPGSYFSEQLYAFGVSKQ 344
             LQ+MRI  K+++ +  QPG+LYL K  +T  RI L+ AV ++ P +   +QLY +GVSK+
Sbjct:  2411 LQDMRIKNKERRHLRLQPGSLYLTK-SSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKE 2469

Query:   345 CLNVNSSNAEHFQFHIQDFFGRECFLDGNGIQLADGGYLIPTDDGKAGKEEFYRALCDTP 404
             C+NVNS NAE+FQF IQD FG+E    G G QLADGG+LIP++DGKAGKEEFYRALCDTP
Sbjct:  2470 CINVNSKNAEYFQFDIQDHFGKEDLCAGKGFQLADGGWLIPSNDGKAGKEEFYRALCDTP 2529

Query:   405 GVDPKLISKAWVYNHYKWIIWKLAAMEVAFPQEFASKCLTPERVLLQLKYRYDVEVDKSC 464
             GVDPKLIS  WV NHY+WI+WKLAAME AFP+EFA++CL PERVLLQLKYRYDVE+D S 
Sbjct:  2530 GVDPKLISSIWVANHYRWIVWKLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDNSR 2589

Query:   465 RSAIKRITERDDVAAKTLVLCISRIISLSSNVSCISGNKSTTEENKKDVAVVEVTDGWYG 524
             RSA+K+I ERDD AAKTLVLCIS IIS S+ VS  SG K++ E+  K V  +E+TDGWY 
Sbjct:  2590 RSALKKILERDDTAAKTLVLCISDIISPSTKVSETSGGKTSGEDANK-VDTIELTDGWYA 2648

Query:   525 IKAVLDPSLQSLLHKQKLTVGQKIVVHGAELMGPQDACSPLDVPESLMLKISGNSTRRAR 584
             ++A LDP L +L+   KLTVGQKI+  GAEL+G  DAC+PL+ P+SL LKIS NSTR AR
Sbjct:  2649 VRAQLDPPLMALVKSGKLTVGQKIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPAR 2708

Query:   585 WYSTLGYYRDPRPFTLPLSSLFSXXXXXXXXXXXXQRIYPTQWMEKTSTGSYMFRNCXXX 644
             W+S LG++RDPRPF LPLSSLFS            QR+YP QW+EKT +G Y+FR+    
Sbjct:  2709 WHSRLGFFRDPRPFPLPLSSLFSDGGNVGCVDIIVQRVYPLQWVEKTVSGLYIFRSEREE 2768

Query:   645 XXXXXXXXXNKQKTLEALLANIQAEFEKNEETGEGKRVLRSRTLTRQQIRSLQDGAELYE 704
                       +QK LEAL   +  EF+ +EE    + VL SRTLTRQQ+ +LQDGAELY 
Sbjct:  2769 EKEALRFAEAQQKKLEALFTKVHTEFKDHEEDTTQRCVL-SRTLTRQQVHALQDGAELYA 2827

Query:   705 AVLNAADPAYMEGYFSEEQLKALNSHRQMVNDKKRAQIEAEFKKAVESAEQDKSSSCSRD 764
             AV  A+DP ++E  FSEEQL+ALN++RQM+NDKK+A+I++EF+KA+ESAE  K    SRD
Sbjct:  2828 AVQYASDPDHLEACFSEEQLRALNNYRQMLNDKKQARIQSEFRKALESAE--KEEGLSRD 2885

Query:   765 VTPVIKVRIVDYRKEEKEVILTIWRPSSHVCTLLKEGCPYRVFHVAASPSKGRAEPTNLQ 824
             VT V K+R+  Y+K+EK  +L+IWRPSS + +LL EG  YR++H+A S SK + E  ++Q
Sbjct:  2886 VTTVWKLRVTSYKKKEKSALLSIWRPSSDLSSLLTEGKRYRIYHLAVSKSKSKFERPSIQ 2945

Query:   825 LTATKKTQYLQLPVSQEVLSQVYRPRECLMFSELLLESFRPACSEVDLVGYVVSLRKGTG 884
             LTATK+TQY QLPVS E L QVY+PRE L FS L   +F+P CSEVD+VG VVS+ K  G
Sbjct:  2946 LTATKRTQYQQLPVSSETLLQVYQPRESLHFSRLSDPAFQPPCSEVDVVGVVVSVVKPIG 3005

Query:   885 FSTLVYLSDKDHNLIAVHICTDLRQFAVEDIIIPSMLISATNLQWRPKFYSNIPSLFAGD 944
              + LVYLSD+  NL+ V    DL     EDI  P +LI+A+NLQ +P+  S +P+LFAG 
Sbjct:  3006 LAPLVYLSDECLNLLVVKFGIDLN----EDIK-PRVLIAASNLQCQPESTSGVPTLFAGH 3060

Query:   945 LSTFSSKPKETRLQEIFNDLRNTVESDSCFQKDAERKLATLLQTNVPQVMNLPKEHDFDP 1004
              S FS+ PKE   QE  N+L++ +E+   F K+AE+KL  +L+ + P+     K+   +P
Sbjct:  3061 FSIFSASPKEAYFQEKVNNLKHAIENIDTFYKEAEKKLIHVLEGDSPKWSTPNKDPTREP 3120

Query:  1005 FPSPW--RSD---AGNKHLISTPNTELRLPSPLS---IKRPNTK-APGSLCSTKVKADLQ 1055
               +     SD   +G + L  +P  +    SPLS   +K  +   A  +  + K  +   
Sbjct:  3121 HAASTCCASDLLGSGGQFLRISPTGQQSYQSPLSHCTLKGKSMPLAHSAQMAAKSWSGEN 3180

Query:  1056 ET--PKNLEKRKAMDLLSQVPSPPPVKPICTFISPSLKRAFQPPRSSDPHHERFLKKTES 1113
             E   PK   KR+A+D LS++P P PV PICTF+SP+ ++AFQPPRS    +   +KK  S
Sbjct:  3181 EIDDPKTCRKRRALDFLSRLPLPSPVSPICTFVSPAAQKAFQPPRSCGTKYATPIKKEPS 3240

Query:  1114 TVRE--PGVKRPNETNFQLENYFVADEELAMINTQAFLSNSTEEKEAGF 1160
             + R   P  K    +    ++  VADEELA+++TQA   +S    E  F
Sbjct:  3241 SPRRRTPFQKTSGVSLPDCDS--VADEELALLSTQALTPDSVGGNEQAF 3287

 Score = 268 (99.4 bits), Expect = 1.9e-253, Sum P(2) = 1.9e-253
 Identities = 78/232 (33%), Positives = 114/232 (49%)

Query:     9 NIPRKGNLYSHCHTYSQTPENYLETEASESARAFMEDDDLTDSEAERNKKAFASNSEINN 68
             ++P K N+  +   YS+  ENY ETEA ESA+AFMEDD+LTDSE    K +  +  + N 
Sbjct:  2155 DVPVKTNVGEY---YSKESENYFETEAVESAKAFMEDDELTDSEQTHAKCSLFTCPQ-NE 2210

Query:    69 SYSYARAGKRCMEKENTFGEPPIKRKLLPEFD---QXXXXXXXXXXXXXDGTMNDRKTNI 125
             +   +R  KR     +  G+PPIKR LL EFD   +             DGT+ DR    
Sbjct:  2211 TLFNSRTRKRGGVTVDAVGQPPIKRSLLNEFDRIIESKGKSLTPSKSTPDGTVKDRSLFT 2270

Query:   126 YGILLKPVNCDSLSFTKE---VKKPNFTTPGRDLKGFKSDGPQQHVXXXXXXXXXCVFKQ 182
             + + L+PV C     +KE    ++P+ T+P ++L       P +H           V   
Sbjct:  2271 HHMSLEPVTCGPFCSSKERQGAQRPHLTSPAQEL--LSKGHPWRHSALEKSPSSPIVSIL 2328

Query:   183 FSNTSVREESKKTDNPTAKTTIKVFVPPFKTKPSASEDE-INSKESYFQNNN 233
              ++      +++T + + K+T KVFVPPFK K     DE  NSK    +  N
Sbjct:  2329 PAHDVSATRTERTRH-SGKST-KVFVPPFKMKSQFHGDEHFNSKNVNLEGKN 2378

 Score = 52 (23.4 bits), Expect = 1.3e-230, Sum P(2) = 1.3e-230
 Identities = 15/78 (19%), Positives = 33/78 (42%)

Query:     5 STPCNIPRKGNL-YSHCHTYSQTPENYLETEASESARAFMEDDDLTDSEAERNKKAFASN 63
             S+ C +  + N+  + C    + PE Y++    E +    + ++L +S+   +  +    
Sbjct:  1267 SSKCQVTLQNNIEMTTCIFVGRNPEKYIKNTKHEDSYTSSQRNNLENSDGSMSSTSGPVY 1326

Query:    64 SEINNSYSYARAGKRCME 81
                 +S   A  G +C E
Sbjct:  1327 IHKGDSDLPADQGSKCPE 1344

 Score = 45 (20.9 bits), Expect = 7.2e-230, Sum P(2) = 7.2e-230
 Identities = 41/179 (22%), Positives = 68/179 (37%)

Query:   131 KPVNCDSLSFTKEVKKPNFTTPGRDLKGFKSDGPQQHVXXXXXXXXXCVFKQFS-NTSVR 189
             KPV   SL +T ++K+     P  +  G + D                     + +   R
Sbjct:   150 KPVVSGSLFYTPKLKEGQTPKPISESLGVEVDPDMSWTSSLATPPTLSSTVLIARDEEAR 209

Query:   190 EESKKTDNP-TAKTTIKVF-VPPFKTK---PSASEDEI-NSKESYFQNNNSVHGELSNTK 243
                   D+P T K+        P K     PS  + E  N +E++ Q    + G+ S  +
Sbjct:   210 SSVTPADSPATLKSCFSNHNESPQKNDRSVPSVIDSENKNQQEAFSQGLGKMLGDSSGKR 269

Query:   244 VHETFLQPEKEKYEKISAVDSEIREIDLGLTNIASLHC-----ARNLQEMRILKKQKQV 297
                +F    ++    I   D E   +D    +  SL C      RNLQ+MR+ K +K++
Sbjct:   270 --NSFKDCLRKPIPNILE-DGETA-VDTSEEDSFSL-CFPKRRTRNLQKMRMGKTRKKI 323

 Score = 43 (20.2 bits), Expect = 1.2e-229, Sum P(2) = 1.2e-229
 Identities = 15/52 (28%), Positives = 24/52 (46%)

Query:     6 TPCNIPRKGNLYSHCHTYSQTPENYLETEASESARAFMEDDDLTDSEAERNK 57
             TP   P    L    +  S  P NY E+ +S + ++   +  L  S+ ERN+
Sbjct:  2067 TP-EYPVNSKLQKTYNDKSSLPSNYKESGSSGNTQSI--EVSLQLSQMERNQ 2115

 Score = 38 (18.4 bits), Expect = 6.9e-17, Sum P(2) = 6.9e-17
 Identities = 8/18 (44%), Positives = 10/18 (55%)

Query:  1152 STEEKEAGFTEKIAHTSH 1169
             S   KEA F EK+ +  H
Sbjct:  3065 SASPKEAYFQEKVNNLKH 3082