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Gene Model: Crk

NomenclatureGenomic Location
SymbolCrkChromosomeX
NameAdapter molecule crkLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChrX: 26 Mbp

Molecular Function

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner.

Molecular Function Terms:

binding
   binding, bridging
      protein binding, bridging
         signaling adaptor activity
   protein binding
      phosphoprotein binding
      protein binding, bridging
      protein domain specific binding

Human Disease Association

No disease association.

Predicted Transcript
     1 CGATTCCGGATCGGGGACCAGGAGTTTGACTCCCTGCCGTCTCTGCTGGAATTCTACAAG
    61 ATCCACTACCTGGACACTACCACCCTGATCGAGCCGGTCTCCAAGGCCAAGCACCGCGGG
   121 AGCGGCGACCTGCAGCAGCCGAGGGCCGAGGAGGAAGCGGAGTTCGTCCGCGCCCTCTTT
   181 GACTTTCAGGGCAACGACGAGGAAGACCTGCCCTTCAAGAAGGGGGACATCCTGCGGATC
   241 CGGGAGAAGCCCGAGGAGCAGTGGTGGAACGCGGAGGACGGCGAGGGCCGGCGGGGCATG
   301 ATCCCGGTGCCCTACGTGGAGAAGTGCCGCCCGGCCCCCCACCCCATCGTCGGGGGCCCC
   361 CCGGAGGGCGTCCCGGCCCCACAGATGCAGCCGCCATTACCGCCTCTGGGAGGGATGGAG
   421 CCCGGCCCGTACGCCCAGCCCAGCGTCGTCAACACCCCGCTCCCCAACCTCCAGAACGGC
   481 CCCATCTTTGCCCGGGTGATCCAGAAGCGGGTCCCCAACGCCTACGACAAGACGGCCCTG
   541 GCTTTGGAGGTGGGGGAGCTGGTCAAAGTGACCAAGATCAACATGAGCGGCCAGTGGGAA
   601 GGCGAGTGTGGGGCCCGGCGGGGCCACTTCCCCTTCACGCACGTCCGGCTCCTCGACCAG
   661 CAGAACCCCGAGGAGGACTTCAGTTGA

Predicted Protein Product
RFRIGDQEFDSLPSLLEFYKIHYLDTTTLIEPVSKAKHRGSGDLQQPRAEEEAEFVRALF
DFQGNDEEDLPFKKGDILRIREKPEEQWWNAEDGEGRRGMIPVPYVEKCRPAPHPIVGGP
PEGVPAPQMQPPLPPLGGMEPGPYAQPSVVNTPLPNLQNGPIFARVIQKRVPNAYDKTAL
ALEVGELVKVTKINMSGQWEGECGARRGHFPFTHVRLLDQQNPEEDFS
Protein Alignment to Mouse
sp|Q64010|CRK_MOUSE Adapter molecule crk OS=Mus musculus GN=Crk PE=1 SV=1
      MGI:88508 Crk v-crk sarcoma virus CT10 oncogene homolog (avian) (Chr 11)
        Length = 304

 Score = 860 (307.8 bits), Expect = 1.1e-86, P = 1.1e-86
 Identities = 172/231 (74%), Positives = 190/231 (82%)

Query:     1 RFRIGDQEFDSLPSLLEFYKIHYLDTTTLIEPVSKAKHRGSGDLQQPRAEEEAEFVRALF 60
             R RIGDQEFDSLP+LLEFYKIHYLDTTTLIEPV++++ +GSG + +   +EEAE+VRALF
Sbjct:    86 RLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVARSR-QGSGVILR---QEEAEYVRALF 141

Query:    61 DFQGNDEEDLPFKKGDILRIREKPEEQWWNAEDGEGRRGMIPVPYVEKCRPAPHPI---V 117
             DF GNDEEDLPFKKGDILRIR+KPEEQWWNAED EG+RGMIPVPYVEK RPA   +   +
Sbjct:   142 DFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALI 201

Query:   118 GGPPEGVXXXXXXXXXXXXXXXXXXXYAQPSVVNTPLPNLQNGPIFARVIQKRVPNAYDK 177
             GG  EG                    YAQPSV NTPLPNLQNGPI+ARVIQKRVPNAYDK
Sbjct:   202 GGNQEG-------SHPQPLGGPEPGPYAQPSV-NTPLPNLQNGPIYARVIQKRVPNAYDK 253

Query:   178 TALALEVGELVKVTKINMSGQWEGECGARRGHFPFTHVRLLDQQNPEEDFS 228
             TALALEVGELVKVTKIN+SGQWEGEC  +RGHFPFTHVRLLDQQNP+EDFS
Sbjct:   254 TALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 304