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Gene Model: Araf

NomenclatureGenomic Location
SymbolArafChromosome1
NameSerine/threonine-protein
kinase A-Raf
Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 97 Mbp

Molecular Function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.

Molecular Function Terms:

binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity

molecular transducer activity
   signal transducer activity
      receptor signaling protein activity

Human Disease Association

No disease association.

Predicted Transcript
     1 GGGACTATCAAGGTGGACCTCCCCAATCAGCAGAGGACGGTGGTGAATGTCCGGCCAGGT
    61 ACGACTGTCTACAGCTCCTTGGACAAGGCTCTGAAGGTGCGTGGCCTCAACCAGGACTGC
   121 TGTGTTGTCTACAATCTTGTAGCAATACGAAAGACCATCACAGATTGGGAGACAGACTTG
   181 GTGAACCTGGAGGGGGCTGAGCTCTCCGTGGAAGTCCTGGAAAATGTACCGCTTACGATG
   241 CACAATTTTGTCCGGAAGACCTACTTCCGCATGGTTTTTTGTGATTTCTGCCTTAAGTTC
   301 CTGTTCCATGGCTTCCGCTGCCAGACGTGTGGCTACAAATTCCACGAACATTGCAGCAGC
   361 AGAGTGCCGACAGTCTGTGTGGACTTGGCAACAACCCACAAGCCTGTTTACAGCCATGAC
   421 CCATGGCAGTATCCTCCACTTTGGTCAGATAATGCTTCAGCTGCCCTGATCCAAGAACCT
   481 ATGACTCCGCAATCCATCAGAACGACTTGTTTTATGTCATGCACTCAAGAGACAAAAATG
   541 AACAAAGATGCCTTCAGCTTCCCCAGCCTGTGTAGCGATGGGCAGCTCCTGCAGCGACAC
   601 CGCTCGACATCCACTCCTAATGTCCACATGGTCAGTACCACCAGCCCTGTGGACAACAGC
   661 ATCCTTGAGTTCATAAGCAGGAGCCACAACGCAGAGGTCATAGTGGTTGGAGCCCTAGGT
   721 GGTCCTGAACTGCCTCCTCGCACCCCACCAGCCACTCCAGTATCCAGTATGGCTGCTGTT
   781 TCTCCAGGCCGACGCTCCCCACACCCCAAATCTCCCGGCGAGTCTCCAAGGGAGCGCAAG
   841 GCTCCTTCAGAAGACAAGAAGAAACCTAAATCCTTGGGCTACCGAGACTCAAGCTATTAT
   901 TGGGAGGTGTCCCCTAAAGAGGTGACCATGCAGAAGCGGATTGGGACCGGGTCCTTTGGT
   961 ACTGTCTTCAAGGGTCGGTGGTATGGGGATGTGGCAATAAAGATTCTGAAGGTCACCAAC
  1021 CCCACCAGTGAACAGGTGCAGGCCTTCAAGAATGAGATGCAAGTTCTCAGGAAGACGCGA
  1081 CATGTTAACATTTTGCTCTTCATGGGGTTCATGACTCACCCCAGTTTTGCCATCATCACC
  1141 CAGTGGTGTGACGGCAGCAGCCTCTACCAGCACCTCCACGTGCAGGAGACACCCCTGGAG
  1201 ATGGTGCAGCGGATTGATGTAGCTCGGCAAACAGCCCAGGGCATGGACTACCTTCATGCT
  1261 AAGCACATAATTCACCGAGACCTCAAATCTAACAACATTTTCCTCCACGAAGGACTGACA
  1321 GTGAAGATCGGTGACTTTGGCCTGGCCACGGTGAAGACACGTTGGAGTGGAGCGCAGCAG
  1381 GTGGAACAGCCCGGTGGCTCCATACTCTGGATGTCACCTGAAGTGATCCGGATGCAGGAC
  1441 CCTAACCCCTACAGCTTCCAGTCAGATGTCTACTCCTATGGAGTTGTCCTATATGAGCTG
  1501 CTCTCTGGGAGCCTTCCCTACAGCCATATCAATAACCGGGACCAGATTATATTCATGGTG
  1561 GGTCGAGGGTACCTGTCCCCTGATGTTAGCAAAGTGCCCAGCAATTGTCCCAAAGCCATG
  1621 CGCAGGCTGATGTGCGACTGTCTGAAATTCAAGCGTGAAGAGAGGCCCCTCTTCCCTCAG
  1681 ATTTTAGCTTCAATTGAGTCTCTGCAGCACTCCTTGCCCCGAATTGAGCGCAGTGCCTCG
  1741 GAGCCCGCACTCCACCGTGTGGCCTGTGATGAAGAAATGAGCTTCTTTGGTCTGCCGTCA
  1801 GCCCAGCGGTTCCGCAGCTAA

Predicted Protein Product
GTIKVDLPNQQRTVVNVRPGTTVYSSLDKALKVRGLNQDCCVVYNLVAIRKTITDWETDL
VNLEGAELSVEVLENVPLTMHNFVRKTYFRMVFCDFCLKFLFHGFRCQTCGYKFHEHCSS
RVPTVCVDLATTHKPVYSHDPWQYPPLWSDNASAALIQEPMTPQSIRTTCFMSCTQETKM
NKDAFSFPSLCSDGQLLQRHRSTSTPNVHMVSTTSPVDNSILEFISRSHNAEVIVVGALG
GPELPPRTPPATPVSSMAAVSPGRRSPHPKSPGESPRERKAPSEDKKKPKSLGYRDSSYY
WEVSPKEVTMQKRIGTGSFGTVFKGRWYGDVAIKILKVTNPTSEQVQAFKNEMQVLRKTR
HVNILLFMGFMTHPSFAIITQWCDGSSLYQHLHVQETPLEMVQRIDVARQTAQGMDYLHA
KHIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQQVEQPGGSILWMSPEVIRMQD
PNPYSFQSDVYSYGVVLYELLSGSLPYSHINNRDQIIFMVGRGYLSPDVSKVPSNCPKAM
RRLMCDCLKFKREERPLFPQILASIESLQHSLPRIERSASEPALHRVACDEEMSFFGLPS
AQRFRS
Protein Alignment to Mouse
sp|P04627|ARAF_MOUSE Serine/threonine-protein kinase A-Raf OS=Mus musculus
            GN=Araf PE=2 SV=2
      MGI:88065 Araf v-raf murine sarcoma 3611 viral oncogene homolog (Chr X)
        Length = 604

 Score = 1540 (547.2 bits), Expect = 1.8e-228, Sum P(2) = 1.8e-228
 Identities = 297/411 (72%), Positives = 343/411 (83%)

Query:   181 NKDAFSFPSLCSDGQLLQRHRSTSTPNVHMVSTTSPVDNSILEFISRSHNAEVIVVGAXX 240
             +++ FSFP+  +    LQR RSTSTPNVHMVSTT+P+D+S+++F ++S + +    G   
Sbjct:   193 DQEHFSFPAPANPP--LQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAGRGGDG 250

Query:   241 XXXXXXXXXXXXXVSSMAAVSPGRRSPHPKSPGESPRERKAPSEDKKKPKSLGYRDSSYY 300
                            S A+VS GR+SPH K P E  RERK+ +++KKK K+LGYRDS YY
Sbjct:   251 APRGS---------PSPASVSSGRKSPHSKLPSEQ-RERKSLADEKKKVKNLGYRDSGYY 300

Query:   301 WEVSPKEVTMQKRIGTGSFGTVFKGRWYGDVAIKILKVTNPTSEQVQAFKNEMQVLRKTR 360
             WEV P EV + KRIGTGSFGTVF+GRW+GDVA+K+LKV  PT+EQ QAFKNEMQVLRKTR
Sbjct:   301 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTR 360

Query:   361 HVNILLFMGFMTHPSFAIITQWCDGSSLYQHLHVQETPLEMVQRIDVARQTAQGMDYLHA 420
             HVNILLFMGFMT P FAIITQWC+GSSLY HLHV +T  +MVQ IDVARQTAQGMDYLHA
Sbjct:   361 HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA 420

Query:   421 KHIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQQVEQPGGSILWMSPEVIRMQD 480
             K+IIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQ +EQP GS+LWM+ EVIRMQD
Sbjct:   421 KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQD 480

Query:   481 PNPYSFQSDVYSYGVVLYELLSGSLPYSHINNRDQIIFMVGRGYLSPDVSKVPSNCPKAM 540
             PNPYSFQSDVY+YGVVLYEL++GSLPYSHI +RDQIIFMVGRGYLSPD+SK+ SNCPKAM
Sbjct:   481 PNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAM 540

Query:   541 RRLMCDCLKFKREERPLFPQILASIESLQHSLPRIERSASEPALHRVACDE 591
             RRL+ DCLKF+REERPLFPQILA+IE LQ SLP+IERSASEP+LHR   DE
Sbjct:   541 RRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADE 591

 Score = 681 (244.8 bits), Expect = 1.8e-228, Sum P(2) = 1.8e-228
 Identities = 136/233 (58%), Positives = 172/233 (73%)

Query:     1 GTIKVDLPNQQRTVVNVRPGTTVYSSLDKALKVRGLNQDCCVVYNLVAIRKTITDWETDL 60
             GT+KV LPN+QRTVV VR G +VY SLDKALKVRGLNQDCCVVY L+  RKT+T W+T +
Sbjct:    19 GTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAI 78

Query:    61 VNLEGAELSVEVLENVPLTMHNFVRKTYFRMVFCDFCLKFLFHGFRCQTCGYKFHEHCSS 120
               L+G EL VEVLE+VPLTMHNFVRKT+F + FCDFCLKFLFHGFRCQTCGYKFH+HCSS
Sbjct:    79 APLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSS 138

Query:   121 RVPTVCVDLATTHKPVY-SHDPWQYPPLWSDNASAALIQEPMTPQSIRTTCFMSCTQETK 179
             +VPTVCVD++T  +  Y S           +  S   + E +TPQ    + F   TQ+  
Sbjct:   139 KVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEAPSNLSVNELLTPQG--PSPF---TQQR- 192

Query:   180 MNKDAFSFPSLCSDGQLLQRHRSTSTPNVHMVSTTSPVDNSILEFISRSHNAE 232
              +++ FSFP+  +    LQR RSTSTPNVHMVSTT+P+D+S+++F ++S + +
Sbjct:   193 -DQEHFSFPAPANPP--LQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTD 242