| Nomenclature | Genomic Location |
| Symbol | Araf | Chromosome | 1 |
| Name | Serine/threonine-protein
kinase A-Raf | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 97 Mbp |
| Molecular Function |
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Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
Molecular Function Terms:
binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
molecular transducer activity
signal transducer activity
receptor signaling protein activity
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| Human Disease Association |
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No disease association.
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1 GGGACTATCAAGGTGGACCTCCCCAATCAGCAGAGGACGGTGGTGAATGTCCGGCCAGGT
61 ACGACTGTCTACAGCTCCTTGGACAAGGCTCTGAAGGTGCGTGGCCTCAACCAGGACTGC
121 TGTGTTGTCTACAATCTTGTAGCAATACGAAAGACCATCACAGATTGGGAGACAGACTTG
181 GTGAACCTGGAGGGGGCTGAGCTCTCCGTGGAAGTCCTGGAAAATGTACCGCTTACGATG
241 CACAATTTTGTCCGGAAGACCTACTTCCGCATGGTTTTTTGTGATTTCTGCCTTAAGTTC
301 CTGTTCCATGGCTTCCGCTGCCAGACGTGTGGCTACAAATTCCACGAACATTGCAGCAGC
361 AGAGTGCCGACAGTCTGTGTGGACTTGGCAACAACCCACAAGCCTGTTTACAGCCATGAC
421 CCATGGCAGTATCCTCCACTTTGGTCAGATAATGCTTCAGCTGCCCTGATCCAAGAACCT
481 ATGACTCCGCAATCCATCAGAACGACTTGTTTTATGTCATGCACTCAAGAGACAAAAATG
541 AACAAAGATGCCTTCAGCTTCCCCAGCCTGTGTAGCGATGGGCAGCTCCTGCAGCGACAC
601 CGCTCGACATCCACTCCTAATGTCCACATGGTCAGTACCACCAGCCCTGTGGACAACAGC
661 ATCCTTGAGTTCATAAGCAGGAGCCACAACGCAGAGGTCATAGTGGTTGGAGCCCTAGGT
721 GGTCCTGAACTGCCTCCTCGCACCCCACCAGCCACTCCAGTATCCAGTATGGCTGCTGTT
781 TCTCCAGGCCGACGCTCCCCACACCCCAAATCTCCCGGCGAGTCTCCAAGGGAGCGCAAG
841 GCTCCTTCAGAAGACAAGAAGAAACCTAAATCCTTGGGCTACCGAGACTCAAGCTATTAT
901 TGGGAGGTGTCCCCTAAAGAGGTGACCATGCAGAAGCGGATTGGGACCGGGTCCTTTGGT
961 ACTGTCTTCAAGGGTCGGTGGTATGGGGATGTGGCAATAAAGATTCTGAAGGTCACCAAC
1021 CCCACCAGTGAACAGGTGCAGGCCTTCAAGAATGAGATGCAAGTTCTCAGGAAGACGCGA
1081 CATGTTAACATTTTGCTCTTCATGGGGTTCATGACTCACCCCAGTTTTGCCATCATCACC
1141 CAGTGGTGTGACGGCAGCAGCCTCTACCAGCACCTCCACGTGCAGGAGACACCCCTGGAG
1201 ATGGTGCAGCGGATTGATGTAGCTCGGCAAACAGCCCAGGGCATGGACTACCTTCATGCT
1261 AAGCACATAATTCACCGAGACCTCAAATCTAACAACATTTTCCTCCACGAAGGACTGACA
1321 GTGAAGATCGGTGACTTTGGCCTGGCCACGGTGAAGACACGTTGGAGTGGAGCGCAGCAG
1381 GTGGAACAGCCCGGTGGCTCCATACTCTGGATGTCACCTGAAGTGATCCGGATGCAGGAC
1441 CCTAACCCCTACAGCTTCCAGTCAGATGTCTACTCCTATGGAGTTGTCCTATATGAGCTG
1501 CTCTCTGGGAGCCTTCCCTACAGCCATATCAATAACCGGGACCAGATTATATTCATGGTG
1561 GGTCGAGGGTACCTGTCCCCTGATGTTAGCAAAGTGCCCAGCAATTGTCCCAAAGCCATG
1621 CGCAGGCTGATGTGCGACTGTCTGAAATTCAAGCGTGAAGAGAGGCCCCTCTTCCCTCAG
1681 ATTTTAGCTTCAATTGAGTCTCTGCAGCACTCCTTGCCCCGAATTGAGCGCAGTGCCTCG
1741 GAGCCCGCACTCCACCGTGTGGCCTGTGATGAAGAAATGAGCTTCTTTGGTCTGCCGTCA
1801 GCCCAGCGGTTCCGCAGCTAA
| Predicted Protein Product |
GTIKVDLPNQQRTVVNVRPGTTVYSSLDKALKVRGLNQDCCVVYNLVAIRKTITDWETDL
VNLEGAELSVEVLENVPLTMHNFVRKTYFRMVFCDFCLKFLFHGFRCQTCGYKFHEHCSS
RVPTVCVDLATTHKPVYSHDPWQYPPLWSDNASAALIQEPMTPQSIRTTCFMSCTQETKM
NKDAFSFPSLCSDGQLLQRHRSTSTPNVHMVSTTSPVDNSILEFISRSHNAEVIVVGALG
GPELPPRTPPATPVSSMAAVSPGRRSPHPKSPGESPRERKAPSEDKKKPKSLGYRDSSYY
WEVSPKEVTMQKRIGTGSFGTVFKGRWYGDVAIKILKVTNPTSEQVQAFKNEMQVLRKTR
HVNILLFMGFMTHPSFAIITQWCDGSSLYQHLHVQETPLEMVQRIDVARQTAQGMDYLHA
KHIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQQVEQPGGSILWMSPEVIRMQD
PNPYSFQSDVYSYGVVLYELLSGSLPYSHINNRDQIIFMVGRGYLSPDVSKVPSNCPKAM
RRLMCDCLKFKREERPLFPQILASIESLQHSLPRIERSASEPALHRVACDEEMSFFGLPS
AQRFRS
| Protein Alignment to Mouse |
sp|P04627|ARAF_MOUSE Serine/threonine-protein kinase A-Raf OS=Mus musculus
GN=Araf PE=2 SV=2
MGI:88065 Araf v-raf murine sarcoma 3611 viral oncogene homolog (Chr X)
Length = 604
Score = 1540 (547.2 bits), Expect = 1.8e-228, Sum P(2) = 1.8e-228
Identities = 297/411 (72%), Positives = 343/411 (83%)
Query: 181 NKDAFSFPSLCSDGQLLQRHRSTSTPNVHMVSTTSPVDNSILEFISRSHNAEVIVVGAXX 240
+++ FSFP+ + LQR RSTSTPNVHMVSTT+P+D+S+++F ++S + + G
Sbjct: 193 DQEHFSFPAPANPP--LQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAGRGGDG 250
Query: 241 XXXXXXXXXXXXXVSSMAAVSPGRRSPHPKSPGESPRERKAPSEDKKKPKSLGYRDSSYY 300
S A+VS GR+SPH K P E RERK+ +++KKK K+LGYRDS YY
Sbjct: 251 APRGS---------PSPASVSSGRKSPHSKLPSEQ-RERKSLADEKKKVKNLGYRDSGYY 300
Query: 301 WEVSPKEVTMQKRIGTGSFGTVFKGRWYGDVAIKILKVTNPTSEQVQAFKNEMQVLRKTR 360
WEV P EV + KRIGTGSFGTVF+GRW+GDVA+K+LKV PT+EQ QAFKNEMQVLRKTR
Sbjct: 301 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTR 360
Query: 361 HVNILLFMGFMTHPSFAIITQWCDGSSLYQHLHVQETPLEMVQRIDVARQTAQGMDYLHA 420
HVNILLFMGFMT P FAIITQWC+GSSLY HLHV +T +MVQ IDVARQTAQGMDYLHA
Sbjct: 361 HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA 420
Query: 421 KHIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQQVEQPGGSILWMSPEVIRMQD 480
K+IIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQ +EQP GS+LWM+ EVIRMQD
Sbjct: 421 KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQD 480
Query: 481 PNPYSFQSDVYSYGVVLYELLSGSLPYSHINNRDQIIFMVGRGYLSPDVSKVPSNCPKAM 540
PNPYSFQSDVY+YGVVLYEL++GSLPYSHI +RDQIIFMVGRGYLSPD+SK+ SNCPKAM
Sbjct: 481 PNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAM 540
Query: 541 RRLMCDCLKFKREERPLFPQILASIESLQHSLPRIERSASEPALHRVACDE 591
RRL+ DCLKF+REERPLFPQILA+IE LQ SLP+IERSASEP+LHR DE
Sbjct: 541 RRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADE 591
Score = 681 (244.8 bits), Expect = 1.8e-228, Sum P(2) = 1.8e-228
Identities = 136/233 (58%), Positives = 172/233 (73%)
Query: 1 GTIKVDLPNQQRTVVNVRPGTTVYSSLDKALKVRGLNQDCCVVYNLVAIRKTITDWETDL 60
GT+KV LPN+QRTVV VR G +VY SLDKALKVRGLNQDCCVVY L+ RKT+T W+T +
Sbjct: 19 GTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAI 78
Query: 61 VNLEGAELSVEVLENVPLTMHNFVRKTYFRMVFCDFCLKFLFHGFRCQTCGYKFHEHCSS 120
L+G EL VEVLE+VPLTMHNFVRKT+F + FCDFCLKFLFHGFRCQTCGYKFH+HCSS
Sbjct: 79 APLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSS 138
Query: 121 RVPTVCVDLATTHKPVY-SHDPWQYPPLWSDNASAALIQEPMTPQSIRTTCFMSCTQETK 179
+VPTVCVD++T + Y S + S + E +TPQ + F TQ+
Sbjct: 139 KVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEAPSNLSVNELLTPQG--PSPF---TQQR- 192
Query: 180 MNKDAFSFPSLCSDGQLLQRHRSTSTPNVHMVSTTSPVDNSILEFISRSHNAE 232
+++ FSFP+ + LQR RSTSTPNVHMVSTT+P+D+S+++F ++S + +
Sbjct: 193 -DQEHFSFPAPANPP--LQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTD 242
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