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Gene Model: Cat

NomenclatureGenomic Location
SymbolCatChromosome1
NameCatalaseLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 95 Mbp

Molecular Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.

2 H2O2 = O2 + 2 H2O.

Molecular Function Terms:

antioxidant activity
   peroxidase activity

binding
   ion binding
      cation binding
         metal ion binding
   tetrapyrrole binding
      heme binding

catalytic activity
   hydrolase activity
      hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
   oxidoreductase activity
      oxidoreductase activity, acting on peroxide as acceptor

Human Disease Association

Defects in CAT are the cause of acatalasia (ACATLAS) [MIM:115500]; also known as acatalasemia. This disease is characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.

Predicted Transcript
     1 ATGGCAGGCGGCCGGGACTATGCCGACGATCAGATGCAGCGCTGGAAAGACCAGCGCGGC
    61 TCTCAGAAAGCAGATGCCTTGACCACGGGCGCAGGAATCCCAGTGGGAGACAAACTGAAT
   121 GTCCTGACTGTGGGTCCACGAGGTCCTCTCTTGGTTCAGGATGTGGTTTTCACTGATGAG
   181 ATGGCACATTTTGACCGAGAGAGGATTCCTGAAAGAGTTGTTCATGCCAAAGGAGCAGGT
   241 GCTTTTGGGTATTTTGAAGTGACTCACGATATCACCAAATATTGCAAAGCAAAAGTGTTT
   301 GAGCACATTGGTAAAAAAACGCTCATCGCCATTCGATTTTCTACTGTTGCTGGTGAAGCA
   361 GGTTCAGCTGACACCGTTCGTGATCCTCGAGGTTTTGCAATGAAGTTCTATACAGAAGAG
   421 GGCAACTGGGACCTTGTAGGGAACAACACTCCCATCTTCTTTATTAGAGATGCAATGCTG
   481 TTTCCATCGTTTATCCATAGCCAAAAAAGGAATCCACAGACTCATCTGAAAGATCCAGAC
   541 ATGGTGTGGGACTTCTGGAGCCTTCGCCCTGAGTCTCTGCACCAGGTATCCTTTCTGTTC
   601 AGTGATCGTGGCATTCCAGATGGACATCGTCACATGAATGGCTATGGATCACATACTTTC
   661 AAGCTAGTGAATGCTGGTGGAAAAGCAGTATACTGCAAATTTCATGTAAAAACTGACCAG
   721 GGAATCAAAAATCTTTCTGTTGAAGAGGCAGGAAGGCTGGCTTCTGAAGATCCTGACTAT
   781 GCTCTACGTGATCTTTATAATGCTATTGCTCATGGCAATTATCCATCATGGACTTTCTAT
   841 ATTCAGGTCATGACATTTGAGCAAGCTGAGAGATTTCCTTTCAATCCTTTTGATTTAACT
   901 AAAATTTGGCCTCACAAGGATTATCCTCTCATCCCTGTGGGAAAGATTGTCTTAAACAAG
   961 AATCCAATCAACTATTTTGCTGAGGTGGAACAACTTGCCTTTGACCCAAGCAACATGCCC
  1021 CCAGGAGTTGAACCCAGCCCTGATAAAATGTTACAGGGGCGTCTTTTTTCCTATCCAGAC
  1081 ACCCATAGACACCGTCTGGGACCCAACTATTTGCAGATTCCTGTAAATTGCCCATGCCGA
  1141 GTTCGAGTGGCCAACTACCAGAGAGATGGATTCATGTGCATATCTGACAACCAAGGTGGT
  1201 GCTCCAAACTATTATCCAAACAGTTTTACTGGCCCTGAAGAGCAACCCAATTTGAAGGAG
  1261 ACCCGTGCAAATATTTCAGGTGATGTACAGCGCTTCAATAGTGCAAATGAAGATAATGTG
  1321 TCTCAGGTGCGAGACTTCTATACCAAAGTGTTGACAGAGGAAGAACGAGCGAGACTGTGT
  1381 AAAAACATTGCTGGCCACCTTAAGGATGCTCAACTTTTCATTCAGAAGAAAGCTGTGAAG
  1441 AACTTCACTGATGTTCATCCTGACTATGGTGCACGCATTCAAGCCCACTTGGATAAACAC
  1501 AATGCTAAAGGACCCAAAAAGGGTTATGTACACACTTATACCCAAACTTCAGATCAAACT
  1561 GGAAAGGAAAGAGCCAATCTGTAA

Predicted Protein Product
MAGGRDYADDQMQRWKDQRGSQKADALTTGAGIPVGDKLNVLTVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYCKAKVFEHIGKKTLIAIRFSTVAGEA
GSADTVRDPRGFAMKFYTEEGNWDLVGNNTPIFFIRDAMLFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNAGGKAVYCKFHVKTDQ
GIKNLSVEEAGRLASEDPDYALRDLYNAIAHGNYPSWTFYIQVMTFEQAERFPFNPFDLT
KIWPHKDYPLIPVGKIVLNKNPINYFAEVEQLAFDPSNMPPGVEPSPDKMLQGRLFSYPD
THRHRLGPNYLQIPVNCPCRVRVANYQRDGFMCISDNQGGAPNYYPNSFTGPEEQPNLKE
TRANISGDVQRFNSANEDNVSQVRDFYTKVLTEEERARLCKNIAGHLKDAQLFIQKKAVK
NFTDVHPDYGARIQAHLDKHNAKGPKKGYVHTYTQTSDQTGKERANL
Protein Alignment to Mouse
sp|P24270|CATA_MOUSE Catalase OS=Mus musculus GN=Cat PE=1 SV=3
        Length = 527

 Score = 2414 (854.8 bits), Expect = 2.3e-251, P = 2.3e-251
 Identities = 441/528 (83%), Positives = 479/528 (90%)

Query:     1 MAGGRDYADDQMQRWKDQRGSQKADALTTGAGIPVGDKLNVLTVGPRGPLLVQDVVFTDE 60
             M+  RD A DQM++WK+QR SQ+ D LTTG G P+GDKLN++T G RGPLLVQDVVFTDE
Sbjct:     1 MSDSRDPASDQMKQWKEQRASQRPDVLTTGGGNPIGDKLNIMTAGSRGPLLVQDVVFTDE 60

Query:    61 MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYCKAKVFEHIGKKTLIAIRFSTVAGEA 120
             MAHFDRERIPERVVHAKGAGAFGYFEVTHDIT+Y KAKVFEHIGK+T IA+RFSTVAGE+
Sbjct:    61 MAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHIGKRTPIAVRFSTVAGES 120

Query:   121 GSADTVRDPRGFAMKFYTEEGNWDLVGNNTPIFFIRDAMLFPSFIHSQKRNPQTHLKDPD 180
             GSADTVRDPRGFA+KFYTE+GNWDLVGNNTPIFFIRDA+LFPSFIHSQKRNPQTHLKDPD
Sbjct:   121 GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAILFPSFIHSQKRNPQTHLKDPD 180

Query:   181 MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNAGGKAVYCKFHVKTDQ 240
             MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNA G+AVYCKFH KTDQ
Sbjct:   181 MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNADGEAVYCKFHYKTDQ 240

Query:   241 GIKNLSVEEAGRLASEDPDYALRDLYNAIAHGNYPSWTFYIQVMTFEQAERFPFNPFDLT 300
             GIKNL V EAGRLA EDPDY LRDL+NAIA+GNYPSWTFYIQVMTF++AE FPFNPFDLT
Sbjct:   241 GIKNLPVGEAGRLAQEDPDYGLRDLFNAIANGNYPSWTFYIQVMTFKEAETFPFNPFDLT 300

Query:   301 KIWPHKDYPLIPVGKIVLNKNPINYFAEVEQLAFDPSNMPPGVEPSPDKMLQGRLFSYPD 360
             K+WPHKDYPLIPVGK+VLNKNP+NYFAEVEQ+AFDPSNMPPG+EPSPDKMLQGRLF+YPD
Sbjct:   301 KVWPHKDYPLIPVGKLVLNKNPVNYFAEVEQMAFDPSNMPPGIEPSPDKMLQGRLFAYPD 360

Query:   361 THRHRLGPNYLQIPVNCPCRVRVANYQRDGFMCISDNQGGAPNYYPNSFTGPEEQPNLKE 420
             THRHRLGPNYLQIPVNCP R RVANYQRDG MC+ DNQGGAPNYYPNSF+ PE+Q +  E
Sbjct:   361 THRHRLGPNYLQIPVNCPYRARVANYQRDGPMCMHDNQGGAPNYYPNSFSAPEQQRSALE 420

Query:   421 TRANISGDVQRFNSANEDNVSQVRDFYTKVLTEEERARLCKNIAGHLKDAQLFIQKKAVK 480
                  + DV+RFNSANEDNV+QVR FYTKVL EEER RLC+NIAGHLKDAQLFIQKKAVK
Sbjct:   421 HSVQCAVDVKRFNSANEDNVTQVRTFYTKVLNEEERKRLCENIAGHLKDAQLFIQKKAVK 480

Query:   481 NFTDVHPDYGARIQAHLDKHNAKGPKKGYVHTYTQT-SDQTGKERANL 527
             NFTDVHPDYGARIQA LDK+NA+ PK   +HTYTQ  S    K +ANL
Sbjct:   481 NFTDVHPDYGARIQALLDKYNAEKPKNA-IHTYTQAGSHMAAKGKANL 527