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Gene Model: Fzd8

NomenclatureGenomic Location
SymbolFzd8Chromosome2
NameFrizzled-8Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 74 Mbp

Molecular Function

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Molecular Function Terms:

binding
   protein binding
      protein domain specific binding
         Wnt-protein binding
      receptor binding

molecular transducer activity
   signal transducer activity
      signaling receptor activity
         transmembrane signaling receptor activity
            Wnt-activated receptor activity

receptor activity
   signaling receptor activity
      transmembrane signaling receptor activity
         Wnt-activated receptor activity

Human Disease Association

No disease association.

Predicted Transcript
     1 AGGGCCCGTTTCCCTTCGCCCAGCATGGATCGGAGTTTGCTCCTTGCTCTCCTGGCGCTG
    61 CTCCCGGCTTCGGCTTCAGCTTCGTCCTCGGCGTCGCTCTCGTGCCAGGAGATCACGGTG
   121 CCGCTGTGCAAAGGCATCGGCTACAACTACACCTCGATGCCCAACCAGTTCAACCACGAC
   181 ACGCAGGACGAGGCCGGGCTGGAGGTGCACCAGTTCTGGCCGCTGGTGGAGATCCAGTGC
   241 TCGTCGGACCTGCGCTTCTTCCTGTGCAGCATGTACACGCCCATCTGCCTGGAGGACTAC
   301 AAGAAGCCCCTGCCGCCCTGCCGCAGCGTCTGCGAGCGCGCCAAGGCCGGCTGCGCCCCG
   361 CTCATGCGCCAGTACGGCTTCGCCTGGCCCGACCGCATGCGCTGCGACCGCCTCCCGGCC
   421 CAGGGCGACCCCGACACGCTCTGCATGGACTACAACCGCAGCGAGGCCGCCACCACGCCG
   481 CCCCCGGCGCCGCCCCCGCAGGCCCCGCCGCCGCCGCCACCCCGGGCGCCCCCGCGCAAG
   541 CCCCTCCCGCCCTTGCCTCCGACGCCGCCCGGGGCGCCCCCGCTCTGCAAGCCCGACTGC
   601 GGGGCGCGGGGAGATGCACGCGCTCTACTTCCTTGTTCAAGACAGGGGCGCATCCCAAAC
   661 TTCCCCTGGCCTGCCAGAATCCTACTTCACCCCAACGAGCGCGCCTTCACCGCCTTCTGG
   721 ATCGGCCTCTGGACCATCATCTGCTTCCTCTCCACCTTCGCCACCGTCTCCACCTTCCTC
   781 ATCGACATGGAGCGCTTCAAGTACCCCGAGAGGCCCATCGTCTTCCTGGCCGCCTGCTAC
   841 CTCTTCGTCTCGCTGGGCTACCTGGTCCGCTTGGTGGCCGGGCACGAGAAGGTGGCCTGC
   901 AGTGCCGGGGCTGAGCATGTGCGCTACGAGAGCACGGGGCCGGCCCTCTGCACTGTGGTC
   961 TTCCTGCTGGTCTACTTCTTCGGCATGGCCAGCTCCATCTGGTGGGTCATCCTCTCCCTC
  1021 ACTTGGTTCCTGGCGGCAGGCATGAAGTGGGGCAACGAGGCCATCGCCAGCTATGCCCAG
  1081 TACTTCCACTTGGCAGCCTGGCTGCTGCCCAGCGTCAAGTCCATTGCGGTGCTGGCCCTC
  1141 AGCTCGGTGGATGGGGACCCCGTGGCCGGCATTTGCTACGTGGGCAACCAGAGTCTGGAG
  1201 AACCTGCGGGGCTTTGTGCTGGCTCCTCTGCTCATCTACCTGGCCATTGGCTCTATGTTC
  1261 CTGCTGGCTGGCTTCGTTTCGCTCTTCCGCATCCGGAGCGTCATCAAGCAGCAGGGCGGG
  1321 CCCACCAAGACACACAAGCTGGAGAAGCTCATGATCCGGTTGGGGCTCTTCACCGTTCTC
  1381 TACACTGTCCCAGCGGCCAGCGTGGTGGCCTGCCTCTTCTACGAGCAGCACAACCGGCCG
  1441 CGCTGGGAGGCCACCCACAACTGCCCCTGCCTCCGGGACCAGCAGCCCGACCAGGCCCGC
  1501 CGGCCGGACTACGCCGTCTTCATGCTCAAATACTTCATGTGCCTGGTGGTGGGCATCACT
  1561 TCCGGGGTGTGGGTCTGGTCCGGGAAGACGCTGGAGTCCTGGAAAGCCTTGTGCACACGT
  1621 TGCTGCTGGGCCAGCAAGGCAGCAGCGGTGGGGGGACTCGGGGGCGGAGCGGGCTCCATG
  1681 TACAGTGACATCAGCACCGGCTTGACGTGGAGGTCTGGCACTGCCAGTTCAGTCTCGTAC
  1741 CCAAAACAGATGCCCTTGTCCCAGGTGTAA

Predicted Protein Product
RARFPSPSMDRSLLLALLALLPASASASSSASLSCQEITVPLCKGIGYNYTSMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSSDLRFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPAQGDPDTLCMDYNRSEAATTPPPAPPPQAPPPPPPRAPPRK
PLPPLPPTPPGAPPLCKPDCGARGDARALLPCSRQGRIPNFPWPARILLHPNERAFTAFW
IGLWTIICFLSTFATVSTFLIDMERFKYPERPIVFLAACYLFVSLGYLVRLVAGHEKVAC
SAGAEHVRYESTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYAQ
YFHLAAWLLPSVKSIAVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLLIYLAIGSMF
LLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAASVVACLFYEQHNRP
RWEATHNCPCLRDQQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWKALCTR
CCWASKAAAVGGLGGGAGSMYSDISTGLTWRSGTASSVSYPKQMPLSQV
Protein Alignment to Mouse
sp|Q61091|FZD8_MOUSE Frizzled-8 OS=Mus musculus GN=Fzd8 PE=1 SV=1
        Length = 685

 Score = 1248 (444.4 bits), Expect = 7.6e-247, Sum P(4) = 7.6e-247
 Identities = 230/242 (95%), Positives = 238/242 (98%)

Query:   305 EHVRYESTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYAQYFHL 364
             +HVRYE+TGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIA Y+QYFHL
Sbjct:   382 QHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHL 441

Query:   365 AAWLLPSVKSIAVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLLIYLAIGSMFLLAG 424
             AAWL+PSVKSIAVLALSSVDGDPVAGICYVGNQSL+NLRGFVLAPL+IYL IG+MFLLAG
Sbjct:   442 AAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAG 501

Query:   425 FVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAASVVACLFYEQHNRPRWEA 484
             FVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAA VVACLFYEQHNRPRWEA
Sbjct:   502 FVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEA 561

Query:   485 THNCPCLRDQQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWKALCTRCCWA 544
             THNCPCLRD QPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESW+ALCTRCCWA
Sbjct:   562 THNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWA 621

Query:   545 SK 546
             SK
Sbjct:   622 SK 623

 Score = 661 (237.7 bits), Expect = 7.6e-247, Sum P(4) = 7.6e-247
 Identities = 114/121 (94%), Positives = 118/121 (97%)

Query:    35 CQEITVPLCKGIGYNYTSMPNQFNHDTQDEAGLEVHQFWPLVEIQCSSDLRFFLCSMYTP 94
             CQEITVPLCKGIGYNYT MPNQFNHDTQDEAGLEVHQFWPLVEIQCS DL+FFLCSMYTP
Sbjct:    35 CQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTP 94

Query:    95 ICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPAQGDPDTLCMDYNRS 154
             ICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLP QG+PDTLCMDYNR+
Sbjct:    95 ICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRT 154

Query:   155 E 155
             +
Sbjct:   155 D 155

 Score = 362 (132.5 bits), Expect = 7.6e-247, Sum P(4) = 7.6e-247
 Identities = 72/117 (61%), Positives = 84/117 (71%)

Query:   196 CKPDCGARG-------DARALLPCSRQGRIPNFPWPARI-LLHPNERAFTAFWIGLWTII 247
             C+P C  R        +   L    + G+I N   P        +ERAFT FWIGLW+++
Sbjct:   225 CEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVL 284

Query:   248 CFLSTFATVSTFLIDMERFKYPERPIVFLAACYLFVSLGYLVRLVAGHEKVACSAGA 304
             CF+STFATVSTFLIDMERFKYPERPI+FL+ACYLFVS+GYLVRLVAGHEKVACS GA
Sbjct:   285 CFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGA 341

 Score = 154 (59.3 bits), Expect = 7.6e-247, Sum P(4) = 7.6e-247
 Identities = 29/31 (93%), Positives = 31/31 (100%)

Query:   559 SMYSDISTGLTWRSGTASSVSYPKQMPLSQV 589
             S+YSD+STGLTWRSGTASSVSYPKQMPLSQV
Sbjct:   655 SLYSDVSTGLTWRSGTASSVSYPKQMPLSQV 685