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Gene Model: Tat

NomenclatureGenomic Location
SymbolTatChromosome2
NameTyrosine aminotransferaseLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 40 Mbp

Molecular Function

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has no transaminase activity towards phenylalanine.

Molecular Function Terms:

binding
   amine binding
      amino acid binding
   cofactor binding
      pyridoxal phosphate binding
   vitamin binding
      vitamin B6 binding
         pyridoxal phosphate binding

catalytic activity
   lyase activity
      carbon-sulfur lyase activity
   transferase activity
      transferase activity, transferring nitrogenous groups
         transaminase activity

Human Disease Association

Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.

Predicted Transcript
     1 ATGGATTCGTACCTGATCCAGGTGACCGGCAAGTCGGCCTTCCCCTCTGTGATGGATGTC
    61 CAGCTGGGACGGGCCGGACGGGGCCCCTGCTGCGTGGCTGGCAAGGGAAAAGGGCACCGC
   121 AAGCCTCACTGGGCCGTCCGGGCCTCTGAGATGTCCAAGCGGACCTTCAACCCCATCCGG
   181 GCCATTGTGGACAGCATGAAGGTGGAGCCCCACCCGCAGAAGCCCCTCATCTCCCTCTCC
   241 ATCGGGGACCCCACGGTCTTTGGGAACCTGCCCACGGACGAACAGGTCACCCAGGCCATG
   301 AAGACGGCCCTGGACTCCAGGAAGTACGATGGCTATGCTCCTTCCACAGGTTACCTGTCC
   361 AGCCGTGACGTGGTTGCAAAGTACTACAGCTGCCCCGAAGCACCCCTCGAAGCCAAGGAT
   421 GTGATCCTGACCAGCGGCTGCAGCCAAGCCATCGAGTTGGCCCTGGCTGTTTTGGCCAAC
   481 CCTGGGCAGAACATTCTGGTGCCGCGTCCAGGCTTCTCCCTCTACAAGACCTTGGCTCAT
   541 TCCTTGGGGATTGAAGTCAAGTTCTACGACCTCTTGCCAGAGAAATCCTGGGAAATTGAC
   601 CTGAAGCAGATGGAGTCCCTGGTGGATGAGAAGACAGCCTGTTTGGTGGTCAACAACCCC
   661 TCCAACCCATGCGGCTCCGTCTTCAGCAAAGGCCACCTCCAGAAGTTCCTGGCAGTGGCT
   721 TCCCGGCAATGCGTCCCCATCCTGGCTGATGAGATCTATGCCGAGATGGTCTTTGAAGAA
   781 GGGCAGTCCGAGTCCCTGGCCAAGCTCAGCACCAATGTGCCCATCCTGTCCTGTGGCGGT
   841 CTGGCGAAGCGGTGGCTGGTGCCCGGCTGGAGGATGGGCTGGATCCTCATCCACGACCGC
   901 AGGGAGATCTTTGGGAAGGAGATCAGGGATGGCCTCCTGCGGCTGAGCCAGAGGATCCTG
   961 GGGCCCTGCACCGTGGTCCAAGGGCTCGCACACATCATGCACCGGACACCCCCTGAATTC
  1021 TACCAAAACACCCTCAGCTTCCTCAAGTCCAATGCTGACCTCTGCTACTCTGCGCTTTCC
  1081 ACCATCTGTGGGCTACGGCCAGTCCGACCCTCGGGAGCCATGTACCTCATGGTGGGCATC
  1141 AAGATGGAGCATTTCCCCGAGTTCGAGAATGACGTGGAGTTCACGGAGCGACTCATTGCA
  1201 GAGCAGTCGGTCTTCTGCCTGCCTGCAACGTGCTTTGAATACCCCAACTTCTTCCGGGTG
  1261 GTGCTCACGGTGCCTGAGGACATGATGGCGGAGGCCTGCCAGCGCATCCAGCAGTTCTGC
  1321 GAGCAGCACTACGAAAGCGCCCAGGACATGGAGTGTGACAAGTAG

Predicted Protein Product
MDSYLIQVTGKSAFPSVMDVQLGRAGRGPCCVAGKGKGHRKPHWAVRASEMSKRTFNPIR
AIVDSMKVEPHPQKPLISLSIGDPTVFGNLPTDEQVTQAMKTALDSRKYDGYAPSTGYLS
SRDVVAKYYSCPEAPLEAKDVILTSGCSQAIELALAVLANPGQNILVPRPGFSLYKTLAH
SLGIEVKFYDLLPEKSWEIDLKQMESLVDEKTACLVVNNPSNPCGSVFSKGHLQKFLAVA
SRQCVPILADEIYAEMVFEEGQSESLAKLSTNVPILSCGGLAKRWLVPGWRMGWILIHDR
REIFGKEIRDGLLRLSQRILGPCTVVQGLAHIMHRTPPEFYQNTLSFLKSNADLCYSALS
TICGLRPVRPSGAMYLMVGIKMEHFPEFENDVEFTERLIAEQSVFCLPATCFEYPNFFRV
VLTVPEDMMAEACQRIQQFCEQHYESAQDMECDK
Protein Alignment to Mouse
sp|Q8QZR1|ATTY_MOUSE Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1
            SV=1
      MGI:98487 Tat tyrosine aminotransferase (Chr 8)
        Length = 454

 Score = 1872 (664.0 bits), Expect = 6.2e-194, P = 6.2e-194
 Identities = 359/457 (78%), Positives = 396/457 (86%)

Query:     1 MDSYLIQVTGKSAFPSVMDVQLGRAGRGPCCVAGKGKGHRKPHWAVRASEMSKRTFNPIR 60
             MDSY+IQ     + PSV+DV++   GR    V G+ KG RK  W VR S+MS +TFNPIR
Sbjct:     1 MDSYVIQTNVNDSLPSVLDVRVNIGGRSS--VQGRAKG-RKARWNVRPSDMSNKTFNPIR 57

Query:    61 AIVDSMKVEPHPQKPLISLSIGDPTVFGNLPTDEQVTQAMKTALDSRKYDGYAPSTGYLS 120
             AIVD+MKV+P+P K +ISLSIGDPTVFGNLPTD +VTQAMK ALDS KY+GYAPS GYLS
Sbjct:    58 AIVDNMKVKPNPNKTVISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGYLS 117

Query:   121 SRDVVAKYYSCPEAPLEAKDVILTSGCSQAIELALAVLANPGQNILVPRPGFSLYKTLAH 180
             SR+ VA YY CPEAPLEAKDVILTSGCSQAIEL LAVLANPGQNIL+PRPGFSLY+TLA 
Sbjct:   118 SREEVASYYHCPEAPLEAKDVILTSGCSQAIELCLAVLANPGQNILIPRPGFSLYRTLAE 177

Query:   181 SLGIEVKFYDLLPEKSWEIDLKQMESLVDEKTACLVVNNPSNPCGSVFSKGHLQKFLAVA 240
             S+GIEVK Y+LLPEKSWEIDLKQ+ESL+DEKTACLVVNNPSNPCGSVFSK HLQK LAVA
Sbjct:   178 SMGIEVKLYNLLPEKSWEIDLKQLESLIDEKTACLVVNNPSNPCGSVFSKRHLQKILAVA 237

Query:   241 SRQCVPILADEIYAEMVFEEGQSESLAKLSTNVPILSCGGLAKRWLVPGWRMGWILIHDR 300
              RQCVPILADEIY +MVF + + E +A LSTNVPILSCGGLAKRWLVPGWR+GWILIHDR
Sbjct:   238 ERQCVPILADEIYGDMVFSDCKYEPMATLSTNVPILSCGGLAKRWLVPGWRLGWILIHDR 297

Query:   301 REIFGKEIRDGLLRLSQRILGPCTVVQG-LAHIMHRTPPEFYQNTLSFLKSNADLCYSAL 359
             R+IFG EIRDGL++LSQRILGPCT+VQG L  I+ RTP EFYQ+TLSFLKSNADLCY AL
Sbjct:   298 RDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILQRTPQEFYQDTLSFLKSNADLCYGAL 357

Query:   360 STICGLRPVRPSGAMYLMVGIKMEHFPEFENDVEFTERLIAEQSVFCLPATCFEYPNFFR 419
             S I GL+PVRPSGAMYLMVGI+MEHFPEFENDVEFTERLIAEQSV CLPATCFEYPNFFR
Sbjct:   358 SAIPGLQPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLIAEQSVHCLPATCFEYPNFFR 417

Query:   420 VVLTVPEDMMAEACQRIQQFCEQHYESAQDM--ECDK 454
             VV+TVPE MM EAC RIQ+FCEQHY  A+    ECDK
Sbjct:   418 VVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK 454