| Nomenclature | Genomic Location |
| Symbol | Als2 | Chromosome | 1 |
| Name | Alsin | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 42 Mbp |
| Molecular Function |
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May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
Molecular Function Terms:
binding
protein binding
enzyme binding
enzyme regulator activity
enzyme activator activity
GTPase activator activity
kinase activator activity
nucleoside-triphosphatase regulator activity
GTPase regulator activity
guanyl-nucleotide exchange factor activity
small GTPase regulator activity
kinase regulator activity
kinase activator activity
protein kinase regulator activity
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| Human Disease Association |
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Defects in ALS2 are the cause of amyotrophic lateral sclerosis type 2 (ALS2) [MIM:205100]. ALS2 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
Defects in ALS2 are the cause of juvenile primary lateral sclerosis (JPLS) [MIM:606353]. JPLS is a neurodegenerative disorder which is closely related to but clinically distinct from amyotrophic lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the upper motor neurons of the motor cortex while the lower neurons are unaffected.
Defects in ALS2 are the cause of infantile-onset ascending spastic paralysis (IAHSP) [MIM:607225]. IAHSP is characterized by progressive spasticity and weakness of limbs.
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1 ATGGACTCGGAAAAAAAAAGTTTGCTAAGCAATTCTGCAGATCAAAACGGTGAAAGAGGC
61 CTGGCTTACATATGGCAAGCTGGTTGCGCTTTTCCAGCCCCAGAAAGGCTTCTAGGTTGG
121 AATGCAAAAACAGTATTGCAGGCAGCACTTGGAGTAAATCATGGTGTGCTTCTATCAGAA
181 GGTGGTGAGGTTTACACGTTTGGAAAACTTCCATGGAGGGTTGGACTGGAAGATGCATAT
241 ATCAGTTGTCCCATTTTGGAAAAGACTTTGAGTGGGCAACACATTACCATAGTGGCAGCT
301 GGGAGCTTCCATTGTGGAGCAGTTGCTGAAGATGGTGTGGTGTACATGTGGGGGGAAAAT
361 TCTTCTGGGCAGTGTGCTGTGGCCAGCCAGTCTGCTGTGCCAGAACCAAAACCTGTCAGT
421 ATTTCAGACTCTGAAGCTAGTAACCTTTTGCCAATACGGATTTTGCAGCTGGCGTGTGGA
481 AAGGAGCACACCCTGGCTCTTTCACTAAACAGAGAGATATGGGCATGGGGAAGCGGCTGT
541 CAGCTCGGCCTTATAACCAACACTTTCCCAGTGACCAAACCTCAAAAGGTTGAGTACCTT
601 GCAGGGCGGGTTGTACTTCAGATTGCTTGTGGGGCTTATCACAGCCTTGCTCTTGTCCAG
661 TGCCTCCCCACTCAAGATGTGAAACCTATCCCAGAAAGATGCAATCATTGCAGTCAGCTC
721 TTGATTACTATGACAGACAAAGAAGATCATGTGATCATCTCGGATAGTCATTGCTGTCCT
781 TTAGGTGTAGTCCTGGCTGACACTCAATCAGAAAACCACCTCAATTGCTCCTCAGTAGAA
841 ACTCTTGGGGAGAAGAGTACAACCAGCAGCCAAAATGGGGATTATCAGAAGACTGCTACA
901 GAAGACCAGGTGCTAATGGCTACAGAATATAATGCAGCTAATGTTTTTTCAAATAGTGTT
961 GGACAGGATGGCCACTGCATTTCAAGTCCAGGAAATCTTTTGGCAACTGACAAAACAGCA
1021 CCGAAACAAGACCATATGAGTCTTCCAAATCACTCATTGAGTGGAGAGAATATAAGAATG
1081 CTGACATTTTTGCATATGCTAGCAGAAAGAAGCAAATTTGTTCAAAAACCTTCTAACTGG
1141 CAGCAATTGGAAGAAAATTACATTGCTTGTCTGCCCAGTCCATCTGGACCAGGTACTTCT
1201 GCCCTTAATAGCCTGGTAGTCTCATGTGCATCAGCAGTTGGAGTAAGAGTAGCTGCCACC
1261 TATGAAGCTGGGGCCTTATCGCTGAAGAAAGTAATGAACTTCTATGGCACCATTCCCAGT
1321 GATGCTGTTTCCCCATCTAGTGGTGGTTCTCCCACCTTGGATAGCCTGAAGGATAGCAGA
1381 GAAGAGCAGGTCAAGCTGGAATCAATGCAAGGAAAAAAGAGTTCCAGCTTGGTAGATATT
1441 CGAGAAGAAGAATCTGAAGGAATTTCTAGAAGACTTTCTTTACCTGGTTTGCTGTCCCAA
1501 GTTTCTCCAAGACTCTTGAGGAAAGTAGGGAGAGCCAGAATGAGAACAGTGGCCCTCACA
1561 CCAACCTATAGTGGTGAAGCTGATGCACTTCTCCCATCTTTGCGAACTGAGGTATGGAGT
1621 TGGGGAAAAGGAAAAGAAGGACAATTAGGACATGGTGATGTCTTGCCAAGGTTACAACCA
1681 ATGTCTGTAAAAAGTCTTGATGGCAAGGAAGTAATTCAATTGTCTGCAGGTGGCCATCAT
1741 TCCTTGGCCCTCACTGCCAAATCACAGGTATATTCATGGGGCAGTAATACTTTTGGACAG
1801 CTCAGTCACTTAAGTTCTCCAACCACAGTTCCTCGTCTTGCAAAGGTTTGCGGTGACAAC
1861 AACATCTGGAATATAGCAGCAGGTCCAGATTATTCACTCTTCCTGATAGATGGAGACGAT
1921 TTCCAACCTTCGTTGTATTATAGTGGTCGACAGGAAAAAGGAAAAGATTACTCTTTATCA
1981 GAAGAAAGCTGTTTCAAGAGTCCAACACTATTGCTAGACTGTAGTAAGCTAGGGTATATT
2041 AGTAGTGTGGCAGCAGGTGGGAGCAACTGTCTGGCTTTGGTGGACAAAAACATTATGGGA
2101 TACATTGCTAGTCTGCATGAGCTGGCTTCAACGGAAAGACAGTTTTACTCCAAACTGAGT
2161 TCCATAAAATCTCAAGTTCTCCGACCTCTCCTGGGGTTAGATAATTTAGGTGCTCCCTCA
2221 ACAGTCCAACTCTTGCAAGAAGTGGCAAGTAAGTTTAGCAAGTTGTGCTACTTAATTGGT
2281 CAACATGGAGCTTCTTTGACTGACTTTCTTCAAGGATTAAAAGAGGCAAAAAACTTGGCT
2341 ATCCTGAAGCATTCAAGCCTTTTTTTGGAAAGTTACACCGAGTATTGTACTTCCTTGACA
2401 AATTTTCTGGTGATGGGAGGATTTGCCCTTCTTGCCAAACCAGCAGTGGATTTCTTAAGT
2461 AAAAACCTGGCATTGCTCCAGGATCTGTCAGAGACAAATGAGGAAAGTTGCCCATTAGTG
2521 GAAGTGCTAAATGCTCTGTTTTTCTTGCCGCTCAGACGACTTCATAATTATGCTAGAGTT
2581 TTACTAAAACTTGCTACATGTTTCGAAGTGACATCTCCAGAATACCAGAGTCTTCAGGAT
2641 TCTAGTTCTTGTTATGAAGCCCTAGCAGTCCATCTGAGTCGAAAAAGAAAAGAGGCAGAA
2701 TATACCCTGGGGTTCTGGAAGACTTTTCCTGGGAAAATGACAGATTCCCTGAGAAAACCT
2761 GAGCGACGATTAATCTGTGAAAGCAGCAACCGTGCTCTGTCCCTGCAGCATGCTGGAAGG
2821 TTCTCAGTGAATTGGTTCATCCTCTTCAATGATGCCTTGGTCCATGCCCAGTTCTCAACT
2881 CATCATATATTTTCCTTATCCACACTGTGGGTTGAACCAGTTTCGGAAGAGTCTGGCAAT
2941 ATGAATGGTTTGAGAGTCACTACACCTGAAGAACAGTTCATTCTTATTTCATCCACTCCA
3001 CAGGAAAAGACTAAATGGTTGAGAGCTATCAGCCAAGCTGTGGATCAGGCCTTAAAGGGG
3061 ACATCTGACTTGCCTCCCTATGTGGGAAGTGGAAGCATTCAGAGGCAGGAACCTCCTATC
3121 TCGCGAAGTGCCAAGTACACCTTTTACAAGGATCCTCGGCTTAAGGATGCCAGTTACGAT
3181 GGCCGATGGCTTTCTGGAAAACCACATGGCAGAGGAGTTTTGAAATGGGCAGATGGAAGA
3241 ATGTATTCTGGCATGTTCAGAAATGGCCTGGAAGATGGACATGGTGAATATACAGTACCA
3301 AACAAAATACTAAAGAAGAATGACCACTATGTTGGATATTGGAAAGAAGGCAAAATGTGC
3361 GGACAAGGCACCTACAACTATGCCACTGGAGAAGTGTATGAAGGGAGCTTTCAGGATAAC
3421 ATGCGCCACGGCCATGGTCTCCTGCGCAGTGGCAAACTGACTTCTTCTTCTCCCAGTATG
3481 TTCATTGGTCAGTGGGTGATGGACAAGAAAACTGGTTATGGAGTATTTGATGACATTACA
3541 AGGGGAGAAAAATATATGGGAATGTGGCAAGATGACCTTTGCCAAGGCAATAGTGTTGTT
3601 GTCACTCAGTTTGGACTGTATTACGAAGGAGCCTTTAACAACAATAAAATGATGGGGTCT
3661 GGTGTTTTGCTTTCTGAAGACGATACAGTGTATGAAGGAGAGTTCTCAGATAACTGGACT
3721 CTTAATGGGAAGGGAACACTGATTTTGCCAAATGGAGACACCATTGAAGGTTCTTTCAGT
3781 GGTGAGTGGGGATCTGGGATAAAGATCACTGGGACATACTTCAAACCCACTTTATATGAT
3841 CCTGAGAAGGAACGACCCAAAAGACTGCGGAAACTTGGAAACCTTGCTGTTCCTGCTGAT
3901 GAGAAGTGGAAGGCAGTGTTTGACGAATGCTGGCATCAATTGGGCTGTGAACAGGCAGGC
3961 CAAGGGGATCGGTGGAAGGCCTGGGATAACATTGCTGTGGCCCTGACAACAAATCGGCGT
4021 CAACACAAAGATAGTCCAGAAATGTTGAGTCGGTCACATACACAAACCCTGGAGAGTTTG
4081 GAGTTTATTCCACAGCATGTCGGCACCTTCTCATTGGAAAAATATGACAGCATTAAAAAA
4141 TATATCATAAAGGCATGTGACACCCCTCTTCATCCTTTGGGTAAGCTTGTGGAGACCTTA
4201 GTAGCGGTCTACCGGATGACATATGTAGGAGTGGGTGCCAATCGGCGGCTGTTGCAGGAA
4261 GCAGTCCGGGAAATTAAATCCTACCTCAAACGCATCTTCCAATTGGTCAGGAGATTCCTG
4321 TTCCCTGACCTTCCTGAAGAGGGCAGTACAATTCCATTTTTGTTGATTGAAACCAAGGGA
4381 AGAAGATCATTCTGTAGTGGGAGAAGTGACTCTAGACCCGATTCTCCAGAACCAGGTTAT
4441 GTCGTCACAAGCTCTGGGTTGCTACTTCCAGTGTTGCTGCCACGACTCTACCCTCCTTTG
4501 TTTATGCTGTATGCCTTGGACAATGAGCGAGAGGAAGATGTTTACTGGGAATGTGTCCTG
4561 CGTCTGAATAAACAACCAGACACAGCACTCTTGAGCTTTTTGGGAGTACAAACGAAATTT
4621 TGGCCAACAACGACATCGGTCCTTGGGGAAAATAAAAAGGTATTGCCAAGTACAAAGAAT
4681 GCCTGTTTTGCTTCTGCGGTGGAATGCTTGCAACAGATCAGTACAACTTTTACACCTGCT
4741 GACAAACTGAAAGTGATCCAGCAGACCTTTGAGGAGATCTCCCAGAATGTACTTGAGAAT
4801 CTTCACGAAGATTTCCTTTGGTCCATGGATGATTTGTTTCCTGTTTTCCTATATGTGGTG
4861 CTACGAGCCAGGATAAGGAATCTGGGATCTGAAGTACACTTGATTGAGGACCTGATGGAC
4921 CCATTTCTTCAGCATGGAGAGCAAGGCATTATGTTTACTACTTTGAAGGCATGTTATTAC
4981 CAGATTCAACATGAAAAGCTGACCTAA
| Predicted Protein Product |
MDSEKKSLLSNSADQNGERGLAYIWQAGCAFPAPERLLGWNAKTVLQAALGVNHGVLLSE
GGEVYTFGKLPWRVGLEDAYISCPILEKTLSGQHITIVAAGSFHCGAVAEDGVVYMWGEN
SSGQCAVASQSAVPEPKPVSISDSEASNLLPIRILQLACGKEHTLALSLNREIWAWGSGC
QLGLITNTFPVTKPQKVEYLAGRVVLQIACGAYHSLALVQCLPTQDVKPIPERCNHCSQL
LITMTDKEDHVIISDSHCCPLGVVLADTQSENHLNCSSVETLGEKSTTSSQNGDYQKTAT
EDQVLMATEYNAANVFSNSVGQDGHCISSPGNLLATDKTAPKQDHMSLPNHSLSGENIRM
LTFLHMLAERSKFVQKPSNWQQLEENYIACLPSPSGPGTSALNSLVVSCASAVGVRVAAT
YEAGALSLKKVMNFYGTIPSDAVSPSSGGSPTLDSLKDSREEQVKLESMQGKKSSSLVDI
REEESEGISRRLSLPGLLSQVSPRLLRKVGRARMRTVALTPTYSGEADALLPSLRTEVWS
WGKGKEGQLGHGDVLPRLQPMSVKSLDGKEVIQLSAGGHHSLALTAKSQVYSWGSNTFGQ
LSHLSSPTTVPRLAKVCGDNNIWNIAAGPDYSLFLIDGDDFQPSLYYSGRQEKGKDYSLS
EESCFKSPTLLLDCSKLGYISSVAAGGSNCLALVDKNIMGYIASLHELASTERQFYSKLS
SIKSQVLRPLLGLDNLGAPSTVQLLQEVASKFSKLCYLIGQHGASLTDFLQGLKEAKNLA
ILKHSSLFLESYTEYCTSLTNFLVMGGFALLAKPAVDFLSKNLALLQDLSETNEESCPLV
EVLNALFFLPLRRLHNYARVLLKLATCFEVTSPEYQSLQDSSSCYEALAVHLSRKRKEAE
YTLGFWKTFPGKMTDSLRKPERRLICESSNRALSLQHAGRFSVNWFILFNDALVHAQFST
HHIFSLSTLWVEPVSEESGNMNGLRVTTPEEQFILISSTPQEKTKWLRAISQAVDQALKG
TSDLPPYVGSGSIQRQEPPISRSAKYTFYKDPRLKDASYDGRWLSGKPHGRGVLKWADGR
MYSGMFRNGLEDGHGEYTVPNKILKKNDHYVGYWKEGKMCGQGTYNYATGEVYEGSFQDN
MRHGHGLLRSGKLTSSSPSMFIGQWVMDKKTGYGVFDDITRGEKYMGMWQDDLCQGNSVV
VTQFGLYYEGAFNNNKMMGSGVLLSEDDTVYEGEFSDNWTLNGKGTLILPNGDTIEGSFS
GEWGSGIKITGTYFKPTLYDPEKERPKRLRKLGNLAVPADEKWKAVFDECWHQLGCEQAG
QGDRWKAWDNIAVALTTNRRQHKDSPEMLSRSHTQTLESLEFIPQHVGTFSLEKYDSIKK
YIIKACDTPLHPLGKLVETLVAVYRMTYVGVGANRRLLQEAVREIKSYLKRIFQLVRRFL
FPDLPEEGSTIPFLLIETKGRRSFCSGRSDSRPDSPEPGYVVTSSGLLLPVLLPRLYPPL
FMLYALDNEREEDVYWECVLRLNKQPDTALLSFLGVQTKFWPTTTSVLGENKKVLPSTKN
ACFASAVECLQQISTTFTPADKLKVIQQTFEEISQNVLENLHEDFLWSMDDLFPVFLYVV
LRARIRNLGSEVHLIEDLMDPFLQHGEQGIMFTTLKACYYQIQHEKLT
| Protein Alignment to Mouse |
sp|Q920R0|ALS2_MOUSE Alsin OS=Mus musculus GN=Als2 PE=1 SV=2
MGI:1921268 Als2 amyotrophic lateral sclerosis 2 (juvenile) homolog (human) (Chr 1)
Length = 1651
Score = 6491 (2290.0 bits), Expect = 0., P = 0.
Identities = 1243/1669 (74%), Positives = 1396/1669 (83%)
Query: 1 MDSEKKSLLSNSADQNGERGLAYIWQAGCAFPAPERLLGWNAKTVLQAALGVNHGVLLSE 60
MDS+KKS S A+ + ERGL ++WQAG PERL GW KTVLQAALGV HGVLL+E
Sbjct: 1 MDSKKKS--STEAEGSKERGLVHVWQAGSFSLTPERLPGWGGKTVLQAALGVRHGVLLTE 58
Query: 61 GGEVYTFGKLPWRVGLEDAYISCPILEKTLSGQHITIVAAGSFHCGAVAEDGVVYMWGEN 120
GEVY+FG LPW+ + S P+LE L G H+ VA GSFH GAV E GVVYMWGEN
Sbjct: 59 DGEVYSFGTLPWKSESAEICPSSPLLESALVGHHVITVATGSFHSGAVTESGVVYMWGEN 118
Query: 121 SSGQCAVASQSAVPEPKPVSISDSEASNLLPIRILQLACGKEHTLALSLNREIWAWGSGC 180
++GQCAVA+Q VPEP PVSISDSE S L +RILQLACG+EHTLALSL+REIWAWG+GC
Sbjct: 119 AAGQCAVANQQYVPEPSPVSISDSETSPSLAVRILQLACGEEHTLALSLSREIWAWGTGC 178
Query: 181 QLGLITNTFPVTKPQKVEYLAGRVVLQIACGAYHSLALVQCLPTQDVKPIPERCNHCSQL 240
QLGLIT TFPVTKPQKVE+LAGRVVLQ+ACGA+HSLALVQCLP QD+KP+PERCN CSQL
Sbjct: 179 QLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPPQDLKPVPERCNQCSQL 238
Query: 241 LITMTDKEDHVIISDSHCCPLGVVLADTQSENHLNCSSVETLGEKSTTSSQNGDYQKTAT 300
LITMTDKEDHVIISDSHCCPLGV L+++Q+E H +S Q ++ T
Sbjct: 239 LITMTDKEDHVIISDSHCCPLGVTLSESQAEKH---ASPAPSPHPEALDEQGEVFENTVV 295
Query: 301 EDQVLMATEYNAANVFSNSVGQDGHCISSPGNLLATDKTAPKQDHMSLPN-HSLSGENIR 359
E ++ M + + G IS+ N++ T + + + S P+ H+++ ++
Sbjct: 296 EAELNMGSSQTTS----------GSAISTQQNIVGTAEVSSARTAPSYPDTHAVTAY-LQ 344
Query: 360 MLTFLHMLAERSKFVQKPSNWQQLEENYIACLPSPSGPGTSALNSLVVSCASAVGVRVAA 419
L+ H + E + +KP Q L E + L SP TSALNSLVVSCASAVGVRVAA
Sbjct: 345 KLSE-HSMRENHEPGEKPPQVQPLVEEAVPDLHSPPTTSTSALNSLVVSCASAVGVRVAA 403
Query: 420 TYEAGALSLKKVMNFYGTIPSDAVSPSSGGSPTLDSLKDSREEQVKLESMQGKKSSSLVD 479
TYEAGALSLKKVMNFY T P + + S S +SLKD REEQVK ES+QGKKSSSL+D
Sbjct: 404 TYEAGALSLKKVMNFYSTAPCETAAQSGSASTGPESLKDLREEQVKQESLQGKKSSSLMD 463
Query: 480 XXXXXXXXXXXXXXXPGLLSQVSPRLLRKVGRARMRTVALTPTYSGEADALLPSLRTEVW 539
PGLLSQVSPRLLRK R + RTV LTPTYSGEADALLPSLRTEVW
Sbjct: 464 IREEESEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVW 523
Query: 540 SWGKGKEGQLGHGDVLPRLQPMSVKSLDGKEVIQLSAGGHHSLALTAKSQVYSWGSNTFG 599
+WGKGKEGQLGHGDVLPRLQP+ VK LDGKEVI L AGG HSLALTAKSQVYSWGSNTFG
Sbjct: 524 TWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFG 583
Query: 600 QLSHLSSPTTVPRLAKVCGDNNIWNIAAGPDYSLFLIDGDDFQPSLYYSGRQEKGKDYSL 659
QL H PTTVPRL+KV +N +W++AAG DYSLFL+D +DFQP LYYSGRQ++ + +L
Sbjct: 584 QLGHSEFPTTVPRLSKVSSENGVWSVAAGQDYSLFLVDTEDFQPGLYYSGRQDRAEGDTL 643
Query: 660 SEE-SCFKSPTLLLDCSKLGYISSVAAGGSNCLALVDKNIMGYIASLHELASTERQFYSK 718
E S K+P +LL CSKLGYIS V AG + LALVDKNIMGYIASLHELASTER+FYSK
Sbjct: 644 PENPSGTKTP-VLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELASTERRFYSK 702
Query: 719 LSSIKSQVLRPLLGLDNLGAPSTVQLLQEVASKFSKLCYLIGQHGASLTDFLQGLKEAKN 778
LS IKSQ+LRPLL L+NLG +TVQLLQEVAS+FSKLCYLIGQHGASL+ +LQG+KEA +
Sbjct: 703 LSEIKSQILRPLLSLENLGTVTTVQLLQEVASRFSKLCYLIGQHGASLSSYLQGMKEASS 762
Query: 779 LAILKHSSLFLESYTEYCTSLTNFLVMGGFALLAKPAVDFLSKNLALLQDLSETNEESCP 838
L I+KHSSLFL+SYTEYCTS++NFLVMGGF LLAKPA+DFL+KN LLQDLSE N+E+
Sbjct: 763 LVIMKHSSLFLDSYTEYCTSVSNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQ 822
Query: 839 LVEVLNALFFLPLRRLHNYARVLLKLATCFEVTSPEYQSLQDSSSCYEALAVHLSRKRKE 898
L+E+LN LFFLP+RRLHNYA+VLLKLATCFEVTSPEYQ LQDSSSCYE+LA+HL +KRKE
Sbjct: 823 LMEILNMLFFLPIRRLHNYAKVLLKLATCFEVTSPEYQKLQDSSSCYESLALHLGKKRKE 882
Query: 899 AEYTLGFWKTFPGKMTDSLRKPERRLICESSNRALSLQHAGRFSVNWFILFNDALVHAQF 958
AEYTL FWKTFPGKMTDSLRKPERRL+CESSNRALSLQHAGRFSVNWFILFNDALVHAQF
Sbjct: 883 AEYTLSFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQF 942
Query: 959 STHHIFSLSTLWVEPVSEESGNMNGLRVTTPEEQFILISSTPQEKTKWLRAISQAVDQAL 1018
STHH+F L+TLW EP+SEE+G++NGL++TTPEEQF LISSTPQEKTKWLRAISQAVDQAL
Sbjct: 943 STHHVFPLATLWAEPLSEEAGSVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQAL 1002
Query: 1019 KGTSDLPPYVGSGSIQRQEPPISRSAKYTFYKDPRLKDASYDGRWLSGKPHGRGVLKWAD 1078
+GTSD P Y G S+QRQEPPISRSAKYTFYKD RLKDA+YDGRWLSGKPHGRGVLKW D
Sbjct: 1003 RGTSDFPLYGGGSSVQRQEPPISRSAKYTFYKDTRLKDATYDGRWLSGKPHGRGVLKWPD 1062
Query: 1079 GRMYSGMFRNGLEDGHGEYTVPNKILKKNDHYVGYWKEGKMCGQGTYNYATGEVYEGSFQ 1138
G+MYSGMFRNGLEDG+GEY +PNK L K DHYVG+WKEGKMCGQG Y+YA+GEV+EG FQ
Sbjct: 1063 GKMYSGMFRNGLEDGYGEYRIPNKALNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQ 1122
Query: 1139 DNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKTGYGVFDDITRGEKYMGMWQDDLCQGNS 1198
DNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKK GYGVFDDITRGEKYMGMWQDD+CQGN
Sbjct: 1123 DNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNG 1182
Query: 1199 VVVTQFGLYYEGAFNNNKMMGSGVLLSEDDTVYEGEFSDNWTLNGKGTLILPNGDTIEGS 1258
VVVTQFGLYYEG F+ NKMMG+GVLLSEDDT+YEGEFSD+WTL+GKGTL +P+GD IEG
Sbjct: 1183 VVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPHGDYIEGY 1242
Query: 1259 FSGEWGSGIKITGTYFKPTLYDPEKERPKRLRKLGNLAVPADEKWKAVFDECWHQLGCEQ 1318
FSGEWGSGIKITGTYFKP+LY+ +K++PK RKLGNLAV ADEKW+AVF+ECW QLGCE
Sbjct: 1243 FSGEWGSGIKITGTYFKPSLYESDKDKPKAFRKLGNLAVAADEKWRAVFEECWRQLGCES 1302
Query: 1319 AGQGDRWKAWDNIAVALTTNRRQHKDSPEMLSRSHTQTLESLEFIPQHVGTFSLEKYDSI 1378
GQG+ WKAWDNIAVALTTNRRQHKDSPE+LSRS TQTLESLE+IPQH+G FS+EKYD I
Sbjct: 1303 PGQGEVWKAWDNIAVALTTNRRQHKDSPEILSRSQTQTLESLEYIPQHIGAFSVEKYDDI 1362
Query: 1379 KKYIIKACDTPLHPLGKLVETLVAVYRMTYVGVGANRRLLQEAVREIKSYLKRIFQLVRR 1438
KKY+IKACDTPLHPLG+LVETLVAVYRMTYVGVGANRRLLQEAV+EIKSYLKRIFQLVR
Sbjct: 1363 KKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVR- 1421
Query: 1439 FLFPDLPEEGSTIPFLLIETKGRRSFCSGRSDSRPDSPEPGYVVTSSGXXXXXXXXXXXX 1498
FLFP+LPEEGSTIP GRRSFC+G+SDSR +SPEPGYVVTSSG
Sbjct: 1422 FLFPELPEEGSTIPLSAPLPTGRRSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYP 1481
Query: 1499 XXFMLYALDNEREEDVYWECVLRLNKQPDTALLSFLGVQTKFWPTTTSVLGENKKVLPST 1558
FMLYALDN+REED+YWECVLRLNKQPD ALL FLGVQ KFWP T S+LGE+KKVL +T
Sbjct: 1482 PLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQKKFWPATLSILGESKKVLSTT 1541
Query: 1559 KNACFASAVECLQQISTTFTPADKLKVIQQTFEEISQNVLENLHEDFLWSMDDLFPVFLY 1618
K+ACFASAVECLQQISTTFTP+DKLKVIQQTFEEISQ+VL +L EDFLWSMDDLFPVFLY
Sbjct: 1542 KDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLQEDFLWSMDDLFPVFLY 1601
Query: 1619 VVLRARIRNLGSEVHLIEDLMDPFLQHGEQGIMFTTLKACYYQIQHEKL 1667
VVLRARIRNLGSEVHLIEDLMDPFLQHGEQGIMFTTLKACY+QIQ EKL
Sbjct: 1602 VVLRARIRNLGSEVHLIEDLMDPFLQHGEQGIMFTTLKACYFQIQREKL 1650
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