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Gene Model: Sod1

NomenclatureGenomic Location
SymbolSod1Chromosome1
NameSuperoxide dismutaseLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 94 Mbp

Molecular Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Molecular Function Terms:

antioxidant activity
   superoxide dismutase activity

binding
   ion binding
      cation binding
         metal ion binding
   protein binding
      chaperone binding
      enzyme binding

catalytic activity
   oxidoreductase activity

Human Disease Association

Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.

Predicted Transcript
     1 ATACTTCACTTCGGCAGAAAAGGTGATGGAGAAGTGCGTGTTGCAGGCCAACTTCAGGGA
    61 TTGACTATAGGAAAGCATGGATTCCATGTCCATGAATTTGGAGACAACACAAATGGATGT
   121 ACCAGTGCTGGTGCTCACTTCAATCCTGAGAATCAAACACATGGCGGGCCGCAAGATGAA
   181 ATGAGGCATGTTGGTGATCTGGGAAATGTGGAGGCAAATGGCTCTGGTGTGGCAGACGTG
   241 GACATAACCGACTGTGTTATTTCTCTCTCGGGGCCACATTCAGTTATCGGACGTACTCTG
   301 GTGGTTCATGCAAAACCGGATGATCTGGGCAGAGGAGGAAATGATGAGAGCTTGAAAACT
   361 GGAAATGCTGGTGCTCGCCTAGCTTGCGGTGTGATTGGACTGGCTAAGGCCTAG

Predicted Protein Product
ILHFGRKGDGEVRVAGQLQGLTIGKHGFHVHEFGDNTNGCTSAGAHFNPENQTHGGPQDE
MRHVGDLGNVEANGSGVADVDITDCVISLSGPHSVIGRTLVVHAKPDDLGRGGNDESLKT
GNAGARLACGVIGLAKA
Protein Alignment to Mouse
sp|P08228|SODC_MOUSE Superoxide dismutase [Cu-Zn] OS=Mus musculus GN=Sod1 PE=1
            SV=2
      MGI:98351 Sod1 superoxide dismutase 1, soluble (Chr 16)
        Length = 154

 Score = 510 (184.6 bits), Expect = 1.3e-49, P = 1.3e-49
 Identities = 94/136 (69%), Positives = 112/136 (82%)

Query:     2 LHFGRKGDGE-VRVAGQLQGLTIGKHGFHVHEFGDNTNGCTSAGAHFNPENQTHGGPQDE 60
             +HF +K  GE V ++GQ+ GLT G+HGFHVH++GDNT GCTSAG HFNP ++ HGGP DE
Sbjct:    19 IHFEQKASGEPVVLSGQITGLTEGQHGFHVHQYGDNTQGCTSAGPHFNPHSKKHGGPADE 78

Query:    61 MRHVGDLGNVEANGSGVADVDITDCVISLSGPHSVIGRTLVVHAKPDDLGRGGNDESLKT 120
              RHVGDLGNV A   GVA+V I D VISLSG HS+IGRT+VVH K DDLG+GGN+ES KT
Sbjct:    79 ERHVGDLGNVTAGKDGVANVSIEDRVISLSGEHSIIGRTMVVHEKQDDLGKGGNEESTKT 138

Query:   121 GNAGARLACGVIGLAK 136
             GNAG+RLACGVIG+A+
Sbjct:   139 GNAGSRLACGVIGIAQ 154