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Gene Model: Bak1

NomenclatureGenomic Location
SymbolBak1Chromosome2
NameBCL2-antagonist/killer 1Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 66 Mbp

Molecular Function

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Molecular Function Terms:

binding
   protein binding
      chaperone binding
      heat shock protein binding
      protein dimerization activity
      protein domain specific binding

Human Disease Association

No disease association.

Predicted Transcript
     1 GCTCTTTCCGTAGGAGGTCTTGGAACTCCACACGTGCACATAAGCAGTCCCAGCATTCCT
    61 TTTGCAGAAGACCAGGTGGCTCAGGAGACGGAGGAGGTGTTCCAGAGCTACGCTTTCTAC
   121 CGGTATCAACAGGAGCGGGAGCAGACTGAGGGGGATGTGCCACATGACCCAGAAATAGCT
   181 GCGATCCCGCATGAGCCAAATAGCACAAATTGCCAGGTGGGCAGGCGCCTGGCCACTATT
   241 GGTGATGACATCAATGCCCGCTATGACAAGGAGTTCTCGGAAATGTTGAAGTCACTCCAG
   301 CCAACAAAGGACAACGCCTATGAGTACTTTATTAGAATAGCCAGCAGTTTGTTTGAAAGT
   361 GGCATAAACTGGGGCCGTGTGATAGCACTGTTGGGCTTCGGCTACAGGATGGCGATCCAT
   421 GTATACCAGCATGGGATGACCGGCTTCCTGAGGAGAATTGCCCGCTACATGGCTGATTTT
   481 GTGCTTCGCAACCGCATTGCCCGGTGGATTGCTCAGCAGGGCGGATGGGTGGCAGCACTG
   541 GACTTAAGCAACGTGTACTTGAAGTATGTGCTGATAGTGGCGGCTGTGATCTTGCTAGGC
   601 CAGTTTGTGGTGCGGCGTTTCTTCAACCCATGA

Predicted Protein Product
ALSVGGLGTPHVHISSPSIPFAEDQVAQETEEVFQSYAFYRYQQEREQTEGDVPHDPEIA
AIPHEPNSTNCQVGRRLATIGDDINARYDKEFSEMLKSLQPTKDNAYEYFIRIASSLFES
GINWGRVIALLGFGYRMAIHVYQHGMTGFLRRIARYMADFVLRNRIARWIAQQGGWVAAL
DLSNVYLKYVLIVAAVILLGQFVVRRFFNP
Protein Alignment to Mouse
sp|O08734|BAK_MOUSE Bcl-2 homologous antagonist/killer OS=Mus musculus GN=Bak1
            PE=1 SV=1
        Length = 208

 Score = 612 (220.5 bits), Expect = 2.1e-60, P = 2.1e-60
 Identities = 123/204 (60%), Positives = 156/204 (76%)

Query:     6 GLGTPHVHIS-SPSIPFAEDQVAQETEEVFQSYAFYRYQQEREQTEGDVPHDPEIAAIPH 64
             G G P V    SPS P +E QVAQ+TEEVF+SY FY +QQE+E T+G  P +PE+  +P 
Sbjct:     6 GPGPPKVGCDESPS-P-SEQQVAQDTEEVFRSYVFYLHQQEQE-TQGRPPANPEMDNLPL 62

Query:    65 EPNSTNCQVGRRLATIGDDINARYDKEFSEMLKSLQPTKDNAYEYFIRIASSLFESGINW 124
             EPNS   QVGR+LA IGDDIN RYD EF  +L+ LQPT  NAYE F +IASSLF+SGI+W
Sbjct:    63 EPNSILGQVGRQLALIGDDINRRYDTEFQNLLEQLQPTAGNAYELFTKIASSLFKSGISW 122

Query:   125 GRVIALLGFGYRMAIHVYQHGMTGFLRRIARYMADFVLRNRIARWIAQQGGWVAALDLSN 184
             GRV+ALLGFGYR+A++VYQ G+TGFL ++  ++AD +L + IARWIAQ+GGWVAAL+L  
Sbjct:   123 GRVVALLGFGYRLALYVYQRGLTGFLGQVTCFLADIILHHYIARWIAQRGGWVAALNLRR 182

Query:   185 VYLKYVLIVAAVILLGQFVVRRFF 208
               +  V+++  V+LLGQFVV RFF
Sbjct:   183 DPILTVMVIFGVVLLGQFVVHRFF 206