Home Search Reports Help

Gene Model: Krt36

NomenclatureGenomic Location
SymbolKrt36Chromosome2
NameKeratin 36Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 60 Mbp

Molecular Function

In skin, only expressed in the suprabasal cells of scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia.

Molecular Function Terms:

structural molecule activity
   structural constituent of epidermis

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGGCTTCCAAGTACTATGCTCAGACCGTTTCTTCTGGTTCCGTCAAGGGTGGCGGTCTC
    61 ACTCGGATTGCTTCTGTCCATTCAGGTGGCTCATGCCGAGTCCCAAGCCTTGCTTTTGGT
   121 AGCAGAAGTGTTTCTTCCTCTTCCATTAAGCTGGGATGTGGGAACTACATGCCCAGCATT
   181 TGCCCACCAAATGCTTCCTTTGCCCCTTTCCTTTCTGGAAATAATGGCTGGCATGATGAG
   241 GGAATCCTCAATTGCAACGAAAAAGAGCTGATGCAGTGCCTCAATGACCGGCTAGCAAAC
   301 TACCTGGAGAGAGTAAGGTGCTTGGAGCAGGACAACGCCAACCTGGAATGCAAGATCAGA
   361 GAATGGCATGAATGCCAAGCACCCTATGAAAGTACTGACTTCCATTCACACTACAAGATT
   421 ATTGAGGAACTCCAACATCAGATACTGTGTGCCAAGACGGAAAATGCCAGGCTGGTTTTG
   481 GAAATTGACAATGCTCGCCTAGCTGCTGATGACTTTAGGACCAAGTATGAGACTGAACTG
   541 GCTCTTCGCCAGTGTGTTGAGTCAGACATCCATGGACTGCGCAAAATTCTGGATGAAATG
   601 ACCTTGTGTCGGGCTGATCTAGAAGCTCAGCTTGAATCCCACAAGGAGGAGCTTCTTTGC
   661 CTCAAGAAGAACCATGAGGAGGAAGCAAATGCCCTGCGTTCAAAACTTGGGGCCAGAGTT
   721 AATGTGGAGGTGGATGCTGCTCCATCCTGTGATCTGAACAAGATGCTGGGTGAGATAAGG
   781 AATCAGTATGAATGCCTTGCTGAAAAAAACCGCAGGGATGTTGAGACCTGGTTCTCTTCC
   841 AAGATGGAAGAGTTGAACCAACAGGTGCTCTCCAGTGATGAAGAGCTGCAGAATTGCCAG
   901 TCAGAGATAATTGAGTTGAGACACACCATGCAAGCACTTGAGATTGATCTGGATGCCCAG
   961 CAAAACATGAAAAATGCTCTTGAATGCACCCTGCATGAAACTGAAGCCCGCTATAGCACC
  1021 CAGCTAGCACAGCTTCAATGCATGATCAGCACCATAGAAGGCCAGTTGGGTGACCTCCGG
  1081 AATGATATGGAACGGCAAAGCCACGAATACAAGATTCTCCTGGATGTCAAGACTCGCCTG
  1141 GAAGCAGAGATTTCAACGTACAGGCGTCTACTGGAGGGAGAAGATCACAAGTTTCCCAGA
  1201 GTCCCAAGTGTGCCAGAGTGTCCCCCACCAGTCTCTGCTCCAGCCCCCCATATCACGAAG
  1261 AAAATCCGCACTATTACGGAGGAGATTAAGGATGGAAAGGTTATATCCTCTAGGGAACAA
  1321 GTCCAGCATGTGGCACTCTAG

Predicted Protein Product
MASKYYAQTVSSGSVKGGGLTRIASVHSGGSCRVPSLAFGSRSVSSSSIKLGCGNYMPSI
CPPNASFAPFLSGNNGWHDEGILNCNEKELMQCLNDRLANYLERVRCLEQDNANLECKIR
EWHECQAPYESTDFHSHYKIIEELQHQILCAKTENARLVLEIDNARLAADDFRTKYETEL
ALRQCVESDIHGLRKILDEMTLCRADLEAQLESHKEELLCLKKNHEEEANALRSKLGARV
NVEVDAAPSCDLNKMLGEIRNQYECLAEKNRRDVETWFSSKMEELNQQVLSSDEELQNCQ
SEIIELRHTMQALEIDLDAQQNMKNALECTLHETEARYSTQLAQLQCMISTIEGQLGDLR
NDMERQSHEYKILLDVKTRLEAEISTYRRLLEGEDHKFPRVPSVPECPPPVSAPAPHITK
KIRTITEEIKDGKVISSREQVQHVAL
Protein Alignment to Mouse
sp|B1AQ75|KRT36_MOUSE Keratin, type I cuticular Ha6 OS=Mus musculus GN=Krt36
            PE=1 SV=1
      MGI:109364 Krt36 keratin 36 (Chr 11)
        Length = 473

 Score = 1273 (453.2 bits), Expect = 6.5e-133, Sum P(2) = 6.5e-133
 Identities = 252/403 (62%), Positives = 315/403 (78%)

Query:     1 MASKYYAQTVSSGSVKG-----GGLTRIASVHSGGSCRVPSLAFGSRSVSSSSIKL-GCG 54
             MA++    T S+GS KG     G  +RI+S+HS GSCR PSL     SVSS      G G
Sbjct:     1 MATQICTPTFSAGSAKGLCGTSGSFSRISSIHSMGSCRAPSLVGTVGSVSSFRTGFSGPG 60

Query:    55 NYMPSICPPNASFAPFLSGNNGWHDEGILNCNEKELMQCLNDRLANYLERVRCLEQDNAN 114
             + +P     +   +   +G+ GW  EG  N NEK  MQ LNDRLANYLE+VR LEQ+N  
Sbjct:    61 SCLPGSYLSSGCHSSGFAGSGGWFCEGAFNGNEKATMQILNDRLANYLEKVRQLEQENTQ 120

Query:   115 LECKIREWHECQAPYESTDFHSHYKIIEELQHQILCAKTENARLVLEIDNARLAADDFRT 174
             LEC+IREW+ECQ PY   D+ S++K  EELQ +IL  K+ENARL+L+IDNA+LAADDFRT
Sbjct:   121 LECRIREWYECQIPYICPDYQSYFKTAEELQQKILLTKSENARLILQIDNAKLAADDFRT 180

Query:   175 KYETELALRQCVESDIHGLRKILDEMTLCRADLEAQLESHKEELLCLKKNHEEEANALRS 234
             KYETEL+LRQ VE+DI+GLR+ILDE+TLC+ADLEAQ+ES KEELLCLK+NHEEE NALRS
Sbjct:   181 KYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELLCLKRNHEEEVNALRS 240

Query:   235 KLGARVNVEVDAAPSCDLNKMLGEIRNQYECLAEKNRRDVETWFSSKMEELNQQVLSSDE 294
             +LG R+NVEVDAAP  DLNK+L ++R QYE L E NRRDVE WF+++ EELNQQV+SS E
Sbjct:   241 QLGDRLNVEVDAAPPVDLNKILDDMRCQYETLVENNRRDVEAWFNTQTEELNQQVVSSSE 300

Query:   295 ELQNCQSEIIELRHTMQALEIDLDAQQNMKNALECTLHETEARYSTQLAQLQCMISTIEG 354
             +LQ CQ+EIIELR T+ +LEI+L AQQ+M+N+LE TL ETEARYS+QL Q+QC+I+ +E 
Sbjct:   301 QLQCCQTEIIELRRTVNSLEIELQAQQSMRNSLESTLAETEARYSSQLGQMQCLITNVES 360

Query:   355 QLGDLRNDMERQSHEYKILLDVKTRLEAEISTYRRLLEGEDHK 397
             QL ++R D+ERQ+HEY++LLDVK RLE+EI+TYRRLL+GED K
Sbjct:   361 QLAEIRCDLERQNHEYQVLLDVKARLESEIATYRRLLDGEDCK 403

 Score = 44 (20.5 bits), Expect = 6.5e-133, Sum P(2) = 6.5e-133
 Identities = 9/11 (81%), Positives = 10/11 (90%)

Query:   431 DGKVISSREQV 441
             DG+VISSRE V
Sbjct:   458 DGRVISSREHV 468