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| Gene Model: Cftr |
| Nomenclature | Genomic Location | ||
| Symbol | Cftr | Chromosome | 1 |
| Name | Cystic fibrosis transmembrane conductance regulator | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 57 Mbp |
| Molecular Function |
|
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. ATP + H2O = ADP + phosphate. Molecular Function Terms: binding
catalytic activity
transporter activity
|
| Human Disease Association |
|
Defects in CFTR are the cause of cystic fibrosis (CF) [MIM:219700]; also known as mucoviscidosis. CF is the most common genetic disease in the Caucasian population, with a prevalence of about 1 in 2000 live births. Inheritance is autosomal recessive. CF is a common generalized disorder of exocrine gland function which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes. |
| Predicted Transcript |
1 ATACTTTCTGATTCATCATCAGAGGTACAGTTGTTTTCTGAAAAATTTATTAGGTGGACT
61 AAGCCAATTTTGAAAAAGGGTTACAGACAGCGCCTAGAATTATCAGATATTTATCAGATC
121 CCTGCCACAGATTCTGCAGATAATCTTTCTGAAAAATTGGAAAGCAGAGAATGGGACAGA
181 GAGTTGGCTTCAAAGAAAAAACCTAGACTCATCAATGCTCTCAGACGCTGTTTCTTTTGG
241 AGGTTTACATTCTATGGAATAATACTATATTTAGGGGAAGTTACTAAATCTGTGCAGCCA
301 CTTTTACTGGGAAGAATAATAGCTTCATATGATCCTTCCAATTCGCTTGAACGATCAATC
361 GCTTACTATTTAGCCATAGGGCTATGCCTTCTCTTCATTGTACGGATGTTGCTTCTTCAC
421 CCAGCAATATTTGGCTTGCATCACATTGGAATGCAGATAAGGATAGCCATGTTTAGCTTA
481 ATTTATAAAAAGACCTTAAAATTGTCAAGCAGAGTCCTAGATAAAATAAGTACCGGGCAA
541 CTCGTTAGCCTCCTTTCAAACAATCTGAATAAATTTGATGAAGGTCTAGCCTTGGCGCAT
601 TTTGTGTGGATTGCTCCTTTACAAGTGGTGTTGCTTATGGGGCTTCTCTGGGAGATGTTG
661 CAGGCTTCAGCGTTTTGTGGACTTGCTCTCTTAATTGTTGTCGCTCTTTTCCAGTCCTGG
781 GTGATCACTTCAGAAATGATTGAAAACATACAATCTGTCAAGGCGTACTGTTGGGAAGAT
841 GCAATGGAAAATATTATTGAAAACCTGCGAAAAAGTGAACTGAAGCTGACCCGAAAAGCT
901 GCTTATGTGAGATATTTCAATAGCTCAGTATTCTTCTTCTCTGGATTTTTTGTGGTGTTT
961 TTGGCTGTGCTTCCATATGCACTGATCGATAAAATTATCCTCAGGAAAATATTTACCACC
1021 ATCTCATTCTGCATTGTCCTTCGAATGGCCATCACAAGGCAGTTTCCTTGGGCCGTGCAG
1081 ACATGGTATGATTCTCTTGGAGCAATAAACAAAATACAGGATTTTTTGCAAAAAGAAGAA
1141 TACAAAACTCTGGAATATAATTTGACAACTACTGGTCTTGAACTGGATAAAATAACAGCT
1201 TTCTGGGATGAGGGAAATGGGGAGCTCTTTACAAAAGCCAAACTGGAAAATGGCAGTAGA
1261 AAAATATCAACAACTAGTGATGGTCTCTTCTTCAGTAATTTTCAACTTCATTTTGCTCCT
1321 GTTCTTAAAGATATCAGCTTCAAAATTGAGAAGGGGCAGTTGCTAGCTGTTGCTGGGTCA
1381 ACAGGAGCAGGCAAGACTTCTCTCCTGATGTTGATCATGGGTGAATTGGAGCCCTTGGAA
1441 GGCAAAGTGAAACACAGTGGAAGAATTTCCTTCTGCCCTCAAGTATCATGGATCATGCCT
1501 GGGACAATTAAAGACAATATCATCTTTGGAGTTTCCTATGATGAATTCCGATATAAGAAT
1561 GTCATCAAAGCCTGTCAGTTAGAAGAGGACATTACAAAATTTCCAGAAAAAGATGATACA
1621 GTTTTGGGAGAAGGTGGAATCACCCTCAGTGGTGGCCAGCGAGCCAGAATTTCCCTAGCC
1681 AGAGCAGTGTATAAAGATGCTGACTTGTATCTCTTGGATTCCCCTTTTGGCTATTTAGAC
1741 ATGCTAACAGAAAAAGAAATATTTGAAAGTTGTGTGTGCAAGCTTATTGTGAACAAAACA
1801 AGAATCCTGGTCACTTCAAAACTGGAACATTTAAAGATAGCAGACAAAATATTGATTTTA
1861 CATGAAGGAACATGCTATTTCTATGGAACATTTTCTGAGCTTCAGGGTCAACGGCCCAAC
1921 TTTAGCTCTGAACTGATGGGATTTGATGCTTTCGATCACTTCAGTGCAGACAGAAGGAAC
1981 TCTATTTTGACTGAAACACTGCGGAGGCTCTCTATTGACAGCGATGGAATGGGTTCACGA
2041 AACGAAATGAAGAAACCTTCTTTTAAGCAAACATCAGATTTTACTGAGAAAAGGAAGAAT
2101 TCTGTGATGAATGCACTAAATTCAAGCCGGAAATTTTCTCTTATACAAAAAACACCACTG
2161 CAGGCTAATGGTATAGAAGAAAGTATTGGAGAACCAGTTGAAAGAAGGTTGTCTTTGGTG
2221 CCTGACTCTGAGCAAGGGGAGGCAATTTTGCCAAGAAGCAATGTACTTAATCCTGGCCCC
2281 ACTTTCAGAGGACCAAGGAGGCAGTCTGTGCTTAACTTGATGACCCGAACCTCTGTTCAT
2341 CCTGGACAGAGTTTTTACACAAAGAACAGCGTATCAGTACGTAAAATGTCTGTAGTTCAC
2401 CAAGCTTCTGAGATAGATATCTATGCCAGGCGCTTGTCTAGAGACAGTGTGGTAGAAATC
2461 ACTGAAGAACTTAATGAAGAGGATTTAAAGGAATGCTTCTTTGATGATACTGAGACAATG
2521 AACACTGTTACAACATGGAACACATACTTCAGATATATTACCGTCCACAAAGCGTTGGTT
2581 GTTGTGTTAATTATGTGTGTAGTTATCTTTTCGATTGAGGTGGTGGCATCCCTCATTGGA
2641 GTACTGTATTTCACCTCTCTTGTTCCTGAAGAAACTACCACAAATGTAACAAAGTCAACA
2701 AACACTACCTCTGAAAATGCTGGCATTGTTGTTACTGAGTCTAGCAGCTATTACATCTTC
2761 TACATTTATGTGGGAGTGGCAGATACTCTACTGGCCATGGGGATCATCCGAGGCATACCC
2821 CTTGTGCACACTCTGATAACAGTTTCTAAAACTCTACATCGCAAGATGTTGCATGCAGTC
2881 CTTCAAGCACCCATGTCTTCCTTGAACAAGCTGAAAGCAGGTGGGATACTTAACAGATTC
2941 TCAAAGGATATAGCAATACTGGATGACCTGCTACCACTTACAATATTTGACTTCATCCAG
3001 TTAATATTAATTGTGATTGGTGCGATATTAGTAGTCTCAGCTATTGAACCGTACATCTTC
3061 TTAGCATCTGTGCCTGTGATAGCAGCCTTTATAATGTTACGAGCATACTTCCTGCACACT
3121 TCTCAGCAGCTGAAGCAACTGGAATCTGAAGCCAGAAGTCCAATTTTCACCCATCTTGTT
3181 ACAAGCTTAAAGGGGCTTTGGACACTGAGAGCTTTTGGCCGGCAGCCGTATTTTGAGACT
3241 CTGTTTCATAAAGCCTTGAACTTGCATACAGCAAACTGGTTCCTGTATCTATCCACATTA
3301 CGTTGGTTCCAGATGAGGATAGAAATGATTTTTGTCATCTTCTTCATCATTGTGACATTT
3361 GTTTCTATTGCTACTACAGGCAATGGGGAAGGACAAGTTGGCATTATTCTTACATTGGCA
3421 ATGAATATTATGGGAACCTTGCAGTGGGCAGTAAACTCAAGCATTGATGTAGACAGCCTG
3481 ATGCGGTCTGTGAGCCGAATATTTAAATTCATTGATATGCCAACCGAAGAATCCACAACT
3541 ACGCCACCATCAAGGAACGGCGGGCTTTCCCAAGTCCTAATAATTGAGAATAAGCATGTA
3601 AAGGAAGAGAATACCTGGCCATCAGGCGGGCAAATGATTGTGAAGGATCTCACTGCCAAG
3661 TATTTAGACGGGGGCTTGGCTATCCTTGAAAACATTTCCTTTTCAATAAGTCCAGGACAA
3721 AGGGTGGGCCTTTTAGGAAGAACTGGCTCAGGGAAAAGTACATTGCTCTTTGCTTTTTTG
3781 AGACTCCTGAATACCGAAGGTGACATTCAAATTGACAGTGTTTCCTGGAACACTGTTCCT
3841 GTACAGCAGTGGAGAAAAGCATTTGGAGTTATACCTCAGAAAGTTTTTATATTCTCTGGA
3901 TCATTTCGGAAGAACTTGGATCCTTATGGACAATGGAGTGACGAAGAACTTTGGAAAGTT
3961 GCTGAGGAGGTTGGACTGAAATCTATAATAGAGCAGTTTCCAGGTCAACTTGATTTCGTT
4021 CTGGTGGATGGTGGCTGTGTCCTCAGCCATGGACATAAACAGTTAATGTGTCTTGCCAGG
4081 TCAATTCTCAGTAAAGCTAAAATTCTTCTTCTTGATGAACCAAGTGCCCATCTAGATCCT
4141 ATGACCTTCCAGGTGATTAAAAAAACCCTCAAGCAAGCTTTTGCAAACTGTACAGTAATA
4201 CTCTCAGAACACAGACTGGAAGCACTACTGGAATGCCAGCGATTTTTGGTGATAGAAGAT
4261 AATAAAGTCAATCAATATGAATCAATCCAGAAGCTACTGAGTGAAAAGAACTCCTTCCGA
4321 CAAGCCATCAGCCATTCAGATCGAGCTAAACTCTTCCCAGTCCATCTCAGGAGCTCGAGC
4381 AAGCGCAGGTCCAGGCCTAAAATAGGAGCCTTGCAAGAAGAAACGGAGGAAGAAGTGCAA
4441 GAAACTCGACTGTGA
| Predicted Protein Product |
ILSDSSSEVQLFSEKFIRWTKPILKKGYRQRLELSDIYQIPATDSADNLSEKLESREWDR ELASKKKPRLINALRRCFFWRFTFYGIILYLGEVTKSVQPLLLGRIIASYDPSNSLERSI AYYLAIGLCLLFIVRMLLLHPAIFGLHHIGMQIRIAMFSLIYKKTLKLSSRVLDKISTGQ LVSLLSNNLNKFDEGLALAHFVWIAPLQVVLLMGLLWEMLQASAFCGLALLIVVALFQSW LGRKMMKYRDQRGGKINERLVITSEMIENIQSVKAYCWEDAMENIIENLRKSELKLTRKA AYVRYFNSSVFFFSGFFVVFLAVLPYALIDKIILRKIFTTISFCIVLRMAITRQFPWAVQ TWYDSLGAINKIQDFLQKEEYKTLEYNLTTTGLELDKITAFWDEGNGELFTKAKLENGSR KISTTSDGLFFSNFQLHFAPVLKDISFKIEKGQLLAVAGSTGAGKTSLLMLIMGELEPLE GKVKHSGRISFCPQVSWIMPGTIKDNIIFGVSYDEFRYKNVIKACQLEEDITKFPEKDDT VLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDMLTEKEIFESCVCKLIVNKT RILVTSKLEHLKIADKILILHEGTCYFYGTFSELQGQRPNFSSELMGFDAFDHFSADRRN SILTETLRRLSIDSDGMGSRNEMKKPSFKQTSDFTEKRKNSVMNALNSSRKFSLIQKTPL QANGIEESIGEPVERRLSLVPDSEQGEAILPRSNVLNPGPTFRGPRRQSVLNLMTRTSVH PGQSFYTKNSVSVRKMSVVHQASEIDIYARRLSRDSVVEITEELNEEDLKECFFDDTETM NTVTTWNTYFRYITVHKALVVVLIMCVVIFSIEVVASLIGVLYFTSLVPEETTTNVTKST NTTSENAGIVVTESSSYYIFYIYVGVADTLLAMGIIRGIPLVHTLITVSKTLHRKMLHAV LQAPMSSLNKLKAGGILNRFSKDIAILDDLLPLTIFDFIQLILIVIGAILVVSAIEPYIF LASVPVIAAFIMLRAYFLHTSQQLKQLESEARSPIFTHLVTSLKGLWTLRAFGRQPYFET LFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIIVTFVSIATTGNGEGQVGIILTLA MNIMGTLQWAVNSSIDVDSLMRSVSRIFKFIDMPTEESTTTPPSRNGGLSQVLIIENKHV KEENTWPSGGQMIVKDLTAKYLDGGLAILENISFSISPGQRVGLLGRTGSGKSTLLFAFL RLLNTEGDIQIDSVSWNTVPVQQWRKAFGVIPQKVFIFSGSFRKNLDPYGQWSDEELWKV AEEVGLKSIIEQFPGQLDFVLVDGGCVLSHGHKQLMCLARSILSKAKILLLDEPSAHLDP MTFQVIKKTLKQAFANCTVILSEHRLEALLECQRFLVIEDNKVNQYESIQKLLSEKNSFR QAISHSDRAKLFPVHLRSSSKRRSRPKIGALQEETEEEVQETRL
| Protein Alignment to Mouse |
sp|P26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator
OS=Mus musculus GN=Cftr PE=1 SV=2
MGI:88388 Cftr cystic fibrosis transmembrane conductance regulator
homolog (Chr 6)
Length = 1476
Score = 5083 (1794.4 bits), Expect = 0., P = 0.
Identities = 989/1450 (68%), Positives = 1167/1450 (80%)
Query: 8 EVQLFSEKFIRWTKPILKKGYRQRLELSDIYQIPATDSADNLSEKLESREWDRELASKKK 67
+ S+ F WT PIL+KGYR LELSDIYQ P+ DSAD+LSEKLE REWDRE ASKK
Sbjct: 8 KASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLE-REWDREQASKKN 66
Query: 68 PRLINALRRCFFWRFTFYGIILYLGEVTKSVQPLLLGRIIASYDPSNSLERSIAYYLAIG 127
P+LI+ALRRCFFWRF FYGI+LYLGEVTK+VQP+LLGRIIASYDP N +ERSIA YL IG
Sbjct: 67 PQLIHALRRCFFWRFLFYGILLYLGEVTKAVQPVLLGRIIASYDPENKVERSIAIYLGIG 126
Query: 128 LCLLFIVRMLLLHPAIFGLHHIGMQIRIAMFSLIYKKTLKLSSRVLDKISTGQLVSLLSN 187
LCLLFIVR LLLHPAIFGLH IGMQ+R AMFSLIYKKTLKLSSRVLDKIS GQLVSLLSN
Sbjct: 127 LCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSN 186
Query: 188 NLNKFDEGLALAHFVWIAPLQVVLLMGLLWEMLQASAFCGLALLIVVALFQSWLGRKMMK 247
NLNKFDEGLALAHF+WIAPLQV LLMGLLW++LQ SAFCGL LLI++ +FQ+ LG+ M+K
Sbjct: 187 NLNKFDEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVK 246
Query: 248 YRDQRGGKINERLVITSEMIENIQSVKAYCWEDAMENIIENLRKSELKLTRKAAYVRYXX 307
YRDQR KINERLVITSE+I+NI SVKAYCWE AME +IENLR+ ELK+TRKAAY+R+
Sbjct: 247 YRDQRAAKINERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFT 306
Query: 308 XXXXXXXXXXXXXLAVLPYALIDKIILRKIFTTISFCIVLRMAITRQFPWAVQTWYDSLG 367
L+VLPY +I+ I+LRKIFTTISFCIVLRM++TRQFP AVQ WYDS G
Sbjct: 307 SSAFFFSGFFVVFLSVLPYTVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSFG 366
Query: 368 AINKIQDFLQKEEYKTLEYNLTTTGLELDKITAFWDEGNGELFTKAKLENGSRKISTTSD 427
I KIQDFLQK+EYK LEYNL TTG+ ++ +TAFW+EG GEL K + NG RK S+ +
Sbjct: 367 MIRKIQDFLQKQEYKVLEYNLMTTGIIMENVTAFWEEGFGELLEKVQQSNGDRKHSSDEN 426
Query: 428 GLFFSNFQLHFAPVLKDISFKIEKGQLLAVAGSTGAGKTSLLMLIMGELEPLEGKVKHSG 487
+ FS+ L PVLK+I+ IEKG++LA+ GSTG+GKTSLLMLI+GELE EG +KHSG
Sbjct: 427 NVSFSHLCLVGNPVLKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSG 486
Query: 488 RISFCPQVSWIMPGTIKDNIIFGVSYDEFRYKNVIKACQLEEDITKFPEKDDTVLGEGGI 547
R+SFC Q SWIMPGTIK+NIIFGVSYDE+RYK+V+KACQL++DITKF E+D+TVLGEGG+
Sbjct: 487 RVSFCSQFSWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGV 546
Query: 548 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDMLTEKEIFESCVCKLIVNKTRILVTSK 607
TLSGGQRARISLARAVYKDADLYLLDSPFGYLD+ TE+++FESCVCKL+ NKTRILVTSK
Sbjct: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSK 606
Query: 608 LEHLKIADKILILHEGTCYFYGTFSELQGQRPNFSSELMGFDAFDHFSADRRNSILTETL 667
+EHL+ ADKILILH+G+ YFYGTFSELQ RP+FSS+LMG+D FD F+ +RR+SILTETL
Sbjct: 607 MEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETL 666
Query: 668 RRLSIDSDGMGSRNEMKKPSFKQTSDFTEKRKNSVMNALNSSRKFSLIQKTPLQANGIEE 727
RR S+D D ++ K+ SF+QT + EKRKNS++N+ +S RK S++QKTPL +G +
Sbjct: 667 RRFSVD-DSSAPWSKPKQ-SFRQTGEVGEKRKNSILNSFSSVRKISIVQKTPLCIDGESD 724
Query: 728 SIGEPVERRLSLVPDSEQGEAILPRSNVLNPGPTFRGPRRQSVLNLMTRTSVHPGQSFYT 787
+ E +RLSLVPDSEQGEA LPRSN++ GPTF G RRQSVL+LMT T + G S
Sbjct: 725 DLQE---KRLSLVPDSEQGEAALPRSNMIATGPTFPGRRRQSVLDLMTFTP-NSGSSNLQ 780
Query: 788 KNSVSVRKMSVVHQAS--EIDIYARRLSRDSVVEITEELNEEDLKECFFDDXXXXXXXXX 845
+ S+RK+S+V Q S E+D+Y+RRLS+DS + ITEE+NEEDLKECF DD
Sbjct: 781 RTRTSIRKISLVPQISLNEVDVYSRRLSQDSTLNITEEINEEDLKECFLDDVIKIPPVTT 840
Query: 846 XXXYFRYITVHKALVVVLIMCVVIFSIEVVASLIGVLYFTSLVPXXXXXXXXXXXXXXXX 905
Y RY T+HK L++VLI CV++F +EV ASL VL+ P
Sbjct: 841 WNTYLRYFTLHKGLLLVLIWCVLVFLVEVAASLF-VLWLLKNNPVNSGNNGTKISNSSYV 899
Query: 906 XAGIVVTESSSYYIFYIYVGVADTLLAMGIIRGIPLVHTLITVSKTLHRKMLHAVLQAPM 965
+++T +S YYIFYIYVGVADTLLA+ + RG+PLVHTLIT SK LHRKMLH++L APM
Sbjct: 900 ---VIITSTSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPM 956
Query: 966 SSLNKLKAGGILNRFSKDIAILDDLLPLTIFDFXXXXXXXXXXXXXXXXXEPYIFLASVP 1025
S+++KLKAGGILNRFSKDIAILDD LPLTIFDF +PYIFLA+VP
Sbjct: 957 STISKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVVSALQPYIFLATVP 1016
Query: 1026 VIAAFIMLRAYFLHTSQQLKQLESEARSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKA 1085
+ FI+LRAYFLHT+QQLKQLESE RSPIFTHLVTSLKGLWTLRAF RQ YFETLFHKA
Sbjct: 1017 GLVVFILLRAYFLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKA 1076
Query: 1086 LNLHTANWFLYLSTLRWFQMRIEMXXXXXXXXXXXXXXXXXGNGEGQVGIILTLAMNIMG 1145
LNLHTANWF+YL+TLRWFQMRI+M G GEG GIILTLAMNIM
Sbjct: 1077 LNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTAGIILTLAMNIMS 1136
Query: 1146 TLQWAVNSSIDVDSLMRSVSRIFKFIDMXXXXXXXXXXXRN---GGLSQVLIIENKHVKE 1202
TLQWAVNSSID DSLMRSVSR+FKFID+ + G S VL+I+N+HVK+
Sbjct: 1137 TLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKK 1196
Query: 1203 ENTWPSGGQMIVKDLTAKYLDGGLAILENISFSISPGQRVGLLGRTGSGKSTLLFAFLRL 1262
+ WPSGG+M+VKDLT KY+D G A+LENISFSISPGQRVGLLGRTGSGKSTLL AFLR+
Sbjct: 1197 SDIWPSGGEMVVKDLTVKYMDDGNAVLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRM 1256
Query: 1263 LNTEGDIQIDSVSWNTVPVQQWRKAFGVIPQKVFIFSGSFRKNLDPYGQWSDEELWKVAE 1322
LN +GDI+ID VSWN+V +Q+WRKAFGVI QKVFIFSG+FR+NLDP G+W DEE+WKVA+
Sbjct: 1257 LNIKGDIEIDGVSWNSVTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWKDEEIWKVAD 1316
Query: 1323 EVGLKSIIEQFPGQLDFVLVDGGCVLSHGHKQLMCLARSILSKAKILLLDEPSAHLDPMT 1382
EVGLKS+IEQFPGQL+F LVDGG VLSHGHKQLMCLARS+LSKAKI+LLDEPSAHLDP+T
Sbjct: 1317 EVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHLDPIT 1376
Query: 1383 FQVIKKTLKQAFANCTVILSEHRLEALLECQRFLVIEDNKVNQYESIQKLLSEKNSFRQA 1442
+QVI++ LKQAFA CTVIL EHR+EA+L+CQRFLVIE++ V QY+S+Q LLSEK+ F+QA
Sbjct: 1377 YQVIRRVLKQAFAGCTVILCEHRIEAMLDCQRFLVIEESNVWQYDSLQALLSEKSIFQQA 1436
Query: 1443 ISHSDRAKLF 1452
IS S++ + F
Sbjct: 1437 ISSSEKMRFF 1446