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| Gene Model: Gli3 |
| Nomenclature | Genomic Location | ||
| Symbol | Gli3 | Chromosome | 1 |
| Name | Transcriptional activator GLI3 | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 41 Mbp |
| Molecular Function |
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Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Molecular Function Terms: binding
nucleic acid binding transcription factor activity
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| Human Disease Association |
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Defects in GLI3 are the cause of Greig cephalo-poly-syndactyly syndrome (GCPS) [MIM:175700]. GCPS is an autosomal dominant disorder affecting limb and craniofacial development. It is characterized by pre- and postaxial polydactyly, syndactyly of fingers and toes, macrocephaly and hypertelorism. Defects in GLI3 are a cause of Pallister-Hall syndrome (PHS) [MIM:146510]. PHS is characterized by a wide range of clinical manifestations. It mainly associates central or postaxial polydactyly, syndactyly, and hypothalamic hamartoma. Malformations are frequent in the viscera, e.g. anal atresia, bifid uvula, congenital heart malformations, pulmonary or renal dysplasia. It is an autosomal dominant disorder. Defects in GLI3 are a cause of type A1/B postaxial polydactyly (PAPA1/PAPB) [MIM:174200, MIM:603596]. PAPA in humans is an autosomal dominant trait characterized by an extra digit in the ulnar and/or fibular side of the upper and/or lower extremities. The extra digit is well formed and articulates with the fifth, or extra, metacarpal/metatarsal, and thus it is usually functional. Defects in GLI3 are a cause of polydactyly preaxial type 4 (POP4) [MIM:174700]. Polydactyly preaxial type 4 (i.e., polydactyly on the radial/tibial side of the hand/foot) covers a heterogeneous group of entities. In preaxial polydactyly type IV, the thumb shows only the mildest degree of duplication, and syndactyly of various degrees affects fingers 3 and 4. Defects in GLI3 are the cause of acrocallosal syndrome (ACS) [MIM:200990]; also abbreviated ACLS. ACS is characterized by postaxial polydactyly, hallux duplication, macrocephaly, and absence of the corpus callosum, usually with severe developmental delay. |
| Predicted Transcript |
1 TCTTTTTCCTCCCTAGAGGATGAAAGTCCTGGACAGACCTATCACAGAGAGAGAAGAAAC
61 GCAATCACAATGCAGCCACAGGGTGGGCAAGGCCTCGGTAAAATCAGTGAAGAGCCTTCG
121 ACATCTAGCGAGGAAAGGGCCTCATTAATCAAGAAGGAGATCCATGGATCTATATCTCAT
181 CTTCCTGAGCCTTCATTACCTTACCGTGGGACAGTCTTTGCCATGGATCCCAGGAATGGT
241 TATATGGATCCTCCTTACCATCCACCTCACCTTTTCCCAGCATTCCACCCTCCTGTACCA
301 ATTGATGCAAGACATCACGAGGGACGTTATCATTATGAACCATCCCCCATTCCTCCGTTA
361 CATGTGCCTTCTGCTCTATCAAGTAGTCCAACATATTCAGACTTGCCGTTCATCAGAATA
421 TCCCCACACAGGAATCCTGTTGCAGCATCAGAGTCTCCTTTTAGCCCACCTCATCCATAT
481 ATTAACCCTTACATGGACTATATCCGATCTTTGCACAGCAGCCCTTCTCTGTCTATGATT
541 TCAGCAGCCCGAGGACTGAGCCCTACAGATGTGCCACATGCTGGAGTTAGTCCAGCTGAA
601 TATTACCATCAGATGGCTCTGCTGGCAGGTCAGCGCAGCCCATATGCAGACATCATTCCT
661 TCAGCAGCCACAGCAGGAGCTGGTGCCCTTCATATGGAGTATCTCCATGCTATGGACAGC
721 GCCAGGTTTCCGAGTCCCAGGCTGCCAACGAGACCAAGTCGAAAGAGAACATTGTCCCTA
781 TCGCCTCTGTCTGATCACAGCTTCGACCTTCAGACCATGATCCGGACATCTCCAAATTCC
841 TTAGTCACAATTCTTAACAATTCCCGTAGCAGTTCTTCAGCAAGTGGCTCCTATGGCCAT
901 TTATCTGCAAGTGCAATAAGCCCAGCTCTGAGTTTTACATATCCTCCCACACCAGTATCC
961 CTCCAACAGATGCACCAACAAATCATCAGTCGCCAGCAAAGCTTGGGCTCAGCCTTTGGA
1021 CACAGTCCTCCACTCATCCATCCTGCTCCAACCTTTCCTACCCAGAGGCCTATCCCTGGG
1081 ATTCCTAGTATCTTGAATCCTGTCCAAGTGAGTTCAGGTCCATCGGAGTCTACACAGCAG
1141 AACAAACCCACAAGTGAATCTGCAGTGAGCAGTACAGGAGACCCGATGCATAACAAACGT
1201 TCAAAGATAAAACCTGATGACGACCTCCCCAGCCCAGGTGCAGGAAGCGTGCAGGAACCA
1261 CCAGAAGGAATGACCTTAGTAAAAGAGGAAGGAGACAAAGATGAAAGCAAGCAGGAGCCT
1321 GAAGTGGTCTATGAGACAAACTGCCATTGGGAAGGCTGTTCACGGGAGTTCGACACTCAG
1381 GAACAGCTAGTGCATCATATAAACAATGATCACATACACGGGGAGAAAAAAGAGTTTGTA
1441 TGTCGATGGCTGGATTGTTCCCGAGAGCAGAAGCCATTCAAAGCCCAGTACATGCTGGTT
1501 GTTCACATGAGGAGGCACACAGGAGAAAAGCCACACAAATGCACTTTTGAAGGTTGTACA
1561 AAAGCCTACTCCAGGCTGGAAAACTTGAAAACCCACTTGAGATCTCACACTGGAGAGAAA
1621 CCATATGTCTGCGAACATGAAGGCTGCAACAAAGCATTTTCCAATGCATCTGATCGTGCC
1681 AAGCACCAAAACAGAACTCATTCCAATGAGAAACCCTATGTCTGCAAAATACCAGGGTGC
1741 ACAAAGCGCTACACAGATCCTAGTTCTCTTCGAAAACATGTAAAGACTGTGCACGGCCCT
1801 GAGGCCCACGTTACCAAGAAGCAGCGTGGAGATATCCACCCACGGCACCCCCCACCTCGA
1861 GACCAAGGCAGCCATTCTCAAAGCAGATCCCCCGGCCATCAGACTCAGGGTGCAATTGGG
1921 GAGCAAAAAGACCTCAGCAACACTACCTCAAAGCGTGAAGAATGCCTCCAGGTCAAAGCT
1981 GTCAAGTCAGAGAAGCCAATGGCATCTCAGCCAAGCCCTGGTGGTCAGTCTACATGCAGC
2041 AGCGAACAGTCCCCCATCAGCAACTATTCCAACCATGGGATCGAGCTTAATCTGACCAGT
2101 AGAGGTAGTGTAGGAGACCTCAGTGTCATAGATGAAACCCCTATCATGGACTCTACCATT
2161 TCAACAGCAACCACAGCACTTGGCTTACAGGCCAGGAGGAATATGACAGAGACCAAATGG
2221 ATGGAGCAAGTCAAGTTAGAAAGGCTGAAACAAATCAATGGAGTGCTTCCAAGACTGAAC
2281 CTCATGCCACCTTCCAAAGGCCCAACCTTGCCACCTCTCATAGGAAATGGTACTCAGTCA
2341 AACAACAGCTGTAGCCTAGGAGGAAACATGGCTATCCTAACCCACAAAAATGAACTCACA
2401 AACACGGATATCACTGTGTTAAACATGCTGAACAGAAGGGACAGCAATACCAGCACAATC
2461 AGCTCAGCCTACATGAGCAGCCGTAGGTCCTCTGGAATTTCACCTTGCTTCTCTAGTCGC
2521 AGATCCAGCAGTGCTTCTCAGGGTGAGGGAAGGCTCCAGAATATCAGTGTGGCTGATTCC
2581 TATGACCCCATTTCAACTGATGCCTCAAGGCGATCTAGCGAAGTCAGCCAGTGTGACGGC
2641 TTACCGGGTCTTCTCAGCCTTACCCCTGCCCAACAGTATAGGCTGAAAGCAAAATATGCA
2701 GCAGCTACTGGTGGACCTCCACCAACACCACTACCTAATATGGAGAGGATGACCTTGAAA
2761 ACAAGAATGGCACTGTTGGGTGACTGCCGGGAATCTGGAATGTCACCACTGCCCCCCGCT
2821 AATTCTCCTAGAAGATGTAGTGATGGTGGGACAAATGGTTACAGCAGGAGACACTTACTG
2881 CCTCATGATGTGATGGGGAATGGTACAAGGAGAGCCAGTGATCCTGTGAGACTAGTCTCT
2941 GAGAATCTTTCTTTCCCCAGAGTGCAGCGTTTCAACAGCCTCAATTGCTTTAACCCTCCT
3001 GCTTTGCCTCCCTCTGCGGAAAAACGCAACTTTGTCCTTCAAAACTACACACGATCTGAT
3061 GGTGGCTTGTTTCGCAACTTCTGTTCACCATGTCCTCCAAGCATCTCTGAAAATGTGGCT
3121 ATGGAGGTTGCTACCATGGAGGCAGATGGCAATTTGAATGATGAAGATCTTCTGCCAGAT
3181 GATGTGGTCCAATATCTGAATTCTCAGAATCAAATGTACAACCAAATGCCAAATGGTGGA
3241 TTAGATAACAACAAAGGGCATAACAGTTCAGTAATAGGGAACAACAACAGCTTTGAGCAA
3301 ACCCCGCCAGAAGCCAGTAAAAATGATCTGCCAATTCAGTGGAATGAAGTAAGCTCAGGA
3361 AGTTCTGAATTGTCTCCATCAAGATTAAAATGTGGGCAGCGATCTCTGATCCAGCAAAAT
3421 CAAACCCCTGGGTTCTATAATAACCTAGTTGTCCAGTCGCAGAACAATGGGCTGGAAAGA
3481 AATGTTATGACTCAACAAAATGGCTACCAGCATCTACTAGACAGCAATGGCTCTTGCAAT
3541 TTACAACATAACATGGCCATGAATAACGGTGACACCAACCGTTCTTACCACTTTCAGTCT
3601 AGTAAGGTACAACTATATAGTGAAAGTACTGGCAGACAACCAATGGACCATACCTCTGAA
3661 ATGGTGGTTCAAGGGCAAAAGGTGAGAAACAATTATATGTTAGCTAATGGGAACCAGCAC
3721 AATTTTGGCTGCCCTGTGGTATCAGATGAGCCATCTGCCAGTGTAATGAATAAGATGCAG
3781 AGCAGAAACATGGTCCTCCAAGAGTACTTTCCTCATCAATCAGCAGATGAAGTCAGTCAC
3841 TACCATGAAGTAGACCATTCCAGTAAAACAATGCTAGAGCAAGTCACTGCTCCCTCACAA
3901 CGCAGCCTTCACCAAGGGTCACAGAGTTATCTGCCACTTTCCGAAAACGTTGGGATCCAA
3961 CCTTCAGGTTTGATGATAGGCAGAGGTTACCAGCCCTGTGTGAGCTATTGTGGTGGCAGA
4021 ATGCAGAACATGGTGAGGAATAATTCCGTGCAACAGGGACATGGTAGGGATGCCAGCCAG
4081 GCACACAAGGTCAATGGCATCAAAGTAGAGTCTCAAAGTCAGTCGCAACAATTCTGTTCT
4141 AATATGCAGAATTACTCTGGTCAGTTGTATGACCAAACCACAGGGTTTATCCAGCAAGCT
4201 TTGAAAACAGGGGCTTTCCCCCTTTCAGAAGCCAACTGCCTCCTGCAGGGGACTAGTGAT
4261 GCAAATTCATCAGAGCTTCTCTCTCCAGGGGCCAACCAGGTGACAAGCACTGTTGACAGC
4321 ATTGACACCAACAGCCTTGAAGGCGTGCAGATCGATTTTGATGCTATCATAGATGATGGT
4381 GATCATGCCAGCTTAATTTCAGGAGCCCTAAGTCCCAGCATCACCCAGAATTTCTCCCAC
4441 AATTCCTCCCGTCTCACCACTCCCCGAGCGTCTCTTACATTTCCA
| Predicted Protein Product |
SFSSLEDESPGQTYHRERRNAITMQPQGGQGLGKISEEPSTSSEERASLIKKEIHGSISH LPEPSLPYRGTVFAMDPRNGYMDPPYHPPHLFPAFHPPVPIDARHHEGRYHYEPSPIPPL HVPSALSSSPTYSDLPFIRISPHRNPVAASESPFSPPHPYINPYMDYIRSLHSSPSLSMI SAARGLSPTDVPHAGVSPAEYYHQMALLAGQRSPYADIIPSAATAGAGALHMEYLHAMDS ARFPSPRLPTRPSRKRTLSLSPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGH LSASAISPALSFTYPPTPVSLQQMHQQIISRQQSLGSAFGHSPPLIHPAPTFPTQRPIPG IPSILNPVQVSSGPSESTQQNKPTSESAVSSTGDPMHNKRSKIKPDDDLPSPGAGSVQEP PEGMTLVKEEGDKDESKQEPEVVYETNCHWEGCSREFDTQEQLVHHINNDHIHGEKKEFV CRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEK PYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGP EAHVTKKQRGDIHPRHPPPRDQGSHSQSRSPGHQTQGAIGEQKDLSNTTSKREECLQVKA VKSEKPMASQPSPGGQSTCSSEQSPISNYSNHGIELNLTSRGSVGDLSVIDETPIMDSTI STATTALGLQARRNMTETKWMEQVKLERLKQINGVLPRLNLMPPSKGPTLPPLIGNGTQS NNSCSLGGNMAILTHKNELTNTDITVLNMLNRRDSNTSTISSAYMSSRRSSGISPCFSSR RSSSASQGEGRLQNISVADSYDPISTDASRRSSEVSQCDGLPGLLSLTPAQQYRLKAKYA AATGGPPPTPLPNMERMTLKTRMALLGDCRESGMSPLPPANSPRRCSDGGTNGYSRRHLL PHDVMGNGTRRASDPVRLVSENLSFPRVQRFNSLNCFNPPALPPSAEKRNFVLQNYTRSD GGLFRNFCSPCPPSISENVAMEVATMEADGNLNDEDLLPDDVVQYLNSQNQMYNQMPNGG LDNNKGHNSSVIGNNNSFEQTPPEASKNDLPIQWNEVSSGSSELSPSRLKCGQRSLIQQN QTPGFYNNLVVQSQNNGLERNVMTQQNGYQHLLDSNGSCNLQHNMAMNNGDTNRSYHFQS SKVQLYSESTGRQPMDHTSEMVVQGQKVRNNYMLANGNQHNFGCPVVSDEPSASVMNKMQ SRNMVLQEYFPHQSADEVSHYHEVDHSSKTMLEQVTAPSQRSLHQGSQSYLPLSENVGIQ PSGLMIGRGYQPCVSYCGGRMQNMVRNNSVQQGHGRDASQAHKVNGIKVESQSQSQQFCS NMQNYSGQLYDQTTGFIQQALKTGAFPLSEANCLLQGTSDANSSELLSPGANQVTSTVDS IDTNSLEGVQIDFDAIIDDGDHASLISGALSPSITQNFSHNSSRLTTPRASLTFP
| Protein Alignment to Mouse |
sp|Q61602|GLI3_MOUSE Transcriptional activator GLI3 OS=Mus musculus GN=Gli3
PE=1 SV=2
MGI:95729 Gli3 GLI-Kruppel family member GLI3 (Chr 13)
Length = 1583
Score = 4408 (1556.8 bits), Expect = 0., Sum P(2) = 0.
Identities = 860/1207 (71%), Positives = 930/1207 (77%)
Query: 1 SFSSLEDESPGQTYHRERRNAITMQPQGGQGLGKISEEPSTSSEERASLIKKEIHGSISH 60
S +S EDESPGQ YHRERRNAITMQPQ QGL KISEEPSTSS+ERASLIKKEIHGS+ H
Sbjct: 37 STTSNEDESPGQIYHRERRNAITMQPQSVQGLNKISEEPSTSSDERASLIKKEIHGSLPH 96
Query: 61 LPEPSLPYRGTVFAMDPRNGYMDXXXXXXXXXXXXXXXXXIDARHHEGRYHYEPSPIPPL 120
L EPSLPYRGTVFAMDPRNGYM+ IDARHHEGRYHY+PSPIPPL
Sbjct: 97 LAEPSLPYRGTVFAMDPRNGYMEPHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPL 156
Query: 121 HVPSALSSSPTYSDLPFIRISPHRNPVAASESPFSPPHPYINPYMDYXXXXXXXXXXXXX 180
HVPSALSSSPTY DLPFIRISPHRNP AASESPFSPPHPYINPYMDY
Sbjct: 157 HVPSALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMI 216
Query: 181 XXXXGLSPTDVPHAGVSPAEYYHQMALLAGQRSPYADIIPSAATAGAGALHMEYLHAMDS 240
GLSPTD PHAGVSPAEYYHQMALL GQRSPYADI+PSAATAGAGA+HMEYLHAMDS
Sbjct: 217 SAARGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDS 276
Query: 241 ARFPSPRLPTRPSRKRTLSLSPLSDHSFDLQTMIRTSPNSLVTILNNXXXXXXXXXXXXX 300
RFPSPRL RPSRKRTLS+SPLSDHSFDLQTMIRTSPNSLVTILNN
Sbjct: 277 TRFPSPRLSARPSRKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGH 336
Query: 301 XXXXXISPALSFTYPPTPVSLXXXXXXXXXXXXXLGSAFGHSPPLIHPAPTFPTQRPIPG 360
ISPALSFTYP PVSL LGSAFGHSPPLIHPAPTFPTQRPIPG
Sbjct: 337 LSASAISPALSFTYPSAPVSLHMHQQILSRQQS-LGSAFGHSPPLIHPAPTFPTQRPIPG 395
Query: 361 IPSILNPVQVSSGPSESTQQNKPTSESAVSSTGDPMHNKRSKIKPDDDLPSPGAGSVQEP 420
IP++LNPVQVSSGPSES+Q +KPTSESAVSSTGDPMHNKRSKIKPD+DLPSPG+ QE
Sbjct: 396 IPTVLNPVQVSSGPSESSQ-SKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGSRGQQEQ 454
Query: 421 PEGMTLVKEEGDKDESKQEPEVVYETNCHWEGCSREFDTQEQLVHHINNDHIHGEKKEFV 480
PEG TLVKEE DKDESKQEPEV+YETNCHWEGC+REFDTQ+QLVHHINNDHIHGEKKEFV
Sbjct: 455 PEGTTLVKEEADKDESKQEPEVIYETNCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFV 514
Query: 481 CRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEK 540
CRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEK
Sbjct: 515 CRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEK 574
Query: 541 PYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGP 600
PYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGP
Sbjct: 575 PYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGP 634
Query: 601 EAHVTKKQRGDIHPRHPPPRDQGSHSQSRSPGHQTQGAIGEQKDLSNTTSKREECLQVKA 660
EAHVTKKQRGD+HPR PPPRD GSHSQSRSPG TQGA GEQK+LSNTTSKREECLQVK
Sbjct: 635 EAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKT 694
Query: 661 VKSEKPMASQPSPGGQSTCSSEQSPISNYSNHGIELNLTSRGSVGDLSVIDETPIMDSTI 720
VK+EKPM SQPSPGGQS+CSS+QSPISNYSN G+EL LT GSV DLS IDETPIMDSTI
Sbjct: 695 VKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSVADLSAIDETPIMDSTI 754
Query: 721 STATTALGLQARRNMTETKWMEQVKLERLKQINGVLPRLNLMPPSKGPTLPPLIGNGTQS 780
STATTAL LQARRN TKWME +KLERLKQ+NG+ PRLN + PSK P + PLIGNGTQS
Sbjct: 755 STATTALALQARRNPAGTKWMEHIKLERLKQVNGMFPRLNPILPSKAPAVSPLIGNGTQS 814
Query: 781 NNSCSLGGNMAILTHKNELTNTDITVLNMLNRRDXXXXXXXXXXXXXXXXXXXXXXXXXX 840
NN+ S GG +L +++L+ D TVLN LNRRD
Sbjct: 815 NNNYSSGGPGTLLPSRSDLSGVDFTVLNTLNRRDSNTSTISSAYLSSRRSSGISPCFSSR 874
Query: 841 XXXXXXQGEGRLQNISVADSYDPISTDASRRSSEVSQCDGLPGLLSLTPAQQYRLKAKYX 900
Q EGR QN+SVADSYDPISTDASRRSSE SQ DGLP LLSLTP QQYRLKAKY
Sbjct: 875 RSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQGDGLPSLLSLTPVQQYRLKAKYA 934
Query: 901 XXXXXXXXXXLPNMERMTLKTRMALLGDCRESGMSPLPPANSPRRCSDGGTNGYSRRHLL 960
LP+MER++LKT+MALLG+ R+SG++ LPP + PRRCSDGG + Y RHL+
Sbjct: 935 AATGGPPPTPLPHMERLSLKTKMALLGEGRDSGVT-LPPVHPPRRCSDGGGHTYRGRHLM 993
Query: 961 PHDVMGNGTRRASDPVRLVSENLSFPRVQRFNSLNCFNPPALPPSAEKRNFVLQNYTRSD 1020
PHD + N RRASDPVR VSEN+S RVQRF+SLN FNPP LPPS EKR+ VLQNYTR +
Sbjct: 994 PHDALANSVRRASDPVRTVSENMSLARVQRFSSLNSFNPPNLPPSVEKRSLVLQNYTRQE 1053
Query: 1021 GGLFRNF-CSPCPPSISENVAMEVATMEADGNLNDEDLLPDDVVQYLNSQNQM-YNQMPN 1078
R F SPCPPSI+ENVA+E TM+AD NLNDEDLLPDDVVQYLNSQNQ Y Q
Sbjct: 1054 SSQPRYFQASPCPPSITENVALEALTMDADANLNDEDLLPDDVVQYLNSQNQTGYGQQLQ 1113
Query: 1079 GGL--DNNKGHN----------SSVIGNNN-SFEQTPPEASKNDLPIQWNEVXXXXXXXX 1125
G+ D+ H S +G + EQ E SK DLPIQWNEV
Sbjct: 1114 SGISEDSKVAHEPEDLDLAGLPDSHVGQEYPALEQPCSEGSKTDLPIQWNEVSSGTSDLS 1173
Query: 1126 XXRLKCGQ-RSLIQQNQTPGFYNNLVVQSQNNGLERNVMTQQNGYQHLLDSNGSCNLQHN 1184
+LKCGQ R QQ + G YNN+VV N L + GYQ L +++ + N +
Sbjct: 1174 SSKLKCGQQRPSAQQPRGFGLYNNMVVHPHN--LWKVGTGPAGGYQTLGENSSTYNGPEH 1231
Query: 1185 MAMNNGD 1191
A+++GD
Sbjct: 1232 FAIHSGD 1238
Score = 899 (321.5 bits), Expect = 0., Sum P(2) = 0.
Identities = 199/410 (48%), Positives = 254/410 (61%)
Query: 1097 SFEQTPPEASKNDLPIQWNEVXXXXXXXXXXRLKCGQ-RSLIQQNQTPGFYNNLVVQSQN 1155
+ EQ E SK DLPIQWNEV +LKCGQ R QQ + G YNN+VV N
Sbjct: 1145 ALEQPCSEGSKTDLPIQWNEVSSGTSDLSSSKLKCGQQRPSAQQPRGFGLYNNMVVHPHN 1204
Query: 1156 NGLERNVMTQQNGYQHLLDSNGSCNLQHNMAMNNGD---TN-RSYHFQSSKVQLYSESTG 1211
L + GYQ L +++ + N + A+++GD TN ++H Q K Q Y
Sbjct: 1205 --LWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYGSQLN 1262
Query: 1212 RQPM-----DHTSEMVVQGQKVRNNYMLANGNQHNFGCPVVSDEPSASVMNKMQSRNMVL 1266
RQP+ DH +QG K++ N + NG +F V +E + + +N MQ+++ +
Sbjct: 1263 RQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDFSLSVAPNELAGNTVNGMQTQDQMG 1322
Query: 1267 QEYFPHQSADEVSHYHEVDHSSKTMLEQVTAPSQRSLHQGSQSYLPLSENVGIQPSGLMI 1326
Q Y HQ + + +L QV A S +++QG++S LP +++ QPS +
Sbjct: 1323 QGYIAHQLLSGSMQHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDNSSQPSSMAA 1382
Query: 1327 GRGYQPCVSYCGGRMQNMVRNN-SVQQGHGRDASQAHKVNGIKVESQSQSQQFCSNMQNY 1385
RGYQPC SY G R Q M R N ++QQG D SQ+ +VN IK+E+Q QSQQ CS +QNY
Sbjct: 1383 IRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLCSTVQNY 1442
Query: 1386 SGQLYDQTTGFIQQALKTGAFPLSEANCLLQGTSDANSSELLSPGANQVTSTVDSIDTNS 1445
SGQ YDQT GF QQ K G+F LS+ANCLLQG NS ELLSPGANQVTSTVDS +++
Sbjct: 1443 SGQFYDQTMGFSQQDRKAGSFSLSDANCLLQGNGTENS-ELLSPGANQVTSTVDSFESHD 1501
Query: 1446 LEGVQIDFDAIIDDGDHASLISGALSPSITQNFSHNSSRLTTPRASLTFP 1495
LEGVQIDFDAIIDDGDH SL+SGALSPSI QN SH+SSRLTTPRASL FP
Sbjct: 1502 LEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFP 1551