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Gene Model: Smo

NomenclatureGenomic Location
SymbolSmoChromosome2
NameSmoothened homologLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 81 Mbp

Molecular Function

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog proteins' signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

Molecular Function Terms:

binding
   protein binding
      protein domain specific binding
         PDZ domain binding
      Wnt-protein binding

molecular transducer activity
   signal transducer activity
      receptor activity
         G-protein coupled receptor activity
         transmembrane receptor activity

receptor activity

Human Disease Association

No disease association.

Predicted Transcript
     1 TGCAAGCGGGAGGCGCCCTGCGAGCCCTTGGAGCAAAGCCTCTGCCTGGGCTCCCCGCTC
    61 CCTTACGCGGCCACTTCCACGCTCCTGGCCGAGGACTCCGCCTCCCAGGCCCAGGCCAGG
   121 CACAAGCTGCTCCTCTGGTCCGGCCTGCGCAACGCTCCCCGCTGCTGGGACGTGATCCAG
   181 CCGCTCCTCTGCGCCGTCTACATGCCCAAGTGCGAGGGCGGGAAGGTGGAGCTGCCCAGC
   241 CAGACCCTGTGCCAGGCCACGCGTGGACCCTGCACCATCGTGGAGCGCGAGCGTGGCTGG
   301 CCCGACTTCCTCAAGTGCTCCACCGACCGCTTCCCCGAAGGATGCCCGAACGAGGTCCAG
   361 AACCTGAAGTTCAACACCTCTGGTCAGTGCGAGGCGCCCTTGGTCCGGACGGACAACCCC
   421 AAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCGTCCAGTGCCAGAACCCGCTCTTCACC
   481 CTCACCGAGCACCAGCAGATGCACCGCTACATCGCCGCCTTCAGCTCCATCACCATCTTC
   541 TGCACCTTCTTCACCCTGGCCACCTTTGTCGCCGACTGGAAGAACTCGAACCGCTACCCG
   601 GCGGTCATCCTCTTCTACGTCAACGCCTGCTTCTTCATGGGGAGCATTGGCTGGCTGGCC
   661 CAGTTCATGGACGGTGCCCGGATGGAGATCGTGTGCCGCGCTGACGGGACCATGCGCCTC
   721 GGGGAGCCCACCTCCAACGAGACATTGTCCTGCGTCATCATCTTTGTCATTGTCTATTAT
   781 TCCTTGATGTCGGGCGTCATCTGGTTCGTGATGCTGACCTACGCCTGGCACACCTCCTTC
   841 AAGGCGCTGGGCACCACTTACCAGCCGCTGCTGGGCAAGACCTCCTACTTCCACCTCCTC
   901 ACCTGGTCCATCCCCTTCGTCCTCACCGTTGCCATCCTAGCTGTCGCCCAGGTGGATGGA
   961 GATTCGGTCAGCGGCATCTGTTTTGTCGGGTACAAGAACTACCGCTACAGAGCCGGGTTC
  1021 GTCCTGGCCCCCATCGGTCTGGTCCTGCTCGTCGGGGGCTATTTCCTGATCCGAGGCGTA
  1081 ATGACATTATTCTCCATTAAGAACAACCACCCAGGCCTCTTGAGCGAGAAGGCCGCCAGC
  1141 AAAATCAATGAGACCATGCTGCGTCTGGGGATCTTTGGCTTCCTGGCTTTCGGCTTCGTC
  1201 TTCATCACCTTCGGCTGCCACTTCTATGACTTCTTCAACCAGGCGGAATGGGAACGCAGT
  1261 TTTCGGGAACATGTTTTGTGCGAGGCCAACGTGACCATTGCCACCGAGACCAAGAAGCCG
  1321 ATCCCCGACTGCGAGATCAAGAACCGCCCCAGCCTCTTGGTGGAGAAGATCAACCTCTTC
  1381 GCCATGTTCGGGACCGGCATCTCCATGAGCACCTGGGTCTGGACCAAGGCCACACTGCTC
  1441 ATCTGGAAGCGCACCTGGGGCAGGCTGACAGGACGGAGCGGGGACGAGCCCAAGCGGATC
  1501 AAGAAGAGCAAGATGATCGCCAAGGCATTCTCCAAGAGGAAGGAGCTGCAGAACAACCCC
  1561 AACCAGGAGCTGTCCTTTAGCCTCCGCACTGTCTCGCACGAGGGTCCTGTCGCTGGTATG
  1621 GTTTTCGATATCAACGAACCCTCAGGAGATGTCTCCTCGGCGTGGGCGCAACACGTCACC
  1681 AAGATGGTGGCCAGGAGAGGGGCCATCCTGTCGCAGGACGTCTCCGTGACACCTGTCGCC
  1741 ACACCTGTGCCTCCGGAGGAGAGGGCCAGTTTGTGGCTGGCGGAGGATGAACGCCGGAGA
  1801 AAGAAAACGAGCCGCAAGGCCAAGAAAACCAAGCGGCGGAAGAGGAAGGAAGTGTCTCCC
  1861 TCACGGATGACGACGGACAACGGCGATCCATACGGCGGGCTGGACTTCTTCGTCAGCTCA
  1921 GTCCCGCGGCTTCCCCGTCTCCCGGAAGCCAAGCGCTTCGTCTCCAGTCCACGGGATGAC
  1981 GCCGGACAACCGGAAGAGAGCGGCGCTTGGCTGTTCCCCGGGAACCGGCACCTGACGACG
  2041 AGTCGGGGTCCCCTTCCGCAGCACCCCTCCACCTCGTGGTTCCAGCAGACGCAAGCGAGG
  2101 AGAGGCCCGTTGCCTCCCATTCATTCCCGGACGAACCTCATGGACGCCGAAGTTCTGGAC
  2161 CTCGATTCCGACTTCTAA

Predicted Protein Product
CKREAPCEPLEQSLCLGSPLPYAATSTLLAEDSASQAQARHKLLLWSGLRNAPRCWDVIQ
PLLCAVYMPKCEGGKVELPSQTLCQATRGPCTIVERERGWPDFLKCSTDRFPEGCPNEVQ
NLKFNTSGQCEAPLVRTDNPKSWYEDVEGCGVQCQNPLFTLTEHQQMHRYIAAFSSITIF
CTFFTLATFVADWKNSNRYPAVILFYVNACFFMGSIGWLAQFMDGARMEIVCRADGTMRL
GEPTSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLLGKTSYFHLL
TWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLLVGGYFLIRGV
MTLFSIKNNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERS
FREHVLCEANVTIATETKKPIPDCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLL
IWKRTWGRLTGRSGDEPKRIKKSKMIAKAFSKRKELQNNPNQELSFSLRTVSHEGPVAGM
VFDINEPSGDVSSAWAQHVTKMVARRGAILSQDVSVTPVATPVPPEERASLWLAEDERRR
KKTSRKAKKTKRRKRKEVSPSRMTTDNGDPYGGLDFFVSSVPRLPRLPEAKRFVSSPRDD
AGQPEESGAWLFPGNRHLTTSRGPLPQHPSTSWFQQTQARRGPLPPIHSRTNLMDAEVLD
LDSDF
Protein Alignment to Mouse
tr|Q4VBD5|Q4VBD5_MOUSE Smoothened OS=Mus musculus GN=Smo PE=2 SV=1
      MGI:108474 Fzd6 frizzled homolog 6 (Drosophila) (Chr 15)
        Length = 793

 Score = 2786 (985.8 bits), Expect = 8.7e-291, P = 8.7e-291
 Identities = 539/730 (73%), Positives = 584/730 (80%)

Query:     1 CKREAPCEPLEQSLCLGSPLPYAATSTLLAEDSASQAQARHKLLLWSGLRNAPRCWDVIQ 60
             C R A CEPL  ++CLGS LPY AT+TLLA DS SQ +A  KL+LWSGLRNAPRCW VIQ
Sbjct:    68 CGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQ 127

Query:    61 PLLCAVYMPKCEGGKVELPSQTLCQATRGPCTIVERERGWPDFLKCSTDRFPEGCPNEVQ 120
             PLLCAVYMPKCE  +VELPS+TLCQATRGPC IVERERGWPDFL+C+ D FPEGCPNEVQ
Sbjct:   128 PLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQ 187

Query:   121 NLKFNTSGQCEAPLVRTDNPKSWYEDVEGCGVQCQNPLFTLTEHQQMHRYIAAXXXXXXX 180
             N+KFN+SGQCEAPLVRTDNPKSWYEDVEGCG+QCQNPLFT  EHQ MH YIAA       
Sbjct:   188 NIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGL 247

Query:   181 XXXXXLATFVADWKNSNRYPAVILFYVNACFFMGSIGWLAQFMDGARMEIVCRADGTMRL 240
                  LATFVADW+NSNRYPAVILFYVNACFF+GSIGWLAQFMDGAR EIVCRADGTMR 
Sbjct:   248 CTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRF 307

Query:   241 GEPTSNETLSCVIIFVIVYYSLMSGVIWFVMLTYAWHTSFKALGTTYQPLLGKTSYFHLL 300
             GEPTS+ETLSCVIIFVIVYY+LM+GV+WFV+LTYAWHTSFKALGTTYQPL GKTSYFHLL
Sbjct:   308 GEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLL 367

Query:   301 TWSIPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLLVGGYFLIRGV 360
             TWS+PFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVL+VGGYFLIRGV
Sbjct:   368 TWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGV 427

Query:   361 MTLFSIKNNHPGLLSEKAASKINETMLRLGIFGFLAFGFVFITFGCHFYDFFNQAEWERS 420
             MTLFSIK+NHPGLLSEKAASKINETMLRLGIFGFLAFGFV ITF CHFYDFFNQAEWERS
Sbjct:   428 MTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERS 487

Query:   421 FREHVLCEANVTIATETKKPIPDCEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATLL 480
             FR++VLC+ANVTI   TKKPIPDCEIKNRPSLLVEKINLFAMFGTGI+MSTWVWTKATLL
Sbjct:   488 FRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLL 547

Query:   481 IWKRTWGRLTGRSGDEPKRIKKSKMIAKAFSKRKELQNNPNQELSFSLRTVSHEGPVAGM 540
             IW+RTW RLTG S DEPKRIKKSKMIAKAFSKR+EL  NP QELSFS+ TVSH+GPVAG+
Sbjct:   548 IWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGL 607

Query:   541 VFDINEPSGDVSSAWAQHVTKMVARRGAILSQDXXXXXXXXXXXXEERASLWLAEDEXX- 599
              FD+NEPS DVSSAWAQHVTKMVARRGAIL QD            EE+A++WL E E   
Sbjct:   608 AFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWLVEAEISP 667

Query:   600 XXXXXXXXXXXXXXXXXEVSPSRMTTD--NGDPYGGLDFFVSSVPRLPRLPEAKRFVSSP 657
                              EV P R   +  +  P        S+VPRLP+LP  K  V++ 
Sbjct:   668 ELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPA----TSAVPRLPQLPRQKCLVAAN 723

Query:   658 RDDAGQPEESGAWLFPGNRHLTT-SRGPLPQHPSTSWFQQ-TQARRGPLPPIHSRTNLMD 715
                 G+    GAW    N      S    P  P  S  +   Q R   L  IHSRTNLM+
Sbjct:   724 AWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLME 783

Query:   716 AEVLDLDSDF 725
             AE+LD DSDF
Sbjct:   784 AEILDADSDF 793