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Gene Model: Tas1r3

NomenclatureGenomic Location
SymbolTas1r3ChromosomeX
NameTaste receptor, type 1, member 3Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChrX: 6 Mbp

Molecular Function

Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.

Molecular Function Terms:

molecular transducer activity
   signal transducer activity
      signaling receptor activity
         transmembrane receptor activity
            G-protein coupled receptor activity

receptor activity

Human Disease Association

No disease association.

Predicted Transcript
     1 TCTCGGGAAATGTTCCTGCTCTTTTTGCTCGGCATCGGTTGGGACGGAGCCTCGGCCCAG
    61 GACTTTCGCTGCATGTCTTCCCAGTTTAGGAAACCCGGGGATTACATCCTGGGTGGCTTG
   121 TTCCCTTTCACAGTCCTCACCACCAACATGTCGGATCGGACCCTGCCTGATATTTACAGC
   181 TGTGACCGGCTTTATGCCGCTGGGCTCATCTGGGCGCTGGGCATGAAGTTTGCTGTGGAG
   241 GAGATCAACAACTCCACCACGCTGCTGCCGGGCATCACATTGGGCTATGACTTCTACGAC
   301 AGTTGCATGGAGCCCGTGGTGGTCCTCCAGCCCAGCTTGCTCTTCCTCTCTGAAATGAAC
   361 ACCAGCAGCATCAGCGTCCATTGCGACTACACCGACTATTGGACCAGAGTGCTGGCCGTC
   421 ATTGGGCCCCACAGCTCAGAGCTCTCCATGGTCACAGCCAAGCTGTTTAGCTTCTTCCTG
   481 ATCCCTCAGGTGAGCTACGGAGCCACATCAGAGAAGCTGAACAATGAGCAATACCCGTCC
   541 TTCTTCCGCACGGTGCCCAGTGACAAGATCCAGATCGACGCTCTCTCCCAGCTCTTGATT
   601 GCTTTCAAGTGGAACTGGATTGCGGTTGTCGCCAGCGACGATGACTACGGCCGCGAAGGC
   661 CTGAGCCTGTTGTCCTCCACGATGAACGGCAAGAGCATCTGCATTGCCTACGAGGGACTC
   721 ATCCCAACCGATCTGTCCAACGCCAACGTCCAAGAGAAGATGTCCCAGGTCATCCACTCC
   781 ATCAACGAGACCAAAGTCAACGTCATCGTCCTGTTCTCCAAAGACCGATCGGTCCGGGAA
   841 TTCTTCAAAATGTGGTTCAAATTGGGATTGGGCCAGAAAGTGTGGCTCGCCACCGAAGCT
   901 TGGGTGATGTCCGATGTGGTCCTCACCTTAAAAGGTGTTCAGAACATCGGGACGGTCATC
   961 GGCTTCGTCATCAAGGCGAGGAACGTCTATGCCTTTGAGGAATACACCTCCGATCTCTTG
  1021 GAGCTGACCCAACAGGAGAGCTTCTGCCGAGAGTCCAGGGAGCAGGCTGGCCAGCTGGGC
  1081 TCCGTCCTGGGACCACAGTGCCCGCAATGCAACAATATTTCCCACCATCAAGTCACCGCC
  1141 GTCCTCGGGCATCGCCAGACCTTCGCTGTGTACACTGCGGTGTACGGAGTGGCCCAGGCC
  1201 CTTCATGAGGCATTGCAATGCCAGAATGGGCAATGCCAGAAACACAGAGTCAAACCTTGG
  1261 CAGCTTCTGGAGAAACTGAATGACCTCAATTTCAGCATCCACAACGAGTCCTTCCATTTT
  1321 GACGAGCAACACAGCATCAACATGGGCTACGAGGTCCTGTCGTGGACCTGGCCCCATAAG
  1381 AAAACTGAGATCGTCAGCATTGGAAGCTTCCATGGAAATCTGAGCATCAACGAATCCATG
  1441 GTCCACTTCCATACCGTGGATCAAAAGGCGCCCCTGTCTGAATGCCTGACCAAATGTTCA
  1501 TCTGGGCAGATCCGTCGTATGAAGGGCTTCCACCTCTGCTGCTACGACTGCATCGACTGT
  1561 GAGAGTGGGACTTTCCACAGTTCCTCGGATGACTCCACTTGCACCCCGTGCCCCGAGCAC
  1621 CAGTGGTCTCCCAAGCGGAGCACTCAATGTTTAGACCGCGGTGAGAAATACATCTTCTGG
  1681 TCTGAGCCACTGGCCGTCTGCTTGCTGGGCCTCTTGCTGGTGGCCTTTGTTCTCACCTGC
  1741 CTTTCGGGTGTGTTGTTCCTGAAGAACCTCCAAACGCCAGCGGTGGAGGCATCTGGAGGT
  1801 GGCCTGTGCCTCGTGGCCCTCCTCGGCCTCGCTGCCACGTGCATCAGTGGCGTCCTCTTC
  1861 CTTGGCAAACCCAGCCCAACCATTTGCCGCATCCAGCAACCCTTTTTCGCCCTGTGCCTC
  1921 AACCTTTGCTTCTCCACCATCTTGGTCAAGGCTCTCCAGATCATGCTGGTCAACGACTTT
  1981 GCCGACAGCCGACCGAACGTCCTCCACACGATCATCCAGAGACATCCCAGTGTCCTTGCG
  2041 ACCGTATCCGTCTTAGCCGAGACCGTACTCTGCGTAGTGTACCTCTACGCCACCCCAACT
  2101 CTCCTGATCCAGAACTACAAGCTCCTCCCCGAGGAAGTCCTCCTCCAATGCCAGGTCCAG
  2161 TCCTGGCTCACCTTTGCCACCATCCATGGGCTCAACGGCATCGTGGCCTTCGTCTCTTTC
  2221 ATTTGCACCTTCATGGTGCAGTCGTCTCCCAAGAAGTACAACATTGCCCGGGCCATCGCC
  2281 TTTGCCATGCTCACCTATTTCATCACCTTGATCATCTTCATACCGACATATGCCACTGTG
  2341 AAGCAAGTGGACCAGCCAGCGGTACAGATCGGCGCCATATTGCTGTGTACTTTTGGCATG
  2401 CTGACGGCTTATTATCTCCCTAAATGCTACATCATTTGGTTTAAGCCGGAATGGAACACG
  2461 CAGAACTATTTT

Predicted Protein Product
SREMFLLFLLGIGWDGASAQDFRCMSSQFRKPGDYILGGLFPFTVLTTNMSDRTLPDIYS
CDRLYAAGLIWALGMKFAVEEINNSTTLLPGITLGYDFYDSCMEPVVVLQPSLLFLSEMN
TSSISVHCDYTDYWTRVLAVIGPHSSELSMVTAKLFSFFLIPQVSYGATSEKLNNEQYPS
FFRTVPSDKIQIDALSQLLIAFKWNWIAVVASDDDYGREGLSLLSSTMNGKSICIAYEGL
IPTDLSNANVQEKMSQVIHSINETKVNVIVLFSKDRSVREFFKMWFKLGLGQKVWLATEA
WVMSDVVLTLKGVQNIGTVIGFVIKARNVYAFEEYTSDLLELTQQESFCRESREQAGQLG
SVLGPQCPQCNNISHHQVTAVLGHRQTFAVYTAVYGVAQALHEALQCQNGQCQKHRVKPW
QLLEKLNDLNFSIHNESFHFDEQHSINMGYEVLSWTWPHKKTEIVSIGSFHGNLSINESM
VHFHTVDQKAPLSECLTKCSSGQIRRMKGFHLCCYDCIDCESGTFHSSSDDSTCTPCPEH
QWSPKRSTQCLDRGEKYIFWSEPLAVCLLGLLLVAFVLTCLSGVLFLKNLQTPAVEASGG
GLCLVALLGLAATCISGVLFLGKPSPTICRIQQPFFALCLNLCFSTILVKALQIMLVNDF
ADSRPNVLHTIIQRHPSVLATVSVLAETVLCVVYLYATPTLLIQNYKLLPEEVLLQCQVQ
SWLTFATIHGLNGIVAFVSFICTFMVQSSPKKYNIARAIAFAMLTYFITLIIFIPTYATV
KQVDQPAVQIGAILLCTFGMLTAYYLPKCYIIWFKPEWNTQNYF
Protein Alignment to Mouse
sp|Q925D8|TS1R3_MOUSE Taste receptor type 1 member 3 OS=Mus musculus GN=Tas1r3
            PE=2 SV=2
      MGI:1933547 Tas1r3 taste receptor, type 1, member 3 (Chr 4)
        Length = 858

 Score = 1753 (622.1 bits), Expect = 2.5e-181, P = 2.5e-181
 Identities = 334/813 (41%), Positives = 496/813 (61%)

Query:    24 CMSSQFRKPGDYILGGLFPF-TVLTTNMSDRTLPDIYSCDRLYAAGLIWALGMKFAVEEI 82
             C+S QF+  GDYILGGLFP  +     ++ RT P+   C+R    GL  A+ MK AVEEI
Sbjct:    24 CLSQQFKAQGDYILGGLFPLGSTEEATLNQRTQPNSIPCNRFSPLGLFLAMAMKMAVEEI 83

Query:    83 NNSTTLLPGITLGYDFYDSCMEPVVVLQPSLLFLSEMNTSSISVHCDYTDYWTRVLAVIG 142
             NN + LLPG+ LGYD +D+C EPVV ++ SL+FL+++ + SI+ +C+YT Y  RVLAVIG
Sbjct:    84 NNGSALLPGLRLGYDLFDTCSEPVVTMKSSLMFLAKVGSQSIAAYCNYTQYQPRVLAVIG 143

Query:   143 PHSSELSMVTAKLFSFFLIPQVSYGATSEKLNN-EQYPSFFRTVPSDKIQIDALSQLLIA 201
             PHSSEL+++T K FSFFL+PQVSY A+ ++L++ E +PSFFRTVPSD++Q+ A+  LL  
Sbjct:   144 PHSSELALITGKFFSFFLMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQN 203

Query:   202 FKWNWIAVVASDDDYGREGLSLLSSTMNGKSICIAYEGLIPTDLSNANVQEKMSQVIHSI 261
             F WNW+A + SDDDYGREGLS+ SS  N + ICIA+EGL+P   ++     K+  V+  +
Sbjct:   204 FSWNWVAALGSDDDYGREGLSIFSSLANARGICIAHEGLVPQHDTSGQQLGKVLDVLRQV 263

Query:   262 NETKVNVIVLFSKDRSVREFFKMWFKLGLGQKVWLATEAWVMSDVVLTLKGVQNIGTVIG 321
             N++KV V+VLF+  R+V   F      GL  KVW+A+E+W+ SD+V+TL  +  +GTV+G
Sbjct:   264 NQSKVQVVVLFASARAVYSLFSYSIHHGLSPKVWVASESWLTSDLVMTLPNIARVGTVLG 323

Query:   322 FVIKARNVYAFEEYTSDLLELTQQESFCRESREQAGQLGSVLGPQCPQCNNISHHQVTAV 381
             F+ +   +  F  Y    L L    +FC     +      V+G +CP+C++I    +++ 
Sbjct:   324 FLQRGALLPEFSHYVETHLALAADPAFCASLNAELDLEEHVMGQRCPRCDDIMLQNLSSG 383

Query:   382 L------G--HRQTFAVYTAVYGVAQALHEALQCQNGQCQ-KHRVKPWQLLEKLNDLNFS 432
             L      G  H Q FA Y AVY VAQALH  LQC    C     V PWQLLE + +++F 
Sbjct:   384 LLQNLSAGQLHHQIFATYAAVYSVAQALHNTLQCNVSHCHVSEHVLPWQLLENMYNMSFH 443

Query:   433 IHNESFHFDEQHSINMGYEVLSWTWPHKKTEIVSIGSFHGNLSINESMVHFHTVDQKAPL 492
               + +  FD + +++M Y++  W W      + ++G+F+G L + +S +++     + P+
Sbjct:   444 ARDLTLQFDAEGNVDMEYDLKMWVWQSPTPVLHTVGTFNGTLQLQQSKMYWP--GNQVPV 501

Query:   493 SECLTKCSSGQIRRMKGFHLCCYDCIDCESGTFHSSSDDSTCTPCPEHQWSPKRSTQCLD 552
             S+C  +C  GQ+RR+KGFH CCYDC+DC++G++    DD TCTPC + QWSP++ST CL 
Sbjct:   502 SQCSRQCKDGQVRRVKGFHSCCYDCVDCKAGSYRKHPDDFTCTPCNQDQWSPEKSTACLP 561

Query:   553 RGEKYIFWSEPXXXXXXXXXXXXXXXXXXSGVLFLKNLQTPAVEXXXXXXXXXXXXXXXX 612
             R  K++ W EP                  +  L + +  +P V+                
Sbjct:   562 RRPKFLAWGEPVVLSLLLLLCLVLGLALAALGLSVHHWDSPLVQASGGSQFCFGLICLGL 621

Query:   613 TCISGVLFLGKPSPTICRIQQPFFALCLNLCFSTILVKALQIMLVNDFADSRPNVLHTII 672
              C+S +LF G+PS   C  QQP   L L  C ST+ ++A +  + ++   S  N L + +
Sbjct:   622 FCLSVLLFPGRPSSASCLAQQPMAHLPLTGCLSTLFLQAAETFVESELPLSWANWLCSYL 681

Query:   673 QRHPSVLATV-SVLAETVLCVVYLYATPTLLIQNYKLLPEEVLLQCQVQSWLTFATIHGL 731
             +   + L  + +   E  LC  YL A P  ++ ++ +LP EVL  C V+SW++   +H  
Sbjct:   682 RGLWAWLVVLLATFVEAALCAWYLIAFPPEVVTDWSVLPTEVLEHCHVRSWVSLGLVHIT 741

Query:   732 NGIVAFVSFICTFMVQSSPKKYNIARAIAFAMLTYFITLIIFIPTYATVKQVDQPAVQIG 791
             N ++AF+ F+ TF+VQS P +YN AR + FAML YFIT + F+P  A V+   QPAVQ+G
Sbjct:   742 NAMLAFLCFLGTFLVQSQPGRYNRARGLTFAMLAYFITWVSFVPLLANVQVAYQPAVQMG 801

Query:   792 AILLCTFGMLTAYYLPKCYIIWFKPEWNTQNYF 824
             AIL+C  G+L  ++LPKCY++ + P+ NTQ +F
Sbjct:   802 AILVCALGILVTFHLPKCYVLLWLPKLNTQEFF 834