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Gene Model: Fbn1

NomenclatureGenomic Location
SymbolFbn1Chromosome2
NameFibrillin 1Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr2: 28 Mbp

Molecular Function

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

Molecular Function Terms:

binding
   ion binding
      cation binding
         metal ion binding

structural molecule activity
   extracellular matrix structural constituent

Human Disease Association

Defects in FBN1 are a cause of Marfan syndrome (MFS) [MIM:154700]. MFS is an autosomal dominant disorder that affects the skeletal, ocular, and cardiovascular systems. A wide variety of skeletal abnormalities occurs with MFS, including scoliosis, chest wall deformity, tall stature, abnormal joint mobility. Ectopia lentis occurs in up to about 80% of MFS patients and is almost always bilateral. The leading cause of premature death in MFS patients is progressive dilation of the aortic root and ascending aorta, causing aortic incompetence and dissection. Note=The majority of the more than 600 mutations in FBN1 currently known are point mutations, the rest are frameshifts and splice site mutations. Marfan syndrome has been suggested in at least 2 historical figures, Abraham Lincoln and Paganini.

Defects in FBN1 are a cause of isolated ectopia lentis (EL) [MIM:129600]. The symptoms of this autosomal dominant fibrillinopathy overlap with those of Marfan syndrome, with the exclusion of the skeletal and cardiovascular manifestations.

Defects in FBN1 are the cause of Weill-Marchesani syndrome autosomal dominant (ADWMS) [MIM:608328]. A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.

Defects in FBN1 are a cause of Shprintzen-Goldberg craniosynostosis syndrome (SGS) [MIM:182212]. SGS is a very rare syndrome characterized by a marfanoid habitus, craniosynostosis, characteristic dysmorphic facial features, skeletal and cardiovascular abnormalities, mental retardation, developmental delay and learning disabilities.

Defects in FBN1 are a cause of MASS syndrome (MASSS) [MIM:604308]. MASS syndrome is a heritable disorder of connective tissue characterized by involvement of the mitral valve, aorta, skeleton, and skin. MASS syndrome is closely resembling both the Marfan syndrome and the Barlow syndrome. However, no dislocation of the lenses or aneurysmal changes occur in the aorta, and the mitral valve prolapse is by no means invariable.

Defects in FBN1 are a cause of stiff skin syndrome (SSKS) [MIM:184900]. It is a syndrome characterized by hard, thick skin, usually over the entire body, which limits joint mobility and causes flexion contractures. Other occasional findings include lipodystrophy and muscle weakness.

Predicted Transcript
     1 AACCTTGTAGATATGGATGAATGCAGCATACGGAATATGTGTCTTAACGGCATGTGCATC
    61 AACGAAGACGGGAGTTTTAAGTGTATCTGCAAACCTGGTTTTCAGTTAGCGTCGGATGGA
   121 CGTTACTGCAGAGATATCGATGAGTGCGAGACGCCGGGAATCTGCATGAACGGGCGCTGC
   181 GTCAACACCGATGGCTCCTTCAGGTGCGAATGTTTCCCGGGCCTTGCTGTGGGGCTGGAT
   241 GGACGCGTGTGTGTTGATACACATATGCGGAGCACATGCTACGGCGAATACAGAAGAGGC
   301 CAATGTGTCAAGCCATTATCTGGTGCAGTTACTAAATCGGAGTGCTGTTGCGCCAGCACC
   361 GACTACGCCTTTGGGGAACCTTGTCAGCCTTGTCCTGCACAGAGTTCAGATGAGTACCAT
   421 GGTCTTTGTAGCAGTGGCCCAGGCATAACAGCAACCGGAACTGATATCAATGAATGTGCT
   481 CTGGACCCTGACATCTGTCCCAACGGAATCTGTGAAAACATGCTTGGAATGTACAAATGC
   541 ATCTGTAATTTTGGGTACGAAGTGGATTCATCTGGGAAAAACTGCTTAGACATTGACGAA
   601 TGTGCCGTGAACAAATTGCTCTGCGACAACGGACAATGCAGGAACACCCCAGGAAGCTTC
   661 ACCTGCACCTGCCCCAAGGGATTTGTATTCAAGCCTGATTTAAAGACATGTGAAGATATC
   721 AACGAGTGTGAATCCAGCCCCTGTGTTAATGGAGTGTGCAAAAACACGCCCGGCTCTTTT
   781 GTCTGTGAATGTTCCCCTGAAAGTACTCTGGATGCAACAAAAACTGTCTGCATTGAGACT
   841 GTTAAAGGCACTTGTTGGCAGACTGTTGTCAATGGGAGATGCGAAATAAATATCAATGGA
   901 GCCACCCTGAAATCTCAGTGCTGTTCTTCGCTTGGTGCTGCTTGGGGAAGCCCTTGTATT
   961 GAATGTGAACGAGTAGATCCGATCTGCTCAAAAGGCTACTCAAGGATTAGAGGAACACTA
  1021 TGTGAAGATGTCAACGAATGTGAAGTGTTCCCTGGAGTGTGCACCAATGGAGTGTGTGTC
  1081 AATACTATGGGATCCTTTGTTTGCCAGTGTCCCAATGGAATGACTTTGGATATAACTGGA
  1141 CGGAAGTGTATCGATATTCGCTTGGAGTCATGCTACCTGGGGCACGACTACGAGGAGTGT
  1201 GCATCGCCCATTGGGGGACGCCACCGGCTGGATGCGTGCTGCTGTTCTGTGGGGGCCGCT
  1261 TGGGGTCCTGACTGTGACGAATGTCCCACCAAAGGAACCCCCGACTATGAAGCGCTTTGC
  1321 CCGAGAGGACCTGGATTTTCTAGCCGGGACCCCGTCAATGGAAAACCATTCTACAAAGAT
  1381 ATCAATGAATGCAAAATGATTCCAAGACTCTGCACTTATGGGAAATGCCGAAACACCATT
  1441 GGGAGTTTCCGGTGTAAATGTGACAGTGGTTTTGCGCTTGATTCCGAAGAGAGAAATTGT
  1501 ACAGATATTGACGAGTGTCGCATTTCTCCGGACTTGTGTGGCCAAGGCATTTGTGTGAAC
  1561 ACGCCTGGAGATTTCCACTGCGAATGCTTTGAAGGCTATGAAAGTGGGTTTATGATGATG
  1621 AAAAACTGCATGGACATAGACGAATGTGAAAGAAACCCACTGTTGTGCCGAGGTGGGGTC
  1681 TGCATTAACACCGAAGGAAGCTTCAAATGCGATTGTCCTCCTGGTCATCAGTTGTTGCCA
  1741 AACATCTCTGCCTGTGTAGACATCAATGAATGTGACTTGAGTATGAACTTGTGCCGAAAC
  1801 GGACGCTGCGTCAATCTCATTGGAAAGTACCAGTGTTCCTGCAACCCGGGATATCACGCC
  1861 ACACCTGACAGATTAGCCTGTGTGGATATTGATGAGTGCAGTATAATGAACGGTGGATGT
  1921 GACACTTTTTGTACAAACTCAGAAGGCAGCTATGAGTGCAGCTGCAGACAAGGCTATGCG
  1981 CTGATGCCGGATCATAGGACTTGCACAGATATCGATGAGTGTGAAGACCATCCTCACATC
  2041 TGCGATGGAGGCCAGTGCACCAATATACCTGGAGAATATAGATGCCTTTGTTATGATGGA
  2101 TTCATGACCTCTGAGGACATGAAGACTTGTTTAGATGTTAACGAATGTGACCTGAACCCA
  2161 AACATCTGCCTGAGCGGAAGCTGTGAGAATACCAAAGGCTCCTTCATCTGTCACTGTGAT
  2221 ATGGGTTATTCTGGCAAAAAGGGAACAACTGGTTGCACAGATATTAATGAATGTGAAATC
  2281 GGAGCTCATAACTGTGACCGACATGCAATATGTACAAACACAGCCGGCAGTTTCAAGTGC
  2341 AGTTGCGCTCCAGGTTGGCTTGGAGATGGCATCAAATGCACAGATCTAGATGAATGCTCC
  2401 AATGGGACACACATGTGCAGCCCACACGCTGACTGCAAAAACACCATGGGCTCATATCGC
  2461 TGCTTATGTAAAGAAGGATACAGTGGTGATGGATTCACGTGTACAGATATTGATGAATGC
  2521 TCAGAAAATGTGAATCTCTGTGGGAATGGCCAGTGTTTAAACACCCCAGGAGGTTACCGT
  2581 TGTGAATGCGATATGGGATTTTTGCCAAGCCCAGATGGGAAAGCCTGTGAAGACATTGAC
  2641 GAGTGCATTCTGCCCAACATTTGTGTCTATGGAACGTGCCACAACCTCCCTGGTCTCTTC
  2701 CGATGCCAATGTGAGACAGGATACGAACTGGACAGAAGTGGCGGCAACTGCACAGATATC
  2761 AACGAATGTGCAGACCCAACAACTTGTATCAGCGGCACTTGCCTCAATATCCCAGGCAGT
  2821 TATACCTGTGAATGTCCTCCAGATTTCGAGCTGAACCCCACTCGTGTTGGATGTGTTGAT
  2881 ACCCGCTCTGGATACTGTTACCTGGAAATTAAACCTCGAGGAGATAATGGAGACATGGCT
  2941 TGCAGCAACGAAATTGGGGTTGGCGTTTCCAAGGCCTCCTGCTGCTGCTCCCTTGGGAAA
  3001 GCCTGGGGAATCCCTTGCGAACAGTGTCCAGCCGTGAACTCAACCGATTACAAGCTGCTG
  3061 TGTCCTGGTGGAGAAGGGTTCCGTCCCAACCCTATTACAGTTATCCTGGAAGATATTGAC
  3121 GAATGTCAGGAGCTGCCTGGACTTTGCCAAGGAGGGCAATGCATCAATTCCTTTGGGAGC
  3181 TTTCAGTGCCAGTGTCCTTCCGGCTACTATTTGAATGAAGAGACACGAGTTTGTGATGAT
  3241 ATTGATGAATGTACTACACCTGGCATCTGTGGTCCTGGTACTTGCTACAATACTATAGGG
  3301 AATTACACTTGCATTTGCCCTCCGGACTACATGCAGGTTAATGGTGGAAACAATTGCATG
  3361 GATATGAGAAGGAGTCTGTGCTACCGAAACTTCTATGCTGACAATCAAACCTGTGATGGA
  3421 GAGCTGCTTTTTAACATGACCAAAAAAATGTGCTGCTGTTCCTACAACATCGGACGAGCC
  3481 TGGAACAGACCTTGTGAACAGTGTCCAATCCCAAGCACCGATGAATTTTCAACCCTATGT
  3541 GGAAGTCAAAGGCCTGGTTTCGTCATAGACATTTACACAGGATTACCTGTTGACATTGAT
  3601 GAATGCCGTGAGATCCCCGGTGTGTGTGAGAATGGCGTCTGTATCAATCTGGTGGGCAGT
  3661 TTCCGGTGCGAATGTCCAGCGGGATTCTTCTACAATGACAAATTACTGATCTGTGAAGCA
  3721 GATATTGACGAATGCCAAAACGGGCACATATGTCAACAAAATGCAGATTGCATCAACACA
  3781 CCTGGAAGCTACCGTTGCGATTGCAAACCTGGCTATCGCTTCACTCCCGTGGGCCGATGT
  3841 GTCGATCGCAATGAGTGTCAAGAAATACCAAACATTTGCAGTCATGGTGATTGTATAGAT
  3901 CGCGAGGGAGGATATACCTGCCGTTGCCACACTGGATTCAAAACTAATGAAGACCAAACC
  3961 ATGTGCATAGATATAAATGAATGTGAGCGAGAGCCATGTGGAAATGGCACATGTAGGAAC
  4021 ACAGTCGGTTCTTTCAACTGCCGCTGCCATACGGGATTCATCCTTTCTCACAATAACGAC
  4081 TGTATAGACATCGATGAATGCGCCACTGGCAATGGGAATCTGTGCAGGAATGGCAGATGC
  4141 AACAACACTATTGGATCTTTCCTATGTATCTGCAATGAAGGTTATGAAATGACTCCAGAT
  4201 GGAAGGGTCTGCCTTGACATCAATGAATGTGCACTGGATCCTGGTAAATGTACACCTGGT
  4261 ACATGTCAGAATCTGGATGGTTCATACAGATGCATCTGTCCTCCTGGATATGCCCTGAAA
  4321 GATGACAACTGCAATGATATCGACGAGTGCTCCGAAGAGGCAGAAATCTGTGCCCTGGGC
  4381 ACATGCAGCAATACCCCCGGCAGCTTTGTTTGCCTGTGTCCCGAAGGATTTGTAGTATCT
  4441 TTCAGCGGACGTAGATGTCAAGATCAGAGAATAAGCTACTGTTTCACTAAATTTGAAGAG
  4501 GGGAAATGTTCTGTGCCCAAATCCAGAAACCACTCTAAGCAAGACTGCTGCTGCAGTATG
  4561 AACGGGGAAGGATGGGGCGATCCATGTGAACTATGTCCCCAAGAAGGAGAAGAAGCTTAT
  4621 CGGCAAATTTGCCCGTTCGGATCTGGTATTCTGGTGGGACCTCGTGGTGAACCAATTGAT
  4681 GCGGATGAATGCCTGGATCCAGACATTTGTAAACATGGCCAGTGCATCAATACGGACGGC
  4741 TCCTACCGCTGTGAATGCCCGTTTGGTTATGTGCTTCAAGGAAATGAATGCACAGATACT
  4801 GACGAATGTTCTGTCGGAGATCCGTGTGGAAATGGGACGTGTAAAAACATCATTGGGAGT
  4861 TTTGAATGCACCTGTGAGGAAGGTTTTGAACCAGGACCCATGGTGACATGTGAAGATGTG
  4921 AATGAATGTGCTCAGAATCCCCTGCTTTGTGCTTTCCGGTGTGTGAACACCTATGGATCA
  4981 TATGAATGCAAATGTCCTGCTGGCTATGTTCTCAGAGAAGACAAGCGGATGTGTAAAGAT
  5041 CAGAATGAGTGTGAAGAAGGAATTCACGATTGTGAGTCGAAGCAAATGACATGCAAAAAC
  5101 CTGATCGGCACATACATGTGCATATGTGGGCCAGGATTCCAACGTCGGCCAGATGGCGAA
  5161 GGTTGCGTAGATGAAAATGAATGTCAAACCAAACCTGGGTTGTGTGAAAACGGACGCTGT
  5221 ATCAACACACAAGGAAGCTTCCGATGTGAATGTCATGATGGGTTCAATGTCAACGAAGCG
  5281 CAGAATGAATGCATAGACACCAGGGAAGGATACTGCTTCACGGAAGTCCTGCAGAGCATG
  5341 TGTCAGGTTGGGTCGAGCAGCGTTGAAACCGTGACCAAGTCCGAATGCTGCTGTGACGGC
  5401 GGGCGAGGATGGGGACCCAACTGCGAGATCTGCCCCTTCATGGGCACCATGGCCTTTAAG
  5461 AAACTCTGCCCTCACGGCCGCGGATTCACAACAGATGGAGCAGATATCGACGAGTGCAAG
  5521 GTTATTCGTGACGCCTGCCAGAACGGAGAGTGTGTCAACAGCATGGGATCGTACCAGTGC
  5581 AAGTGCAAGGAGGGCTACATTACCGATATCACGGGCACACTTTGTATAGATCTCAATGAA
  5641 TGCAACCAGTCTCCAAAGCCATGCAATTTTATCTGCAAAAATACGGAGGGGAGTTATCAA
  5701 TGCTCGTGTCCCAAAGGCTACATTTTGCAAGAAGACGGGAGAAGCTGCAAAGATCTTGAC
  5761 GAATGTGCAACCAAGCAACACAACTGCCAATTCTTGTGCGTCAACACCATTGGGGGCTTC
  5821 ACTTGTAAATGTCCTCCTGGATTTACTCAACATCATTCAGCATGTATTGATAACAACGAA
  5881 TGTGCCGGTGACGTCAATCTTTGTGGATCTAAGGGCATTTGCCAGAACACCCCTGGAAGC
  5941 TTCACTTGTGAATGTCAGCGAGGCTTTTCCCTTGACCAGTCCGGTGCCAGTTGCGAAGTA
  6001 GACGTTGATGAGTGTGAAGGAAGCCACCGATGCCAGCATGGCTGCCAGAATATAATTGGA
  6061 GGATACCGGTGCAGTTGCCCACAAGGATATCTCCAGCACTACCAGTGGAACCAGTGTGTC
  6121 GATGAAAACGAATGCCTCAGTAGCCATATTTGTGGCGGAGCATCTTGCCACAATACTTTG
  6181 GGAAGCTTCAAATGCATGTGCCCGACTGGATACCATTATGAGCAGTTCAGTGGAGCATGT
  6241 CAAGACGTGAACGAGTGTGGCTCTTCACAAGCACCATGTAGCTATGGCTGTTCCAACACC
  6301 GATGGCGGTTACGTATGTGGGTGCCCTCCGGGGTATTTCCGAATAGGACAAGGGCATTGT
  6361 GTTTCTGGCCTGGGGCTGGGAAAAGGCCATGGCCATGGCCAAGACTTATCAGCCAGCAGT
  6421 GAAGTGGATGAGAACTCACTTTCTCCTGAAGGATGTTACGACTGTAAAATCAATGGCTAT
  6481 CCTAAGCGGGGAAGAAAACGGCGAAGCACAAATGAAACCGATGGACTTGATGCAGAGGAT
  6541 CAGCCTGAGATAGAGATGGCTGTGAACCTCGCCAGCTGGGATATTGAAAAGCCAGCCACC
  6601 CTTTCGTTCAACATTTCCGATCTTAATAACAAAGACCGGCTCTTGCAACTGATCCCTGCT
  6661 CTCACGACGTTGACCAACCACAACCGATATTTAATAGACCACGGGAACGAGGGCGGCTTC
  6721 TTTCGGATTAATCAGAAAGAAGGCGTAAGTTTCCTTCACCTAACAAAGAAGAAGCCGGTG
  6781 CCTGGAGCCTACTCATTACAGATCAGTAGCATCCCGCTTTATAAAAAGAAGGAACTCAAC
  6841 CAGCTTGAAGACAAACACGACAAAGACTACCTCAGTGGTGAGCTAGGAGACAACCTGAAA
  6901 ATGAGAATTGAAATTTTGCTGCATTAA

Predicted Protein Product
NLVDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCRDIDECETPGICMNGRC
VNTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCAST
DYAFGEPCQPCPAQSSDEYHGLCSSGPGITATGTDINECALDPDICPNGICENMLGMYKC
ICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDI
NECESSPCVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQTVVNGRCEINING
ATLKSQCCSSLGAAWGSPCIECERVDPICSKGYSRIRGTLCEDVNECEVFPGVCTNGVCV
NTMGSFVCQCPNGMTLDITGRKCIDIRLESCYLGHDYEECASPIGGRHRLDACCCSVGAA
WGPDCDECPTKGTPDYEALCPRGPGFSSRDPVNGKPFYKDINECKMIPRLCTYGKCRNTI
GSFRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMMM
KNCMDIDECERNPLLCRGGVCINTEGSFKCDCPPGHQLLPNISACVDINECDLSMNLCRN
GRCVNLIGKYQCSCNPGYHATPDRLACVDIDECSIMNGGCDTFCTNSEGSYECSCRQGYA
LMPDHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFMTSEDMKTCLDVNECDLNP
NICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAGSFKC
SCAPGWLGDGIKCTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYSGDGFTCTDIDEC
SENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECILPNICVYGTCHNLPGLF
RCQCETGYELDRSGGNCTDINECADPTTCISGTCLNIPGSYTCECPPDFELNPTRVGCVD
TRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAWGIPCEQCPAVNSTDYKLL
CPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQCQCPSGYYLNEETRVCDD
IDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNFYADNQTCDG
ELLFNMTKKMCCCSYNIGRAWNRPCEQCPIPSTDEFSTLCGSQRPGFVIDIYTGLPVDID
ECREIPGVCENGVCINLVGSFRCECPAGFFYNDKLLICEADIDECQNGHICQQNADCINT
PGSYRCDCKPGYRFTPVGRCVDRNECQEIPNICSHGDCIDREGGYTCRCHTGFKTNEDQT
MCIDINECEREPCGNGTCRNTVGSFNCRCHTGFILSHNNDCIDIDECATGNGNLCRNGRC
NNTIGSFLCICNEGYEMTPDGRVCLDINECALDPGKCTPGTCQNLDGSYRCICPPGYALK
DDNCNDIDECSEEAEICALGTCSNTPGSFVCLCPEGFVVSFSGRRCQDQRISYCFTKFEE
GKCSVPKSRNHSKQDCCCSMNGEGWGDPCELCPQEGEEAYRQICPFGSGILVGPRGEPID
ADECLDPDICKHGQCINTDGSYRCECPFGYVLQGNECTDTDECSVGDPCGNGTCKNIIGS
FECTCEEGFEPGPMVTCEDVNECAQNPLLCAFRCVNTYGSYECKCPAGYVLREDKRMCKD
QNECEEGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGRC
INTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDG
GRGWGPNCEICPFMGTMAFKKLCPHGRGFTTDGADIDECKVIRDACQNGECVNSMGSYQC
KCKEGYITDITGTLCIDLNECNQSPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLD
ECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNNECAGDVNLCGSKGICQNTPGS
FTCECQRGFSLDQSGASCEVDVDECEGSHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCV
DENECLSSHICGGASCHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCSYGCSNT
DGGYVCGCPPGYFRIGQGHCVSGLGLGKGHGHGQDLSASSEVDENSLSPEGCYDCKINGY
PKRGRKRRSTNETDGLDAEDQPEIEMAVNLASWDIEKPATLSFNISDLNNKDRLLQLIPA
LTTLTNHNRYLIDHGNEGGFFRINQKEGVSFLHLTKKKPVPGAYSLQISSIPLYKKKELN
QLEDKHDKDYLSGELGDNLKMRIEILLH
Protein Alignment to Mouse
sp|Q61554|FBN1_MOUSE Fibrillin-1 OS=Mus musculus GN=Fbn1 PE=1 SV=1
        Length = 2871

 Score = 11426 (4027.2 bits), Expect = 0., P = 0.
 Identities = 1905/2309 (82%), Positives = 2101/2309 (90%)

Query:     1 NLVDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCRDIDECETPGICMNGRC 60
             N  DMDEC   NMC NGMCINEDGSFKCICKPGFQLASDGRYC+DI+ECETPGICMNGRC
Sbjct:   569 NCEDMDECRTPNMCPNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRC 628

Query:    61 VNTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCAST 120
             VNTDGS+RCECFPGLAVGLDGR CVDTHMRS+CYG YRRGQCVKPL GAVTKSECCCAST
Sbjct:   629 VNTDGSYRCECFPGLAVGLDGRWCVDTHMRSSCYGGYRRGQCVKPLFGAVTKSECCCAST 688

Query:   121 DYAFGEPCQPCPAQSSDEYHGLCSSGPGITATGTDINECALDPDICPNGICENMLGMYKC 180
             +YAFGEPCQPCPAQ+S EY  LCSSGPG+T+ GTDINECALDPDICPNGICEN+ G YKC
Sbjct:   689 EYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGTDINECALDPDICPNGICENLRGTYKC 748

Query:   181 ICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDI 240
             ICN GYEVD +GKNC+DI+EC +N LLCDNGQCRNTPGSF CTCPKGFV+KPDLKTCEDI
Sbjct:   749 ICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVYKPDLKTCEDI 808

Query:   241 NECESSPCVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQTVVNGRCEINING 300
             +ECESSPC+NGVCKN+PGSF+CECSPESTLD TKT+CIET+KGTCWQTV++GRCEINING
Sbjct:   809 DECESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIKGTCWQTVIDGRCEINING 868

Query:   301 ATLKSQCCSSLGAAWGSPCIECERVDPICSKGYSRIRGTLCEDVNECEVFPGVCTNGVCV 360
             ATLKS+CCSSLGAAWGSPC  C+ +DPIC KG+SRI+GT CED+NECEVFPGVC NG+CV
Sbjct:   869 ATLKSECCSSLGAAWGSPCTICQ-LDPICGKGFSRIKGTQCEDINECEVFPGVCKNGLCV 927

Query:   361 NTMGSFVCQCPNGMTLDITGRKCIDIRLESCYLGHDYEECASPIGGRHRLDACCCSVGAA 420
             N+ GSF C+CPNGMTLD TGR C+DIRLE+C+L +D EEC  PI GRHR+DACCCSVGAA
Sbjct:   928 NSRGSFKCECPNGMTLDATGRICLDIRLETCFLKYDDEECTLPIAGRHRMDACCCSVGAA 987

Query:   421 WGPD-CDECPTKGTPDYEALCPRGPGFSSRDPVNGKPFYKDINECKMIPRLCTYGKCRNT 479
             WG + C+ECP + + +YE LCPRGPGF+++D  NGKPF+KDINECKMIP LCT+GKCRNT
Sbjct:   988 WGTEECEECPLRNSREYEELCPRGPGFATKDITNGKPFFKDINECKMIPSLCTHGKCRNT 1047

Query:   480 IGSFRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMM 539
             IGSF+C+CDSGFALDSEERNCTDIDECRISPDLCG+G CVNTPGDF C+C EGYESGFMM
Sbjct:  1048 IGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMM 1107

Query:   540 MKNCMDIDECERNPLLCRGGVCINTEGSFKCDCPPGHQLLPNISACVDINECDLSMNLCR 599
             MKNCMDIDEC+R+PLLCRGG+C NTEG+++C+CPPGHQL PNISAC+DINEC+LS NLC 
Sbjct:  1108 MKNCMDIDECQRDPLLCRGGICHNTEGTYRCECPPGHQLSPNISACIDINECELSANLCP 1167

Query:   600 NGRCVNLIGKYQCSCNPGYHATPDRLACVDIDECSIMNGGCDTFCTNSEGSYECSCRQGY 659
             +GRCVNLIGKYQC+CNPGYH T DRL CVDIDECSIMNGGC+TFCTNS+GSYECSC+ G+
Sbjct:  1168 HGRCVNLIGKYQCACNPGYHPTHDRLFCVDIDECSIMNGGCETFCTNSDGSYECSCQPGF 1227

Query:   660 ALMPDHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFMTSEDMKTCLDVNECDLN 719
             ALMPD R+CTDID+CED+P+ICDGGQCTNIPGEYRCLCYDGFM SEDMKTC+DVNECDLN
Sbjct:  1228 ALMPDQRSCTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLN 1287

Query:   720 PNICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAGSFK 779
             PNICLSG+CENTKGSFICHCDMGYSGKKG TGCTDINECEIGAHNC RHA+CTNTAGSFK
Sbjct:  1288 PNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFK 1347

Query:   780 CSCAPGWLGDGIKCTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYSGDGFTCTDIDE 839
             CSC+PGW+GDGIKCTDLDECSNGTHMCS HADCKNTMGSYRCLCK+GY+GDGFTCTD+DE
Sbjct:  1348 CSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTCTDLDE 1407

Query:   840 CSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECILPNICVYGTCHNLPGL 899
             CSEN+NLCGNGQCLN PGGYRCECDMGF+PS DGKACEDIDEC LPNICV+GTCHNLPGL
Sbjct:  1408 CSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGL 1467

Query:   900 FRCQCETGYELDRSGGNCTDINECADPTTCISGTCLNIPGSYTCECPPDFELNPTRVGCV 959
             FRC+CE GYELDRSGGNCTD+NEC DPTTCISG C+N PGSYTC+C PDFELNPTRVGCV
Sbjct:  1468 FRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYTCDCSPDFELNPTRVGCV 1527

Query:   960 DTRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAWGIPCEQCPAVNSTDYKL 1019
             DTRSG CYL I+PRGDNGD ACSNEIGVGVSKASCCCSLGKAWG PCE CP+VN+++YK+
Sbjct:  1528 DTRSGNCYLNIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCELCPSVNTSEYKI 1587

Query:  1020 LCPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQCQCPSGYYLNEETRVCD 1079
             LCPGGEGFRPNPITVILEDIDECQELPGLCQGG+CIN+FGSFQC+CP+GYYLNE+TRVCD
Sbjct:  1588 LCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCD 1647

Query:  1080 DIDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNFYADNQTCD 1139
             D++EC TPGICGPGTCYNT+GNYTCICPPDYMQVNGGNNCMDMRRS+CYRN+YADNQTCD
Sbjct:  1648 DVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSICYRNYYADNQTCD 1707

Query:  1140 GELLFNMTKKMCCCSYNIGRAWNRPCEQCPIPSTDEFSTLCGSQRPGFVIDIYTGLPVDI 1199
             GELLFNMTKKMCCCSYNI RAWN+PCEQCPIPSTDEF+TLCGSQRPGFVIDIYTGLPVDI
Sbjct:  1708 GELLFNMTKKMCCCSYNIRRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDI 1767

Query:  1200 DECREIPGVCENGVCINLVGSFRCECPAGFFYNDKLLICEADIDECQNGHICQQNADCIN 1259
             DECREIPGVCENGVCIN+VGSFRCECP GFFYNDKLL+CE DIDECQNG +C +NA+CIN
Sbjct:  1768 DECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCE-DIDECQNGPVCLRNAECIN 1826

Query:  1260 TPGSYRCDCKPGYRFTPVGRCVDRNECQEIPNICSHGDCIDREGGYTCRCHTGFKTNEDQ 1319
             T GSYRCDCKPGYR T  G+C DRNECQEIPNICSHG CID  G + C CHTGFKTNEDQ
Sbjct:  1827 TAGSYRCDCKPGYRLTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNEDQ 1886

Query:  1320 TMCIDINECEREPCGNGTCRNTVGSFNCRCHTGFILSHNNDCIDIDECATXXXXXXXXXX 1379
             TMC+DINECER+ CGNGTCRNT+GSFNCRC+ GFILSHNNDCID+DECAT          
Sbjct:  1887 TMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQ 1946

Query:  1380 XXXTIGSFLCICNEGYEMTPDGRVCLDINECALDPGKCTPGTCQNLDGSYRCICPPGYAL 1439
                T+GSF C CNEGYE+ PDGR C+DINEC LDPGKC PGTCQNLDGSYRCICPPGY+L
Sbjct:  1947 CVNTVGSFQCRCNEGYEVAPDGRTCVDINECVLDPGKCAPGTCQNLDGSYRCICPPGYSL 2006

Query:  1440 KDDNCNDIDECSEEAEICALGTCSNTPGSFVCLCPEGFVVSFSGRRCQDQRISYCFTKFE 1499
             ++D C DIDEC EE EICALGTCSNT GSF CLCPEGF  S SGRRCQD R+SYC+ KFE
Sbjct:  2007 QNDKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSWSSSGRRCQDLRMSYCYAKFE 2066

Query:  1500 EGKCSVPKSRNHSKQDCCCSMNGEGWGDPCELCPQEGEEAYRQICPFGSGILVGPRGEPI 1559
              GKCS PKSRNHSKQ+CCC++ GEGWGDPCELCP E +EA+RQICPFGSGI+VGP    +
Sbjct:  2067 GGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPFGSGIIVGPDDSAV 2126

Query:  1560 DADECLDPDICKHGQCINTDGSYRCECPFGYVLQGNECTDTDECSVGDPCGNGTCKNIIG 1619
             D DEC +PD+C+HGQCINTDGSYRCECPFGY+L+GNEC DTDECSVG+PCGNGTCKN+IG
Sbjct:  2127 DMDECKEPDVCRHGQCINTDGSYRCECPFGYILEGNECVDTDECSVGNPCGNGTCKNVIG 2186

Query:  1620 SFECTCEEGFEPGPMVTCEDVNECAQNPLLCAFRCVNTYGSYECKCPAGYVLREDKRMCK 1679
              FECTCEEGFEPGPM+TCED+NECAQNPLLCAFRCVNTYGSYECKCP GYVLRED+RMCK
Sbjct:  2187 GFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCK 2246

Query:  1680 DQNECEEGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGR 1739
             D++EC EG HDC  KQM CKNLIGTYMCICGPG+QRRPDGEGC+DENECQTKPG+CENGR
Sbjct:  2247 DEDECAEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICENGR 2306

Query:  1740 CINTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCD 1799
             C+NT GS+ CEC+DGF  +  Q+EC+D REGYCF+EV ++MCQ+GSS+   VTKSECCC 
Sbjct:  2307 CLNTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVFENMCQIGSSNRNPVTKSECCCV 2366

Query:  1800 GGRGWGPNCEICPFMGTMAFKKLCPHGRGFTTDGADIDECKVIRDACQNGECVNSMGSYQ 1859
             GGRGWG +CEICPF GT+A+KKLCPHGRGF T+GAD+DECKVI D C+NGECVN  GSY 
Sbjct:  2367 GGRGWGLHCEICPFEGTVAYKKLCPHGRGFMTNGADVDECKVIHDVCRNGECVNDRGSYH 2426

Query:  1860 CKCKEGYITDITGTLCIDLNECNQSPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDL 1919
             C CK GY  DITGT C+DLNECNQ+PKPCNFICKNTEGSYQCSCP GYILQEDGRSCKDL
Sbjct:  2427 CICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPNGYILQEDGRSCKDL 2486

Query:  1920 DECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNNECAGDVNLCGSKGICQNTPG 1979
             DECATKQHNCQFLCVNTIGGFTCKCPPGFTQHH+ACIDNNEC  D+NLCGSKGICQNTPG
Sbjct:  2487 DECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTACIDNNECTSDINLCGSKGICQNTPG 2546

Query:  1980 SFTCECQRGFSLDQSGASCEVDVDECEGSHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQC 2039
             SFTCECQRGFSLDQSGASCE DVDECEG+HRCQHGCQNIIGGYRCSCPQGYLQHYQWNQC
Sbjct:  2547 SFTCECQRGFSLDQSGASCE-DVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQC 2605

Query:  2040 VDENECLSSHICGGASCHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCSYGCSN 2099
             VDENECLS+H+CGGASCHNTLGS+KCMCP G+ YEQFSG CQD+NECGSSQAPCSYGCSN
Sbjct:  2606 VDENECLSAHVCGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSSQAPCSYGCSN 2665

Query:  2100 TDGGYVCGCPPGYFRIGQGHCVSXXXXXXXXXXXQDLSASSEVDENSLSPEGCYDCKING 2159
             T+GGY+CGCPPGYFRIGQGHC+S            +  ASSE+D+NSLSPE CY+CKING
Sbjct:  2666 TEGGYLCGCPPGYFRIGQGHCLSGMGMGRGA---PEPPASSEMDDNSLSPEACYECKING 2722

Query:  2160 YPKRGRKRRSTNETDGLDAEDQPEIEMAVNLASWDIEKPATLSFNISDLNNKDRLLQLIP 2219
             YPKRGRKRRSTNETD  D +D  E+E  V+LASWD+EKPA+ +FNIS ++NK R+L+L+P
Sbjct:  2723 YPKRGRKRRSTNETDASDIQDGSEMEANVSLASWDVEKPASFAFNISHVSNKVRILELLP 2782

Query:  2220 ALTTLTNHNRYLIDHGNEGGFFRINQKEGVSFLHLTKKKPVPGAYSLQISSIPLYKKKEL 2279
             ALTTL NHNRYLI+ GNE GFF+INQKEGVS+LH TKK  V G YSLQISS PLYKKKEL
Sbjct:  2783 ALTTLMNHNRYLIESGNEDGFFKINQKEGVSYLHFTKKNAVAGTYSLQISSTPLYKKKEL 2842

Query:  2280 NQLEDKHDKDYLSGELGDNLKMRIEILLH 2308
             NQLED++DKDYLSGELGDNLKM+I+ILLH
Sbjct:  2843 NQLEDRYDKDYLSGELGDNLKMKIQILLH 2871

 Score = 2615 (925.6 bits), Expect = 1.1e-272, P = 1.1e-272
 Identities = 733/2195 (33%), Positives = 1005/2195 (45%)

Query:    47 DECETPG-ICMNGRCVNTDGSFRCECFPGLAVGLDGRVCVDTHM--RSTCYG-EYRRGQ- 101
             D C+    +C NGRC+ T GS+RCEC  G  + + G  C+D     ++ C G E    Q 
Sbjct:   451 DYCQLVRYLCQNGRCIPTPGSYRCECNKGFQLDIRGE-CIDVDECEKNPCTGGECINNQG 509

Query:   102 -----CVKPLSGAVTKSECCCASTDYAFGEPCQPCPAQSSD-EYHGLCSSGPGITATGT- 154
                  C       +T++EC         G  C      ++D  +H +C++G  +++ G  
Sbjct:   510 SYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVSSEGKN 569

Query:   155 --DINECALDPDICPNGICENMLGMYKCICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQ 212
               D++EC   P++CPNG+C N  G +KCIC  G+++ S G+ C DI+EC    + C NG+
Sbjct:   570 CEDMDECRT-PNMCPNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGI-CMNGR 627

Query:   213 CRNTPGSFTCTCPKGFVFKPDLKTCEDINECESSPCVNGVCKNTPGSFVCECSPESTLDA 272
             C NT GS+ C C  G     D + C D +    S C  G  +        +C        
Sbjct:   628 CVNTDGSYRCECFPGLAVGLDGRWCVDTHM--RSSCYGGYRRG-------QCVKPLFGAV 678

Query:   273 TKTVCIETVKGTCWQTVVNGRCEININGATLKSQCCSSLG-AAWGSPCIECERVDP-ICS 330
             TK+ C        +       C    N A  ++ C S  G  + G+   EC  +DP IC 
Sbjct:   679 TKSECCCASTEYAFGEPCQP-CPAQ-NSAEYQALCSSGPGMTSAGTDINECA-LDPDICP 735

Query:   331 KGY-SRIRGT---LCEDVNECEVFPGVCTN-GVCVNTMGSFVC---QCPNGM-TLDITGR 381
              G    +RGT   +C    E ++    C +   CV  + S +C   QC N   +   T  
Sbjct:   736 NGICENLRGTYKCICNSGYEVDITGKNCVDINECV--LNSLLCDNGQCRNTPGSFVCTCP 793

Query:   382 KCIDIR--LESCYLGHDYEEC-ASP-IGGRHRLDACCCSVGAAWGPDCDECPTKGTPD-Y 436
             K    +  L++C    D +EC +SP I G      C  S G+     C EC  + T D  
Sbjct:   794 KGFVYKPDLKTC---EDIDECESSPCING-----VCKNSPGSFI---C-ECSPESTLDPT 841

Query:   437 EALCPRG-PGFSSRDPVNGKPFYKDINECKMIPRLCT-----YGK-CRNTIGSFRCKCDS 489
             + +C     G   +  ++G+    +IN   +    C+     +G  C  TI      C  
Sbjct:   842 KTICIETIKGTCWQTVIDGRCEI-NINGATLKSECCSSLGAAWGSPC--TICQLDPICGK 898

Query:   490 GFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMMMKNCMDIDEC 549
             GF+   +   C DI+EC + P +C  G+CVN+ G F CEC  G           M +D  
Sbjct:   899 GFSR-IKGTQCEDINECEVFPGVCKNGLCVNSRGSFKCECPNG-----------MTLDAT 946

Query:   550 ERNPLLCRGGVCINTEGSFKCDCP-PG-HQL---LPNISACVDINECDLSMNLCRNGRCV 604
              R  L  R   C       +C  P  G H++     ++ A     EC+    L RN R  
Sbjct:   947 GRICLDIRLETCFLKYDDEECTLPIAGRHRMDACCCSVGAAWGTEECE-ECPL-RNSR-- 1002

Query:   605 NLIGKYQ--CSCNPGYHATPD----RLACVDIDECSIMNGGCDTF-CTNSEGSYECSCRQ 657
                 +Y+  C   PG+ AT D    +    DI+EC ++   C    C N+ GS++C C  
Sbjct:  1003 ----EYEELCPRGPGF-ATKDITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDS 1057

Query:   658 GYALMPDHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFMTS-EDMKTCLDVNEC 716
             G+AL  + R CTDIDEC   P +C  GQC N PG++ C C +G+ +    MK C+D++EC
Sbjct:  1058 GFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDEC 1117

Query:   717 DLNPNICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAG 776
               +P +C  G C NT+G++ C C  G+      + C DINECE+ A+ C  H  C N  G
Sbjct:  1118 QRDPLLCRGGICHNTEGTYRCECPPGHQLSPNISACIDINECELSANLCP-HGRCVNLIG 1176

Query:   777 SFKCSCAPGW--LGDGIKCTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYS--GDGF 832
              ++C+C PG+    D + C D+DECS     C     C N+ GSY C C+ G++   D  
Sbjct:  1177 KYQCACNPGYHPTHDRLFCVDIDECSIMNGGCETF--CTNSDGSYECSCQPGFALMPDQR 1234

Query:   833 TCTDIDECSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECIL-PNICVYG 891
             +CTDID+C +N N+C  GQC N PG YRC C  GF+ S D K C D++EC L PNIC+ G
Sbjct:  1235 SCTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSG 1294

Query:   892 TCHNLPGLFRCQCETGYELDRSGGNCTDINECA-DPTTC-ISGTCLNIPGSYTCECPPDF 949
             TC N  G F C C+ GY   +    CTDINEC      C     C N  GS+ C C P +
Sbjct:  1295 TCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPGW 1354

Query:   950 ELNPTRVGCVDTRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAW-GIPC-- 1006
               +  +  C D     C         + D  C N +G       C C  G    G  C  
Sbjct:  1355 IGDGIK--CTDLDE--CSNGTHMCSQHAD--CKNTMG----SYRCLCKDGYTGDGFTCTD 1404

Query:  1007 -EQCPA-VN--STDYKLLCPGGE------GFRPNPITVILEDIDECQELPGLCQGGQCIN 1056
              ++C   +N       L  PGG       GF P+      EDIDEC  LP +C  G C N
Sbjct:  1405 LDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECS-LPNICVFGTCHN 1463

Query:  1057 SFGSFQCQCPSGYYLNEETRVCDDIDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGG 1116
               G F+C+C  GY L+     C D++EC  P  C  G C NT G+YTC C PD+ ++N  
Sbjct:  1464 LPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYTCDCSPDF-ELNPT 1522

Query:  1117 N-NCMDMRRSLCYRNFY--ADN--QTCDGELLFNMTKKMCCCSYNIGRAWNRPCEQCPIP 1171
                C+D R   CY N     DN    C  E+   ++K  CCCS  +G+AW  PCE CP  
Sbjct:  1523 RVGCVDTRSGNCYLNIRPRGDNGDTACSNEIGVGVSKASCCCS--LGKAWGTPCELCPSV 1580

Query:  1172 STDEFSTLC-GSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINLVGSFRCECPAGFF 1230
             +T E+  LC G +  GF  +  T +  DIDEC+E+PG+C+ G CIN  GSF+C CP G++
Sbjct:  1581 NTSEYKILCPGGE--GFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1638

Query:  1231 YNDKLLICEADIDECQNGHICQQNADCINTPGSYRCDCKPGYRFTPVGRCVDRNECQEIP 1290
              N+   +C+ D++EC+   IC     C NT G+Y C C P Y     G     N C ++ 
Sbjct:  1639 LNEDTRVCD-DVNECETPGICGPGT-CYNTVGNYTCICPPDYMQVNGG-----NNCMDMR 1691

Query:  1291 -NICSHGDCIDREGGYTCRCHTGFKTNEDQTMC-IDINECEREPCGNGTCRNTVGSFNCR 1348
              +IC      D +   TC     F   +    C  +I     +PC      +T   F   
Sbjct:  1692 RSICYRNYYADNQ---TCDGELLFNMTKKMCCCSYNIRRAWNKPCEQCPIPST-DEFATL 1747

Query:  1349 CHT---GFILS-HNNDCIDIDECATXXXXXXXXXXXXXTIGSFLCICNEGYEMTPDGRVC 1404
             C +   GF++  +    +DIDEC                +GSF C C  G+       VC
Sbjct:  1748 CGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINM-VGSFRCECPVGFFYNDKLLVC 1806

Query:  1405 LDINECALDPGKCTPGTCQNLDGSYRCICPPGYALKDDN-CNDIDECSEEAEICALGTCS 1463
              DI+EC   P       C N  GSYRC C PGY L     CND +EC E   IC+ G C 
Sbjct:  1807 EDIDECQNGPVCLRNAECINTAGSYRCDCKPGYRLTSTGQCNDRNECQEIPNICSHGQCI 1866

Query:  1464 NTPGSFVCLCPEGFVVSFSGRRCQDQRISYCFTKFEEGKCSVPKSRNH-SKQDCCC---- 1518
             +T GSF CLC  GF  +     C D  I+ C    E   C     RN     +C C    
Sbjct:  1867 DTVGSFYCLCHTGFKTNEDQTMCLD--INEC----ERDACGNGTCRNTIGSFNCRCNHGF 1920

Query:  1519 --SMNGEGWG-DPC-----ELCPQEGEEAYRQI----CPFGSGILVGPRGEP-IDADEC- 1564
               S N +    D C      LC + G+     +    C    G  V P G   +D +EC 
Sbjct:  1921 ILSHNNDCIDVDECATGNGNLC-RNGQ-CVNTVGSFQCRCNEGYEVAPDGRTCVDINECV 1978

Query:  1565 LDPDICKHGQCINTDGSYRCECPFGYVLQGNECTDTDECSVGDP--CGNGTCKNIIGSFE 1622
             LDP  C  G C N DGSYRC CP GY LQ ++C D DEC V +P  C  GTC N  GSF+
Sbjct:  1979 LDPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDIDEC-VEEPEICALGTCSNTEGSFK 2037

Query:  1623 CTCEEGFE-PGPMVTCEDVNECAQNPLLCAFRCVNTYGSYECKCPAGYVLREDKRMCKDQ 1681
             C C EGF        C+D        L  ++ C   +   +C  P      + +  C  +
Sbjct:  2038 CLCPEGFSWSSSGRRCQD--------LRMSY-CYAKFEGGKCSSPKSRNHSKQECCCALK 2088

Query:  1682 NECEEGIHD-CESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGRC 1740
              E   G  D CE    T  +     +C  G G    PD +  VD +EC+ +P +C +G+C
Sbjct:  2089 GE---GWGDPCELCP-TEPDEAFRQICPFGSGIIVGPD-DSAVDMDECK-EPDVCRHGQC 2142

Query:  1741 INTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDG 1800
             INT GS+RCEC  G+ + E  NEC+DT E  C    + + C  G+     +   EC C+ 
Sbjct:  2143 INTDGSYRCECPFGY-ILEG-NECVDTDE--CS---VGNPCGNGTCK-NVIGGFECTCEE 2194

Query:  1801 GRGWGP--NCE----------ICPF--MGTM-AFKKLCPHGRGFTTDGA---DIDECKVI 1842
             G   GP   CE          +C F  + T  +++  CP G     D     D DEC   
Sbjct:  2195 GFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECAEG 2254

Query:  1843 RDAC--QNGECVNSMGSYQCKCKEGYITDITGTLCIDLNECNQSPKPC-NFICKNTEGSY 1899
             +  C  +  EC N +G+Y C C  GY     G  CID NEC   P  C N  C NT GSY
Sbjct:  2255 KHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICENGRCLNTLGSY 2314

Query:  1900 QCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNN 1959
              C C  G+        C D  E        + +C   IG    + P   T+    C+   
Sbjct:  2315 TCECNDGFTASPTQDECLDNREGYCFSEVFENMC--QIGSSN-RNP--VTKSECCCVGGR 2369

Query:  1960 ECAGDVNLCGSKGICQNTPGSFTCECQRGFSLDQSGASCEVDVDECEGSHR-CQHG-CQN 2017
                    +C  +G          C   RGF  +  GA    DVDEC+  H  C++G C N
Sbjct:  2370 GWGLHCEICPFEGTVAYKK---LCPHGRGFMTN--GA----DVDECKVIHDVCRNGECVN 2420

Query:  2018 IIGGYRCSCPQGYLQHYQWNQCVDENECLSSHICGGASCHNTLGSFKCMCPTGYHYEQFS 2077
               G Y C C  GY        CVD NEC  +       C NT GS++C CP GY  ++  
Sbjct:  2421 DRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPNGYILQEDG 2480

Query:  2078 GACQDVNECGSSQAPCSYGCSNTDGGYVCGCPPGY 2112
              +C+D++EC + Q  C + C NT GG+ C CPPG+
Sbjct:  2481 RSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF 2515

 Score = 2323 (822.8 bits), Expect = 1.0e-241, P = 1.0e-241
 Identities = 698/2243 (31%), Positives = 981/2243 (43%)

Query:     3 VDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCRDIDECETPG-ICMNGRCV 61
             +D+DEC  +N C  G CIN  GS+ C C+ G+Q       CRDIDEC   G IC NGRC+
Sbjct:   489 IDVDECE-KNPCTGGECINNQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCI 547

Query:    62 NTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCASTD 121
             NTDGSF C C  G  V  +G+ C D     T       G C+    G+    +C C    
Sbjct:   548 NTDGSFHCVCNAGFHVSSEGKNCEDMDECRTP-NMCPNGMCINE-DGSF---KCIC-KPG 601

Query:   122 YAFGEPCQPCPAQSSDEYHGLCSSGPGITATGTDINEC------ALDPDICPNG-ICENM 174
             +      + C   +  E  G+C +G  +   G+   EC       LD   C +  +  + 
Sbjct:   602 FQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSSC 661

Query:   175 LGMYK---CICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFK 231
              G Y+   C+      V  S + C    E A  +  C     +N+   +   C  G    
Sbjct:   662 YGGYRRGQCVKPLFGAVTKS-ECCCASTEYAFGEP-CQPCPAQNS-AEYQALCSSG---- 714

Query:   232 PDLKTC-EDINECESSP--CVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQT 288
             P + +   DINEC   P  C NG+C+N  G++ C C+    +D T   C++ +      +
Sbjct:   715 PGMTSAGTDINECALDPDICPNGICENLRGTYKCICNSGYEVDITGKNCVD-INECVLNS 773

Query:   289 VV--NGRCEININGATLKSQCCSSLGAAWGSPCIECERVDPI----CSKGYSRIR-GT-L 340
             ++  NG+C  N  G+ +   C    G  +      CE +D      C  G  +   G+ +
Sbjct:   774 LLCDNGQCR-NTPGSFV---CTCPKGFVYKPDLKTCEDIDECESSPCINGVCKNSPGSFI 829

Query:   341 CEDVNECEVFPGVCTNGVCVNTMGSFVCQCPNGMTLDITGRKCIDIRLESCYLGHDYEEC 400
             CE   E  + P   T  +C+ T+     Q     T+ I GR C +I +    L     EC
Sbjct:   830 CECSPESTLDP---TKTICIETIKGTCWQ-----TV-IDGR-C-EININGATLK---SEC 875

Query:   401 ASPIGGRHRLDACCCSV----GAAW----GPDCD---ECPTKGTPDYEALCPRGPG-FSS 448
              S +G         C +    G  +    G  C+   EC          LC    G F  
Sbjct:   876 CSSLGAAWGSPCTICQLDPICGKGFSRIKGTQCEDINECEVFPGVCKNGLCVNSRGSFKC 935

Query:   449 RDPVNGKPFYKDINECKMIPRLCT----YG--KCRNTI-GSFR---CKCDSGFALDSEER 498
               P NG         C  I RL T    Y   +C   I G  R   C C  G A  +EE 
Sbjct:   936 ECP-NGMTLDATGRICLDI-RLETCFLKYDDEECTLPIAGRHRMDACCCSVGAAWGTEE- 992

Query:   499 NCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMMMKNCMDIDECERNPLLCRG 558
              C   +EC +      + +C   PG F     +   +G    K   DI+EC+  P LC  
Sbjct:   993 -C---EECPLRNSREYEELCPRGPG-F---ATKDITNGKPFFK---DINECKMIPSLCTH 1041

Query:   559 GVCINTEGSFKCDCPPGHQLLPNISACVDINECDLSMNLCRNGRCVNLIGKYQCSCNPGY 618
             G C NT GSFKC C  G  L      C DI+EC +S +LC  G+CVN  G ++C C+ GY
Sbjct:  1042 GKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGY 1101

Query:   619 HATPDRLA-CVDIDECS----IMNGGCDTFCTNSEGSYECSCRQGYALMPDHRTCTDIDE 673
              +    +  C+DIDEC     +  GG    C N+EG+Y C C  G+ L P+   C DI+E
Sbjct:  1102 ESGFMMMKNCMDIDECQRDPLLCRGG---ICHNTEGTYRCECPPGHQLSPNISACIDINE 1158

Query:   674 CEDHPHICDGGQCTNIPGEYRCLCYDGFMTSEDMKTCLDVNECDLNPNICLSGSCENTKG 733
             CE   ++C  G+C N+ G+Y+C C  G+  + D   C+D++EC +    C +  C N+ G
Sbjct:  1159 CELSANLCPHGRCVNLIGKYQCACNPGYHPTHDRLFCVDIDECSIMNGGCET-FCTNSDG 1217

Query:   734 SFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAGSFKCSCAPGWLG-DGIK 792
             S+ C C  G++       CTDI++CE   + CD    CTN  G ++C C  G++  + +K
Sbjct:  1218 SYECSCQPGFALMPDQRSCTDIDQCEDNPNICDGGQ-CTNIPGEYRCLCYDGFMASEDMK 1276

Query:   793 -CTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYSGD-GFT-CTDIDECSENVNLCG- 848
              C D++EC    ++C     C+NT GS+ C C  GYSG  G T CTDI+EC    + CG 
Sbjct:  1277 TCVDVNECDLNPNICLS-GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGR 1335

Query:   849 NGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECIL-PNICV-YGTCHNLPGLFRCQCET 906
             +  C NT G ++C C  G++   DG  C D+DEC    ++C  +  C N  G +RC C+ 
Sbjct:  1336 HAVCTNTAGSFKCSCSPGWIG--DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKD 1393

Query:   907 GYELDRSGGNCTDINECADPTT-CISGTCLNIPGSYTCECPPDFELNPTRVGCVDTRSGY 965
             GY  D  G  CTD++EC++    C +G CLN PG Y CEC   F  +     C D     
Sbjct:  1394 GYTGD--GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDE-- 1449

Query:   966 CYL-EIKPRGD--N--GDMACSNEIGVGVSKASC-CCSLGKAWG-IPCEQCPAVNSTDYK 1018
             C L  I   G   N  G   C  EIG  + ++   C  + +      C     VN T   
Sbjct:  1450 CSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVN-TPGS 1508

Query:  1019 LLCPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQCQCPSGYYLNEETRVC 1078
               C     F  NP  V   D         +   G   N  G   C    G  +++ +  C
Sbjct:  1509 YTCDCSPDFELNPTRVGCVDTRSGNCYLNIRPRGD--N--GDTACSNEIGVGVSKASCCC 1564

Query:  1079 DDIDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNFYADNQT- 1137
                    TP  C      NT   Y  +CP       GG        ++   +     +  
Sbjct:  1565 SLGKAWGTP--CELCPSVNT-SEYKILCP-------GGEGFRPNPITVILEDIDECQELP 1614

Query:  1138 --CDGELLFNMTKKMCC-CSYNIGRAWNRPCEQCPIPSTDEFSTLCGSQRPGFVIDIYTG 1194
               C G    N      C C    G   N     C   +  E   +CG       +  YT 
Sbjct:  1615 GLCQGGKCINTFGSFQCRCP--TGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTC 1672

Query:  1195 L-PVDIDECREIPGVCE--NGVCINLVGSFRCECPAGFFYN--DKLLICEADIDECQNGH 1249
             + P D  +        +    +C     +    C     +N   K+  C  +I    N  
Sbjct:  1673 ICPPDYMQVNGGNNCMDMRRSICYRNYYADNQTCDGELLFNMTKKMCCCSYNIRRAWNKP 1732

Query:  1250 ICQQNADC-INTPGSYRCDC---KPGYRFTP-VGRCVDRNECQEIPNICSHGDCIDREGG 1304
              C+Q   C I +   +   C   +PG+      G  VD +EC+EIP +C +G CI+  G 
Sbjct:  1733 -CEQ---CPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGS 1788

Query:  1305 YTCRCHTGFKTNEDQTMCIDINECEREP-C-GNGTCRNTVGSFNCRCHTGFILSHNNDCI 1362
             + C C  GF  N+   +C DI+EC+  P C  N  C NT GS+ C C  G+ L+    C 
Sbjct:  1789 FRCECPVGFFYNDKLLVCEDIDECQNGPVCLRNAECINTAGSYRCDCKPGYRLTSTGQCN 1848

Query:  1363 DIDECATXXXXXXXXXXXXXTIGSFLCICNEGYEMTPDGRVCLDINECALDPGKCTPGTC 1422
             D +EC               T+GSF C+C+ G++   D  +CLDINEC  D   C  GTC
Sbjct:  1849 DRNECQEIPNICSHGQCID-TVGSFYCLCHTGFKTNEDQTMCLDINECERDA--CGNGTC 1905

Query:  1423 QNLDGSYRCICPPGYALKDDN-CNDIDECSE-EAEICALGTCSNTPGSFVCLCPEGFVVS 1480
             +N  GS+ C C  G+ L  +N C D+DEC+     +C  G C NT GSF C C EG+ V+
Sbjct:  1906 RNTIGSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQCRCNEGYEVA 1965

Query:  1481 FSGRRCQDQRISYCFTKFEEGKCSVPKSRN-HSKQDCCCSMNGEGWGDPCELCPQEGEEA 1539
               GR C D  I+ C    + GKC+    +N      C C        D CE   +  EE 
Sbjct:  1966 PDGRTCVD--INECV--LDPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDIDECVEEP 2021

Query:  1540 YRQICPFGSGILVGPRGEPIDADECLDPDICKHGQCINTDGSYRCE---CPFGYV-LQGN 1595
               +IC  G+       G    + +CL    C  G   ++ G  RC+     + Y   +G 
Sbjct:  2022 --EICALGT--CSNTEG----SFKCL----CPEGFSWSSSGR-RCQDLRMSYCYAKFEGG 2068

Query:  1596 ECTDT-------DECSV-------GDPCGNGTCKNIIG-SFECTCE--EGFEPGPMVTCE 1638
             +C+          EC         GDPC    C      +F   C    G   GP  +  
Sbjct:  2069 KCSSPKSRNHSKQECCCALKGEGWGDPCE--LCPTEPDEAFRQICPFGSGIIVGPDDSAV 2126

Query:  1639 DVNECAQNPLLCAF-RCVNTYGSYECKCPAGYVLREDKRMCKDQNECEEGIHDCESKQMT 1697
             D++EC + P +C   +C+NT GSY C+CP GY+L  ++  C D +EC  G + C +   T
Sbjct:  2127 DMDECKE-PDVCRHGQCINTDGSYRCECPFGYILEGNE--CVDTDECSVG-NPCGNG--T 2180

Query:  1698 CKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGRCINTQGSFRCECHDGFNV 1757
             CKN+IG + C C  GF+  P    C D NEC   P LC   RC+NT GS+ C+C  G+ +
Sbjct:  2181 CKNVIGGFECTCEEGFEPGPMMT-CEDINECAQNPLLCAF-RCVNTYGSYECKCPVGYVL 2238

Query:  1758 NEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDGGRGWGPNCEICPFMGTM 1817
              E +  C D  E  C  E      +        +    C C  G    P+ E C      
Sbjct:  2239 REDRRMCKDEDE--C-AEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENEC 2295

Query:  1818 AFKK-LCPHGRGFTTDGADIDECK------VIRDAC---QNGECVNSMGSYQCKCKEGYI 1867
               K  +C +GR   T G+   EC         +D C   + G C + +    C+      
Sbjct:  2296 QTKPGICENGRCLNTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVFENMCQIGSSNR 2355

Query:  1868 TDITGTLCIDLNECNQSPKPCNFICKNTEGS--YQCSCPKGYILQEDGRSCKDLDECATK 1925
               +T + C  +         C  IC   EG+  Y+  CP G     +G    D+DEC   
Sbjct:  2356 NPVTKSECCCVGGRGWGLH-CE-ICP-FEGTVAYKKLCPHGRGFMTNGA---DVDECKVI 2409

Query:  1926 QHNCQF-LCVNTIGGFTCKCPPGFTQH--HSACIDNNECAGDVNLCGSKGICQNTPGSFT 1982
                C+   CVN  G + C C  G+T     ++C+D NEC      C    IC+NT GS+ 
Sbjct:  2410 HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNF--ICKNTEGSYQ 2467

Query:  1983 CECQRGFSLDQSGASCEVDVDECEGS-HRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVD 2041
             C C  G+ L + G SC+ D+DEC    H CQ  C N IGG+ C CP G+ QH+    C+D
Sbjct:  2468 CSCPNGYILQEDGRSCK-DLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHH--TACID 2524

Query:  2042 ENECLSS-HICGGAS-CHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCSYGCSN 2099
              NEC S  ++CG    C NT GSF C C  G+  +Q   +C+DV+EC  +   C +GC N
Sbjct:  2525 NNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHR-CQHGCQN 2583

Query:  2100 TDGGYVCGCPPGYFRIGQ-GHCV 2121
               GGY C CP GY +  Q   CV
Sbjct:  2584 IIGGYRCSCPQGYLQHYQWNQCV 2606

 Score = 1646 (584.5 bits), Expect = 5.5e-167, P = 5.5e-167
 Identities = 439/1339 (32%), Positives = 626/1339 (46%)

Query:   845 NLCG---NGQCL----NTPGGYRCECDMGFLPSPDGKACEDIDECILPNICVYGTCHNLP 897
             N+CG   N  C       PGG +C   +      DG  C   + C  P+  +  +C +  
Sbjct:    57 NVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDG-FCSRPNMCTCPSGQISPSCGSR- 114

Query:   898 GLFRCQCETGYELDRSGGNCTDIN----------ECADPTTCISGTCLN---IPGSYTCE 944
              +  C          +GG+C+D +           C  P  C SG CLN         C 
Sbjct:   115 SIQHCNIRC-----MNGGSCSDDHCLCQKGYIGTHCGQPV-CESG-CLNGGRCVAPNRCA 167

Query:   945 CPPDFELNPTRVGCV-DTRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAWG 1003
             C   F    T   C  D R+G C+  +  +   G ++     G+  +K  CC ++G+AWG
Sbjct:   168 CTYGF----TGPQCERDYRTGPCFTVVSNQMCQGQLS-----GIVCTKTLCCATVGRAWG 218

Query:  1004 IPCEQCPAVNSTDYKLLCPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQC 1063
              PCE CPA          P   GF PN  T   +D+DECQ +PG+CQGG CIN+ GSF+C
Sbjct:   219 HPCEMCPAQPH-------PCRRGFIPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFEC 271

Query:  1064 QCPSGYYLNEETRVCDDIDECTT-PGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDM 1122
             +CP+G+  NE ++ C+DIDEC+T PG+C  G C NT+ +Y C CPP +     G  C+D+
Sbjct:   272 KCPAGHKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDV 331

Query:  1123 RRSLCYRNFYADNQTCDGELLFNMTKKMCCCSYNIGRAWNRPC----EQCPIPSTDEFST 1178
             R   CY      N  C  +L  ++TK  CCC  ++GR W+       E CPI ST++F+ 
Sbjct:   332 RPGYCYTALA--NGRCSNQLPQSITKMQCCC--DLGRCWSPGVTVAPEMCPIRSTEDFNK 387

Query:  1179 LCGSQR--PGFVIDIYTGLPVD-IDECREIPGVCENGVCINLVGSFRCECPAGFFY--ND 1233
             LC      PG     Y   P+  +   + +P     G  I +        P  + Y   +
Sbjct:   388 LCSVPLVIPGR--PEYPPPPIGPLPPVQPVPPGYPPGPVIPVPRP-----PPEYLYPSRE 440

Query:  1234 KLLICEADI-DECQN-GHICQQNADCINTPGSYRCDCKPGYRFTPVGRCVDRNECQEIPN 1291
                +   ++ D CQ   ++CQ N  CI TPGSYRC+C  G++    G C+D +EC++ P 
Sbjct:   441 PPRVLPVNVTDYCQLVRYLCQ-NGRCIPTPGSYRCECNKGFQLDIRGECIDVDECEKNP- 498

Query:  1292 ICSHGDCIDREGGYTCRCHTGFKTNEDQTMCIDINECEREP--CGNGTCRNTVGSFNCRC 1349
              C+ G+CI+ +G YTC C  G+++   +T C DI+EC +    C NG C NT GSF+C C
Sbjct:   499 -CTGGECINNQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVC 557

Query:  1350 HTGF-ILSHNNDCIDIDECATXXXXXXXXXXXXXTIGSFLCICNEGYEMTPDGRVCLDIN 1408
             + GF + S   +C D+DEC T               GSF CIC  G+++  DGR C DIN
Sbjct:   558 NAGFHVSSEGKNCEDMDECRTPNMCPNGMCINED--GSFKCICKPGFQLASDGRYCKDIN 615

Query:  1409 ECALDPGKCTPGTCQNLDGSYRCICPPGYALKDDNCNDIDECSEEAEICALGTCSNTPGS 1468
             EC   PG C  G C N DGSYRC C PG A+  D    +D     +  C  G      G 
Sbjct:   616 ECET-PGICMNGRCVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSS--CYGGY---RRGQ 669

Query:  1469 FVCLCPEGFVVSFSGRRCQDQRISYCFTKFEEGKCSVPKSRNHSKQDCCCS----MNGEG 1524
               C+ P    V+ S   C      Y F +     C    ++N ++    CS    M   G
Sbjct:   670 --CVKPLFGAVTKS--ECCCASTEYAFGE----PCQPCPAQNSAEYQALCSSGPGMTSAG 721

Query:  1525 WG-DPC----ELCPQ---EG-EEAYRQICPFGSGILVGPRGEP-IDADEC-LDPDICKHG 1573
                + C    ++CP    E     Y+ IC   SG  V   G+  +D +EC L+  +C +G
Sbjct:   722 TDINECALDPDICPNGICENLRGTYKCIC--NSGYEVDITGKNCVDINECVLNSLLCDNG 779

Query:  1574 QCINTDGSYRCECPFGYVLQGN--ECTDTDECSVGDPCGNGTCKNIIGSFECTC--EEGF 1629
             QC NT GS+ C CP G+V + +   C D DEC    PC NG CKN  GSF C C  E   
Sbjct:   780 QCRNTPGSFVCTCPKGFVYKPDLKTCEDIDECE-SSPCINGVCKNSPGSFICECSPESTL 838

Query:  1630 EPGPMVTCEDVNECAQNPLLCAFRC-VNTYGSY---ECKCPAGYVLREDKRMCKDQNECE 1685
             +P   +  E +       ++   RC +N  G+    EC    G        +C+    C 
Sbjct:   839 DPTKTICIETIKGTCWQTVIDG-RCEININGATLKSECCSSLGAAWGSPCTICQLDPICG 897

Query:  1686 EGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDEN---ECQTKPGLCENGRCIN 1742
             +G    +  Q  C+++     C   PG  +  +G  CV+     +C+     C NG  ++
Sbjct:   898 KGFSRIKGTQ--CEDI---NECEVFPGVCK--NGL-CVNSRGSFKCE-----CPNGMTLD 944

Query:  1743 TQGSFRCECH-DGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDGG 1801
               G    +   +   +     EC     G    +     C VG++   T    EC     
Sbjct:   945 ATGRICLDIRLETCFLKYDDEECTLPIAGRHRMDAC--CCSVGAAW-GTEECEECPLRNS 1001

Query:  1802 RGWGPNCEICPFMGTMAFKKLCPHGRGFTTDGADIDECKVIRDACQNGECVNSMGSYQCK 1861
             R +    E+CP     A K +  +G+ F  D   I+ECK+I   C +G+C N++GS++C+
Sbjct:  1002 REYE---ELCPRGPGFATKDIT-NGKPFFKD---INECKMIPSLCTHGKCRNTIGSFKCR 1054

Query:  1862 CKEGYITDITGTLCIDLNECNQSPKPCNF-ICKNTEGSYQCSCPKGYILQ-EDGRSCKDL 1919
             C  G+  D     C D++EC  SP  C    C NT G ++C C +GY       ++C D+
Sbjct:  1055 CDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDI 1114

Query:  1920 DECATKQHNCQF-LCVNTIGGFTCKCPPG--FTQHHSACIDNNECAGDVNLCGSKGICQN 1976
             DEC      C+  +C NT G + C+CPPG   + + SACID NEC    NLC   G C N
Sbjct:  1115 DECQRDPLLCRGGICHNTEGTYRCECPPGHQLSPNISACIDINECELSANLC-PHGRCVN 1173

Query:  1977 TPGSFTCECQRGFSLDQSGASCEVDVDECEGSHR-CQHGCQNIIGGYRCSCPQGYLQHYQ 2035
               G + C C  G+        C VD+DEC   +  C+  C N  G Y CSC  G+     
Sbjct:  1174 LIGKYQCACNPGYHPTHDRLFC-VDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPD 1232

Query:  2036 WNQCVDENECLSS-HICGGASCHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCS 2094
                C D ++C  + +IC G  C N  G ++C+C  G+   +    C DVNEC  +   C 
Sbjct:  1233 QRSCTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICL 1292

Query:  2095 YG-CSNTDGGYVCGCPPGY 2112
              G C NT G ++C C  GY
Sbjct:  1293 SGTCENTKGSFICHCDMGY 1311

 Score = 1603 (569.3 bits), Expect = 7.6e-194, Sum P(2) = 7.6e-194
 Identities = 457/1429 (31%), Positives = 626/1429 (43%)

Query:   758 CEIGAHNCDRHAICTNTAGSFKCSCAPGWLGD--GIKCTDLDECSNGTHMCSPHADCKNT 815
             C++  + C ++  C  T GS++C C  G+  D  G +C D+DEC      C+   +C N 
Sbjct:   453 CQLVRYLC-QNGRCIPTPGSYRCECNKGFQLDIRG-ECIDVDECEKNP--CTG-GECINN 507

Query:   816 MGSYRCLCKEGYSGD--GFTCTDIDECSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDG 873
              GSY C C+ GY        C DIDEC +N  +C NG+C+NT G + C C+ GF  S +G
Sbjct:   508 QGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVSSEG 567

Query:   874 KACEDIDECILPNICVYGTCHNLPGLFRCQCETGYELDRSGGNCTDINECADPTTCISGT 933
             K CED+DEC  PN+C  G C N  G F+C C+ G++L   G  C DINEC  P  C++G 
Sbjct:   568 KNCEDMDECRTPNMCPNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGR 627

Query:   934 CLNIPGSYTCECPPDFELNPTRVGCVDT--RSGYCYLEIKPRGDNGDMACSNEIGVGVSK 991
             C+N  GSY CEC P   +      CVDT  RS  CY   + RG      C   +   V+K
Sbjct:   628 CVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSS-CYGGYR-RGQ-----CVKPLFGAVTK 680

Query:   992 ASCCC-SLGKAWGIPCEQCPAVNSTDYKLLCPGGEGFRPNPITVILEDIDECQELPGLCQ 1050
             + CCC S   A+G PC+ CPA NS +Y+ LC  G G     +T    DI+EC   P +C 
Sbjct:   681 SECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPG-----MTSAGTDINECALDPDICP 735

Query:  1051 GGQCINSFGSFQCQCPSGYYLNEETRVCDDIDECTTPGI-CGPGTCYNTIGNYTCICPPD 1109
              G C N  G+++C C SGY ++   + C DI+EC    + C  G C NT G++ C CP  
Sbjct:   736 NGICENLRGTYKCICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKG 795

Query:  1110 YMQVNGGNNCMDM---RRSLCYRNFYADNQ-----TCDGELLFNMTKKMCCCSYNIGRAW 1161
             ++       C D+     S C      ++       C  E   + TK +C  +   G  W
Sbjct:   796 FVYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIK-GTCW 854

Query:  1162 NRPCE-QCPIPSTDEF--STLCGSQRP--GFVIDIYTGLPVDIDECREIPGV-CENGVCI 1215
                 + +C I        S  C S     G    I    P+       I G  CE+   I
Sbjct:   855 QTVIDGRCEININGATLKSECCSSLGAAWGSPCTICQLDPICGKGFSRIKGTQCED---I 911

Query:  1216 NLVGSFRCECPAGFFYNDK-LLICEAD--IDECQNGHICQ--QNADCINTPGSYRCDCKP 1270
             N    F   C  G   N +    CE    +     G IC   +   C        C    
Sbjct:   912 NECEVFPGVCKNGLCVNSRGSFKCECPNGMTLDATGRICLDIRLETCFLKYDDEECTLPI 971

Query:  1271 GYRFT------PVGRCVDRNECQEIPNICSHGDCIDREGGYTCRCHTGFKTNE---DQTM 1321
               R         VG      EC+E P   S      RE    C    GF T +    +  
Sbjct:   972 AGRHRMDACCCSVGAAWGTEECEECPLRNS------REYEELCPRGPGFATKDITNGKPF 1025

Query:  1322 CIDINECEREP--CGNGTCRNTVGSFNCRCHTGFIL-SHNNDCIDIDECATXXXXXXXXX 1378
               DINEC+  P  C +G CRNT+GSF CRC +GF L S   +C DIDEC           
Sbjct:  1026 FKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQ 1085

Query:  1379 XXXXTIGSFLCICNEGYEMT-PDGRVCLDINECALDPGKCTPGTCQNLDGSYRCICPPGY 1437
                 T G F C C+EGYE      + C+DI+EC  DP  C  G C N +G+YRC CPPG+
Sbjct:  1086 CVN-TPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGICHNTEGTYRCECPPGH 1144

Query:  1438 ALKDD--NCNDIDECSEEAEICALGTCSNTPGSFVCLCPEGFVVSFSGRRCQDQRISYCF 1495
              L  +   C DI+EC   A +C  G C N  G + C C  G+  +     C D       
Sbjct:  1145 QLSPNISACIDINECELSANLCPHGRCVNLIGKYQCACNPGYHPTHDRLFCVD------- 1197

Query:  1496 TKFEEGKCSVPKSRNHSKQDCCCSMNGEGWGDPCELCPQEGEEAYRQICPFGSGILVGPR 1555
                +E  CS+              MNG G    CE      + +Y   C  G  ++   R
Sbjct:  1198 --IDE--CSI--------------MNG-G----CETFCTNSDGSYECSCQPGFALMPDQR 1234

Query:  1556 GEPIDADECLD-PDICKHGQCINTDGSYRCECPFGYVLQGN--ECTDTDECSVG-DPCGN 1611
                 D D+C D P+IC  GQC N  G YRC C  G++   +   C D +EC +  + C +
Sbjct:  1235 S-CTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLS 1293

Query:  1612 GTCKNIIGSFECTCEEGFEPGPMVT-CEDVNECAQNPLLCAFR--CVNTYGSYECKCPAG 1668
             GTC+N  GSF C C+ G+      T C D+NEC      C     C NT GS++C C  G
Sbjct:  1294 GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPG 1353

Query:  1669 YVLREDKRMCKDQNECEEGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENEC 1728
             ++   D   C D +EC  G H C S+   CKN +G+Y C+C  G+    DG  C D +EC
Sbjct:  1354 WI--GDGIKCTDLDECSNGTHMC-SQHADCKNTMGSYRCLCKDGYTG--DGFTCTDLDEC 1408

Query:  1729 QTKPGLCENGRCINTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQ--VGSS 1786
                  LC NG+C+N  G +RCEC  GF  +     C D  E       +   C    G  
Sbjct:  1409 SENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLF 1468

Query:  1787 SVETVTKSECCCDGGRGWGPNCEICPFMGTMAFKKLCPHGRG-FTTDGADIDECKVIRDA 1845
               E     E    GG     N  + P   T      C +  G +T D +   E    R  
Sbjct:  1469 RCECEIGYELDRSGGNCTDVNECLDP---TTCISGNCVNTPGSYTCDCSPDFELNPTRVG 1525

Query:  1846 C---QNGECVNSM------GSYQCKCKEGYITDITGTLCIDLNECNQSPKPCNFICKNTE 1896
             C   ++G C  ++      G   C  + G +     + C  L +   +P  C  +C +  
Sbjct:  1526 CVDTRSGNCYLNIRPRGDNGDTACSNEIG-VGVSKASCCCSLGKAWGTP--CE-LCPSVN 1581

Query:  1897 GS-YQCSCPKGYILQEDGRSC--KDLDECATKQHNCQF-LCVNTIGGFTCKCPPGF--TQ 1950
              S Y+  CP G   + +  +   +D+DEC      CQ   C+NT G F C+CP G+   +
Sbjct:  1582 TSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNE 1641

Query:  1951 HHSACIDNNECAGDVNLCGSKGICQNTPGSFTCECQRGFSLDQSGASCEVDVDE--CEGS 2008
                 C D NEC     +CG  G C NT G++TC C   +     G +C +D+    C  +
Sbjct:  1642 DTRVCDDVNECETP-GICGP-GTCYNTVGNYTCICPPDYMQVNGGNNC-MDMRRSICYRN 1698

Query:  2009 HRCQHG-CQN--IIGGYRCSCPQGYLQHYQWNQCVDENECLSSHICGGASCHNTLGSFKC 2065
             +   +  C    +    +  C   Y     WN+      C    I          GS + 
Sbjct:  1699 YYADNQTCDGELLFNMTKKMCCCSYNIRRAWNK-----PCEQCPIPSTDEFATLCGSQR- 1752

Query:  2066 MCPTGYHYEQFSGACQDVNECGSSQAPCSYG-CSNTDGGYVCGCPPGYF 2113
               P G+  + ++G   D++EC      C  G C N  G + C CP G+F
Sbjct:  1753 --P-GFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFF 1798

 Score = 354 (129.7 bits), Expect = 7.6e-194, Sum P(2) = 7.6e-194
 Identities = 100/301 (33%), Positives = 134/301 (44%)

Query:     8 CSIRNM--CLNGMCINEDGSFK---CICKPGFQLASDGRYCRDIDECETPGICMNG-RCV 61
             C  R++  C N  C+N  GS     C+C+ G+     G +C     CE+ G C+NG RCV
Sbjct:   111 CGSRSIQHC-NIRCMN-GGSCSDDHCLCQKGYI----GTHCGQ-PVCES-G-CLNGGRCV 161

Query:    62 NTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCASTD 121
               +   RC C      G  G  C   +    C+       C   LSG V     CCA+  
Sbjct:   162 APN---RCAC----TYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVG 214

Query:   122 YAFGEPCQPCPAQSSDEYHGLCSSGPGI-TATGTDINECALDPDICPNGICENMLGMYKC 180
              A+G PC+ CPAQ      G     P I T    D++EC   P +C  G C N +G ++C
Sbjct:   215 RAWGHPCEMCPAQPHPCRRGFI---PNIRTGACQDVDECQAIPGMCQGGNCINTVGSFEC 271

Query:   181 ICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDI 240
              C  G++ +   + C DIDEC+    +CD G+C NT  S+ C CP GF   PD   C D+
Sbjct:   272 KCPAGHKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDV 331

Query:   241 NE--CESSPCVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQ---TVVNGRCE 295
                 C ++   NG C N          P+S    TK  C   + G CW    TV    C 
Sbjct:   332 RPGYCYTA-LANGRCSNQ--------LPQSI---TKMQCCCDL-GRCWSPGVTVAPEMCP 378

Query:   296 I 296
             I
Sbjct:   379 I 379

 Score = 293 (108.2 bits), Expect = 2.1e-187, Sum P(2) = 2.1e-187
 Identities = 103/353 (29%), Positives = 143/353 (40%)

Query:   358 VCVNTMGSFVCQCPNGMTLDITGRKCI-DIRLESCYLGHDYEE--CASPIGGRHRLDACC 414
             VC +   ++ C CP   TL   G +CI  I   SC  G       C  P G   ++   C
Sbjct:    58 VCGSRYNAY-C-CPGWKTLP-GGNQCIVPICRHSCGDGFCSRPNMCTCPSG---QISPSC 111

Query:   415 CSVGAAWGPDCD-ECPTKGT-PDYEALCPRGP-GFSSRDPVNGKPFYKDINECKMIPRL- 470
                G+     C+  C   G+  D   LC +G  G     PV           C    R  
Sbjct:   112 ---GSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNG-GRCVAPNRCA 167

Query:   471 CTYG----KCRNTIGSFRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDF- 525
             CTYG    +C     +  C     F + S +  C    + ++S  +C + +C  T G   
Sbjct:   168 CTYGFTGPQCERDYRTGPC-----FTVVSNQM-C----QGQLSGIVCTKTLCCATVGRAW 217

Query:   526 -H-CE--------CFEGYESGFMMMKNCMDIDECERNPLLCRGGVCINTEGSFKCDCPPG 575
              H CE        C  G+    +    C D+DEC+  P +C+GG CINT GSF+C CP G
Sbjct:   218 GHPCEMCPAQPHPCRRGFIPN-IRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCPAG 276

Query:   576 HQLLPNISACVDINECDLSMNLCRNGRCVNLIGKYQCSCNPGYHATPDRLACVDIDE--C 633
             H+       C DI+EC     +C  G C N +  Y C C PG++ +PD   CVD+    C
Sbjct:   277 HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDVRPGYC 336

Query:   634 --SIMNGGCDTFCTNSEGSYECSCRQGYALMPDHRTCTD---IDECEDHPHIC 681
               ++ NG C      S    +C C  G    P      +   I   ED   +C
Sbjct:   337 YTALANGRCSNQLPQSITKMQCCCDLGRCWSPGVTVAPEMCPIRSTEDFNKLC 389

 Score = 275 (101.9 bits), Expect = 1.7e-185, Sum P(2) = 1.7e-185
 Identities = 92/322 (28%), Positives = 136/322 (42%)

Query:   605 NLIG-KYQCSCNPGYHATPDRLACVDIDECSIMNGGCDTFCTNSEGSYECSCRQGYALMP 663
             N+ G +Y   C PG+   P    C+ +  C    G  D FC+       C+C  G  + P
Sbjct:    57 NVCGSRYNAYCCPGWKTLPGGNQCI-VPICRHSCG--DGFCSRPN---MCTCPSGQ-ISP 109

Query:   664 DHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFM-TSEDMKTCLDVNECDLNPNI 722
                +   I  C  +    +GG C+    +  CLC  G++ T      C   + C LN   
Sbjct:   110 SCGS-RSIQHC--NIRCMNGGSCS----DDHCLCQKGYIGTHCGQPVC--ESGC-LNGGR 159

Query:   723 CLSGS-CENTKGSFICHCDMGY-SGKKGTTGCTDINECEIGAHNCDRHAICTNTAG---S 777
             C++ + C  T G     C+  Y +G   T     + + ++    C +  +C  T G    
Sbjct:   160 CVAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTK-TLCCATVGRAWG 218

Query:   778 FKCSCAP--------GWLGDGIK---CTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEG 826
               C   P        G++ + I+   C D+DEC     MC    +C NT+GS+ C C  G
Sbjct:   219 HPCEMCPAQPHPCRRGFIPN-IRTGACQDVDECQAIPGMCQG-GNCINTVGSFECKCPAG 276

Query:   827 YSGDGFT--CTDIDECSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECIL 884
             +  +  +  C DIDECS    +C  G+C NT   Y C+C  GF  SPDG  C D+     
Sbjct:   277 HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDVRPGYC 336

Query:   885 PNICVYGTCHN-LP-GLFRCQC 904
                   G C N LP  + + QC
Sbjct:   337 YTALANGRCSNQLPQSITKMQC 358

 Score = 263 (97.6 bits), Expect = 3.2e-184, Sum P(2) = 3.2e-184
 Identities = 83/295 (28%), Positives = 119/295 (40%)

Query:   478 NTIGS-FRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYES- 535
             N  GS +   C  G+        C  +  CR S   CG G C + P    C C  G  S 
Sbjct:    57 NVCGSRYNAYCCPGWKTLPGGNQCI-VPICRHS---CGDGFC-SRPN--MCTCPSGQISP 109

Query:   536 --GFMMMKNC----MDIDECERNPLLCRGGVCINTE-GSFKCD--CPPGHQLL-PNISAC 585
               G   +++C    M+   C  +  LC+ G  I T  G   C+  C  G + + PN  AC
Sbjct:   110 SCGSRSIQHCNIRCMNGGSCSDDHCLCQKGY-IGTHCGQPVCESGCLNGGRCVAPNRCAC 168

Query:   586 V---DINECDLSMNLCRNGRCVNLIGKYQCSCNPGYHATPDRLACVDIDECSIMNGGCDT 642
                    +C+      R G C  ++    C            L C  +         C+ 
Sbjct:   169 TYGFTGPQCERDY---RTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRA--WGHPCE- 222

Query:   643 FCTNSEGSYECSCRQGYALMPDHRT--CTDIDECEDHPHICDGGQCTNIPGEYRCLCYDG 700
              C     +    CR+G+  +P+ RT  C D+DEC+  P +C GG C N  G + C C  G
Sbjct:   223 MCP----AQPHPCRRGF--IPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCPAG 276

Query:   701 FMTSEDMKTCLDVNECDLNPNICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDI 755
                +E  + C D++EC   P +C  G C NT  S+ C C  G+      T C D+
Sbjct:   277 HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDV 331

 Score = 257 (95.5 bits), Expect = 1.2e-17, P = 1.2e-17
 Identities = 81/285 (28%), Positives = 117/285 (41%)

Query:  1853 NSMGS-YQCKCKEGYITDITGTLCIDLNECNQSPKPC-NFICKNTEGSYQCSCPKGYILQ 1910
             N  GS Y   C  G+ T   G  CI +  C  S   C +  C        C+CP G I  
Sbjct:    57 NVCGSRYNAYCCPGWKTLPGGNQCI-VPICRHS---CGDGFCSRPN---MCTCPSGQISP 109

Query:  1911 EDG-RS-------CKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNNECA 1962
               G RS       C +   C+     CQ   + T  G    C  G   +   C+  N CA
Sbjct:   110 SCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPV-CESGCL-NGGRCVAPNRCA 167

Query:  1963 GDVNLCGSKGICQN---TPGSFTCECQRGFSLDQSGASCEVDVDECEGSHRCQHGCQNII 2019
                   G +  C+    T   FT    +      SG  C   +          H C+ + 
Sbjct:   168 CTYGFTGPQ--CERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRAWGHPCE-MC 224

Query:  2020 GGYRCSCPQGYLQHYQWNQCVDENECLS-SHICGGASCHNTLGSFKCMCPTGYHYEQFSG 2078
                   C +G++ + +   C D +EC +   +C G +C NT+GSF+C CP G+ + + S 
Sbjct:   225 PAQPHPCRRGFIPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCPAGHKFNEVSQ 284

Query:  2079 ACQDVNECGSSQAPCSYG-CSNTDGGYVCGCPPGYFRIGQG-HCV 2121
              C+D++EC +    C  G C+NT   Y C CPPG++    G  CV
Sbjct:   285 KCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCV 329

 Score = 253 (94.1 bits), Expect = 3.6e-183, Sum P(2) = 3.6e-183
 Identities = 93/318 (29%), Positives = 126/318 (39%)

Query:   143 CSSGPGITATGT-DINECALDPDICPNG-ICENMLGMYKCICNFGYEVDSSGKNCLDIDE 200
             C SG    + G+  I  C +    C NG  C +      C+C  GY     G +C     
Sbjct:   102 CPSGQISPSCGSRSIQHCNIR---CMNGGSCSDD----HCLCQKGY----IGTHCGQ-PV 149

Query:   201 CAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDINECESSPCVNGVCKNTPGSF 260
             C    L  + G+C   P    C C  GF   P    CE   +  + PC   V  N     
Sbjct:   150 CESGCL--NGGRCV-APNR--CACTYGFT-GPQ---CE--RDYRTGPCFT-VVSNQ---- 193

Query:   261 VCECSPESTLDATKTVCIETVKGTCW---------QTVVNGRCEI-NIN-GATLKSQCCS 309
             +C+    S +  TKT+C  TV G  W         Q     R  I NI  GA      C 
Sbjct:   194 MCQ-GQLSGIVCTKTLCCATV-GRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQ 251

Query:   310 SL-GAAWGSPCIECE-RVDPICSKGYSRIR-GTLCEDVNECEVFPGVCTNGVCVNTMGSF 366
             ++ G   G  CI      +  C  G+        CED++EC   PGVC  G C NT+ S+
Sbjct:   252 AIPGMCQGGNCINTVGSFECKCPAGHKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSY 311

Query:   367 VCQCPNGMTLDITGRKCIDIRLESCYLGHDYEECASPIGGRHRLDACCCSVGAAWGPDC- 425
              C+CP G      G +C+D+R   CY       C++ +        CCC +G  W P   
Sbjct:   312 FCKCPPGFYTSPDGTRCVDVRPGYCYTALANGRCSNQLPQSITKMQCCCDLGRCWSPGVT 371

Query:   426 ---DECPTKGTPDYEALC 440
                + CP + T D+  LC
Sbjct:   372 VAPEMCPIRSTEDFNKLC 389