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| Gene Model: Fbn1 |
| Nomenclature | Genomic Location | ||
| Symbol | Fbn1 | Chromosome | 2 |
| Name | Fibrillin 1 | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr2: 28 Mbp |
| Molecular Function |
|
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Molecular Function Terms: binding
structural molecule activity
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| Human Disease Association |
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Defects in FBN1 are a cause of Marfan syndrome (MFS) [MIM:154700]. MFS is an autosomal dominant disorder that affects the skeletal, ocular, and cardiovascular systems. A wide variety of skeletal abnormalities occurs with MFS, including scoliosis, chest wall deformity, tall stature, abnormal joint mobility. Ectopia lentis occurs in up to about 80% of MFS patients and is almost always bilateral. The leading cause of premature death in MFS patients is progressive dilation of the aortic root and ascending aorta, causing aortic incompetence and dissection. Note=The majority of the more than 600 mutations in FBN1 currently known are point mutations, the rest are frameshifts and splice site mutations. Marfan syndrome has been suggested in at least 2 historical figures, Abraham Lincoln and Paganini. Defects in FBN1 are a cause of isolated ectopia lentis (EL) [MIM:129600]. The symptoms of this autosomal dominant fibrillinopathy overlap with those of Marfan syndrome, with the exclusion of the skeletal and cardiovascular manifestations. Defects in FBN1 are the cause of Weill-Marchesani syndrome autosomal dominant (ADWMS) [MIM:608328]. A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma. Defects in FBN1 are a cause of Shprintzen-Goldberg craniosynostosis syndrome (SGS) [MIM:182212]. SGS is a very rare syndrome characterized by a marfanoid habitus, craniosynostosis, characteristic dysmorphic facial features, skeletal and cardiovascular abnormalities, mental retardation, developmental delay and learning disabilities. Defects in FBN1 are a cause of MASS syndrome (MASSS) [MIM:604308]. MASS syndrome is a heritable disorder of connective tissue characterized by involvement of the mitral valve, aorta, skeleton, and skin. MASS syndrome is closely resembling both the Marfan syndrome and the Barlow syndrome. However, no dislocation of the lenses or aneurysmal changes occur in the aorta, and the mitral valve prolapse is by no means invariable. Defects in FBN1 are a cause of stiff skin syndrome (SSKS) [MIM:184900]. It is a syndrome characterized by hard, thick skin, usually over the entire body, which limits joint mobility and causes flexion contractures. Other occasional findings include lipodystrophy and muscle weakness. |
| Predicted Transcript |
1 AACCTTGTAGATATGGATGAATGCAGCATACGGAATATGTGTCTTAACGGCATGTGCATC
61 AACGAAGACGGGAGTTTTAAGTGTATCTGCAAACCTGGTTTTCAGTTAGCGTCGGATGGA
121 CGTTACTGCAGAGATATCGATGAGTGCGAGACGCCGGGAATCTGCATGAACGGGCGCTGC
181 GTCAACACCGATGGCTCCTTCAGGTGCGAATGTTTCCCGGGCCTTGCTGTGGGGCTGGAT
241 GGACGCGTGTGTGTTGATACACATATGCGGAGCACATGCTACGGCGAATACAGAAGAGGC
301 CAATGTGTCAAGCCATTATCTGGTGCAGTTACTAAATCGGAGTGCTGTTGCGCCAGCACC
361 GACTACGCCTTTGGGGAACCTTGTCAGCCTTGTCCTGCACAGAGTTCAGATGAGTACCAT
421 GGTCTTTGTAGCAGTGGCCCAGGCATAACAGCAACCGGAACTGATATCAATGAATGTGCT
481 CTGGACCCTGACATCTGTCCCAACGGAATCTGTGAAAACATGCTTGGAATGTACAAATGC
541 ATCTGTAATTTTGGGTACGAAGTGGATTCATCTGGGAAAAACTGCTTAGACATTGACGAA
601 TGTGCCGTGAACAAATTGCTCTGCGACAACGGACAATGCAGGAACACCCCAGGAAGCTTC
661 ACCTGCACCTGCCCCAAGGGATTTGTATTCAAGCCTGATTTAAAGACATGTGAAGATATC
721 AACGAGTGTGAATCCAGCCCCTGTGTTAATGGAGTGTGCAAAAACACGCCCGGCTCTTTT
781 GTCTGTGAATGTTCCCCTGAAAGTACTCTGGATGCAACAAAAACTGTCTGCATTGAGACT
841 GTTAAAGGCACTTGTTGGCAGACTGTTGTCAATGGGAGATGCGAAATAAATATCAATGGA
901 GCCACCCTGAAATCTCAGTGCTGTTCTTCGCTTGGTGCTGCTTGGGGAAGCCCTTGTATT
961 GAATGTGAACGAGTAGATCCGATCTGCTCAAAAGGCTACTCAAGGATTAGAGGAACACTA
1021 TGTGAAGATGTCAACGAATGTGAAGTGTTCCCTGGAGTGTGCACCAATGGAGTGTGTGTC
1081 AATACTATGGGATCCTTTGTTTGCCAGTGTCCCAATGGAATGACTTTGGATATAACTGGA
1141 CGGAAGTGTATCGATATTCGCTTGGAGTCATGCTACCTGGGGCACGACTACGAGGAGTGT
1201 GCATCGCCCATTGGGGGACGCCACCGGCTGGATGCGTGCTGCTGTTCTGTGGGGGCCGCT
1261 TGGGGTCCTGACTGTGACGAATGTCCCACCAAAGGAACCCCCGACTATGAAGCGCTTTGC
1321 CCGAGAGGACCTGGATTTTCTAGCCGGGACCCCGTCAATGGAAAACCATTCTACAAAGAT
1381 ATCAATGAATGCAAAATGATTCCAAGACTCTGCACTTATGGGAAATGCCGAAACACCATT
1441 GGGAGTTTCCGGTGTAAATGTGACAGTGGTTTTGCGCTTGATTCCGAAGAGAGAAATTGT
1501 ACAGATATTGACGAGTGTCGCATTTCTCCGGACTTGTGTGGCCAAGGCATTTGTGTGAAC
1561 ACGCCTGGAGATTTCCACTGCGAATGCTTTGAAGGCTATGAAAGTGGGTTTATGATGATG
1621 AAAAACTGCATGGACATAGACGAATGTGAAAGAAACCCACTGTTGTGCCGAGGTGGGGTC
1681 TGCATTAACACCGAAGGAAGCTTCAAATGCGATTGTCCTCCTGGTCATCAGTTGTTGCCA
1741 AACATCTCTGCCTGTGTAGACATCAATGAATGTGACTTGAGTATGAACTTGTGCCGAAAC
1801 GGACGCTGCGTCAATCTCATTGGAAAGTACCAGTGTTCCTGCAACCCGGGATATCACGCC
1861 ACACCTGACAGATTAGCCTGTGTGGATATTGATGAGTGCAGTATAATGAACGGTGGATGT
1921 GACACTTTTTGTACAAACTCAGAAGGCAGCTATGAGTGCAGCTGCAGACAAGGCTATGCG
1981 CTGATGCCGGATCATAGGACTTGCACAGATATCGATGAGTGTGAAGACCATCCTCACATC
2041 TGCGATGGAGGCCAGTGCACCAATATACCTGGAGAATATAGATGCCTTTGTTATGATGGA
2101 TTCATGACCTCTGAGGACATGAAGACTTGTTTAGATGTTAACGAATGTGACCTGAACCCA
2161 AACATCTGCCTGAGCGGAAGCTGTGAGAATACCAAAGGCTCCTTCATCTGTCACTGTGAT
2221 ATGGGTTATTCTGGCAAAAAGGGAACAACTGGTTGCACAGATATTAATGAATGTGAAATC
2281 GGAGCTCATAACTGTGACCGACATGCAATATGTACAAACACAGCCGGCAGTTTCAAGTGC
2341 AGTTGCGCTCCAGGTTGGCTTGGAGATGGCATCAAATGCACAGATCTAGATGAATGCTCC
2401 AATGGGACACACATGTGCAGCCCACACGCTGACTGCAAAAACACCATGGGCTCATATCGC
2461 TGCTTATGTAAAGAAGGATACAGTGGTGATGGATTCACGTGTACAGATATTGATGAATGC
2521 TCAGAAAATGTGAATCTCTGTGGGAATGGCCAGTGTTTAAACACCCCAGGAGGTTACCGT
2581 TGTGAATGCGATATGGGATTTTTGCCAAGCCCAGATGGGAAAGCCTGTGAAGACATTGAC
2641 GAGTGCATTCTGCCCAACATTTGTGTCTATGGAACGTGCCACAACCTCCCTGGTCTCTTC
2701 CGATGCCAATGTGAGACAGGATACGAACTGGACAGAAGTGGCGGCAACTGCACAGATATC
2761 AACGAATGTGCAGACCCAACAACTTGTATCAGCGGCACTTGCCTCAATATCCCAGGCAGT
2821 TATACCTGTGAATGTCCTCCAGATTTCGAGCTGAACCCCACTCGTGTTGGATGTGTTGAT
2881 ACCCGCTCTGGATACTGTTACCTGGAAATTAAACCTCGAGGAGATAATGGAGACATGGCT
2941 TGCAGCAACGAAATTGGGGTTGGCGTTTCCAAGGCCTCCTGCTGCTGCTCCCTTGGGAAA
3001 GCCTGGGGAATCCCTTGCGAACAGTGTCCAGCCGTGAACTCAACCGATTACAAGCTGCTG
3061 TGTCCTGGTGGAGAAGGGTTCCGTCCCAACCCTATTACAGTTATCCTGGAAGATATTGAC
3121 GAATGTCAGGAGCTGCCTGGACTTTGCCAAGGAGGGCAATGCATCAATTCCTTTGGGAGC
3181 TTTCAGTGCCAGTGTCCTTCCGGCTACTATTTGAATGAAGAGACACGAGTTTGTGATGAT
3241 ATTGATGAATGTACTACACCTGGCATCTGTGGTCCTGGTACTTGCTACAATACTATAGGG
3301 AATTACACTTGCATTTGCCCTCCGGACTACATGCAGGTTAATGGTGGAAACAATTGCATG
3361 GATATGAGAAGGAGTCTGTGCTACCGAAACTTCTATGCTGACAATCAAACCTGTGATGGA
3421 GAGCTGCTTTTTAACATGACCAAAAAAATGTGCTGCTGTTCCTACAACATCGGACGAGCC
3481 TGGAACAGACCTTGTGAACAGTGTCCAATCCCAAGCACCGATGAATTTTCAACCCTATGT
3541 GGAAGTCAAAGGCCTGGTTTCGTCATAGACATTTACACAGGATTACCTGTTGACATTGAT
3601 GAATGCCGTGAGATCCCCGGTGTGTGTGAGAATGGCGTCTGTATCAATCTGGTGGGCAGT
3661 TTCCGGTGCGAATGTCCAGCGGGATTCTTCTACAATGACAAATTACTGATCTGTGAAGCA
3721 GATATTGACGAATGCCAAAACGGGCACATATGTCAACAAAATGCAGATTGCATCAACACA
3781 CCTGGAAGCTACCGTTGCGATTGCAAACCTGGCTATCGCTTCACTCCCGTGGGCCGATGT
3841 GTCGATCGCAATGAGTGTCAAGAAATACCAAACATTTGCAGTCATGGTGATTGTATAGAT
3901 CGCGAGGGAGGATATACCTGCCGTTGCCACACTGGATTCAAAACTAATGAAGACCAAACC
3961 ATGTGCATAGATATAAATGAATGTGAGCGAGAGCCATGTGGAAATGGCACATGTAGGAAC
4021 ACAGTCGGTTCTTTCAACTGCCGCTGCCATACGGGATTCATCCTTTCTCACAATAACGAC
4081 TGTATAGACATCGATGAATGCGCCACTGGCAATGGGAATCTGTGCAGGAATGGCAGATGC
4141 AACAACACTATTGGATCTTTCCTATGTATCTGCAATGAAGGTTATGAAATGACTCCAGAT
4201 GGAAGGGTCTGCCTTGACATCAATGAATGTGCACTGGATCCTGGTAAATGTACACCTGGT
4261 ACATGTCAGAATCTGGATGGTTCATACAGATGCATCTGTCCTCCTGGATATGCCCTGAAA
4321 GATGACAACTGCAATGATATCGACGAGTGCTCCGAAGAGGCAGAAATCTGTGCCCTGGGC
4381 ACATGCAGCAATACCCCCGGCAGCTTTGTTTGCCTGTGTCCCGAAGGATTTGTAGTATCT
4441 TTCAGCGGACGTAGATGTCAAGATCAGAGAATAAGCTACTGTTTCACTAAATTTGAAGAG
4501 GGGAAATGTTCTGTGCCCAAATCCAGAAACCACTCTAAGCAAGACTGCTGCTGCAGTATG
4561 AACGGGGAAGGATGGGGCGATCCATGTGAACTATGTCCCCAAGAAGGAGAAGAAGCTTAT
4621 CGGCAAATTTGCCCGTTCGGATCTGGTATTCTGGTGGGACCTCGTGGTGAACCAATTGAT
4681 GCGGATGAATGCCTGGATCCAGACATTTGTAAACATGGCCAGTGCATCAATACGGACGGC
4741 TCCTACCGCTGTGAATGCCCGTTTGGTTATGTGCTTCAAGGAAATGAATGCACAGATACT
4801 GACGAATGTTCTGTCGGAGATCCGTGTGGAAATGGGACGTGTAAAAACATCATTGGGAGT
4861 TTTGAATGCACCTGTGAGGAAGGTTTTGAACCAGGACCCATGGTGACATGTGAAGATGTG
4921 AATGAATGTGCTCAGAATCCCCTGCTTTGTGCTTTCCGGTGTGTGAACACCTATGGATCA
4981 TATGAATGCAAATGTCCTGCTGGCTATGTTCTCAGAGAAGACAAGCGGATGTGTAAAGAT
5041 CAGAATGAGTGTGAAGAAGGAATTCACGATTGTGAGTCGAAGCAAATGACATGCAAAAAC
5101 CTGATCGGCACATACATGTGCATATGTGGGCCAGGATTCCAACGTCGGCCAGATGGCGAA
5161 GGTTGCGTAGATGAAAATGAATGTCAAACCAAACCTGGGTTGTGTGAAAACGGACGCTGT
5221 ATCAACACACAAGGAAGCTTCCGATGTGAATGTCATGATGGGTTCAATGTCAACGAAGCG
5281 CAGAATGAATGCATAGACACCAGGGAAGGATACTGCTTCACGGAAGTCCTGCAGAGCATG
5341 TGTCAGGTTGGGTCGAGCAGCGTTGAAACCGTGACCAAGTCCGAATGCTGCTGTGACGGC
5401 GGGCGAGGATGGGGACCCAACTGCGAGATCTGCCCCTTCATGGGCACCATGGCCTTTAAG
5461 AAACTCTGCCCTCACGGCCGCGGATTCACAACAGATGGAGCAGATATCGACGAGTGCAAG
5521 GTTATTCGTGACGCCTGCCAGAACGGAGAGTGTGTCAACAGCATGGGATCGTACCAGTGC
5581 AAGTGCAAGGAGGGCTACATTACCGATATCACGGGCACACTTTGTATAGATCTCAATGAA
5641 TGCAACCAGTCTCCAAAGCCATGCAATTTTATCTGCAAAAATACGGAGGGGAGTTATCAA
5701 TGCTCGTGTCCCAAAGGCTACATTTTGCAAGAAGACGGGAGAAGCTGCAAAGATCTTGAC
5761 GAATGTGCAACCAAGCAACACAACTGCCAATTCTTGTGCGTCAACACCATTGGGGGCTTC
5821 ACTTGTAAATGTCCTCCTGGATTTACTCAACATCATTCAGCATGTATTGATAACAACGAA
5881 TGTGCCGGTGACGTCAATCTTTGTGGATCTAAGGGCATTTGCCAGAACACCCCTGGAAGC
5941 TTCACTTGTGAATGTCAGCGAGGCTTTTCCCTTGACCAGTCCGGTGCCAGTTGCGAAGTA
6001 GACGTTGATGAGTGTGAAGGAAGCCACCGATGCCAGCATGGCTGCCAGAATATAATTGGA
6061 GGATACCGGTGCAGTTGCCCACAAGGATATCTCCAGCACTACCAGTGGAACCAGTGTGTC
6121 GATGAAAACGAATGCCTCAGTAGCCATATTTGTGGCGGAGCATCTTGCCACAATACTTTG
6181 GGAAGCTTCAAATGCATGTGCCCGACTGGATACCATTATGAGCAGTTCAGTGGAGCATGT
6241 CAAGACGTGAACGAGTGTGGCTCTTCACAAGCACCATGTAGCTATGGCTGTTCCAACACC
6301 GATGGCGGTTACGTATGTGGGTGCCCTCCGGGGTATTTCCGAATAGGACAAGGGCATTGT
6361 GTTTCTGGCCTGGGGCTGGGAAAAGGCCATGGCCATGGCCAAGACTTATCAGCCAGCAGT
6421 GAAGTGGATGAGAACTCACTTTCTCCTGAAGGATGTTACGACTGTAAAATCAATGGCTAT
6481 CCTAAGCGGGGAAGAAAACGGCGAAGCACAAATGAAACCGATGGACTTGATGCAGAGGAT
6541 CAGCCTGAGATAGAGATGGCTGTGAACCTCGCCAGCTGGGATATTGAAAAGCCAGCCACC
6601 CTTTCGTTCAACATTTCCGATCTTAATAACAAAGACCGGCTCTTGCAACTGATCCCTGCT
6661 CTCACGACGTTGACCAACCACAACCGATATTTAATAGACCACGGGAACGAGGGCGGCTTC
6721 TTTCGGATTAATCAGAAAGAAGGCGTAAGTTTCCTTCACCTAACAAAGAAGAAGCCGGTG
6781 CCTGGAGCCTACTCATTACAGATCAGTAGCATCCCGCTTTATAAAAAGAAGGAACTCAAC
6841 CAGCTTGAAGACAAACACGACAAAGACTACCTCAGTGGTGAGCTAGGAGACAACCTGAAA
6901 ATGAGAATTGAAATTTTGCTGCATTAA
| Predicted Protein Product |
NLVDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCRDIDECETPGICMNGRC VNTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCAST DYAFGEPCQPCPAQSSDEYHGLCSSGPGITATGTDINECALDPDICPNGICENMLGMYKC ICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDI NECESSPCVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQTVVNGRCEINING ATLKSQCCSSLGAAWGSPCIECERVDPICSKGYSRIRGTLCEDVNECEVFPGVCTNGVCV NTMGSFVCQCPNGMTLDITGRKCIDIRLESCYLGHDYEECASPIGGRHRLDACCCSVGAA WGPDCDECPTKGTPDYEALCPRGPGFSSRDPVNGKPFYKDINECKMIPRLCTYGKCRNTI GSFRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMMM KNCMDIDECERNPLLCRGGVCINTEGSFKCDCPPGHQLLPNISACVDINECDLSMNLCRN GRCVNLIGKYQCSCNPGYHATPDRLACVDIDECSIMNGGCDTFCTNSEGSYECSCRQGYA LMPDHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFMTSEDMKTCLDVNECDLNP NICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAGSFKC SCAPGWLGDGIKCTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYSGDGFTCTDIDEC SENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECILPNICVYGTCHNLPGLF RCQCETGYELDRSGGNCTDINECADPTTCISGTCLNIPGSYTCECPPDFELNPTRVGCVD TRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAWGIPCEQCPAVNSTDYKLL CPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQCQCPSGYYLNEETRVCDD IDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNFYADNQTCDG ELLFNMTKKMCCCSYNIGRAWNRPCEQCPIPSTDEFSTLCGSQRPGFVIDIYTGLPVDID ECREIPGVCENGVCINLVGSFRCECPAGFFYNDKLLICEADIDECQNGHICQQNADCINT PGSYRCDCKPGYRFTPVGRCVDRNECQEIPNICSHGDCIDREGGYTCRCHTGFKTNEDQT MCIDINECEREPCGNGTCRNTVGSFNCRCHTGFILSHNNDCIDIDECATGNGNLCRNGRC NNTIGSFLCICNEGYEMTPDGRVCLDINECALDPGKCTPGTCQNLDGSYRCICPPGYALK DDNCNDIDECSEEAEICALGTCSNTPGSFVCLCPEGFVVSFSGRRCQDQRISYCFTKFEE GKCSVPKSRNHSKQDCCCSMNGEGWGDPCELCPQEGEEAYRQICPFGSGILVGPRGEPID ADECLDPDICKHGQCINTDGSYRCECPFGYVLQGNECTDTDECSVGDPCGNGTCKNIIGS FECTCEEGFEPGPMVTCEDVNECAQNPLLCAFRCVNTYGSYECKCPAGYVLREDKRMCKD QNECEEGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGRC INTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDG GRGWGPNCEICPFMGTMAFKKLCPHGRGFTTDGADIDECKVIRDACQNGECVNSMGSYQC KCKEGYITDITGTLCIDLNECNQSPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLD ECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNNECAGDVNLCGSKGICQNTPGS FTCECQRGFSLDQSGASCEVDVDECEGSHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCV DENECLSSHICGGASCHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCSYGCSNT DGGYVCGCPPGYFRIGQGHCVSGLGLGKGHGHGQDLSASSEVDENSLSPEGCYDCKINGY PKRGRKRRSTNETDGLDAEDQPEIEMAVNLASWDIEKPATLSFNISDLNNKDRLLQLIPA LTTLTNHNRYLIDHGNEGGFFRINQKEGVSFLHLTKKKPVPGAYSLQISSIPLYKKKELN QLEDKHDKDYLSGELGDNLKMRIEILLH
| Protein Alignment to Mouse |
sp|Q61554|FBN1_MOUSE Fibrillin-1 OS=Mus musculus GN=Fbn1 PE=1 SV=1
Length = 2871
Score = 11426 (4027.2 bits), Expect = 0., P = 0.
Identities = 1905/2309 (82%), Positives = 2101/2309 (90%)
Query: 1 NLVDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCRDIDECETPGICMNGRC 60
N DMDEC NMC NGMCINEDGSFKCICKPGFQLASDGRYC+DI+ECETPGICMNGRC
Sbjct: 569 NCEDMDECRTPNMCPNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRC 628
Query: 61 VNTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCAST 120
VNTDGS+RCECFPGLAVGLDGR CVDTHMRS+CYG YRRGQCVKPL GAVTKSECCCAST
Sbjct: 629 VNTDGSYRCECFPGLAVGLDGRWCVDTHMRSSCYGGYRRGQCVKPLFGAVTKSECCCAST 688
Query: 121 DYAFGEPCQPCPAQSSDEYHGLCSSGPGITATGTDINECALDPDICPNGICENMLGMYKC 180
+YAFGEPCQPCPAQ+S EY LCSSGPG+T+ GTDINECALDPDICPNGICEN+ G YKC
Sbjct: 689 EYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGTDINECALDPDICPNGICENLRGTYKC 748
Query: 181 ICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDI 240
ICN GYEVD +GKNC+DI+EC +N LLCDNGQCRNTPGSF CTCPKGFV+KPDLKTCEDI
Sbjct: 749 ICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVYKPDLKTCEDI 808
Query: 241 NECESSPCVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQTVVNGRCEINING 300
+ECESSPC+NGVCKN+PGSF+CECSPESTLD TKT+CIET+KGTCWQTV++GRCEINING
Sbjct: 809 DECESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIKGTCWQTVIDGRCEINING 868
Query: 301 ATLKSQCCSSLGAAWGSPCIECERVDPICSKGYSRIRGTLCEDVNECEVFPGVCTNGVCV 360
ATLKS+CCSSLGAAWGSPC C+ +DPIC KG+SRI+GT CED+NECEVFPGVC NG+CV
Sbjct: 869 ATLKSECCSSLGAAWGSPCTICQ-LDPICGKGFSRIKGTQCEDINECEVFPGVCKNGLCV 927
Query: 361 NTMGSFVCQCPNGMTLDITGRKCIDIRLESCYLGHDYEECASPIGGRHRLDACCCSVGAA 420
N+ GSF C+CPNGMTLD TGR C+DIRLE+C+L +D EEC PI GRHR+DACCCSVGAA
Sbjct: 928 NSRGSFKCECPNGMTLDATGRICLDIRLETCFLKYDDEECTLPIAGRHRMDACCCSVGAA 987
Query: 421 WGPD-CDECPTKGTPDYEALCPRGPGFSSRDPVNGKPFYKDINECKMIPRLCTYGKCRNT 479
WG + C+ECP + + +YE LCPRGPGF+++D NGKPF+KDINECKMIP LCT+GKCRNT
Sbjct: 988 WGTEECEECPLRNSREYEELCPRGPGFATKDITNGKPFFKDINECKMIPSLCTHGKCRNT 1047
Query: 480 IGSFRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMM 539
IGSF+C+CDSGFALDSEERNCTDIDECRISPDLCG+G CVNTPGDF C+C EGYESGFMM
Sbjct: 1048 IGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMM 1107
Query: 540 MKNCMDIDECERNPLLCRGGVCINTEGSFKCDCPPGHQLLPNISACVDINECDLSMNLCR 599
MKNCMDIDEC+R+PLLCRGG+C NTEG+++C+CPPGHQL PNISAC+DINEC+LS NLC
Sbjct: 1108 MKNCMDIDECQRDPLLCRGGICHNTEGTYRCECPPGHQLSPNISACIDINECELSANLCP 1167
Query: 600 NGRCVNLIGKYQCSCNPGYHATPDRLACVDIDECSIMNGGCDTFCTNSEGSYECSCRQGY 659
+GRCVNLIGKYQC+CNPGYH T DRL CVDIDECSIMNGGC+TFCTNS+GSYECSC+ G+
Sbjct: 1168 HGRCVNLIGKYQCACNPGYHPTHDRLFCVDIDECSIMNGGCETFCTNSDGSYECSCQPGF 1227
Query: 660 ALMPDHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFMTSEDMKTCLDVNECDLN 719
ALMPD R+CTDID+CED+P+ICDGGQCTNIPGEYRCLCYDGFM SEDMKTC+DVNECDLN
Sbjct: 1228 ALMPDQRSCTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLN 1287
Query: 720 PNICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAGSFK 779
PNICLSG+CENTKGSFICHCDMGYSGKKG TGCTDINECEIGAHNC RHA+CTNTAGSFK
Sbjct: 1288 PNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFK 1347
Query: 780 CSCAPGWLGDGIKCTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYSGDGFTCTDIDE 839
CSC+PGW+GDGIKCTDLDECSNGTHMCS HADCKNTMGSYRCLCK+GY+GDGFTCTD+DE
Sbjct: 1348 CSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTCTDLDE 1407
Query: 840 CSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECILPNICVYGTCHNLPGL 899
CSEN+NLCGNGQCLN PGGYRCECDMGF+PS DGKACEDIDEC LPNICV+GTCHNLPGL
Sbjct: 1408 CSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGL 1467
Query: 900 FRCQCETGYELDRSGGNCTDINECADPTTCISGTCLNIPGSYTCECPPDFELNPTRVGCV 959
FRC+CE GYELDRSGGNCTD+NEC DPTTCISG C+N PGSYTC+C PDFELNPTRVGCV
Sbjct: 1468 FRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYTCDCSPDFELNPTRVGCV 1527
Query: 960 DTRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAWGIPCEQCPAVNSTDYKL 1019
DTRSG CYL I+PRGDNGD ACSNEIGVGVSKASCCCSLGKAWG PCE CP+VN+++YK+
Sbjct: 1528 DTRSGNCYLNIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCELCPSVNTSEYKI 1587
Query: 1020 LCPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQCQCPSGYYLNEETRVCD 1079
LCPGGEGFRPNPITVILEDIDECQELPGLCQGG+CIN+FGSFQC+CP+GYYLNE+TRVCD
Sbjct: 1588 LCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCD 1647
Query: 1080 DIDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNFYADNQTCD 1139
D++EC TPGICGPGTCYNT+GNYTCICPPDYMQVNGGNNCMDMRRS+CYRN+YADNQTCD
Sbjct: 1648 DVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSICYRNYYADNQTCD 1707
Query: 1140 GELLFNMTKKMCCCSYNIGRAWNRPCEQCPIPSTDEFSTLCGSQRPGFVIDIYTGLPVDI 1199
GELLFNMTKKMCCCSYNI RAWN+PCEQCPIPSTDEF+TLCGSQRPGFVIDIYTGLPVDI
Sbjct: 1708 GELLFNMTKKMCCCSYNIRRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDI 1767
Query: 1200 DECREIPGVCENGVCINLVGSFRCECPAGFFYNDKLLICEADIDECQNGHICQQNADCIN 1259
DECREIPGVCENGVCIN+VGSFRCECP GFFYNDKLL+CE DIDECQNG +C +NA+CIN
Sbjct: 1768 DECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCE-DIDECQNGPVCLRNAECIN 1826
Query: 1260 TPGSYRCDCKPGYRFTPVGRCVDRNECQEIPNICSHGDCIDREGGYTCRCHTGFKTNEDQ 1319
T GSYRCDCKPGYR T G+C DRNECQEIPNICSHG CID G + C CHTGFKTNEDQ
Sbjct: 1827 TAGSYRCDCKPGYRLTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNEDQ 1886
Query: 1320 TMCIDINECEREPCGNGTCRNTVGSFNCRCHTGFILSHNNDCIDIDECATXXXXXXXXXX 1379
TMC+DINECER+ CGNGTCRNT+GSFNCRC+ GFILSHNNDCID+DECAT
Sbjct: 1887 TMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQ 1946
Query: 1380 XXXTIGSFLCICNEGYEMTPDGRVCLDINECALDPGKCTPGTCQNLDGSYRCICPPGYAL 1439
T+GSF C CNEGYE+ PDGR C+DINEC LDPGKC PGTCQNLDGSYRCICPPGY+L
Sbjct: 1947 CVNTVGSFQCRCNEGYEVAPDGRTCVDINECVLDPGKCAPGTCQNLDGSYRCICPPGYSL 2006
Query: 1440 KDDNCNDIDECSEEAEICALGTCSNTPGSFVCLCPEGFVVSFSGRRCQDQRISYCFTKFE 1499
++D C DIDEC EE EICALGTCSNT GSF CLCPEGF S SGRRCQD R+SYC+ KFE
Sbjct: 2007 QNDKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSWSSSGRRCQDLRMSYCYAKFE 2066
Query: 1500 EGKCSVPKSRNHSKQDCCCSMNGEGWGDPCELCPQEGEEAYRQICPFGSGILVGPRGEPI 1559
GKCS PKSRNHSKQ+CCC++ GEGWGDPCELCP E +EA+RQICPFGSGI+VGP +
Sbjct: 2067 GGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPFGSGIIVGPDDSAV 2126
Query: 1560 DADECLDPDICKHGQCINTDGSYRCECPFGYVLQGNECTDTDECSVGDPCGNGTCKNIIG 1619
D DEC +PD+C+HGQCINTDGSYRCECPFGY+L+GNEC DTDECSVG+PCGNGTCKN+IG
Sbjct: 2127 DMDECKEPDVCRHGQCINTDGSYRCECPFGYILEGNECVDTDECSVGNPCGNGTCKNVIG 2186
Query: 1620 SFECTCEEGFEPGPMVTCEDVNECAQNPLLCAFRCVNTYGSYECKCPAGYVLREDKRMCK 1679
FECTCEEGFEPGPM+TCED+NECAQNPLLCAFRCVNTYGSYECKCP GYVLRED+RMCK
Sbjct: 2187 GFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCK 2246
Query: 1680 DQNECEEGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGR 1739
D++EC EG HDC KQM CKNLIGTYMCICGPG+QRRPDGEGC+DENECQTKPG+CENGR
Sbjct: 2247 DEDECAEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICENGR 2306
Query: 1740 CINTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCD 1799
C+NT GS+ CEC+DGF + Q+EC+D REGYCF+EV ++MCQ+GSS+ VTKSECCC
Sbjct: 2307 CLNTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVFENMCQIGSSNRNPVTKSECCCV 2366
Query: 1800 GGRGWGPNCEICPFMGTMAFKKLCPHGRGFTTDGADIDECKVIRDACQNGECVNSMGSYQ 1859
GGRGWG +CEICPF GT+A+KKLCPHGRGF T+GAD+DECKVI D C+NGECVN GSY
Sbjct: 2367 GGRGWGLHCEICPFEGTVAYKKLCPHGRGFMTNGADVDECKVIHDVCRNGECVNDRGSYH 2426
Query: 1860 CKCKEGYITDITGTLCIDLNECNQSPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDL 1919
C CK GY DITGT C+DLNECNQ+PKPCNFICKNTEGSYQCSCP GYILQEDGRSCKDL
Sbjct: 2427 CICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPNGYILQEDGRSCKDL 2486
Query: 1920 DECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNNECAGDVNLCGSKGICQNTPG 1979
DECATKQHNCQFLCVNTIGGFTCKCPPGFTQHH+ACIDNNEC D+NLCGSKGICQNTPG
Sbjct: 2487 DECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTACIDNNECTSDINLCGSKGICQNTPG 2546
Query: 1980 SFTCECQRGFSLDQSGASCEVDVDECEGSHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQC 2039
SFTCECQRGFSLDQSGASCE DVDECEG+HRCQHGCQNIIGGYRCSCPQGYLQHYQWNQC
Sbjct: 2547 SFTCECQRGFSLDQSGASCE-DVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQC 2605
Query: 2040 VDENECLSSHICGGASCHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCSYGCSN 2099
VDENECLS+H+CGGASCHNTLGS+KCMCP G+ YEQFSG CQD+NECGSSQAPCSYGCSN
Sbjct: 2606 VDENECLSAHVCGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSSQAPCSYGCSN 2665
Query: 2100 TDGGYVCGCPPGYFRIGQGHCVSXXXXXXXXXXXQDLSASSEVDENSLSPEGCYDCKING 2159
T+GGY+CGCPPGYFRIGQGHC+S + ASSE+D+NSLSPE CY+CKING
Sbjct: 2666 TEGGYLCGCPPGYFRIGQGHCLSGMGMGRGA---PEPPASSEMDDNSLSPEACYECKING 2722
Query: 2160 YPKRGRKRRSTNETDGLDAEDQPEIEMAVNLASWDIEKPATLSFNISDLNNKDRLLQLIP 2219
YPKRGRKRRSTNETD D +D E+E V+LASWD+EKPA+ +FNIS ++NK R+L+L+P
Sbjct: 2723 YPKRGRKRRSTNETDASDIQDGSEMEANVSLASWDVEKPASFAFNISHVSNKVRILELLP 2782
Query: 2220 ALTTLTNHNRYLIDHGNEGGFFRINQKEGVSFLHLTKKKPVPGAYSLQISSIPLYKKKEL 2279
ALTTL NHNRYLI+ GNE GFF+INQKEGVS+LH TKK V G YSLQISS PLYKKKEL
Sbjct: 2783 ALTTLMNHNRYLIESGNEDGFFKINQKEGVSYLHFTKKNAVAGTYSLQISSTPLYKKKEL 2842
Query: 2280 NQLEDKHDKDYLSGELGDNLKMRIEILLH 2308
NQLED++DKDYLSGELGDNLKM+I+ILLH
Sbjct: 2843 NQLEDRYDKDYLSGELGDNLKMKIQILLH 2871
Score = 2615 (925.6 bits), Expect = 1.1e-272, P = 1.1e-272
Identities = 733/2195 (33%), Positives = 1005/2195 (45%)
Query: 47 DECETPG-ICMNGRCVNTDGSFRCECFPGLAVGLDGRVCVDTHM--RSTCYG-EYRRGQ- 101
D C+ +C NGRC+ T GS+RCEC G + + G C+D ++ C G E Q
Sbjct: 451 DYCQLVRYLCQNGRCIPTPGSYRCECNKGFQLDIRGE-CIDVDECEKNPCTGGECINNQG 509
Query: 102 -----CVKPLSGAVTKSECCCASTDYAFGEPCQPCPAQSSD-EYHGLCSSGPGITATGT- 154
C +T++EC G C ++D +H +C++G +++ G
Sbjct: 510 SYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVSSEGKN 569
Query: 155 --DINECALDPDICPNGICENMLGMYKCICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQ 212
D++EC P++CPNG+C N G +KCIC G+++ S G+ C DI+EC + C NG+
Sbjct: 570 CEDMDECRT-PNMCPNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGI-CMNGR 627
Query: 213 CRNTPGSFTCTCPKGFVFKPDLKTCEDINECESSPCVNGVCKNTPGSFVCECSPESTLDA 272
C NT GS+ C C G D + C D + S C G + +C
Sbjct: 628 CVNTDGSYRCECFPGLAVGLDGRWCVDTHM--RSSCYGGYRRG-------QCVKPLFGAV 678
Query: 273 TKTVCIETVKGTCWQTVVNGRCEININGATLKSQCCSSLG-AAWGSPCIECERVDP-ICS 330
TK+ C + C N A ++ C S G + G+ EC +DP IC
Sbjct: 679 TKSECCCASTEYAFGEPCQP-CPAQ-NSAEYQALCSSGPGMTSAGTDINECA-LDPDICP 735
Query: 331 KGY-SRIRGT---LCEDVNECEVFPGVCTN-GVCVNTMGSFVC---QCPNGM-TLDITGR 381
G +RGT +C E ++ C + CV + S +C QC N + T
Sbjct: 736 NGICENLRGTYKCICNSGYEVDITGKNCVDINECV--LNSLLCDNGQCRNTPGSFVCTCP 793
Query: 382 KCIDIR--LESCYLGHDYEEC-ASP-IGGRHRLDACCCSVGAAWGPDCDECPTKGTPD-Y 436
K + L++C D +EC +SP I G C S G+ C EC + T D
Sbjct: 794 KGFVYKPDLKTC---EDIDECESSPCING-----VCKNSPGSFI---C-ECSPESTLDPT 841
Query: 437 EALCPRG-PGFSSRDPVNGKPFYKDINECKMIPRLCT-----YGK-CRNTIGSFRCKCDS 489
+ +C G + ++G+ +IN + C+ +G C TI C
Sbjct: 842 KTICIETIKGTCWQTVIDGRCEI-NINGATLKSECCSSLGAAWGSPC--TICQLDPICGK 898
Query: 490 GFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMMMKNCMDIDEC 549
GF+ + C DI+EC + P +C G+CVN+ G F CEC G M +D
Sbjct: 899 GFSR-IKGTQCEDINECEVFPGVCKNGLCVNSRGSFKCECPNG-----------MTLDAT 946
Query: 550 ERNPLLCRGGVCINTEGSFKCDCP-PG-HQL---LPNISACVDINECDLSMNLCRNGRCV 604
R L R C +C P G H++ ++ A EC+ L RN R
Sbjct: 947 GRICLDIRLETCFLKYDDEECTLPIAGRHRMDACCCSVGAAWGTEECE-ECPL-RNSR-- 1002
Query: 605 NLIGKYQ--CSCNPGYHATPD----RLACVDIDECSIMNGGCDTF-CTNSEGSYECSCRQ 657
+Y+ C PG+ AT D + DI+EC ++ C C N+ GS++C C
Sbjct: 1003 ----EYEELCPRGPGF-ATKDITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDS 1057
Query: 658 GYALMPDHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFMTS-EDMKTCLDVNEC 716
G+AL + R CTDIDEC P +C GQC N PG++ C C +G+ + MK C+D++EC
Sbjct: 1058 GFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDEC 1117
Query: 717 DLNPNICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAG 776
+P +C G C NT+G++ C C G+ + C DINECE+ A+ C H C N G
Sbjct: 1118 QRDPLLCRGGICHNTEGTYRCECPPGHQLSPNISACIDINECELSANLCP-HGRCVNLIG 1176
Query: 777 SFKCSCAPGW--LGDGIKCTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYS--GDGF 832
++C+C PG+ D + C D+DECS C C N+ GSY C C+ G++ D
Sbjct: 1177 KYQCACNPGYHPTHDRLFCVDIDECSIMNGGCETF--CTNSDGSYECSCQPGFALMPDQR 1234
Query: 833 TCTDIDECSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECIL-PNICVYG 891
+CTDID+C +N N+C GQC N PG YRC C GF+ S D K C D++EC L PNIC+ G
Sbjct: 1235 SCTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSG 1294
Query: 892 TCHNLPGLFRCQCETGYELDRSGGNCTDINECA-DPTTC-ISGTCLNIPGSYTCECPPDF 949
TC N G F C C+ GY + CTDINEC C C N GS+ C C P +
Sbjct: 1295 TCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPGW 1354
Query: 950 ELNPTRVGCVDTRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAW-GIPC-- 1006
+ + C D C + D C N +G C C G G C
Sbjct: 1355 IGDGIK--CTDLDE--CSNGTHMCSQHAD--CKNTMG----SYRCLCKDGYTGDGFTCTD 1404
Query: 1007 -EQCPA-VN--STDYKLLCPGGE------GFRPNPITVILEDIDECQELPGLCQGGQCIN 1056
++C +N L PGG GF P+ EDIDEC LP +C G C N
Sbjct: 1405 LDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECS-LPNICVFGTCHN 1463
Query: 1057 SFGSFQCQCPSGYYLNEETRVCDDIDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGG 1116
G F+C+C GY L+ C D++EC P C G C NT G+YTC C PD+ ++N
Sbjct: 1464 LPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYTCDCSPDF-ELNPT 1522
Query: 1117 N-NCMDMRRSLCYRNFY--ADN--QTCDGELLFNMTKKMCCCSYNIGRAWNRPCEQCPIP 1171
C+D R CY N DN C E+ ++K CCCS +G+AW PCE CP
Sbjct: 1523 RVGCVDTRSGNCYLNIRPRGDNGDTACSNEIGVGVSKASCCCS--LGKAWGTPCELCPSV 1580
Query: 1172 STDEFSTLC-GSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINLVGSFRCECPAGFF 1230
+T E+ LC G + GF + T + DIDEC+E+PG+C+ G CIN GSF+C CP G++
Sbjct: 1581 NTSEYKILCPGGE--GFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYY 1638
Query: 1231 YNDKLLICEADIDECQNGHICQQNADCINTPGSYRCDCKPGYRFTPVGRCVDRNECQEIP 1290
N+ +C+ D++EC+ IC C NT G+Y C C P Y G N C ++
Sbjct: 1639 LNEDTRVCD-DVNECETPGICGPGT-CYNTVGNYTCICPPDYMQVNGG-----NNCMDMR 1691
Query: 1291 -NICSHGDCIDREGGYTCRCHTGFKTNEDQTMC-IDINECEREPCGNGTCRNTVGSFNCR 1348
+IC D + TC F + C +I +PC +T F
Sbjct: 1692 RSICYRNYYADNQ---TCDGELLFNMTKKMCCCSYNIRRAWNKPCEQCPIPST-DEFATL 1747
Query: 1349 CHT---GFILS-HNNDCIDIDECATXXXXXXXXXXXXXTIGSFLCICNEGYEMTPDGRVC 1404
C + GF++ + +DIDEC +GSF C C G+ VC
Sbjct: 1748 CGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINM-VGSFRCECPVGFFYNDKLLVC 1806
Query: 1405 LDINECALDPGKCTPGTCQNLDGSYRCICPPGYALKDDN-CNDIDECSEEAEICALGTCS 1463
DI+EC P C N GSYRC C PGY L CND +EC E IC+ G C
Sbjct: 1807 EDIDECQNGPVCLRNAECINTAGSYRCDCKPGYRLTSTGQCNDRNECQEIPNICSHGQCI 1866
Query: 1464 NTPGSFVCLCPEGFVVSFSGRRCQDQRISYCFTKFEEGKCSVPKSRNH-SKQDCCC---- 1518
+T GSF CLC GF + C D I+ C E C RN +C C
Sbjct: 1867 DTVGSFYCLCHTGFKTNEDQTMCLD--INEC----ERDACGNGTCRNTIGSFNCRCNHGF 1920
Query: 1519 --SMNGEGWG-DPC-----ELCPQEGEEAYRQI----CPFGSGILVGPRGEP-IDADEC- 1564
S N + D C LC + G+ + C G V P G +D +EC
Sbjct: 1921 ILSHNNDCIDVDECATGNGNLC-RNGQ-CVNTVGSFQCRCNEGYEVAPDGRTCVDINECV 1978
Query: 1565 LDPDICKHGQCINTDGSYRCECPFGYVLQGNECTDTDECSVGDP--CGNGTCKNIIGSFE 1622
LDP C G C N DGSYRC CP GY LQ ++C D DEC V +P C GTC N GSF+
Sbjct: 1979 LDPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDIDEC-VEEPEICALGTCSNTEGSFK 2037
Query: 1623 CTCEEGFE-PGPMVTCEDVNECAQNPLLCAFRCVNTYGSYECKCPAGYVLREDKRMCKDQ 1681
C C EGF C+D L ++ C + +C P + + C +
Sbjct: 2038 CLCPEGFSWSSSGRRCQD--------LRMSY-CYAKFEGGKCSSPKSRNHSKQECCCALK 2088
Query: 1682 NECEEGIHD-CESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGRC 1740
E G D CE T + +C G G PD + VD +EC+ +P +C +G+C
Sbjct: 2089 GE---GWGDPCELCP-TEPDEAFRQICPFGSGIIVGPD-DSAVDMDECK-EPDVCRHGQC 2142
Query: 1741 INTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDG 1800
INT GS+RCEC G+ + E NEC+DT E C + + C G+ + EC C+
Sbjct: 2143 INTDGSYRCECPFGY-ILEG-NECVDTDE--CS---VGNPCGNGTCK-NVIGGFECTCEE 2194
Query: 1801 GRGWGP--NCE----------ICPF--MGTM-AFKKLCPHGRGFTTDGA---DIDECKVI 1842
G GP CE +C F + T +++ CP G D D DEC
Sbjct: 2195 GFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECAEG 2254
Query: 1843 RDAC--QNGECVNSMGSYQCKCKEGYITDITGTLCIDLNECNQSPKPC-NFICKNTEGSY 1899
+ C + EC N +G+Y C C GY G CID NEC P C N C NT GSY
Sbjct: 2255 KHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICENGRCLNTLGSY 2314
Query: 1900 QCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNN 1959
C C G+ C D E + +C IG + P T+ C+
Sbjct: 2315 TCECNDGFTASPTQDECLDNREGYCFSEVFENMC--QIGSSN-RNP--VTKSECCCVGGR 2369
Query: 1960 ECAGDVNLCGSKGICQNTPGSFTCECQRGFSLDQSGASCEVDVDECEGSHR-CQHG-CQN 2017
+C +G C RGF + GA DVDEC+ H C++G C N
Sbjct: 2370 GWGLHCEICPFEGTVAYKK---LCPHGRGFMTN--GA----DVDECKVIHDVCRNGECVN 2420
Query: 2018 IIGGYRCSCPQGYLQHYQWNQCVDENECLSSHICGGASCHNTLGSFKCMCPTGYHYEQFS 2077
G Y C C GY CVD NEC + C NT GS++C CP GY ++
Sbjct: 2421 DRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPNGYILQEDG 2480
Query: 2078 GACQDVNECGSSQAPCSYGCSNTDGGYVCGCPPGY 2112
+C+D++EC + Q C + C NT GG+ C CPPG+
Sbjct: 2481 RSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF 2515
Score = 2323 (822.8 bits), Expect = 1.0e-241, P = 1.0e-241
Identities = 698/2243 (31%), Positives = 981/2243 (43%)
Query: 3 VDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCRDIDECETPG-ICMNGRCV 61
+D+DEC +N C G CIN GS+ C C+ G+Q CRDIDEC G IC NGRC+
Sbjct: 489 IDVDECE-KNPCTGGECINNQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCI 547
Query: 62 NTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCASTD 121
NTDGSF C C G V +G+ C D T G C+ G+ +C C
Sbjct: 548 NTDGSFHCVCNAGFHVSSEGKNCEDMDECRTP-NMCPNGMCINE-DGSF---KCIC-KPG 601
Query: 122 YAFGEPCQPCPAQSSDEYHGLCSSGPGITATGTDINEC------ALDPDICPNG-ICENM 174
+ + C + E G+C +G + G+ EC LD C + + +
Sbjct: 602 FQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSSC 661
Query: 175 LGMYK---CICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFK 231
G Y+ C+ V S + C E A + C +N+ + C G
Sbjct: 662 YGGYRRGQCVKPLFGAVTKS-ECCCASTEYAFGEP-CQPCPAQNS-AEYQALCSSG---- 714
Query: 232 PDLKTC-EDINECESSP--CVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQT 288
P + + DINEC P C NG+C+N G++ C C+ +D T C++ + +
Sbjct: 715 PGMTSAGTDINECALDPDICPNGICENLRGTYKCICNSGYEVDITGKNCVD-INECVLNS 773
Query: 289 VV--NGRCEININGATLKSQCCSSLGAAWGSPCIECERVDPI----CSKGYSRIR-GT-L 340
++ NG+C N G+ + C G + CE +D C G + G+ +
Sbjct: 774 LLCDNGQCR-NTPGSFV---CTCPKGFVYKPDLKTCEDIDECESSPCINGVCKNSPGSFI 829
Query: 341 CEDVNECEVFPGVCTNGVCVNTMGSFVCQCPNGMTLDITGRKCIDIRLESCYLGHDYEEC 400
CE E + P T +C+ T+ Q T+ I GR C +I + L EC
Sbjct: 830 CECSPESTLDP---TKTICIETIKGTCWQ-----TV-IDGR-C-EININGATLK---SEC 875
Query: 401 ASPIGGRHRLDACCCSV----GAAW----GPDCD---ECPTKGTPDYEALCPRGPG-FSS 448
S +G C + G + G C+ EC LC G F
Sbjct: 876 CSSLGAAWGSPCTICQLDPICGKGFSRIKGTQCEDINECEVFPGVCKNGLCVNSRGSFKC 935
Query: 449 RDPVNGKPFYKDINECKMIPRLCT----YG--KCRNTI-GSFR---CKCDSGFALDSEER 498
P NG C I RL T Y +C I G R C C G A +EE
Sbjct: 936 ECP-NGMTLDATGRICLDI-RLETCFLKYDDEECTLPIAGRHRMDACCCSVGAAWGTEE- 992
Query: 499 NCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYESGFMMMKNCMDIDECERNPLLCRG 558
C +EC + + +C PG F + +G K DI+EC+ P LC
Sbjct: 993 -C---EECPLRNSREYEELCPRGPG-F---ATKDITNGKPFFK---DINECKMIPSLCTH 1041
Query: 559 GVCINTEGSFKCDCPPGHQLLPNISACVDINECDLSMNLCRNGRCVNLIGKYQCSCNPGY 618
G C NT GSFKC C G L C DI+EC +S +LC G+CVN G ++C C+ GY
Sbjct: 1042 GKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGY 1101
Query: 619 HATPDRLA-CVDIDECS----IMNGGCDTFCTNSEGSYECSCRQGYALMPDHRTCTDIDE 673
+ + C+DIDEC + GG C N+EG+Y C C G+ L P+ C DI+E
Sbjct: 1102 ESGFMMMKNCMDIDECQRDPLLCRGG---ICHNTEGTYRCECPPGHQLSPNISACIDINE 1158
Query: 674 CEDHPHICDGGQCTNIPGEYRCLCYDGFMTSEDMKTCLDVNECDLNPNICLSGSCENTKG 733
CE ++C G+C N+ G+Y+C C G+ + D C+D++EC + C + C N+ G
Sbjct: 1159 CELSANLCPHGRCVNLIGKYQCACNPGYHPTHDRLFCVDIDECSIMNGGCET-FCTNSDG 1217
Query: 734 SFICHCDMGYSGKKGTTGCTDINECEIGAHNCDRHAICTNTAGSFKCSCAPGWLG-DGIK 792
S+ C C G++ CTDI++CE + CD CTN G ++C C G++ + +K
Sbjct: 1218 SYECSCQPGFALMPDQRSCTDIDQCEDNPNICDGGQ-CTNIPGEYRCLCYDGFMASEDMK 1276
Query: 793 -CTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEGYSGD-GFT-CTDIDECSENVNLCG- 848
C D++EC ++C C+NT GS+ C C GYSG G T CTDI+EC + CG
Sbjct: 1277 TCVDVNECDLNPNICLS-GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGR 1335
Query: 849 NGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECIL-PNICV-YGTCHNLPGLFRCQCET 906
+ C NT G ++C C G++ DG C D+DEC ++C + C N G +RC C+
Sbjct: 1336 HAVCTNTAGSFKCSCSPGWIG--DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKD 1393
Query: 907 GYELDRSGGNCTDINECADPTT-CISGTCLNIPGSYTCECPPDFELNPTRVGCVDTRSGY 965
GY D G CTD++EC++ C +G CLN PG Y CEC F + C D
Sbjct: 1394 GYTGD--GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDE-- 1449
Query: 966 CYL-EIKPRGD--N--GDMACSNEIGVGVSKASC-CCSLGKAWG-IPCEQCPAVNSTDYK 1018
C L I G N G C EIG + ++ C + + C VN T
Sbjct: 1450 CSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVN-TPGS 1508
Query: 1019 LLCPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQCQCPSGYYLNEETRVC 1078
C F NP V D + G N G C G +++ + C
Sbjct: 1509 YTCDCSPDFELNPTRVGCVDTRSGNCYLNIRPRGD--N--GDTACSNEIGVGVSKASCCC 1564
Query: 1079 DDIDECTTPGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNFYADNQT- 1137
TP C NT Y +CP GG ++ + +
Sbjct: 1565 SLGKAWGTP--CELCPSVNT-SEYKILCP-------GGEGFRPNPITVILEDIDECQELP 1614
Query: 1138 --CDGELLFNMTKKMCC-CSYNIGRAWNRPCEQCPIPSTDEFSTLCGSQRPGFVIDIYTG 1194
C G N C C G N C + E +CG + YT
Sbjct: 1615 GLCQGGKCINTFGSFQCRCP--TGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTC 1672
Query: 1195 L-PVDIDECREIPGVCE--NGVCINLVGSFRCECPAGFFYN--DKLLICEADIDECQNGH 1249
+ P D + + +C + C +N K+ C +I N
Sbjct: 1673 ICPPDYMQVNGGNNCMDMRRSICYRNYYADNQTCDGELLFNMTKKMCCCSYNIRRAWNKP 1732
Query: 1250 ICQQNADC-INTPGSYRCDC---KPGYRFTP-VGRCVDRNECQEIPNICSHGDCIDREGG 1304
C+Q C I + + C +PG+ G VD +EC+EIP +C +G CI+ G
Sbjct: 1733 -CEQ---CPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGS 1788
Query: 1305 YTCRCHTGFKTNEDQTMCIDINECEREP-C-GNGTCRNTVGSFNCRCHTGFILSHNNDCI 1362
+ C C GF N+ +C DI+EC+ P C N C NT GS+ C C G+ L+ C
Sbjct: 1789 FRCECPVGFFYNDKLLVCEDIDECQNGPVCLRNAECINTAGSYRCDCKPGYRLTSTGQCN 1848
Query: 1363 DIDECATXXXXXXXXXXXXXTIGSFLCICNEGYEMTPDGRVCLDINECALDPGKCTPGTC 1422
D +EC T+GSF C+C+ G++ D +CLDINEC D C GTC
Sbjct: 1849 DRNECQEIPNICSHGQCID-TVGSFYCLCHTGFKTNEDQTMCLDINECERDA--CGNGTC 1905
Query: 1423 QNLDGSYRCICPPGYALKDDN-CNDIDECSE-EAEICALGTCSNTPGSFVCLCPEGFVVS 1480
+N GS+ C C G+ L +N C D+DEC+ +C G C NT GSF C C EG+ V+
Sbjct: 1906 RNTIGSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQCRCNEGYEVA 1965
Query: 1481 FSGRRCQDQRISYCFTKFEEGKCSVPKSRN-HSKQDCCCSMNGEGWGDPCELCPQEGEEA 1539
GR C D I+ C + GKC+ +N C C D CE + EE
Sbjct: 1966 PDGRTCVD--INECV--LDPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDIDECVEEP 2021
Query: 1540 YRQICPFGSGILVGPRGEPIDADECLDPDICKHGQCINTDGSYRCE---CPFGYV-LQGN 1595
+IC G+ G + +CL C G ++ G RC+ + Y +G
Sbjct: 2022 --EICALGT--CSNTEG----SFKCL----CPEGFSWSSSGR-RCQDLRMSYCYAKFEGG 2068
Query: 1596 ECTDT-------DECSV-------GDPCGNGTCKNIIG-SFECTCE--EGFEPGPMVTCE 1638
+C+ EC GDPC C +F C G GP +
Sbjct: 2069 KCSSPKSRNHSKQECCCALKGEGWGDPCE--LCPTEPDEAFRQICPFGSGIIVGPDDSAV 2126
Query: 1639 DVNECAQNPLLCAF-RCVNTYGSYECKCPAGYVLREDKRMCKDQNECEEGIHDCESKQMT 1697
D++EC + P +C +C+NT GSY C+CP GY+L ++ C D +EC G + C + T
Sbjct: 2127 DMDECKE-PDVCRHGQCINTDGSYRCECPFGYILEGNE--CVDTDECSVG-NPCGNG--T 2180
Query: 1698 CKNLIGTYMCICGPGFQRRPDGEGCVDENECQTKPGLCENGRCINTQGSFRCECHDGFNV 1757
CKN+IG + C C GF+ P C D NEC P LC RC+NT GS+ C+C G+ +
Sbjct: 2181 CKNVIGGFECTCEEGFEPGPMMT-CEDINECAQNPLLCAF-RCVNTYGSYECKCPVGYVL 2238
Query: 1758 NEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDGGRGWGPNCEICPFMGTM 1817
E + C D E C E + + C C G P+ E C
Sbjct: 2239 REDRRMCKDEDE--C-AEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENEC 2295
Query: 1818 AFKK-LCPHGRGFTTDGADIDECK------VIRDAC---QNGECVNSMGSYQCKCKEGYI 1867
K +C +GR T G+ EC +D C + G C + + C+
Sbjct: 2296 QTKPGICENGRCLNTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVFENMCQIGSSNR 2355
Query: 1868 TDITGTLCIDLNECNQSPKPCNFICKNTEGS--YQCSCPKGYILQEDGRSCKDLDECATK 1925
+T + C + C IC EG+ Y+ CP G +G D+DEC
Sbjct: 2356 NPVTKSECCCVGGRGWGLH-CE-ICP-FEGTVAYKKLCPHGRGFMTNGA---DVDECKVI 2409
Query: 1926 QHNCQF-LCVNTIGGFTCKCPPGFTQH--HSACIDNNECAGDVNLCGSKGICQNTPGSFT 1982
C+ CVN G + C C G+T ++C+D NEC C IC+NT GS+
Sbjct: 2410 HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNF--ICKNTEGSYQ 2467
Query: 1983 CECQRGFSLDQSGASCEVDVDECEGS-HRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVD 2041
C C G+ L + G SC+ D+DEC H CQ C N IGG+ C CP G+ QH+ C+D
Sbjct: 2468 CSCPNGYILQEDGRSCK-DLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHH--TACID 2524
Query: 2042 ENECLSS-HICGGAS-CHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCSYGCSN 2099
NEC S ++CG C NT GSF C C G+ +Q +C+DV+EC + C +GC N
Sbjct: 2525 NNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHR-CQHGCQN 2583
Query: 2100 TDGGYVCGCPPGYFRIGQ-GHCV 2121
GGY C CP GY + Q CV
Sbjct: 2584 IIGGYRCSCPQGYLQHYQWNQCV 2606
Score = 1646 (584.5 bits), Expect = 5.5e-167, P = 5.5e-167
Identities = 439/1339 (32%), Positives = 626/1339 (46%)
Query: 845 NLCG---NGQCL----NTPGGYRCECDMGFLPSPDGKACEDIDECILPNICVYGTCHNLP 897
N+CG N C PGG +C + DG C + C P+ + +C +
Sbjct: 57 NVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDG-FCSRPNMCTCPSGQISPSCGSR- 114
Query: 898 GLFRCQCETGYELDRSGGNCTDIN----------ECADPTTCISGTCLN---IPGSYTCE 944
+ C +GG+C+D + C P C SG CLN C
Sbjct: 115 SIQHCNIRC-----MNGGSCSDDHCLCQKGYIGTHCGQPV-CESG-CLNGGRCVAPNRCA 167
Query: 945 CPPDFELNPTRVGCV-DTRSGYCYLEIKPRGDNGDMACSNEIGVGVSKASCCCSLGKAWG 1003
C F T C D R+G C+ + + G ++ G+ +K CC ++G+AWG
Sbjct: 168 CTYGF----TGPQCERDYRTGPCFTVVSNQMCQGQLS-----GIVCTKTLCCATVGRAWG 218
Query: 1004 IPCEQCPAVNSTDYKLLCPGGEGFRPNPITVILEDIDECQELPGLCQGGQCINSFGSFQC 1063
PCE CPA P GF PN T +D+DECQ +PG+CQGG CIN+ GSF+C
Sbjct: 219 HPCEMCPAQPH-------PCRRGFIPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFEC 271
Query: 1064 QCPSGYYLNEETRVCDDIDECTT-PGICGPGTCYNTIGNYTCICPPDYMQVNGGNNCMDM 1122
+CP+G+ NE ++ C+DIDEC+T PG+C G C NT+ +Y C CPP + G C+D+
Sbjct: 272 KCPAGHKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDV 331
Query: 1123 RRSLCYRNFYADNQTCDGELLFNMTKKMCCCSYNIGRAWNRPC----EQCPIPSTDEFST 1178
R CY N C +L ++TK CCC ++GR W+ E CPI ST++F+
Sbjct: 332 RPGYCYTALA--NGRCSNQLPQSITKMQCCC--DLGRCWSPGVTVAPEMCPIRSTEDFNK 387
Query: 1179 LCGSQR--PGFVIDIYTGLPVD-IDECREIPGVCENGVCINLVGSFRCECPAGFFY--ND 1233
LC PG Y P+ + + +P G I + P + Y +
Sbjct: 388 LCSVPLVIPGR--PEYPPPPIGPLPPVQPVPPGYPPGPVIPVPRP-----PPEYLYPSRE 440
Query: 1234 KLLICEADI-DECQN-GHICQQNADCINTPGSYRCDCKPGYRFTPVGRCVDRNECQEIPN 1291
+ ++ D CQ ++CQ N CI TPGSYRC+C G++ G C+D +EC++ P
Sbjct: 441 PPRVLPVNVTDYCQLVRYLCQ-NGRCIPTPGSYRCECNKGFQLDIRGECIDVDECEKNP- 498
Query: 1292 ICSHGDCIDREGGYTCRCHTGFKTNEDQTMCIDINECEREP--CGNGTCRNTVGSFNCRC 1349
C+ G+CI+ +G YTC C G+++ +T C DI+EC + C NG C NT GSF+C C
Sbjct: 499 -CTGGECINNQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVC 557
Query: 1350 HTGF-ILSHNNDCIDIDECATXXXXXXXXXXXXXTIGSFLCICNEGYEMTPDGRVCLDIN 1408
+ GF + S +C D+DEC T GSF CIC G+++ DGR C DIN
Sbjct: 558 NAGFHVSSEGKNCEDMDECRTPNMCPNGMCINED--GSFKCICKPGFQLASDGRYCKDIN 615
Query: 1409 ECALDPGKCTPGTCQNLDGSYRCICPPGYALKDDNCNDIDECSEEAEICALGTCSNTPGS 1468
EC PG C G C N DGSYRC C PG A+ D +D + C G G
Sbjct: 616 ECET-PGICMNGRCVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSS--CYGGY---RRGQ 669
Query: 1469 FVCLCPEGFVVSFSGRRCQDQRISYCFTKFEEGKCSVPKSRNHSKQDCCCS----MNGEG 1524
C+ P V+ S C Y F + C ++N ++ CS M G
Sbjct: 670 --CVKPLFGAVTKS--ECCCASTEYAFGE----PCQPCPAQNSAEYQALCSSGPGMTSAG 721
Query: 1525 WG-DPC----ELCPQ---EG-EEAYRQICPFGSGILVGPRGEP-IDADEC-LDPDICKHG 1573
+ C ++CP E Y+ IC SG V G+ +D +EC L+ +C +G
Sbjct: 722 TDINECALDPDICPNGICENLRGTYKCIC--NSGYEVDITGKNCVDINECVLNSLLCDNG 779
Query: 1574 QCINTDGSYRCECPFGYVLQGN--ECTDTDECSVGDPCGNGTCKNIIGSFECTC--EEGF 1629
QC NT GS+ C CP G+V + + C D DEC PC NG CKN GSF C C E
Sbjct: 780 QCRNTPGSFVCTCPKGFVYKPDLKTCEDIDECE-SSPCINGVCKNSPGSFICECSPESTL 838
Query: 1630 EPGPMVTCEDVNECAQNPLLCAFRC-VNTYGSY---ECKCPAGYVLREDKRMCKDQNECE 1685
+P + E + ++ RC +N G+ EC G +C+ C
Sbjct: 839 DPTKTICIETIKGTCWQTVIDG-RCEININGATLKSECCSSLGAAWGSPCTICQLDPICG 897
Query: 1686 EGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDEN---ECQTKPGLCENGRCIN 1742
+G + Q C+++ C PG + +G CV+ +C+ C NG ++
Sbjct: 898 KGFSRIKGTQ--CEDI---NECEVFPGVCK--NGL-CVNSRGSFKCE-----CPNGMTLD 944
Query: 1743 TQGSFRCECH-DGFNVNEAQNECIDTREGYCFTEVLQSMCQVGSSSVETVTKSECCCDGG 1801
G + + + EC G + C VG++ T EC
Sbjct: 945 ATGRICLDIRLETCFLKYDDEECTLPIAGRHRMDAC--CCSVGAAW-GTEECEECPLRNS 1001
Query: 1802 RGWGPNCEICPFMGTMAFKKLCPHGRGFTTDGADIDECKVIRDACQNGECVNSMGSYQCK 1861
R + E+CP A K + +G+ F D I+ECK+I C +G+C N++GS++C+
Sbjct: 1002 REYE---ELCPRGPGFATKDIT-NGKPFFKD---INECKMIPSLCTHGKCRNTIGSFKCR 1054
Query: 1862 CKEGYITDITGTLCIDLNECNQSPKPCNF-ICKNTEGSYQCSCPKGYILQ-EDGRSCKDL 1919
C G+ D C D++EC SP C C NT G ++C C +GY ++C D+
Sbjct: 1055 CDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDI 1114
Query: 1920 DECATKQHNCQF-LCVNTIGGFTCKCPPG--FTQHHSACIDNNECAGDVNLCGSKGICQN 1976
DEC C+ +C NT G + C+CPPG + + SACID NEC NLC G C N
Sbjct: 1115 DECQRDPLLCRGGICHNTEGTYRCECPPGHQLSPNISACIDINECELSANLC-PHGRCVN 1173
Query: 1977 TPGSFTCECQRGFSLDQSGASCEVDVDECEGSHR-CQHGCQNIIGGYRCSCPQGYLQHYQ 2035
G + C C G+ C VD+DEC + C+ C N G Y CSC G+
Sbjct: 1174 LIGKYQCACNPGYHPTHDRLFC-VDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPD 1232
Query: 2036 WNQCVDENECLSS-HICGGASCHNTLGSFKCMCPTGYHYEQFSGACQDVNECGSSQAPCS 2094
C D ++C + +IC G C N G ++C+C G+ + C DVNEC + C
Sbjct: 1233 QRSCTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICL 1292
Query: 2095 YG-CSNTDGGYVCGCPPGY 2112
G C NT G ++C C GY
Sbjct: 1293 SGTCENTKGSFICHCDMGY 1311
Score = 1603 (569.3 bits), Expect = 7.6e-194, Sum P(2) = 7.6e-194
Identities = 457/1429 (31%), Positives = 626/1429 (43%)
Query: 758 CEIGAHNCDRHAICTNTAGSFKCSCAPGWLGD--GIKCTDLDECSNGTHMCSPHADCKNT 815
C++ + C ++ C T GS++C C G+ D G +C D+DEC C+ +C N
Sbjct: 453 CQLVRYLC-QNGRCIPTPGSYRCECNKGFQLDIRG-ECIDVDECEKNP--CTG-GECINN 507
Query: 816 MGSYRCLCKEGYSGD--GFTCTDIDECSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDG 873
GSY C C+ GY C DIDEC +N +C NG+C+NT G + C C+ GF S +G
Sbjct: 508 QGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVSSEG 567
Query: 874 KACEDIDECILPNICVYGTCHNLPGLFRCQCETGYELDRSGGNCTDINECADPTTCISGT 933
K CED+DEC PN+C G C N G F+C C+ G++L G C DINEC P C++G
Sbjct: 568 KNCEDMDECRTPNMCPNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGR 627
Query: 934 CLNIPGSYTCECPPDFELNPTRVGCVDT--RSGYCYLEIKPRGDNGDMACSNEIGVGVSK 991
C+N GSY CEC P + CVDT RS CY + RG C + V+K
Sbjct: 628 CVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSS-CYGGYR-RGQ-----CVKPLFGAVTK 680
Query: 992 ASCCC-SLGKAWGIPCEQCPAVNSTDYKLLCPGGEGFRPNPITVILEDIDECQELPGLCQ 1050
+ CCC S A+G PC+ CPA NS +Y+ LC G G +T DI+EC P +C
Sbjct: 681 SECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPG-----MTSAGTDINECALDPDICP 735
Query: 1051 GGQCINSFGSFQCQCPSGYYLNEETRVCDDIDECTTPGI-CGPGTCYNTIGNYTCICPPD 1109
G C N G+++C C SGY ++ + C DI+EC + C G C NT G++ C CP
Sbjct: 736 NGICENLRGTYKCICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKG 795
Query: 1110 YMQVNGGNNCMDM---RRSLCYRNFYADNQ-----TCDGELLFNMTKKMCCCSYNIGRAW 1161
++ C D+ S C ++ C E + TK +C + G W
Sbjct: 796 FVYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIK-GTCW 854
Query: 1162 NRPCE-QCPIPSTDEF--STLCGSQRP--GFVIDIYTGLPVDIDECREIPGV-CENGVCI 1215
+ +C I S C S G I P+ I G CE+ I
Sbjct: 855 QTVIDGRCEININGATLKSECCSSLGAAWGSPCTICQLDPICGKGFSRIKGTQCED---I 911
Query: 1216 NLVGSFRCECPAGFFYNDK-LLICEAD--IDECQNGHICQ--QNADCINTPGSYRCDCKP 1270
N F C G N + CE + G IC + C C
Sbjct: 912 NECEVFPGVCKNGLCVNSRGSFKCECPNGMTLDATGRICLDIRLETCFLKYDDEECTLPI 971
Query: 1271 GYRFT------PVGRCVDRNECQEIPNICSHGDCIDREGGYTCRCHTGFKTNE---DQTM 1321
R VG EC+E P S RE C GF T + +
Sbjct: 972 AGRHRMDACCCSVGAAWGTEECEECPLRNS------REYEELCPRGPGFATKDITNGKPF 1025
Query: 1322 CIDINECEREP--CGNGTCRNTVGSFNCRCHTGFIL-SHNNDCIDIDECATXXXXXXXXX 1378
DINEC+ P C +G CRNT+GSF CRC +GF L S +C DIDEC
Sbjct: 1026 FKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQ 1085
Query: 1379 XXXXTIGSFLCICNEGYEMT-PDGRVCLDINECALDPGKCTPGTCQNLDGSYRCICPPGY 1437
T G F C C+EGYE + C+DI+EC DP C G C N +G+YRC CPPG+
Sbjct: 1086 CVN-TPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGICHNTEGTYRCECPPGH 1144
Query: 1438 ALKDD--NCNDIDECSEEAEICALGTCSNTPGSFVCLCPEGFVVSFSGRRCQDQRISYCF 1495
L + C DI+EC A +C G C N G + C C G+ + C D
Sbjct: 1145 QLSPNISACIDINECELSANLCPHGRCVNLIGKYQCACNPGYHPTHDRLFCVD------- 1197
Query: 1496 TKFEEGKCSVPKSRNHSKQDCCCSMNGEGWGDPCELCPQEGEEAYRQICPFGSGILVGPR 1555
+E CS+ MNG G CE + +Y C G ++ R
Sbjct: 1198 --IDE--CSI--------------MNG-G----CETFCTNSDGSYECSCQPGFALMPDQR 1234
Query: 1556 GEPIDADECLD-PDICKHGQCINTDGSYRCECPFGYVLQGN--ECTDTDECSVG-DPCGN 1611
D D+C D P+IC GQC N G YRC C G++ + C D +EC + + C +
Sbjct: 1235 S-CTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLS 1293
Query: 1612 GTCKNIIGSFECTCEEGFEPGPMVT-CEDVNECAQNPLLCAFR--CVNTYGSYECKCPAG 1668
GTC+N GSF C C+ G+ T C D+NEC C C NT GS++C C G
Sbjct: 1294 GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPG 1353
Query: 1669 YVLREDKRMCKDQNECEEGIHDCESKQMTCKNLIGTYMCICGPGFQRRPDGEGCVDENEC 1728
++ D C D +EC G H C S+ CKN +G+Y C+C G+ DG C D +EC
Sbjct: 1354 WI--GDGIKCTDLDECSNGTHMC-SQHADCKNTMGSYRCLCKDGYTG--DGFTCTDLDEC 1408
Query: 1729 QTKPGLCENGRCINTQGSFRCECHDGFNVNEAQNECIDTREGYCFTEVLQSMCQ--VGSS 1786
LC NG+C+N G +RCEC GF + C D E + C G
Sbjct: 1409 SENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLF 1468
Query: 1787 SVETVTKSECCCDGGRGWGPNCEICPFMGTMAFKKLCPHGRG-FTTDGADIDECKVIRDA 1845
E E GG N + P T C + G +T D + E R
Sbjct: 1469 RCECEIGYELDRSGGNCTDVNECLDP---TTCISGNCVNTPGSYTCDCSPDFELNPTRVG 1525
Query: 1846 C---QNGECVNSM------GSYQCKCKEGYITDITGTLCIDLNECNQSPKPCNFICKNTE 1896
C ++G C ++ G C + G + + C L + +P C +C +
Sbjct: 1526 CVDTRSGNCYLNIRPRGDNGDTACSNEIG-VGVSKASCCCSLGKAWGTP--CE-LCPSVN 1581
Query: 1897 GS-YQCSCPKGYILQEDGRSC--KDLDECATKQHNCQF-LCVNTIGGFTCKCPPGF--TQ 1950
S Y+ CP G + + + +D+DEC CQ C+NT G F C+CP G+ +
Sbjct: 1582 TSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNE 1641
Query: 1951 HHSACIDNNECAGDVNLCGSKGICQNTPGSFTCECQRGFSLDQSGASCEVDVDE--CEGS 2008
C D NEC +CG G C NT G++TC C + G +C +D+ C +
Sbjct: 1642 DTRVCDDVNECETP-GICGP-GTCYNTVGNYTCICPPDYMQVNGGNNC-MDMRRSICYRN 1698
Query: 2009 HRCQHG-CQN--IIGGYRCSCPQGYLQHYQWNQCVDENECLSSHICGGASCHNTLGSFKC 2065
+ + C + + C Y WN+ C I GS +
Sbjct: 1699 YYADNQTCDGELLFNMTKKMCCCSYNIRRAWNK-----PCEQCPIPSTDEFATLCGSQR- 1752
Query: 2066 MCPTGYHYEQFSGACQDVNECGSSQAPCSYG-CSNTDGGYVCGCPPGYF 2113
P G+ + ++G D++EC C G C N G + C CP G+F
Sbjct: 1753 --P-GFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFF 1798
Score = 354 (129.7 bits), Expect = 7.6e-194, Sum P(2) = 7.6e-194
Identities = 100/301 (33%), Positives = 134/301 (44%)
Query: 8 CSIRNM--CLNGMCINEDGSFK---CICKPGFQLASDGRYCRDIDECETPGICMNG-RCV 61
C R++ C N C+N GS C+C+ G+ G +C CE+ G C+NG RCV
Sbjct: 111 CGSRSIQHC-NIRCMN-GGSCSDDHCLCQKGYI----GTHCGQ-PVCES-G-CLNGGRCV 161
Query: 62 NTDGSFRCECFPGLAVGLDGRVCVDTHMRSTCYGEYRRGQCVKPLSGAVTKSECCCASTD 121
+ RC C G G C + C+ C LSG V CCA+
Sbjct: 162 APN---RCAC----TYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVG 214
Query: 122 YAFGEPCQPCPAQSSDEYHGLCSSGPGI-TATGTDINECALDPDICPNGICENMLGMYKC 180
A+G PC+ CPAQ G P I T D++EC P +C G C N +G ++C
Sbjct: 215 RAWGHPCEMCPAQPHPCRRGFI---PNIRTGACQDVDECQAIPGMCQGGNCINTVGSFEC 271
Query: 181 ICNFGYEVDSSGKNCLDIDECAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDI 240
C G++ + + C DIDEC+ +CD G+C NT S+ C CP GF PD C D+
Sbjct: 272 KCPAGHKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDV 331
Query: 241 NE--CESSPCVNGVCKNTPGSFVCECSPESTLDATKTVCIETVKGTCWQ---TVVNGRCE 295
C ++ NG C N P+S TK C + G CW TV C
Sbjct: 332 RPGYCYTA-LANGRCSNQ--------LPQSI---TKMQCCCDL-GRCWSPGVTVAPEMCP 378
Query: 296 I 296
I
Sbjct: 379 I 379
Score = 293 (108.2 bits), Expect = 2.1e-187, Sum P(2) = 2.1e-187
Identities = 103/353 (29%), Positives = 143/353 (40%)
Query: 358 VCVNTMGSFVCQCPNGMTLDITGRKCI-DIRLESCYLGHDYEE--CASPIGGRHRLDACC 414
VC + ++ C CP TL G +CI I SC G C P G ++ C
Sbjct: 58 VCGSRYNAY-C-CPGWKTLP-GGNQCIVPICRHSCGDGFCSRPNMCTCPSG---QISPSC 111
Query: 415 CSVGAAWGPDCD-ECPTKGT-PDYEALCPRGP-GFSSRDPVNGKPFYKDINECKMIPRL- 470
G+ C+ C G+ D LC +G G PV C R
Sbjct: 112 ---GSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNG-GRCVAPNRCA 167
Query: 471 CTYG----KCRNTIGSFRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDF- 525
CTYG +C + C F + S + C + ++S +C + +C T G
Sbjct: 168 CTYGFTGPQCERDYRTGPC-----FTVVSNQM-C----QGQLSGIVCTKTLCCATVGRAW 217
Query: 526 -H-CE--------CFEGYESGFMMMKNCMDIDECERNPLLCRGGVCINTEGSFKCDCPPG 575
H CE C G+ + C D+DEC+ P +C+GG CINT GSF+C CP G
Sbjct: 218 GHPCEMCPAQPHPCRRGFIPN-IRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCPAG 276
Query: 576 HQLLPNISACVDINECDLSMNLCRNGRCVNLIGKYQCSCNPGYHATPDRLACVDIDE--C 633
H+ C DI+EC +C G C N + Y C C PG++ +PD CVD+ C
Sbjct: 277 HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDVRPGYC 336
Query: 634 --SIMNGGCDTFCTNSEGSYECSCRQGYALMPDHRTCTD---IDECEDHPHIC 681
++ NG C S +C C G P + I ED +C
Sbjct: 337 YTALANGRCSNQLPQSITKMQCCCDLGRCWSPGVTVAPEMCPIRSTEDFNKLC 389
Score = 275 (101.9 bits), Expect = 1.7e-185, Sum P(2) = 1.7e-185
Identities = 92/322 (28%), Positives = 136/322 (42%)
Query: 605 NLIG-KYQCSCNPGYHATPDRLACVDIDECSIMNGGCDTFCTNSEGSYECSCRQGYALMP 663
N+ G +Y C PG+ P C+ + C G D FC+ C+C G + P
Sbjct: 57 NVCGSRYNAYCCPGWKTLPGGNQCI-VPICRHSCG--DGFCSRPN---MCTCPSGQ-ISP 109
Query: 664 DHRTCTDIDECEDHPHICDGGQCTNIPGEYRCLCYDGFM-TSEDMKTCLDVNECDLNPNI 722
+ I C + +GG C+ + CLC G++ T C + C LN
Sbjct: 110 SCGS-RSIQHC--NIRCMNGGSCS----DDHCLCQKGYIGTHCGQPVC--ESGC-LNGGR 159
Query: 723 CLSGS-CENTKGSFICHCDMGY-SGKKGTTGCTDINECEIGAHNCDRHAICTNTAG---S 777
C++ + C T G C+ Y +G T + + ++ C + +C T G
Sbjct: 160 CVAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTK-TLCCATVGRAWG 218
Query: 778 FKCSCAP--------GWLGDGIK---CTDLDECSNGTHMCSPHADCKNTMGSYRCLCKEG 826
C P G++ + I+ C D+DEC MC +C NT+GS+ C C G
Sbjct: 219 HPCEMCPAQPHPCRRGFIPN-IRTGACQDVDECQAIPGMCQG-GNCINTVGSFECKCPAG 276
Query: 827 YSGDGFT--CTDIDECSENVNLCGNGQCLNTPGGYRCECDMGFLPSPDGKACEDIDECIL 884
+ + + C DIDECS +C G+C NT Y C+C GF SPDG C D+
Sbjct: 277 HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDVRPGYC 336
Query: 885 PNICVYGTCHN-LP-GLFRCQC 904
G C N LP + + QC
Sbjct: 337 YTALANGRCSNQLPQSITKMQC 358
Score = 263 (97.6 bits), Expect = 3.2e-184, Sum P(2) = 3.2e-184
Identities = 83/295 (28%), Positives = 119/295 (40%)
Query: 478 NTIGS-FRCKCDSGFALDSEERNCTDIDECRISPDLCGQGICVNTPGDFHCECFEGYES- 535
N GS + C G+ C + CR S CG G C + P C C G S
Sbjct: 57 NVCGSRYNAYCCPGWKTLPGGNQCI-VPICRHS---CGDGFC-SRPN--MCTCPSGQISP 109
Query: 536 --GFMMMKNC----MDIDECERNPLLCRGGVCINTE-GSFKCD--CPPGHQLL-PNISAC 585
G +++C M+ C + LC+ G I T G C+ C G + + PN AC
Sbjct: 110 SCGSRSIQHCNIRCMNGGSCSDDHCLCQKGY-IGTHCGQPVCESGCLNGGRCVAPNRCAC 168
Query: 586 V---DINECDLSMNLCRNGRCVNLIGKYQCSCNPGYHATPDRLACVDIDECSIMNGGCDT 642
+C+ R G C ++ C L C + C+
Sbjct: 169 TYGFTGPQCERDY---RTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRA--WGHPCE- 222
Query: 643 FCTNSEGSYECSCRQGYALMPDHRT--CTDIDECEDHPHICDGGQCTNIPGEYRCLCYDG 700
C + CR+G+ +P+ RT C D+DEC+ P +C GG C N G + C C G
Sbjct: 223 MCP----AQPHPCRRGF--IPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCPAG 276
Query: 701 FMTSEDMKTCLDVNECDLNPNICLSGSCENTKGSFICHCDMGYSGKKGTTGCTDI 755
+E + C D++EC P +C G C NT S+ C C G+ T C D+
Sbjct: 277 HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDV 331
Score = 257 (95.5 bits), Expect = 1.2e-17, P = 1.2e-17
Identities = 81/285 (28%), Positives = 117/285 (41%)
Query: 1853 NSMGS-YQCKCKEGYITDITGTLCIDLNECNQSPKPC-NFICKNTEGSYQCSCPKGYILQ 1910
N GS Y C G+ T G CI + C S C + C C+CP G I
Sbjct: 57 NVCGSRYNAYCCPGWKTLPGGNQCI-VPICRHS---CGDGFCSRPN---MCTCPSGQISP 109
Query: 1911 EDG-RS-------CKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHSACIDNNECA 1962
G RS C + C+ CQ + T G C G + C+ N CA
Sbjct: 110 SCGSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPV-CESGCL-NGGRCVAPNRCA 167
Query: 1963 GDVNLCGSKGICQN---TPGSFTCECQRGFSLDQSGASCEVDVDECEGSHRCQHGCQNII 2019
G + C+ T FT + SG C + H C+ +
Sbjct: 168 CTYGFTGPQ--CERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRAWGHPCE-MC 224
Query: 2020 GGYRCSCPQGYLQHYQWNQCVDENECLS-SHICGGASCHNTLGSFKCMCPTGYHYEQFSG 2078
C +G++ + + C D +EC + +C G +C NT+GSF+C CP G+ + + S
Sbjct: 225 PAQPHPCRRGFIPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCPAGHKFNEVSQ 284
Query: 2079 ACQDVNECGSSQAPCSYG-CSNTDGGYVCGCPPGYFRIGQG-HCV 2121
C+D++EC + C G C+NT Y C CPPG++ G CV
Sbjct: 285 KCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCV 329
Score = 253 (94.1 bits), Expect = 3.6e-183, Sum P(2) = 3.6e-183
Identities = 93/318 (29%), Positives = 126/318 (39%)
Query: 143 CSSGPGITATGT-DINECALDPDICPNG-ICENMLGMYKCICNFGYEVDSSGKNCLDIDE 200
C SG + G+ I C + C NG C + C+C GY G +C
Sbjct: 102 CPSGQISPSCGSRSIQHCNIR---CMNGGSCSDD----HCLCQKGY----IGTHCGQ-PV 149
Query: 201 CAVNKLLCDNGQCRNTPGSFTCTCPKGFVFKPDLKTCEDINECESSPCVNGVCKNTPGSF 260
C L + G+C P C C GF P CE + + PC V N
Sbjct: 150 CESGCL--NGGRCV-APNR--CACTYGFT-GPQ---CE--RDYRTGPCFT-VVSNQ---- 193
Query: 261 VCECSPESTLDATKTVCIETVKGTCW---------QTVVNGRCEI-NIN-GATLKSQCCS 309
+C+ S + TKT+C TV G W Q R I NI GA C
Sbjct: 194 MCQ-GQLSGIVCTKTLCCATV-GRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQ 251
Query: 310 SL-GAAWGSPCIECE-RVDPICSKGYSRIR-GTLCEDVNECEVFPGVCTNGVCVNTMGSF 366
++ G G CI + C G+ CED++EC PGVC G C NT+ S+
Sbjct: 252 AIPGMCQGGNCINTVGSFECKCPAGHKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSY 311
Query: 367 VCQCPNGMTLDITGRKCIDIRLESCYLGHDYEECASPIGGRHRLDACCCSVGAAWGPDC- 425
C+CP G G +C+D+R CY C++ + CCC +G W P
Sbjct: 312 FCKCPPGFYTSPDGTRCVDVRPGYCYTALANGRCSNQLPQSITKMQCCCDLGRCWSPGVT 371
Query: 426 ---DECPTKGTPDYEALC 440
+ CP + T D+ LC
Sbjct: 372 VAPEMCPIRSTEDFNKLC 389