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Gene Model: Nlk

NomenclatureGenomic Location
SymbolNlkChromosome1
NameSerine/threonine-protein kinase NLKLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 73 Mbp

Molecular Function

Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.

Molecular Function Terms:

binding
   ion binding
      cation binding
         metal ion binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding
   protein binding
      enzyme binding
         ubiquitin protein ligase binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity
            protein kinase activity
               protein serine/threonine kinase activity

molecular transducer activity
   signal transducer activity
      receptor signaling protein activity
         receptor signaling protein serine/threonine kinase activity
            MAP kinase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGTCTCTGTGTAGTGCCACAGCCGGCGCAAAAATGATGGCGGCTTACAATGGCGGTACA
    61 TCCGCCGCCGCTGCAGGTCACCACCACCACCATCACCACCACCTTGCCCACCTCCCTCCT
   121 CCTCATCTCCATCACCACCATCATCCCCAGCACCACTTGCACCCAGGCTCTGCGGCTGCA
   181 GTGCATCCTGTGCAGCAACATGCTTCTTCGGCGGCTGCAGCGGCGGCGGCTGCGGCGGCA
   241 GCTGCAGCCATGTTAAATCCAGGCCAGCAGCAGCCATATTTCCCGTCACCGGCACCAGGT
   301 CAGGCTCCTGGGCCAGCTGCAGCTGCCCCAGCTCAGGTACAAGCTGCAGCAGCGGCTGCA
   361 GTTAAAGCGCATCATCATCAGCACACACATCACCCGCAGCAGCAACTGGATATCGAGCCA
   421 GATCGGCCTATTGGATATGGAGCCTTTGGTGTCGTCTGGTCAGTCACAGATCCACGCGAT
   481 GGAAAGAGAGTTGCACTCAAAAAGATGCCCAACGTCTTCCAAAATCTGGTCTCTTGCAAA
   541 AGGGTCTTCCGCGAATTGAAGATGTTGTGTTTTTTTAAGCATGACAATGTACTCTCTGCT
   601 CTTGACATTCTTCAGCCACCACACATTGACTACTTTGAAGAAATATATGTTGTTACAGAA
   661 TTGATGCAGAGTGACCTTCATAAGATTATCGTCTCTCCTCAACCACTCAGTTCAGATCAT
   721 GTCAAAGTTTTTCTTTACCAGATTTTGAGAGGTCTGAAATACCTACATTCTGCTGGTATT
   781 TTGCATCGAGACATTAAACCAGGGAATCTGCTTGTGAACAGCAACTGTGTTCTTAAGATC
   841 TGTGATTTTGGCTTGGCGCGGGTGGAAGAGTTAGACGAATCGCGTCACATGACTCAGGAA
   901 GTCGTCACTCAGTATTACCGAGCTCCCGAAATCCTGATGGGCAGCCGCCACTACAGCAAT
   961 GCTATTGATATTTGGTCTGTGGGCTGTATATTTGCTGAATTACTAGGGCGGCGAATACTG
  1021 TTTCAAGCTCAGAGTCCCATTCAGCAGTTGGATTTGATCACAGATCTTCTGGGAACACCG
  1081 TCACTGGAAGCAATGAGGACGGCTTGTGAAGGCGCCAAGGCACACATACTCAGGGGTCCT
  1141 CATAAACAGCCATCCCTTCCTGTCCTGTATACATTATCAAGTCAAGCTACACATGAAGCC
  1201 GTTCATCTCCTTTGTAGGATGTTGGTCTTTGATCCATCCAAGCGAATATCTGCTAAGGAT
  1261 GCCTTAGCTCATCCATATCTGGACGAAGGGCGTTTGCGATACCACACCTGCATGTGTAAA
  1321 TGTTGCTTCTCCACCTCGACGGGACGCGTTTACACCAACGATTTCGAACCTATCACGAAC
  1381 CCCAAGTTCGACGATACGTTTGAAAAGAACCTCAGTTCTGTTCGGCAGGTGAAAGAAATT
  1441 ATTCATCAGTTCATTTTGGAACAGCAGAAAGGAAGCAGAGTACCGCTGTGCATCAACCCA
  1501 CAATCTGCTGCTTTTAAGAGCTTTATTAGTTCCACTGTTGCCCAGCCGTCCGAGATGCCG
  1561 CCGTCTCCACTGGTCTGGGAGTAA

Predicted Protein Product
MSLCSATAGAKMMAAYNGGTSAAAAGHHHHHHHHLAHLPPPHLHHHHHPQHHLHPGSAAA
VHPVQQHASSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAA
VKAHHHQHTHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTNDFEPITNPKFDDTFEKNLSSVRQVKEI
IHQFILEQQKGSRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Protein Alignment to Mouse
sp|O54949|NLK_MOUSE Serine/threonine-protein kinase NLK OS=Mus musculus GN=Nlk
            PE=1 SV=2
      MGI:1201387 Nlk nemo like kinase (Chr 11)
        Length = 527

 Score = 2160 (765.4 bits), Expect = 1.1e-226, Sum P(2) = 1.1e-226
 Identities = 414/472 (87%), Positives = 417/472 (88%)

Query:    56 GSAAAVHPVQQHXXXXXXXXXXXXXXXXMLNPGQQQPYFPSXXXXXXXXXXXXXXXXXXX 115
             GSAAAVHPVQQH                MLNPGQQQPYFPS                   
Sbjct:    56 GSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQA 115

Query:   116 XXXXXXXXXXXXXXXXXXXXLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQN 175
                                 LDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQN
Sbjct:   116 AAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQN 175

Query:   176 LVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQP 235
             LVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQP
Sbjct:   176 LVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQP 235

Query:   236 LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESR 295
             LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESR
Sbjct:   236 LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESR 295

Query:   296 HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITD 355
             HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITD
Sbjct:   296 HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITD 355

Query:   356 LLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKR 415
             LLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKR
Sbjct:   356 LLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKR 415

Query:   416 ISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTNDFEPITNPKFDDTFEKNLSSVR 475
             ISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYT+DFEP+TNPKFDDTFEKNLSSVR
Sbjct:   416 ISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVR 475

Query:   476 QVKEIIHQFILEQQKGSRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527
             QVKEIIHQFILEQQKG+RVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Sbjct:   476 QVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527

 Score = 44 (20.5 bits), Expect = 1.1e-226, Sum P(2) = 1.1e-226
 Identities = 9/13 (69%), Positives = 9/13 (69%)

Query:     1 MSLCSATAGAKMM 13
             MSLC   A AKMM
Sbjct:     1 MSLCGTRANAKMM 13