| Nomenclature | Genomic Location |
| Symbol | Nlk | Chromosome | 1 |
| Name | Serine/threonine-protein kinase NLK | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | Chr1: 73 Mbp |
| Molecular Function |
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Role in cell fate determination, required for differentiation of bone marrow stromal cells.
Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway
and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of
transcription factors by phosphorylation of the coactivator, CREBBP. Involved in TGFbeta-mediated
mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
Molecular Function Terms:
binding
ion binding
cation binding
metal ion binding
nucleotide binding
purine nucleotide binding
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
protein binding
enzyme binding
ubiquitin protein ligase binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein serine/threonine kinase activity
molecular transducer activity
signal transducer activity
receptor signaling protein activity
receptor signaling protein serine/threonine kinase activity
MAP kinase activity
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| Human Disease Association |
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No disease association.
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1 ATGTCTCTGTGTAGTGCCACAGCCGGCGCAAAAATGATGGCGGCTTACAATGGCGGTACA
61 TCCGCCGCCGCTGCAGGTCACCACCACCACCATCACCACCACCTTGCCCACCTCCCTCCT
121 CCTCATCTCCATCACCACCATCATCCCCAGCACCACTTGCACCCAGGCTCTGCGGCTGCA
181 GTGCATCCTGTGCAGCAACATGCTTCTTCGGCGGCTGCAGCGGCGGCGGCTGCGGCGGCA
241 GCTGCAGCCATGTTAAATCCAGGCCAGCAGCAGCCATATTTCCCGTCACCGGCACCAGGT
301 CAGGCTCCTGGGCCAGCTGCAGCTGCCCCAGCTCAGGTACAAGCTGCAGCAGCGGCTGCA
361 GTTAAAGCGCATCATCATCAGCACACACATCACCCGCAGCAGCAACTGGATATCGAGCCA
421 GATCGGCCTATTGGATATGGAGCCTTTGGTGTCGTCTGGTCAGTCACAGATCCACGCGAT
481 GGAAAGAGAGTTGCACTCAAAAAGATGCCCAACGTCTTCCAAAATCTGGTCTCTTGCAAA
541 AGGGTCTTCCGCGAATTGAAGATGTTGTGTTTTTTTAAGCATGACAATGTACTCTCTGCT
601 CTTGACATTCTTCAGCCACCACACATTGACTACTTTGAAGAAATATATGTTGTTACAGAA
661 TTGATGCAGAGTGACCTTCATAAGATTATCGTCTCTCCTCAACCACTCAGTTCAGATCAT
721 GTCAAAGTTTTTCTTTACCAGATTTTGAGAGGTCTGAAATACCTACATTCTGCTGGTATT
781 TTGCATCGAGACATTAAACCAGGGAATCTGCTTGTGAACAGCAACTGTGTTCTTAAGATC
841 TGTGATTTTGGCTTGGCGCGGGTGGAAGAGTTAGACGAATCGCGTCACATGACTCAGGAA
901 GTCGTCACTCAGTATTACCGAGCTCCCGAAATCCTGATGGGCAGCCGCCACTACAGCAAT
961 GCTATTGATATTTGGTCTGTGGGCTGTATATTTGCTGAATTACTAGGGCGGCGAATACTG
1021 TTTCAAGCTCAGAGTCCCATTCAGCAGTTGGATTTGATCACAGATCTTCTGGGAACACCG
1081 TCACTGGAAGCAATGAGGACGGCTTGTGAAGGCGCCAAGGCACACATACTCAGGGGTCCT
1141 CATAAACAGCCATCCCTTCCTGTCCTGTATACATTATCAAGTCAAGCTACACATGAAGCC
1201 GTTCATCTCCTTTGTAGGATGTTGGTCTTTGATCCATCCAAGCGAATATCTGCTAAGGAT
1261 GCCTTAGCTCATCCATATCTGGACGAAGGGCGTTTGCGATACCACACCTGCATGTGTAAA
1321 TGTTGCTTCTCCACCTCGACGGGACGCGTTTACACCAACGATTTCGAACCTATCACGAAC
1381 CCCAAGTTCGACGATACGTTTGAAAAGAACCTCAGTTCTGTTCGGCAGGTGAAAGAAATT
1441 ATTCATCAGTTCATTTTGGAACAGCAGAAAGGAAGCAGAGTACCGCTGTGCATCAACCCA
1501 CAATCTGCTGCTTTTAAGAGCTTTATTAGTTCCACTGTTGCCCAGCCGTCCGAGATGCCG
1561 CCGTCTCCACTGGTCTGGGAGTAA
| Predicted Protein Product |
MSLCSATAGAKMMAAYNGGTSAAAAGHHHHHHHHLAHLPPPHLHHHHHPQHHLHPGSAAA
VHPVQQHASSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAA
VKAHHHQHTHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTNDFEPITNPKFDDTFEKNLSSVRQVKEI
IHQFILEQQKGSRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
| Protein Alignment to Mouse |
sp|O54949|NLK_MOUSE Serine/threonine-protein kinase NLK OS=Mus musculus GN=Nlk
PE=1 SV=2
MGI:1201387 Nlk nemo like kinase (Chr 11)
Length = 527
Score = 2160 (765.4 bits), Expect = 1.1e-226, Sum P(2) = 1.1e-226
Identities = 414/472 (87%), Positives = 417/472 (88%)
Query: 56 GSAAAVHPVQQHXXXXXXXXXXXXXXXXMLNPGQQQPYFPSXXXXXXXXXXXXXXXXXXX 115
GSAAAVHPVQQH MLNPGQQQPYFPS
Sbjct: 56 GSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQA 115
Query: 116 XXXXXXXXXXXXXXXXXXXXLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQN 175
LDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQN
Sbjct: 116 AAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQN 175
Query: 176 LVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQP 235
LVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQP
Sbjct: 176 LVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQP 235
Query: 236 LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESR 295
LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESR
Sbjct: 236 LSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESR 295
Query: 296 HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITD 355
HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITD
Sbjct: 296 HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITD 355
Query: 356 LLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKR 415
LLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKR
Sbjct: 356 LLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKR 415
Query: 416 ISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTNDFEPITNPKFDDTFEKNLSSVR 475
ISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYT+DFEP+TNPKFDDTFEKNLSSVR
Sbjct: 416 ISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVR 475
Query: 476 QVKEIIHQFILEQQKGSRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527
QVKEIIHQFILEQQKG+RVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Sbjct: 476 QVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527
Score = 44 (20.5 bits), Expect = 1.1e-226, Sum P(2) = 1.1e-226
Identities = 9/13 (69%), Positives = 9/13 (69%)
Query: 1 MSLCSATAGAKMM 13
MSLC A AKMM
Sbjct: 1 MSLCGTRANAKMM 13
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