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Gene Model: Egfr

NomenclatureGenomic Location
SymbolEgfrChromosome1
NameEpidermal growth factor receptorLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesChr1: 76 Mbp

Molecular Function

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

Molecular Function Terms:

binding
   protein binding
      enzyme binding
         kinase binding
            protein kinase binding
         phosphatase binding
            protein phosphatase binding
      receptor binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity
            protein kinase activity
               protein tyrosine kinase activity

molecular transducer activity
   signal transducer activity
      receptor signaling protein activity
         receptor signaling protein tyrosine kinase activity
      receptor activity
         transmembrane receptor activity

receptor activity

Human Disease Association

Defects in EGFR are associated with lung cancer (LNCR) [MIM:211980].

Predicted Transcript
     1 GTTTGTCAAGGAACCAGCAACAGATTATCACAGCTTGGAAGTGTGGAAGATCACTACAAC
    61 AGCTTAAAGAGAATGTATGAAGACTGTGAAGTGGTACTTGGCAACCTAGAAATCACATGT
   121 CTAGAACCAAACTATAATCTCACTTTCTTGAAGAGCATACAGGAGGTAGCTGGTTATGTG
   181 CTCATAGCATTAAACACAGTGAAAGTTATTCCTTTGGAGAATCTCCAGATAATCCGAGGA
   241 AATACCCTTTATGAAAACGCTGCTCTCACTATTTTACTAAATTATAATGAAATCGAGGGA
   301 CTCGAAGAACTTCCAATGAGACGTTTAGCAGCAGAAATTCTAAATGGAGGTGTTAAAATA
   361 GTTGGTAACCCTTATCTCTGCAACATTAATAATATTCTGTGGAATGACATTATAGAATCA
   421 ACCAAAGGTTTTTTGCTTAATTTACTATTCTTTTTTAAAATAACTACAGGTGTTCGTCTC
   481 CCATGCCATCCCAACTGTACAAGTGGACACTGTTGGGGTCCTGATTTAGAAAATTGCCAA
   541 ATATTAACAAAGATTGGCTGTGCAGAACAGTGTTCAGGTCGATGCAAGGGGAAGTTGCCA
   601 AGTGACTGTTGTCATACTCAGTGTGCAGCAGGATGTACAGGCCCTAAAGAGAGTGATTGC
   661 TTGGCATGCCGCAAATTTTGGGATGATGCAACCTGTAAGGAATCTTGCCCCCCTTTGCAA
   721 GTGTATAATCCTACAGCCTATCAGTTGGAAGACAACCCAGATGGAAAGTACAGCTTTGGA
   781 GCCACTTGTGTGAAAAAGTGTCCACATAACTATGTTGTAACAGACTACGGCTCATGTGTC
   841 CGATCATGTAATCCAGACTCCACTGAGGTGGAGGAAAATGGAATTAGAAAGTGTAAAAAA
   901 TGTGATGGGCCATGTAGCAAGGTGTGCAATGGAGTTGGAGCAGGTAATCTTACAAGTGCT
   961 CTTGCTGTGAATGGATCCAACATTGACTATTTCAAAAACTGTACCACAATCAGTGGGGAT
  1021 CTCATATTCCTTCACGTATCATTTAAAGGTGATGTATATACACATACTCCTCCTTTAGAC
  1081 CCAAAGAAATTGGATATTTTTCGAACAGTTAAAGAAATAACAGGGTTTTTGTCAATCCAG
  1141 GATTGGCCAGCAAATGCCACTGACTTGAGTGTTTTTGAAAATCTAAAAGTTATACGAGGC
  1201 AGAACAAAACAAATGGGCCGGTATGCTCTTGCTATCAGTTCCTTAGATATAAAACAATTG
  1261 GGTTTGCGGTCTCTCAAGGAAATAAGCGATGGAGATGTTGTCATTATGAGAAACAAGAAC
  1321 CTATGCTTTGGTAATACAGTAGACTGGACTACACTTTTTGTGACAGAAAAACAGAATATA
  1381 AAAATTGCCCAGAACAGAAATGAAAGTTCATGTGCTGCTGCAAGGCAGGTTTGTGATCCA
  1441 CTCTGCTCACCTGTGGGCTGCTGGGGCCCAGGTCCCACCCAATGCTATTCTTGCCATCAC
  1501 TTCATTCGTCAGCAGGAGTGTGTAAAGGAATGCAATGTAATGCAGGGGGAACCTCGGGAA
  1561 TTTATAAGAGATTCTGAATGCCTTCAATGCCATCCAGAATGCCTGGTGCAAAATTCAACT
  1621 AAAACTTGCACAGGACCTGGTCCAGACAACTGCACCAAATGTGCCCATTTAATAGACGGC
  1681 CCTCACTGTGTTAAATCATGCCCTGCTGGGATCATGGGTGAAAATAGTACTTTAATCTGG
  1741 AAATATACAGATGAAAATTCAGTGTGCCAGCCATGTCATCCAAATTGTATTCGTGGATGC
  1801 AAAGGACCAGGACTTGAAGGTTGTCCTATTGGCTCGAAGGTCCCATCAATTGCTGCTGGA
  1861 GTTGTTGGAAGTATTCTTGGCTTAGTTGTTATAGCATTGGGCATTGGTCTCTATGTACGC
  1921 AGGCGTCACATTGTTCGGAAACGTACTTTGCGCAGGCTGCTACAAGAAAGAGAGCTTGTT
  1981 GAGCCCCTGACTCCCAGTGGTGAGGCACCAAACCAAGCACTCCTAAGAATTCTAAAGGAA
  2041 ACGGAATTAAAAAAAGTCAAGGTTCTTGGTTCTGGCGCTTTTGGTACTGTCTTTAAGGGA
  2101 CTGTGGATTCCAGAAGGGGAGAAGGTTAAAATTCCTGTGGCCATTAAGGAATTGAGAGAA
  2161 GCCACGTCCCCCAAAGCCAACAAAGAAATTCTTGATGAAGCCTATGTAATGGCAAGCGTA
  2221 GACAACCCCCATGTGTGCCGTTTGCTGGGAATTTGCCTCACATCTACAGTCCAGCTCATC
  2281 ACACAACTTATGCCATATGGGTGTCTTCTTGATTATATCCGAGAGCACAAGGATAACATT
  2341 GGATCCCAATACCTTCTCAATTGGTGTGTGCAGATTGCAAAGGGAATGAATTATTTGGAA
  2401 GAACGTCGTTTAGTACATCGTGATTTGGCTGCCAGGAATGTTCTAGTTAAGACTCCTCAA
  2461 CATGTAAAGATTACTGACTTTGGACTGGCAAAATTGCTTGGCGCAGAAGAAAAGGAGTAC
  2521 CATGCAGAAGGAGGAAAAGTTCCTATTAAGTGGATGGCTTTGGAGTCTATTCTGCACCGC
  2581 ATATATACCCATCAAAGTGATGTTTGGAGTTATGGTGTCACTGTCTGGGAATTAATGACA
  2641 TTTGGATCAAAACCATATGATGGCATCCCGGCCAGTGAAATTTCCTGTGTCCTGGAAAAG
  2701 GGGGAGAGGTTGCCCCAGCCTCCAGTTTGTACAATTGATGTCTACATGATCATGGTCAAA
  2761 TGTTGGATGATTGATGCAGAGAGTCGTCCCAAATTTCGGGAACTGATAGCAGAATTCTCC
  2821 AAAATGGCTCGGGACCCACAGCGCTATCTGGTTATACAGGGAGATGAAAGAATGAACCTA
  2881 CCAAGCCCAACAGACTCAAAATTTTACCGTAGCCTCATGGAAGAAGAGGACATGGAAGAC
  2941 ATTGTGGATGCAGATGAATACCTTATTCCACACCAAGGATTTTTCAGCAGCCCATCAAAT
  3001 TCCCGGACACCTCTCCTAAGTTCACTGAGTGCTACTAGTGATAATTCTGCACCTGTAACC
  3061 TGCTTGGATATTAATGGGGTACATCGAGTGAGAGAAGACAGCTTTATCCAGCGATATAGT
  3121 TCAGACCCAACTAGAAGTTGCCTGGATGACAGTCTGGATGATGGTTTTCTACCTGCTCCA
  3181 GAATACATGAACCAACTGGCAGCCAAACCCCCATCTGTTTCTGTCATGCAAACCCCAGTC
  3241 TACAACAATTTCTCCCTTCCAATTGAGCCCAACCATGTGGTTGATTCAAACCATCAGAAT
  3301 CCGCACAACACAGCACTGGATAATCCAGAATATCTCAACACAAGCCTCTCTCCTTTTGCT
  3361 AATACAATTTTTGACAGCTCCCCCTTTTTGGGCCAGAAAGACAACCCCCAAATCAATCTG
  3421 GATAATCCGGATTATCAGCAAGATTTCTTGCCCAATGAGACCAAATCTAATGGCTTCCCT
  3481 AAGATTCCTACAGCCGAGAATCCAGAATACCTACGGGTAGCAACAGGAAAAAGTGAATAC
  3541 ATTCAAGCC

Predicted Protein Product
VCQGTSNRLSQLGSVEDHYNSLKRMYEDCEVVLGNLEITCLEPNYNLTFLKSIQEVAGYV
LIALNTVKVIPLENLQIIRGNTLYENAALTILLNYNEIEGLEELPMRRLAAEILNGGVKI
VGNPYLCNINNILWNDIIESTKGFLLNLLFFFKITTGVRLPCHPNCTSGHCWGPDLENCQ
ILTKIGCAEQCSGRCKGKLPSDCCHTQCAAGCTGPKESDCLACRKFWDDATCKESCPPLQ
VYNPTAYQLEDNPDGKYSFGATCVKKCPHNYVVTDYGSCVRSCNPDSTEVEENGIRKCKK
CDGPCSKVCNGVGAGNLTSALAVNGSNIDYFKNCTTISGDLIFLHVSFKGDVYTHTPPLD
PKKLDIFRTVKEITGFLSIQDWPANATDLSVFENLKVIRGRTKQMGRYALAISSLDIKQL
GLRSLKEISDGDVVIMRNKNLCFGNTVDWTTLFVTEKQNIKIAQNRNESSCAAARQVCDP
LCSPVGCWGPGPTQCYSCHHFIRQQECVKECNVMQGEPREFIRDSECLQCHPECLVQNST
KTCTGPGPDNCTKCAHLIDGPHCVKSCPAGIMGENSTLIWKYTDENSVCQPCHPNCIRGC
KGPGLEGCPIGSKVPSIAAGVVGSILGLVVIALGIGLYVRRRHIVRKRTLRRLLQERELV
EPLTPSGEAPNQALLRILKETELKKVKVLGSGAFGTVFKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNI
GSQYLLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY
HAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISCVLEK
GERLPQPPVCTIDVYMIMVKCWMIDAESRPKFRELIAEFSKMARDPQRYLVIQGDERMNL
PSPTDSKFYRSLMEEEDMEDIVDADEYLIPHQGFFSSPSNSRTPLLSSLSATSDNSAPVT
CLDINGVHRVREDSFIQRYSSDPTRSCLDDSLDDGFLPAPEYMNQLAAKPPSVSVMQTPV
YNNFSLPIEPNHVVDSNHQNPHNTALDNPEYLNTSLSPFANTIFDSSPFLGQKDNPQINL
DNPDYQQDFLPNETKSNGFPKIPTAENPEYLRVATGKSEYIQA
Protein Alignment to Mouse
sp|Q01279|EGFR_MOUSE Epidermal growth factor receptor OS=Mus musculus GN=Egfr
            PE=1 SV=1
      MGI:95294 Egfr epidermal growth factor receptor (Chr 11)
        Length = 1210

 Score = 4355 (1538.1 bits), Expect = 0., P = 0.
 Identities = 815/1188 (68%), Positives = 933/1188 (78%)

Query:     1 VCQGTSNRLSQLGSVEDHYNSLKRMYEDCEVVLGNLEITCLEPNYNLTFLKSIQEVAGYV 60
             VCQGTSNRL+QLG+ EDH+ SL+RMY +CEVVLGNLEIT ++ NY+L+FLK+IQEVAGYV
Sbjct:    30 VCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYV 89

Query:    61 LIALNTVKVIPLENLQIIRGNTLYENA-ALTILLNYNEIE-GLEELPMRRLAAEILNGGV 118
             LIALNTV+ IPLENLQIIRGN LYEN  AL IL NY     GL ELPMR L  EIL G V
Sbjct:    90 LIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQ-EILIGAV 148

Query:   119 KIVGNPYLCNINNILWNDIIESTKGXXXXXXXXXKITTGVRLPCHPNCTSGHCWGPDLEN 178
             +   NP LCN++ I W DI+++              ++  +  C P+C +G CWG   EN
Sbjct:   149 RFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPK--CDPSCPNGSCWGGGEEN 206

Query:   179 CQILTKIGCAEQCSGRCKGKLPSDCCHTQCAAGCTGPKESDCLACRKFWDDATCKESCPP 238
             CQ LTKI CA+QCS RC+G+ PSDCCH QCAAGCTGP+ESDCL C+KF D+ATCK++CPP
Sbjct:   207 CQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPP 266

Query:   239 LQVYNPTAYQLEDNPDGKYSFGATCVKKCPHNYVVTDYGSCVRSCNPDSTEVEENGIRKC 298
             L +YNPT YQ++ NP+GKYSFGATCVKKCP NYVVTD+GSCVR+C PD  EVEE+GIRKC
Sbjct:   267 LMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKC 326

Query:   299 KKCDGPCSKVCNGVGAGNLTSALAVNGSNIDYFKNCTTISGDLIFLHVSFKGDVYTHTPP 358
             KKCDGPC KVCNG+G G     L++N +NI +FK CT ISGDL  L V+FKGD +T TPP
Sbjct:   327 KKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPP 386

Query:   359 LDPKKLDIFRTVKEITGFLSIQDWPANATDLSVFENLKVIRGRTKQMGRYALAISSLDIK 418
             LDP++L+I +TVKEITGFL IQ WP N TDL  FENL++IRGRTKQ G+++LA+  L+I 
Sbjct:   387 LDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNIT 446

Query:   419 QLGLRSLKEISDGDVVIMRNKNLCFGNTVDWTTLFVTEKQNIKIAQNRNESSCAAARQVC 478
              LGLRSLKEISDGDV+I  N+NLC+ NT++W  LF T  Q  KI  NR E  C A   VC
Sbjct:   447 SLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVC 506

Query:   479 DPLCSPVGCWGPGPTQCYSCHHFIRQQECVKECNVMQGEPREFIRDSECLQCHPECLVQN 538
             +PLCS  GCWGP P  C SC +  R +ECV++CN+++GEPREF+ +SEC+QCHPECL Q 
Sbjct:   507 NPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQA 566

Query:   539 STKTCTGPGPDNCTKCAHLIDGPHCVKSCPAGIMGENSTLIWKYTDENSVCQPCHPNCIR 598
                TCTG GPDNC +CAH IDGPHCVK+CPAGIMGEN+TL+WKY D N+VC  CH NC  
Sbjct:   567 MNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTY 626

Query:   599 GCKGPGLEGC---PIGSKVPSIXXXXXXXXXXXXXXXXXXXXYVRRRHIVXXXXXXXXXX 655
             GC GPGL+GC   P G K+PSI                    ++RRRHIV          
Sbjct:   627 GCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQ 686

Query:   656 XXXXXXXXTPSGEAPNQALLRIXXXXXXXXXXXXGSGAFGTVFKGLWIPEGEKVKIPVAI 715
                     TPSGEAPNQA LRI            GSGAFGTV+KGLWIPEGEKVKIPVAI
Sbjct:   687 ERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAI 746

Query:   716 KELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYIRE 775
             KELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDY+RE
Sbjct:   747 KELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVRE 806

Query:   776 HKDNIGSQYLLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA 835
             HKDNIGSQYLLNWCVQIAKGMNYLE+RRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA
Sbjct:   807 HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA 866

Query:   836 EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEIS 895
             EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPAS+IS
Sbjct:   867 EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDIS 926

Query:   896 CVLEKGERLPQPPVCTIDVYMIMVKCWMIDAESRPKFRELIAEFSKMARDPQRYLVIQGD 955
              +LEKGERLPQPP+CTIDVYMIMVKCWMIDA+SRPKFRELI EFSKMARDPQRYLVIQGD
Sbjct:   927 SILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGD 986

Query:   956 ERMNLPSPTDSKFYRSLMEEEDMEDIVDADEYLIPHQGFFSSPSNSRTPLLSSLSATSDN 1015
             ERM+LPSPTDS FYR+LM+EEDMED+VDADEYLIP QGFF+SPS SRTPLLSSLSATS+N
Sbjct:   987 ERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNN 1046

Query:  1016 SAPVTCLDINGVHRVREDSFIQRYSSDPTRSCLDDSLDDGFLPAPEYMNQLAAKPPSVSV 1075
             S  V C++ NG  RV+ED+F+QRYSSDPT +  +D++DD FLP PEY+NQ   K P+ SV
Sbjct:  1047 ST-VACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSV 1105

Query:  1076 MQTPVYNNFSLPIEPNHVVDSNHQNPHNTALDNPEYLNTSLSPFANTIFDSSPFLGQKDN 1135
              Q PVY+N   P+ P    D ++QNPH+ A+ NPEYLNT+     ++ F+S     QK +
Sbjct:  1106 -QNPVYHN--QPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTCLSSGFNSPALWIQKGS 1162

Query:  1136 PQINLDNPDYQQDFLPNETKSNGFPKIPTAENPEYLRVATGKSEYIQA 1183
              Q++LDNPDYQQDF P ETK NG  K PTAEN EYLRVA   SE+I A
Sbjct:  1163 HQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPSSEFIGA 1210