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Gene Model: Bcat1

NomenclatureGenomic Location
SymbolBcat1Chromosome2
NameBranched-chain-amino-acid
aminotransferase		Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates2: 70 Mbp

Molecular Function

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.

2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.

2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.

Molecular Function Terms:

catalytic activity
   transferase activity
      transferase activity, transferring nitrogenous groups
         transaminase activity
            branched-chain-amino-acid transaminase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 CAGGCTGCTGATCTGATAATCAACCCATCCACCACTTTGAAAGAAAAACCCGACCCAAAT
    61 GGCTTGGTTTTTGGAACTGTTTTCACAGATAACATGCTATTCGTAGAGTGGTCGTTGACG
   121 TCCGGATGGGAGGCCCCTCATATCAAGCCGTTGGAGAACCTCTCTCTACATCCTGCTGTA
   181 TCAGCTTTTCACTATGCTGTAGAACTATTTGAAGGCATGAAGGCATACCGAGGAGTAGAT
   241 GGGAAAATCCGCTTTTTCCGACCAAGACTCAACATGGACAGGATGTTGCGGTCAGCTGTC
   301 CGAGCCACTTTGCCAGGATTTGACAAAGAAGAACTTTTGGAGTGCATCCGGAAACTGGTG
   361 GAAGTTGAAAAGGAGTGGGTGCCGTATTCGACCTCCGCTAGCTTGTATATTCGCCCTACT
   421 TTAATTGGGACAGAGCCCTCCCTCGGAGTCAAGAAGCCATCAAAGGCCATTCTCTATGTC
   481 ATATTGAGCCCTGTTGGTCCGTACTTCTCGAGTGGGACTTTCAGCCCCATATCCTTGTGG
   541 GCAGATCCGAAATACGTCCGAGCCTGGAAAGGAGGGACCGGGGACTGTAAACTGGGAGGG
   601 AACTATGGGTCTTCTATTTATGCCCAGCGTGAAGCTATGGAATTAGGATGCCAGCAGGTT
   661 CTCTGGCTTTATGGAGACGAGCATCAAATTACAGAAGTTGGGACCATGAATCTCTTTCTG
   721 TATTGGCGAAATGAAGATGGAGAAGAAGAGCTGGCAACCCCGCCTCTAGATGGCATCATT
   781 CTTCCTGGAGTGACAAGGCAAAGCATTTTGGACCTAGCGCGCAAGTGGGAAGAATTCAAA
   841 GTGTCCGAACGATACATTACCATGAGCGATCTCCAAGCTGCTTTAAAGGAAAACAGGGTG
   901 AAGGAGATGTTTGGAGCTGGGACAGCTTGTGTTGTGTGTCCTATTTCCACAATATTATAC
   961 CTAGGAGAGAATTTGCACATTCCAACCATGGAAAATGGACCTCAAATAGCTACCCGGTTT
  1021 TTGAACCAACTGAGTGATATCCAATATGGAAGAGAAGACAGTGAGTGGTCGGTTGTGGTA
  1081 TCATGA

Predicted Protein Product
QAADLIINPSTTLKEKPDPNGLVFGTVFTDNMLFVEWSLTSGWEAPHIKPLENLSLHPAV
SAFHYAVELFEGMKAYRGVDGKIRFFRPRLNMDRMLRSAVRATLPGFDKEELLECIRKLV
EVEKEWVPYSTSASLYIRPTLIGTEPSLGVKKPSKAILYVILSPVGPYFSSGTFSPISLW
ADPKYVRAWKGGTGDCKLGGNYGSSIYAQREAMELGCQQVLWLYGDEHQITEVGTMNLFL
YWRNEDGEEELATPPLDGIILPGVTRQSILDLARKWEEFKVSERYITMSDLQAALKENRV
KEMFGAGTACVVCPISTILYLGENLHIPTMENGPQIATRFLNQLSDIQYGREDSEWSVVV
S
Protein Alignment to Mouse
sp|P24288|BCAT1_MOUSE Branched-chain-amino-acid aminotransferase, cytosolic
            OS=Mus musculus GN=Bcat1 PE=2 SV=2
      MGI:104861 Bcat1 branched chain aminotransferase 1, cytosolic (Chr 6)
        Length = 386

 Score = 1501 (533.4 bits), Expect = 1.3e-154, P = 1.3e-154
 Identities = 272/358 (75%), Positives = 317/358 (88%)

Query:     1 QAADLIINPSTTLKEKPDPNGLVFGTVFTDNMLFVEWSLTSGWEAPHIKPLENLSLHPAV 60
             +A DLII P+T LKEKPDP+ LVFG  FTD+ML VEWS  SGWE PHIKP  NL +HPA 
Sbjct:    26 RAKDLIITPATVLKEKPDPDSLVFGATFTDHMLTVEWSSASGWEKPHIKPFGNLPIHPAA 85

Query:    61 SAFHYAVELFEGMKAYRGVDGKIRFFRPRLNMDRMLRSAVRATLPGFDKEELLECIRKLV 120
             S  HYAVELFEG+KA+RGVD KIR FRP LNMDRM RSAVR TLP FDKEELL+CI +L+
Sbjct:    86 SVLHYAVELFEGLKAFRGVDNKIRLFRPDLNMDRMCRSAVRTTLPMFDKEELLKCILQLL 145

Query:   121 EVEKEWVPYSTSASLYIRPTLIGTEPSLGVKKPSKAILYVILSPVGPYFSSGTFSPISLW 180
             ++++EWVPYSTSASLYIRPT IGTEPSLGVKKPSKA+L+VILSPVGPYFSSG+F+P+SLW
Sbjct:   146 QIDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPSKALLFVILSPVGPYFSSGSFTPVSLW 205

Query:   181 ADPKYVRAWKGGTGDCKLGGNYGSSIYAQREAMELGCQQVLWLYGDEHQITEVGTMNLFL 240
             A+PKY+RAWKGGTGDCK+GGNYG+S+ AQ EA+E GCQQVLWLYG ++QITEVGTMNLFL
Sbjct:   206 ANPKYIRAWKGGTGDCKMGGNYGASLLAQCEAVENGCQQVLWLYGKDNQITEVGTMNLFL 265

Query:   241 YWRNEDGEEELATPPLDGIILPGVTRQSILDLARKWEEFKVSERYITMSDLQAALKENRV 300
             YW NEDGEEELATPPLDGIILPGVTRQSIL+LA++W EFKV ER++TM DL  AL+ NRV
Sbjct:   266 YWINEDGEEELATPPLDGIILPGVTRQSILELAQQWGEFKVCERHLTMDDLATALEGNRV 325

Query:   301 KEMFGAGTACVVCPISTILYLGENLHIPTMENGPQIATRFLNQLSDIQYGREDSEWSV 358
             KEMFG+GTACVVCP+S ILY G+ LHIPTMENGP++A+R L +L+DIQYGR +S+W++
Sbjct:   326 KEMFGSGTACVVCPVSDILYKGQMLHIPTMENGPKLASRILGKLTDIQYGRVESDWTI 383